ライフサイエンスコーパス: prolonged survival

1 f age; however, injection of WT FOXP3+ Tregs prolonged survival.

2 bacterial burden, attenuated pathology, and prolonged survival.

3 genes, and peripheral anti-miR-155 treatment prolonged survival.

4 nce and type I muscle fiber atrophy; it also prolonged survival.

5 ladder carcinoma and B16-melanoma growth and prolonged survival.

6 tastases now have the potential to achieve a prolonged survival.

7 markedly reduced leukemia burden in mice and prolonged survival.

8 nd of the study resulting in a significantly prolonged survival.

9 hearts significantly reduced heart mass and prolonged survival.

10 iated all symptoms of murine HLH and allowed prolonged survival.

11 reduced tumor burden, extended latency, and prolonged survival.

12 vels dramatically decreased tumor burden and prolonged survival.

13 ll-, NK cell-, and B cell-dependent means of prolonged survival.

14 l marrow function, reduced tumor burden, and prolonged survival.

15 ded to dexamethasone and was associated with prolonged survival.

16 vivo, along with decreased tumor burden and prolonged survival.

17 viral loads in peripheral organs and showed prolonged survival.

18 nal Lin28b deletion reduced tumor burden and prolonged survival.

19 , as evidenced by lower peak parasitemia and prolonged survival.

20 ormation, and Wnt7b expression, and markedly prolonged survival.

21 n lymphomas in vivo reduced tumor burden and prolonged survival.

22 with leukemic MCL; both were associated with prolonged survival.

23 SOX2 peptides delayed tumor development and prolonged survival.

24 on, decreased immune-mediated pathology, and prolonged survival.

25 anced accumulation of functional T cells and prolonged survival.

26 d tumors in vivo, abrogated tumor growth and prolonged survival.

27 ein concentrations in spinal cord tissue and prolonged survival.

28 downregulated Mcl-1, activated caspases, and prolonged survival.

29 y, normalization of behavioral deficits, and prolonged survival.

30 resulted in reduced tissue pathology and in prolonged survival.

31 trophy, reduced intracellular aggregates and prolonged survival.

32 lly, that patients with these responses have prolonged survival.

33 ersus tumor responses, tumor regression, and prolonged survival.

34 o phenformin as a single agent, resulting in prolonged survival.

35 omes the differentiation block, and leads to prolonged survival.

36 nt induced tumor reduction and significantly prolonged survival.

37 in tumor growth inhibition and significantly prolonged survival.

38 mmunotherapy group, corresponding with their prolonged survival.

39 ling in LSCs delayed disease progression and prolonged survival.

40 including a reduction in neuronal death and prolonged survival.

41 in an increased response to chemotherapy and prolonged survival.

42 s exchange, renal flow and urine output, and prolonged survival.

43 and STAT5 phosphorylation and significantly prolonged survival.

44 reduce infectious complications has greatly prolonged survival.

45 treatment stabilized nephritis and markedly prolonged survival.

46 /mTOR in these mice delayed tumor growth and prolonged survival.

47 tumor isolates with lapatinib- and obatoclax-prolonged survival.

48 acid and dehydroascorbic acid significantly prolonged survival.

49 lymphocytes lengthened disease duration and prolonged survival.

50 tibody and observed reduced tumor growth and prolonged survival.

51 cifications, with the resulting effect being prolonged survival.

52 ce; whereas, Nrf2(-/-)//gp91(phox-/-) showed prolonged survival.

53 significantly reduced tumor progression and prolonged survival.

54 ted with in vivo tumor growth inhibition and prolonged survival.

55 ults in human lung xenograft eradication and prolonged survival.

56 onizing radiation inhibited tumor growth and prolonged survival.

57 atumoral injection of G47Delta significantly prolonged survival.

58 tion attenuated GVHD-related weight loss and prolonged survival.

59 egulation of the activation marker CD69, and prolonged survival.

60 CR(+) ALL, ibrutinib treatment significantly prolonged survival.

61 revented neurodegeneration and significantly prolonged survival.

62 gosity of Atoh1 reduced tumor occurrence and prolonged survival.

63 T cell abundance, delayed tumour growth, and prolonged survival.

64 ayed a delayed weight loss and significantly prolonged survival.

