ライフサイエンスコーパス: prolonged exposure

1 forced by glucocorticoid, and continued with prolonged exposure.

2 Castleman's disease and well tolerated with prolonged exposure.

3 ough reductions in photoreceptor levels upon prolonged exposure.

4 apoptosis was observed at lower [DIDS] with prolonged exposure.

5 versible at a high NO concentration or after prolonged exposure.

6 in a virtual reality environment, even after prolonged exposure.

7 epress myometrial contractility is lost with prolonged exposure.

8 uvancy may be transient or require higher or prolonged exposure.

9 wer attrition and higher response rates than prolonged exposure.

10 epression may fare better with IPT than with prolonged exposure.

11 (a difference <12.5 points in CAPS score) to prolonged exposure.

12 domly assigned to 10 weeks of treatment with prolonged exposure (10 sessions) plus paroxetine (N=19)

13 clock transcriptional oscillations, whereas prolonged exposure (10 weeks) to LL disrupts islet circa

14 In contrast, prolonged exposure (24 h) of isolated hepatocytes to ins

15 In addition, prolonged exposure (6-7 min) to hypoxia ( = 11 +/- 1 mmH

16 ANOG, SOX2) remained unaffected, until after prolonged exposure (96 hrs).

17 CPT and prolonged exposure also outperformed waitlist and treatm

18 ed a randomized 14-week trial comparing IPT, prolonged exposure (an exposure-based exemplar), and rel

19 receptor (GLP-1R) potency and in obtaining a prolonged exposure and action of the GLP-1 analogue.

20 indicate a well-developed 'reef stage' with prolonged exposure and colonization of the bones prior t

21 exposure, dermal absorption of BPA leads to prolonged exposure and may lead to higher proportions of

22 ated in combination with pazopanib, allowing prolonged exposure and promising durable responses in pa

23 After week 10, patients discontinued prolonged exposure and were offered 12 additional weeks

24 30% in CAPS score, were 63% for IPT, 47% for prolonged exposure, and 38% for relaxation therapy (not

25 Further study of repeated exposure, prolonged exposure, and vulnerable subgroups is needed.

26 ent to 70% of participants receiving CPT and prolonged exposure attained clinically meaningful sympto

27 the incidence of these tumors plateaus with prolonged exposure, but the incidence of other skin canc

28 However, prolonged exposures can exacerbate respiratory failure.

29 During treatment, participants receiving prolonged exposure demonstrated greater improvement on t

30 ion along the intracellular route and, under prolonged exposure, desensitization.

31 CAPS outcomes for IPT and prolonged exposure differed by 5.5 points (not significa

32 We observed that prolonged exposure due to FcRn-mediated enhancement of h

33 nd in the cell number was observed after the prolonged exposure except for 5.0 g/L nZVI at which bact

34 Women who received prolonged exposure experienced greater reduction of PTSD

35 sessment was used to identify compounds with prolonged exposure following oral dosing.

36 er to achieve acceptable bioavailability and prolonged exposures for once-daily dosing, good colonic

37 A random subset of the prolonged exposure group (N=17) underwent single-pulse t

38 The prolonged exposure group was more likely than the presen

39 y, thymidine was restricted to patients with prolonged exposure (> 96 hours) to methotrexate (MTX) or

40 ated CFTR channels in excised patches during prolonged exposure (>5 min).

41 st-line trauma-focused interventions CPT and prolonged exposure have shown clinically meaningful impr

42 pies, cognitive processing therapy (CPT) and prolonged exposure, have been the most frequently studie

43 IPT and prolonged exposure improved quality of life and social f

44 ts the DNA-binding signature of ERalpha upon prolonged exposure in breast cancer.

45 m in human liver microsomes and which showed prolonged exposure in mice.

46 ose) through these composite coatings during prolonged exposure in PBS.

47 Capacity to benefit from prolonged exposure in PTSD is gated by the degree to whi

48 r agents, paclitaxel also displayed a unique prolonged exposure in sciatic nerve and DRG.

49 tion is the capacity of the amended AC after prolonged exposure in the field.