65 tration of gemcitabine after tumor resection prolonged survival.

66 melanoma exhibit a slower tumour growth and prolonged survival.

67 radicated CD19-negative leukemia, leading to prolonged survival.

68 D2 suppression decreased leukemia burden and prolonged survival.

69 tal day 5 delayed neurological pathology and prolonged survival.

70 t changes in the tumor vasculature but still prolonged survival.

71 drive correlates with improved outcomes and prolonged survival.

72 potent antitumor responses and significantly prolonged survival.

73 IR2DS4*00101 was independently prognostic of prolonged survival.

74 l treatment modality that offers a chance of prolonged survival.

75 otection from pulmonary embolism, leading to prolonged survival.

76 ression of MYCN all reduced tumor growth and prolonged survival.

77 Conversion to resection is associated with prolonged survival.

78 )) significantly improved kidney disease and prolonged survival.

79 4, significantly attenuated tumor growth and prolonged survival.

80 nefit in cancer patients was mostly noted as prolonged survival.

81 ssion or low POMP expression associates with prolonged survival.

82 dneys long term, one demonstrated a modestly prolonged survival (11 days), and two rejected rapidly (

83 nterestingly, NZB IRF4(+/-) B1 cells exhibit prolonged survival, accelerated self-renewal, and defect

84 We found that RT significantly prolonged survival across the whole BC patient populatio

85 llular recruitment to the lungs but modestly prolonged survival after infection in Rag1(-/-) mice.

86 ontainment of the bacterial growth and their prolonged survival after primary infection, and upon sec

87 ic cancer cell growth and is associated with prolonged survival after surgery.

88 Prolonged survival after two-stage resection (TSR) of ad

89 f infection suppressed virus replication and prolonged survival, allowing the mice to make adaptive C

90 fits of immediate initiation of ART, such as prolonged survival and AIDS-free survival and increased

91 (+), ameliorated aspects of MSN dysfunction, prolonged survival and attenuated some motor phenotypes

92 phocytes therefore have qualities indicating prolonged survival and effector function favorable to im

93 , enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together

94 cholinesterase inhibitor neostigmine showed prolonged survival and improved outcome.

95 DAS181 prevented pneumonia and significantly prolonged survival and inhibited the IFV titer by > or =

96 rejection and recipient death; 3 mg and 5 mg prolonged survival and led to severe or moderate chronic

97 3B1, or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1-mutate

98 uencing, and concomitant palliative care has prolonged survival and made living with the disease more

99 Blood, Appelmann et al provide evidence for prolonged survival and prevention of resistance in a mou

100 Lactobacillus priming also resulted in prolonged survival and protection against the lethal seq

101 ective agonist before allo-HCT significantly prolonged survival and reduced GvHD severity in a TNFR2-

102 Finally, prophylactic M8 treatment in vivo prolonged survival and reduced lung viral titers of mice

103 deling microbiota with Lactobacillus reuteri prolonged survival and reduced multiorgan inflammation i

104 nINs), depleted of Treg cells, significantly prolonged survival and reduced PanIN progression (median

105 tinib/GlaxoSmithKline 1120212) significantly prolonged survival and reduced proliferation but did not

106 Treatment with a peptide antagonist of CXCR4 prolonged survival and reduced serum autoantibodies, spl

107 m amyloid P (SAP; pentraxin-2) significantly prolonged survival and slowed the development of BM fibr

108 me point in determining vaccine efficacy and prolonged survival and that BCG promotes the capacity of

109 in the brain, did not induce adverse events, prolonged survival, and cured a fraction of glioma-beari

110 xpression have significantly less nephritis, prolonged survival, and decreased infiltrating inflammat

111 d that crizotinib decreased tumor dimension, prolonged survival, and increased blood and tissue conce

112 In MMTV-ErbB2 transgenic mice, loss of Pak1 prolonged survival, and mammary tissues of such mice sho

113 of IkappaBalphaSR attenuated leukemogenesis, prolonged survival, and reduced myeloid leukemic stem ce

114 line chemoimmunotherapy approaches now offer prolonged survival, and there is a need to identify pati

115 ished tumors with ppp-TGF-beta significantly prolonged survival as compared with ppp-RNA or TGF-beta

116 but the difference did not translate into a prolonged survival benefit.

117 litinib combined with Navitoclax or BV alone prolonged survival but did not cure HDLM-2 tumor-bearing

118 ed that a single dose of 10 Gy significantly prolonged survival by 27% (P = 0.0002) but perifosine di

119 his case-control study seems to confirm that prolonged survival can be achieved in highly selected pa

120 1Delta/Delta mutant strain had significantly prolonged survival compared to that of mice infected wit

121 ed vessel density, delayed tumor growth, and prolonged survival compared with B20.

122 syngeneic NK cells reduced tumor growth and prolonged survival compared with controls receiving bort

123 iR-21 knockdown tumor-bearing mice exhibited prolonged survival compared with empty vector tumor-bear

124 d radiation therapy results in substantially prolonged survival compared with historical controls.

125 cruitment, enhanced bacterial clearance, and prolonged survival compared with infected WT mice, sugge

126 versus-host disease (GVHD) and significantly prolonged survival compared with MAC-transplanted recipi

127 BCR-ABL1-transduced AID(-/-) bone marrow had prolonged survival compared with mice transplanted with

128 ipients treated with 20-mg/kg 4SC-101 showed prolonged survival compared with placebo-treated animals

129 macologic treatment delayed tumor growth and prolonged survival compared with subjects receiving sing

130 antly delayed PanIN formation and ultimately prolonged survival compared with vehicle-treated control

131 ce are protected from renal disease and have prolonged survival compared with wild-type littermates;

132 MMP-2(-/-) mice showed reduced tumor burden, prolonged survival, decreased lung metastasis, and decre

133 tion, along with ameliorated weight loss and prolonged survival, depends on microbiota-enhanced IFNga

134 ll depletion by repeated CD20 mAb treatments prolonged survival during pristane-accelerated lupus in

135 Kit(W-sh/W-sh) mice showed a prolonged survival during the first few days after media

136 gen-challenged wild-type mice are capable of prolonged survival ex vivo, in contrast to eosinophils f

137 warranted because this regimen may allow for prolonged survival following LXT.

138 CD mouse model and found that statin therapy prolonged survival following pneumococcal challenge.

139 ve Lactobacillus species promotes robust and prolonged survival from an otherwise lethal infection wi

140 Improved therapeutic options and prolonged survival have further increased the need for s

141 SI-IPT 1 region inhibited brain invasion and prolonged survival in a glioblastoma multiforme model, p

142 and significantly inhibited tumor growth and prolonged survival in a human MM.1S plasmacytoma murine

143 Furthermore, this mutein prolonged survival in a model of graft-versus-host disea

144 n tumor xenografts and tumor regression with prolonged survival in a mouse model of lung adenocarcino

145 ption, correlating with tumor regression and prolonged survival in a mouse model of MYCN-driven neuro

146 tovaquone to mice inhibited tumor growth and prolonged survival in a murine model of multiple myeloma

147 T5 knockdown or PJ-68 treatment dramatically prolonged survival in a murine model of retroviral BCR-A

148 bined with temozolomide) was associated with prolonged survival in a prospective phase I/II trial enr

149 No blood pressure-lowering strategy prolonged survival in adults with diabetes and kidney di

150 glia substantially delayed disease onset and prolonged survival in ALS mice, suggesting that ALS-link

151 cell maturation, induced growth arrest, and prolonged survival in an AML mouse model.

152 tantly, an orally bioavailable PKC inhibitor prolonged survival in an experimental cerebral malaria m

153 kedly reduced tumor growth and significantly prolonged survival in association with Mcl-1 down-regula

154 B6.Mig(-/-) allografts had a 10-day prolonged survival in B6.H-2(bm12) recipients when compa

155 and B6.H-2(bm12) skin allografts had a 5-day prolonged survival in B6.Mig(-/-) versus wild-type recip

156 tosis of human EVI1-positive cell lines, and prolonged survival in both orthotopic xenograft models a

157 ression of miR33b inhibited tumor growth and prolonged survival in both subcutaneous and disseminated

158 ccines and immune checkpoint blockades, have prolonged survival in certain solid tumors and are being

159 ical data showing biochemical correction and prolonged survival in col7 -/- mice, we hypothesized tha

160 , culminating in suppressed tumor growth and prolonged survival in GBM-bearing mice after temozolomid

161 HIV-1) load, higher CD4(+) T-cell count, and prolonged survival in HIV-1 coinfected patients.

162 h GB virus type C (GBV-C) is associated with prolonged survival in HIV-1-infected individuals, and am

163 ro, and GBV-C coinfection is associated with prolonged survival in HIV-infected people.