50 The intervention consisted of modified prolonged exposure including imaginal exposure to the tr

51 Prolonged exposure increased cell triglycerides, induced

52 erol) or synthetic agonists acutely or after prolonged exposure induces insulin hypersecretion.

53 These findings suggest that the modified prolonged exposure intervention initiated within hours o

54 Prolonged exposure is an effective treatment for PTSD in

55 modified peptide counterpart; however, after prolonged exposure it also caused liposome lysis.

56 ysfunction and loss of neuronal integrity on prolonged exposure of Abeta in cells transfected with al

57 Prolonged exposure of adenocarcinoma xenografts to andro

58 The authors have demonstrated that prolonged exposure of adult rabbit extraocular muscle (E

59 Prolonged exposure of beta-cells to cytokines or thapsig

60 Sharma and colleagues demonstrated that prolonged exposure of cancer cells to TKIs give rise to

61 Prolonged exposure of cartilage surfaces to stick-slip s

62 ant (CPA) chemicals and the damage caused by prolonged exposure of cells to these high concentrations

63 Prolonged exposure of cultured hepatocytes to insulin in

64 Here we provide evidence that prolonged exposure of cultured human airway smooth muscl

65 Prolonged exposure of cultures to 2.5 microM TMRM produc

66 We conclude that prolonged exposure of ECs to rapamycin increases p27(Kip

67 A(2A)ARs in regulating STAT protein levels, prolonged exposure of endogenous A(2A)ARs in endothelial

68 Furthermore, a prolonged exposure of hepatocytes to oleate decreased in

69 In the presence of p38 inhibition, prolonged exposure of hepatocytes to oleate failed to re

70 Prolonged exposure of hippocampal neurons to antibodies

71 Prolonged exposure of human gastric epithelial cells and

72 We found that prolonged exposure of human macrophages to TNF resulted

73 Prolonged exposure of human subcutaneous fibroblast cult

74 Prolonged exposure of islets to high concentrations of I

75 Together, our results show prolonged exposure of isolated hepatocytes to insulin su

76 halation with improved anti-cancer efficacy, prolonged exposure of lung-resident tumors to the antine

77 Prolonged exposure of mice to diet containing 0.1% 3,5-d

78 Here we found that prolonged exposure of naive wild-type mice to EE signifi

79 Prolonged exposure of NRVMs to LUF7244 or LUF7244 plus a

80 Prolonged exposure of porcine TM cells to a hyperoxic en

81 We further show that a prolonged exposure of primary hepatocytes to oleate elev

82 who may not respond to eculizumab will avoid prolonged exposure of such individuals to the infectious

83 s neutralization, supports the proposal that prolonged exposure of the bNAb epitope enabled the matur

84 ower and incomplete viral escape resulted in prolonged exposure of the bNAb epitope, which may in tur

85 al factors such as stressful experiences and prolonged exposure of the brain to addictive drugs promo

86 dest and required both prolonged fasting and prolonged exposure of the brain to insulin, raising doub

87 nance of chronic anxiety and pain induced by prolonged exposure of the CeA to CORT.

88 cerevisiae Grx5 purified aerobically, after prolonged exposure of the cell-free extract to air or af

89 Prolonged exposure of the central amygdala (CeA) to elev

90 e of enhanced susceptibility to MPER mAbs is prolonged exposure of the MPER neutralizing epitope duri

91 st likely as a result of the higher and more prolonged exposure of the sulfone derivative.

92 Here, we report that prolonged exposure of TRPV1 to agonists induces rapid re

93 Prolonged exposure of trypanosomes to AEE788 inhibited t

94 Moreover, prolonged exposure or increased levels of GSNO caused in

95 is possible that changes in the brain due to prolonged exposure or to the progression of dependence l

96 Prolonged exposure (PE) therapy has been shown to be hig

97 Patients treated with prolonged exposure plus paroxetine experienced significa

98 sure (10 sessions) plus paroxetine (N=19) or prolonged exposure plus placebo (N=18).

99 prolonged exposure was more efficacious than prolonged exposure plus placebo for PTSD related to the

100 erapy (a CBT) plus paroxetine (an SSRI) with prolonged exposure plus placebo in the treatment of terr

101 ombined treatment than patients treated with prolonged exposure plus placebo.

102 wever, mean posttreatment scores for CPT and prolonged exposure remained at or above clinical criteri

103 blocked border cell migration (BCM), whereas prolonged exposure resulted in the first documented acce

104 tely two-thirds of patients receiving CPT or prolonged exposure retained their PTSD diagnosis after t

105 However, higher concentrations of H2O2, or prolonged exposure, reversed these changes and led to an

106 On prolonged exposure, Semapimod causes accumulation of TLR

107 T (that included 481 patients) and 4 RCTs of prolonged exposure (that included 402 patients) met incl

108 The authors compared prolonged exposure therapy (a CBT) plus paroxetine (an S

109 ceived fourteen 60- to 90-minute sessions of prolonged exposure therapy (n = 31) or supportive counse

110 ors assessed changes in brain function after prolonged exposure therapy across three emotional reacti

111 Combined treatment medication and prolonged exposure therapy deserves further study in lar

112 In addition, there is a concern that prolonged exposure therapy for PTSD may exacerbate alcoh

113 We examined whether augmentation of prolonged exposure therapy for PTSD with DCS enhances tr

114 debilitating anxiety disorder, and, although prolonged exposure therapy has been proven effective, ma

115 Participants were randomly assigned to (1) prolonged exposure therapy plus naltrexone (100 mg/d), (

116 However, those in the prolonged exposure therapy plus naltrexone group had the

117 hange, -63.9% [95% CI, -73.6% to -54.2%] for prolonged exposure therapy plus naltrexone; -63.9% [95%

118 sure therapy plus naltrexone (100 mg/d), (2) prolonged exposure therapy plus pill placebo, (3) suppor

119 exone; -63.9% [95% CI, -73.9% to -53.8%] for prolonged exposure therapy plus placebo; -69.9% [95% CI,

120 Counselors previously naive to prolonged exposure therapy provided the treatments in a

121 elated PTSD experienced greater benefit from prolonged exposure therapy than from supportive counseli

122 Prolonged exposure therapy was composed of 12 weekly 90-

123 Prolonged exposure therapy was not associated with an ex

124 toms in all 4 groups, but the main effect of prolonged exposure therapy was not statistically signifi

125 Both veterans were treated with prolonged exposure therapy, which includes imaginal and

126 ly than nondepressed patients to drop out of prolonged exposure therapy.

127 ituximab suggest that increased doses and/or prolonged exposure times can improve the outcome of elde

128 re pronounced than that of control mice with prolonged exposure times.

129 uld be simultaneously transformed to ethene, prolonged exposure to 1,2-dichloroethane diminished the

130 nsformed into K(2)(H(2)O)(4)B(12)F(12) after prolonged exposure to 21 Torr H(2)O((g)) at 25 degrees C

131 lexes exhibited little photodegradation upon prolonged exposure to 400 nm light.

132 During prolonged exposure to a given motosensory gain, persiste

133 fect of DNA demethylation was transient, and prolonged exposure to a methylation inhibitor induced di

134 utralizing titers in response to intense and prolonged exposure to a primary measles case patient.

135 We combined visual adaptation, in which the prolonged exposure to a specific visual feature alters p

136 Our data show that prolonged exposure to a-syn oligomers, but not monomers

137 n and interaction of signaling pathways upon prolonged exposure to Abeta in model nerve cells express

138 ptors has been widely studied, the impact of prolonged exposure to Abeta on nAChR expression and sign

139 ells lacking this enzyme might be subject to prolonged exposure to adenosine, which has immunosuppres

140 After an immediate contraction, prolonged exposure to ADP causes BSM to become refractor

141 ed to date is achieved and maintained during prolonged exposure to air.

142 dala on excessive alcohol intake produced by prolonged exposure to alcohol and alcohol deprivation.