164 lecules also decreased BTIC propagation, and prolonged survival in mice bearing orthotopic GBM xenogr

165 peg-Arg I plus chemotherapy agent Cytarabine prolonged survival in mice bearing T-ALL tumors.

166 ted that AS101 abrogated drug resistance and prolonged survival in mice receiving chemotherapy.

167 after alloHSCT decreased aGVHD severity and prolonged survival in mice.

168 further delayed development of MM tumor and prolonged survival in mice.

169 ding to reduced HPV(+) TC-1 tumor growth and prolonged survival in mice.

170 endent fashion, causing tumor regression and prolonged survival in mouse models.

171 ransplantation (HDT/ASCT) is a surrogate for prolonged survival in multiple myeloma; however, patient

172 owth and colony formation, and significantly prolonged survival in murine AML xenografts.

173 eatment leads to robust tumor regression and prolonged survival in pancreatic cancer xenografts and g

174 t, is associated with reduced metastasis and prolonged survival in pancreatic ductal adenocarcinoma (

175 The findings of prolonged survival in patients treated with concomitant

176 b, a monoclonal antibody VEGFR-2 antagonist, prolonged survival in patients with advanced gastric can

177 arine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disea

178 Salvage surgery was associated with prolonged survival in patients with lung-only and liver-

179 ecreased USP1 expression was associated with prolonged survival in patients with proneural glioblasto

180 ed and associated with durable responses and prolonged survival in patients with refractory metastati

181 wth in a xenograft model and correlates with prolonged survival in patients.

182 Furthermore, HPssCD-HET0016 significantly prolonged survival in PDX GBM811 model.

183 etastasis of human prostate cancer cells and prolonged survival in recipient mice.

184 Increased DNMT3B expression prolonged survival in retrovirally induced Myc-Bcl2- or

185 CXCR2, prevented HTR-elicited acute VOC and prolonged survival in SCD mice.

186 ls of Il1beta/18 and splenic cell death, and prolonged survival in septic Sharpin-deficient mice.

187 afts results in slower tumor growth rate and prolonged survival in the ABC-like DLBCL xenografts comp

188 , indicating that bb0449 is not required for prolonged survival in the nutrient-limited environment i

189 s, reduced spontaneous seizure frequency and prolonged survival in the Scn1a (+/-) mice.

190 the parent, the double mutant also exhibited prolonged survival in the stationary phase.

191 gnify immune surveillance as a mechanism for prolonged survival in these patients and indicate improv

192 s conventional, cisplatin-based chemotherapy prolonged survival in this model compared with chemother

193 Prolonged survival in this subgroup was supported by pos

194 Therapy with Z12-formulated vaccines prolonged survival in three robust tumor models, with th

195 at iron chelation therapy is associated with prolonged survival in transfusion-dependent MDS patients

196 ecreased tumor growth rate and significantly prolonged survival in vivo.

197 nduced regression of established tumors, and prolonged survival in xenograft and transgenic models of

198 ncidence might increase in the future due to prolonged survival observed after pancreaticoduodenectom

199 ve environment was maintained, with markedly prolonged survival of a second identical allograft.

200 ressed MET/CAT-induced tumor development and prolonged survival of animals with MET/CAT-induced HCC.

201 ore infection, transfer of hyperimmune serum prolonged survival of C3aR(-/-) mice.

202 mproved immune control by activated NK cells prolonged survival of CD27-trunc-expressing lymphoma-bea

203 Conversely, overexpression of PDKs prolonged survival of cells in suspension.

204 s; and 2) a weaker GVH/HVG in females allows prolonged survival of donor CD4 and CD8 T cells, allowin

205 mmune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts that m

206 These findings as well as the prolonged survival of f10(-/-) mutants will enable us to

207 rate to prevent immune attack, even enabling prolonged survival of foreign allografts without immunos

208 of Stat5 causes excessive granulopoiesis and prolonged survival of granulocytes in circulation.