143 nes, alcohol consumption can be increased by prolonged exposure to alcohol, and it is unclear what ef

144 Prolonged exposure to alcohol, tobacco, and pathogenic a

145 Furthermore, after prolonged exposure to allergen, hyperplastic epithelial

146 Prolonged exposure to an AWC sensed odor in the absence

147 Here, we show that prolonged exposure to an enriched environment (EE) facil

148 cinated individuals following intense and/or prolonged exposure to an infected individual and may pre

149 appaB signaling components can be induced by prolonged exposure to an NF-kappaB-activating signal, su

150 malignant cells following 24-hour treatment, prolonged exposure to androgen was required to detect th

151 at Ang II acutely increases ENaC Po, whereas prolonged exposure to Ang II also induces translocation

152 permits a small fraction of cells to survive prolonged exposure to antibiotics.

153 organisms persist in ocular tissues despite prolonged exposure to antifungal agents.

154 ss in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to

155 Furthermore, prolonged exposure to BQCA markedly extended the lifespa

156 inute virus of mice (MVMp) virions following prolonged exposure to buffers containing 0.5 mM EDTA.

157 ist sensitivity of receptors desensitized by prolonged exposure to capsaicin.

158 Interestingly, prolonged exposure to catalytic inactive thrombin incuba

159 -nephrin(+) EVs ratio and may be mediated by prolonged exposure to cellfree HbF.

160 reventive role in breast cancer (BC) whereas prolonged exposure to chemically similar mammalian estro

161 can develop multidrug resistance (MDR) after prolonged exposure to chemotherapeutic drugs, which is a

162 rom macaque primary visual cortex (V1), that prolonged exposure to chromatic modulation reveals two f

163 hysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major p

164 rated a reduction in VMAT2 binding following prolonged exposure to cocaine.

165 These mechanistic insights support using prolonged exposure to cognitive novelty and/or oral beta

166 The impact of other risk factors, including prolonged exposure to combined antiretroviral therapy (c

167 Melatonin therapy or prolonged exposure to complete darkness reduces biliary

168 emble carcinoma-associated myofibroblasts on prolonged exposure to conditioned medium from MDAMB231 h

169 to progeny virion production, we found that prolonged exposure to COPI complex disruption through si

170 In rats, escalation occurs following prolonged exposure to cycles of alcohol intoxication, an

171 Prolonged exposure to dialysis before transplantation an

172 Prolonged exposure to diet-induced euglycemia improves r

173 Prolonged exposure to distorted feedback may cause this

174 Prolonged exposure to drugs of abuse, such as cannabinoi

175 ral feature of addictions or are a result of prolonged exposure to drugs of abuse.

176 Upon prolonged exposure to DT, cells with an abnormal morphol

177 Increased concentration of or prolonged exposure to Dyn A is neurotoxic and these dele

178 Intriguingly, prolonged exposure to either PF299804 or WZ4002 results

179 Prolonged exposure to environmental chemicals (ECs) can

180 After prolonged exposure to estradiol, P. aeruginosa adopted e

181 Given that prolonged exposure to estrogen and increased telomerase

182 evant to cardiomyopathies associated with 1) prolonged exposure to ET-1; 2) degeneration of T-tubules

183 We show that prolonged exposure to ethanol can promote an upregulatio

184 Analysis shows that prolonged exposure to ethyl acetate and several related

185 Adults with prolonged exposure to even moderate elevations in non-hi

186 With prolonged exposure to extreme high altitude (>5500 m), m

187 ZAMs to stimulate axon growth was transient; prolonged exposure to factors produced by ZAMs enhanced

188 As a consequence, prolonged exposure to FF depletes intracellular ATP, act

189 Importantly, prolonged exposure to FGF19, but not M70, led to the for

190 A prolonged exposure to finer particles can thus cause adv

191 Prolonged exposure to fluid shear stress alters leukocyt

192 Prolonged exposure to H2 O2 (200 mum, 60 min) induced ap

193 structure and gas sorption properties after prolonged exposure to heat and humidity.

194 on with Gram-negative bacterial pathogens or prolonged exposure to heat-killed Salmonella enterica, t

195 The impact of this prolonged exposure to high Ag loads on the functionality

196 Under prolonged exposure to high glucose conditions, alms1-def

197 In addition, prolonged exposure to high glucose further increases IL-

198 air defect was mimicked in cultured cells by prolonged exposure to high glucose.

199 mary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone.

200 Studies have also shown that such prolonged exposure to high-dose estrogen results in huma

201 Prolonged exposure to high-efficacy agonists results in

202 abdominal aorta risk scores, as a result of prolonged exposure to HIV and antiretroviral therapy.

203 rogram at the PD-1 locus becomes fixed after prolonged exposure to HIV virus.

204 s of these parasites are complex and involve prolonged exposure to host and vector defence mechanisms

205 ized material were fully retained even after prolonged exposure to hot liquid water.

206 these defects could be overcome by early or prolonged exposure to IL-2, or by addition of IL-12 to c

207 sence of IFN-gamma (Th1 inflammation) or the prolonged exposure to IL-4 (chronic Th2 inflammation) pr

208 ions, the effects on and mechanisms by which prolonged exposure to IL-6 alters HuMC numbers and funct

209 Initial EMT was induced by prolonged exposure to IL6, a cytokine also generated by

210 In more severe GVHD, prolonged exposure to immunosuppressive therapies, failu

211 Furthermore, our results showed that prolonged exposure to insulin caused oxidative stress, a

212 ose of lipogenic genes were increased by the prolonged exposure to insulin.

213 prevented insulin resistance induced by the prolonged exposure to insulin.

214 oM Ca2+ and that desensitizes in response to prolonged exposure to intracellular Ca2+.

215 In contrast, prolonged exposure to junk-food resulted in cross-sensit

216 Prolonged exposure to K5 ultimately led to apoptosis via

217 ouse compared with the wild type mouse after prolonged exposure to kainate.

218 High doses or prolonged exposure to ketamine increase neuronal apoptos

219 atment with nucleos(t)ide analogues, despite prolonged exposure to large loads of antigen.

220 sible in order to avoid damage to cells from prolonged exposure to laser radiation.

221 ion, especially for health care workers with prolonged exposure to LHR plume.

222 red responses to certain stresses, including prolonged exposure to low temperatures.

223 Prolonged exposure to lower LDL-C beginning early in lif

224 nge and is achieved by monocytic cells after prolonged exposure to LPS.

225 ing and phenotypic changes we observed after prolonged exposure to lumican.

226 Our results suggest that prolonged exposure to MEK or ERK inhibitors may not only

227 These metabolic adaptations to prolonged exposure to mild cold may lead to improved glu

228 Research on prolonged exposure to MJ and comprehensive risk characte

229 Only after prolonged exposure to more extreme water stress did acti

230 During prolonged exposure to morphine (two hours), action poten

231 these findings provide direct evidence that prolonged exposure to morphine induces homeostatic plast

232 Likewise, colonic inflammation related to prolonged exposure to morphine was significantly attenua

233 A static stimulus can seem to move after prolonged exposure to movement (the motion aftereffect),

234 Strikingly, prolonged exposure to mutant IDH1 results in irreversibl

235 of neuronal population activity showed that prolonged exposure to nicotine limited cholinergic signa

236 representation in auditory cortex, and that prolonged exposure to noise is necessary to produce this

237 eatures remained fully functional even after prolonged exposure to nonpolar solvents (20 min).

238 Overoxidation by prolonged exposure to O(2) or contact with H(2)O(2) or N

239 in wt but not betaarr-2 ko LC neurons after prolonged exposure to opioids.

240 s important to consider the possibility that prolonged exposure to other sensory stimuli will reveal

241 To investigate whether prolonged exposure to overweight during adult life incre

242 uctase NQO1, a detoxifying enzyme induced by prolonged exposure to oxidative stress.

243 Lower air temperature and prolonged exposure to oxygen resulted in greater degrada

244 ydrogen oxidation activity to both brief and prolonged exposure to oxygen.

245 We gave monkeys prolonged exposure to pairs of images presented in fixed

246 chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea o

247 tance mechanism in MET-amplified cells after prolonged exposure to PF2341066.