209 pressing murine interleukin-12 (IL-12; M002) prolonged survival of immunocompetent mice in intracrani

210 y a reduction in tissue bacterial burden and prolonged survival of infected animals.

211 y, depletion of CD4(+) T cells abrogated the prolonged survival of infected CD8(-/-) mice, demonstrat

212 Anti-CD40 treatment also greatly prolonged survival of infected CII(-/-) mice.

213 nsplantation model, alloTregs but not nTregs prolonged survival of islet allografts without any other

214 gle systemic administration of MDSC markedly prolonged survival of islet allografts without requireme

215 Cotransplantation with WT MDSCs markedly prolonged survival of islet allografts, which was associ

216 (+) T cells or Foxp3(+) Treg cells exhibited prolonged survival of major histocompatibility complex (

217 uximab vedotin promoted tumor regression and prolonged survival of mice bearing previously reported U

218 mbination therapy inhibited tumor growth and prolonged survival of mice bearing the WU-BC4 line, but

219 oliferating cells in neurofibroma and MPNST, prolonged survival of mice implanted with human MPNST ce

220 and synergistically reduced tumor growth and prolonged survival of mice in 2 of the subcutaneous and

221 In contrast, the CD24-specific T-bodies prolonged survival of mice in which only a subpopulation

222 ily oral administration of 20g significantly prolonged survival of mice injected intravenously with B

223 erapy with compound 7 and gammadelta T cells prolonged survival of mice inoculated with either human

224 showed that (90)Y-DOTA-biotin significantly prolonged survival of mice treated with pretargeted anti

225 injection of T-bodies reduced tumor size and prolonged survival of mice with orthotopically transplan

226 In addition, the HSP90 inhibitor AUY922 prolonged survival of mice xenografted with primary huma

227 eukemia onset, reduced CNS infiltration, and prolonged survival of mice.

228 creased Jo2-induced liver cell apoptosis and prolonged survival of mice.

229 of PSMA-expressing tumors, and significantly prolonged survival of mice.

230 , resulting in reduced tumor progression and prolonged survival of mice.

231 -free (GF) donors and recipients resulted in prolonged survival of minor antigen-mismatched skin graf

232 ction by T cells and upon transfer no longer prolonged survival of MRL.Fas(lpr) mice.

233 ALT-803 treatment also significantly prolonged survival of myeloma-bearing mice and provided

234 Chemotherapy combined with Natalizumab prolonged survival of NOD/SCID recipients of primary ALL

235 lumican and its presence is associated with prolonged survival of patients with localized PDAC.

236 The prolonged survival of patients with stable, compensated

237 Treatment with high-dose IE prolonged survival of patients with uveal melanoma who r

238 mately lead to improved immune therapies and prolonged survival of patients.

239 s PEL cell death, resulting in significantly prolonged survival of PEL-bearing mice.

240 The studies demonstrated prolonged survival of rats subjected to hemorrhagic inju

241 ransient H57-597 mAb treatment significantly prolonged survival of skin allografts in naive recipient

242 delayed denervation of hindlimb muscles, and prolonged survival of spinal motor neurons.

243 ater therapeutic efficacy as demonstrated by prolonged survival of the mice compared with either mIL-

244 dney grafts from LTT animals showed markedly prolonged survival of the naive renal grafts (day 28, >1

245 nkage, restoration of immune competence, and prolonged survival of TRAMP mice, repeated boosting did

246 d pre-B ALL cells in vitro and significantly prolonged survival of transplant recipient mice in vivo.

247 deficiency (ob/ob) increased lipogenesis and prolonged survival of Trex1(-/-) mice without dampening

248 nhibition of mTORC1 by rapamycin resulted in prolonged survival of Tsc1c/cSM22cre+/- mice, with regre

249 LNPs induced gene silencing in MCL cells and prolonged survival of tumor-bearing mice with no observe

250 f memory cells from this combination therapy prolonged survival of tumor-bearing recipients.

251 edly protected against I/R, improved LR, and prolonged survival of tumor-laden mice.

252 Erlotinib prolonged survival of unselected patients with advanced

253 hatch; however, intrabursal injection of PE prolonged survival of VLR(PE)Tmu(+) bursal and periphera

254 linical factors associated with survival and prolonged survival (of at least 10 years).

255 The pathogenic strain exhibited prolonged survival on stainless steel surfaces compared

256 yte-dependent primary tumor growth delay and prolonged survival only in T-cell-inflamed tumor models

257 rveillance was associated with significantly prolonged survival (OR 1.90, 95% CI 1.67-2.17), which re

258 ol, resulting in tumor growth inhibition and prolonged survival over paclitaxel alone.

259 ulting double knockout mice exhibit slightly prolonged survival over RIP1-deficient animals.

260 t decrease in leukemic burden (P < .001) and prolonged survival (P < .01) was observed compared with

261 T) and AG genotype of rs2279343 (c.785A > G) prolonged survival (p < 0.05).

262 as a continuous variable was associated with prolonged survival (P = .042).

263 This prolonged survival providing a longer window for initiat

264 nt cell transplant or zileuton treatment had prolonged survival, reduced GVHD clinical scores, reduce

265 ve to the wild-type strain, as manifested by prolonged survival, reduced pulmonary fungal burden and

266 radiotherapy (SRS and/or WBRT) and TKIs have prolonged survival, suggesting that interventions to con

267 a higher lymph node yield, and resulted in a prolonged survival than THE in pT3, cT3, and node-positi

268 ations show that this strategy can result in prolonged survival that is substantially greater than th

269 ing IL-23 in the absence of IL-12 manifested prolonged survival that was IL-17 dependent.

270 IR prolonged survival; the mean number of life-years per pa

271 resulting in lengthened disease duration and prolonged survival; the stable disease phase was extende

272 growth of Hh-associated medulloblastoma and prolonged survival through inhibition of cell proliferat

273 xenografts to radiotherapy and significantly prolonged survival, thus suggesting the likelihood of tr

274 early times after infection in WT mice and a prolonged survival time in immunocompromised Ifnar1(-/-)

275 xposed to total venom or purified porin, and prolonged survival time in mice following venom injectio

276 apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue

277 latelet activation prevented sudden death or prolonged survival time via the suppression of the acute

278 f tumors in 4 of 5 cases and a significantly prolonged survival time, compared with untreated control

279 of bacteremia at 12 h postinfection and had prolonged survival times compared with the saline-treate

280 STN prolonged survival times of non-human primate kidney all

281 caudal levels of the spinal cord even after prolonged survival times.

282 patient derived xenografts of GBM811, showed prolonged survival to 26 weeks in animals treated with f

283 Importantly, glycOMVs significantly prolonged survival upon subsequent challenge with F. tul

284 reduction in splenomegaly had significantly prolonged survival versus those with < 25% reduction (P

285 This prolonged survival was associated with increase in numbe

286 Prolonged survival was associated with metastases in few

287 idation with transplantation strategies, and prolonged survival was observed in a proportion of patie

288 e of anaplastic oligodendroglioma as well as prolonged survival was observed.

289 Prolonged survival was only achieved in a few patients i

290 or by trafficking from the bone marrow or by prolonged survival, was correlated with the homing of c-

291 ng positive results in terms of response and prolonged survival were determined using receiver operat

292 Synergistic antitumor efficacy and prolonged survival were noted in human orthotopic pancre

293 e VWF D'D3-Fc chimera also exhibits markedly prolonged survival when transfused into FVIII-deficient

294 tic and led to complete tumor resolution and prolonged survival, which was dependent on the presence

295 ven their elevated risk for many cancers and prolonged survival with immunosuppression, ART exposure,

296 representative B-ALL xenografts demonstrated prolonged survival with rapamycin treatment compared wit

297 Here, we demonstrate that GBS shows prolonged survival within J774 macrophages and that the

298 -1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) prolonged survival without any apparent toxicities.

299 neoplastic cells, resulting in significantly prolonged survival without myelosuppressive or immunosup

300 ial antitumor immune responses, resulting in prolonged survival without toxic effects.