248 hosphatase, is required for viability during prolonged exposure to pheromone and acts through multipl

249 Prolonged exposure to phosphate is associated with endot

250 Prolonged exposure to polystyrene microplastics signific

251 We hypothesized that prolonged exposure to pro-oxidants in vehicle emissions

252 We observed that prolonged exposure to pro-oxidants in vehicle exhaust in

253 fficient autophagy for cytoprotection, while prolonged exposure to propofol induced cell apoptosis vi

254 Prolonged exposure to proteases and reductants produced

255 Prolonged exposure to proteases deproteinized the DNA, l

256 sters do not sinter or deactivate even after prolonged exposure to reactants at high temperature, and

257 studies for the ORR demonstrated that after prolonged exposure to reaction conditions, the Pt-bimeta

258 of-the-art platinum-carbon catalysts) during prolonged exposure to reaction conditions.

259 e combination of reduced nephron numbers and prolonged exposure to renal compensatory mechanisms (i.e

260 Each subject showed prolonged exposure to rFVIIIFc relative to rFVIII.

261 rotects sensory neurons and their axons from prolonged exposure to ROS.

262 Although prolonged exposure to serum during growth was needed for

263 amsters undergoes profound changes following prolonged exposure to short winter-like day lengths.

264 Prolonged exposure to silica can lead to the development

265 Prolonged exposure to some antiretroviral drugs might in

266 derstand and predict device service time for prolonged exposure to space environment.

267 tic distortions in gaze perception following prolonged exposure to static face images reveal dynamic

268 Prolonged exposure to stress leads to the activation of

269 However, they degrade under prolonged exposure to sunlight.

270 Finally, we observed that prolonged exposure to supraphysiological glucose concent

271 es were less pronounced, probably because of prolonged exposure to TDB found with lower-affinity CD3

272 ter discontinuation of TDF therapy, and more-prolonged exposure to TDF were associated with an increa

273 rolled, or LCMV CL-13, which leads to a more prolonged exposure to the boosting antigen.

274 ing and is defined as the process by which a prolonged exposure to the cold of winter results in comp

275 Certain plant varieties typically require prolonged exposure to the cold of winter to become compe

276 was only observed in select cell lines after prolonged exposure to the drug combination and was caspa

277 A double strand breaks being generated after prolonged exposure to the drug.

278 However, prolonged exposure to the neurotransmitter drives the re

279 However, prolonged exposure to the SASP causes a subsequent cell-

280 After prolonged exposure to the selective and potent CDK4/6 in

281 g evidence from animal studies suggests that prolonged exposure to these compounds may induce widespr

282 zole prophylaxis, there was no evidence that prolonged exposure to this antibiotic has a concurrent e

283 ive was to establish the safety threshold of prolonged exposure to trace amounts of gluten (ie, conta

284 nt tritium had become incorporated following prolonged exposure to tritiated water vapor (HTO) or tri

285 logical and neurobiological complications of prolonged exposure to vehicle emissions remain unknown.

286 alizing antibodies during infection requires prolonged exposure to viral variants.

287 e to temperatures warmer than T(c), and that prolonged exposure to warmer temperatures alters express

288 Prolonged exposure to winter cold enables flowering in m

289 Thus, prolonged exposures to IH mimicking sleep apnea are asso

290 play a role in respiratory plasticity after prolonged exposures to low oxygen.

291 tively slow with toxic manganese and require prolonged exposures to the metal.

292 als were then randomly assigned to immediate prolonged exposure treatment (N=36) or a waiting list co

293 nts were then randomly assigned to immediate prolonged exposure treatment (N=36) or a waiting list co

294 Neither prolonged exposure (up to 120 h) nor consideration of su

295 Initial treatment with paroxetine plus prolonged exposure was more efficacious than prolonged e

296 With prolonged exposure, we recorded additional responses in

297 group posttreatment effect sizes for CPT and prolonged exposure were large (Cohen d range, 0.78-1.10)

298 CPT and prolonged exposure were marginally superior compared wit

299 Acute and prolonged exposures were both associated with a large bu

300 f the nanofibrils in rats results in greatly prolonged exposure, with a constant oxyntomodulin bioact