ライフサイエンスコーパス: promiscuity

1 an be presented by multiple alleles (epitope promiscuity).

2 loss, evolution of substrate preference and promiscuity.

3 ferases that often show broad sugar acceptor promiscuity.

4 inversely correlated with AhR ligand-binding promiscuity.

5 providing a structural explanation for AI4's promiscuity.

6 d for the tolerance of enzymes to metabolite promiscuity.

7 which is likely a result of their functional promiscuity.

8 etoxication enzymes, which exhibit catalytic promiscuity.

9 exhibit equivalent levels of T cell epitope promiscuity.

10 the effect of physicochemical parameters on promiscuity.

11 at the condom machines led to an increase in promiscuity.

12 interactions responsible for this selective promiscuity.

13 that can be re-engineered to increase intein promiscuity.

14 rstanding both pocket promiscuity and ligand promiscuity.

15 alleles, referred to as an epitope's binding promiscuity.

16 between COX isoforms that explain substrate promiscuity.

17 ich implies an impressive level of substrate promiscuity.

18 cided to perform a systematic study on their promiscuity.

19 at are generally responsible for introducing promiscuity.

20 ses may be a stronger predictor of inhibitor promiscuity.

21 ss was maximal under conditions of catalytic promiscuity.

22 gle enzymes with varying levels of catalytic promiscuity.

23 jects with different HLA alleles, indicating promiscuity.

24 ledge the biological importance of catalytic promiscuity.

25 d kinase inhibitors, with a wide spectrum of promiscuity.

26 loaded WT1 peptide, indicative of Ag-binding promiscuity.

27 enzymes have retained substrate and reaction promiscuity.

28 suggests a thermodynamic basis for catalytic promiscuity.

29 of tools to quantitatively assess catalytic promiscuity.

30 n also assess enzyme binding specificity and promiscuity.

31 d a reassessment of the therapeutic value of promiscuity.

32 active sites, these inhibitors often exhibit promiscuity.

33 d elsewhere to understand the ligand-binding promiscuity.

34 B. anthracis arginase displays unusual metal promiscuity.

35 circle of increasing male fatigue and female promiscuity.

36 y in ligand-receptor interactions as well as promiscuity.

37 ther regions of the human PrP(c) to increase promiscuity.

38 at demonstrate specificity in the context of promiscuity.

39 ed off-target metabolism arising from enzyme promiscuity.

40 ns, while also leading to pro-B cell lineage promiscuity.

41 te a potentially valuable source of chemical promiscuity.

42 lexibility may enhance T cell receptor (TCR) promiscuity.

43 le sites in manifesting such pharmacological promiscuity.

44 pensation, lipophilic ligand efficiency, and promiscuity.

45 erface to binding affinity, specificity, and promiscuity.

46 ous scaffolds with very different degrees of promiscuity.

47 gsIJK, which possessed significant substrate promiscuities.

48 t is successfully prevented by female sexual promiscuity, a paternity dilution strategy.

49 tructural plasticity in the groove generates promiscuity allowing accommodation of hundreds of differ

50 c mechanistic understanding is confounded by promiscuity among E3 ligase/substrate interactions and u

51 for studies of correlation between substrate promiscuity and an enzyme's activity toward its most-fav

52 s of performing counter-screens for bioassay promiscuity and assay interference, and raise caution ab

53 Both promiscuity and dependence on F1760 seen in Nav1.5 were

54 ed undesirable, but the combination of their promiscuity and difficulties associated with optimizing

55 istic features that underline this converged promiscuity and how this promiscuity drove the parallel

56 bpA-X provides additional insight into anion promiscuity and importance.

57 promiscuous activity, Ca(2+) suppresses the promiscuity and induces high cleavage fidelity.

58 The extent of AID's promiscuity and its predilection for immunoglobulin gene

59 vide insights into understanding both pocket promiscuity and ligand promiscuity.

60 Wanting to understand how catalytic promiscuity and other factors may influence evolution ac

61 Binding promiscuity and plasticity allow IDPs to interact with m

62 By exploiting substrate promiscuity and protein engineering, the scope of reacti

63 a molecular basis for either selectivity or promiscuity and provides a benchmark for experimental de

64 say can have utility for predicting compound promiscuity and should complement predictive methods tha

65 our study provides the structural basis for promiscuity and specificity of Epa adhesins, which might

66 Catalytic promiscuity and substrate ambiguity are keys to evolvabi

67 ivities of proteins, which reflect catalytic promiscuity and substrate ambiguity, are plausible start

68 Enzyme promiscuity and the large number of enzymes with unknown

69 opy, an overall measure of signaling pathway promiscuity, and computable from integrating a sample's

70 ts the first example of photo-induced enzyme promiscuity, and highlights the potential for accessing

71 biases and promotes helping; and sib-mating, promiscuity, and reproductive autonomy also modulate the

72 rinciples and properties of enzyme function, promiscuity, and repurposing provides lessons for engine

73 Overall, we suggest that catalytic promiscuity, and the ease or difficulty of remodeling an

74 The ligand promiscuity appears to be an adaptation to match a broad

75 ffinity (<500 nM), a level of ligand-binding promiscuity approaching the level of heat shock protein

76 rase) isoforms with high specificity or high promiscuity are compared.

77 Two quantitative measures of domain promiscuity are introduced and applied to the analysis o

78 ombination therapies, discuss potential drug promiscuity arising from off-target effects, comment on

79 moiety, but could show increasing substrate promiscuity as a function of the distance of the modific

80 other's reactions, consistent with catalytic promiscuity as an important driver in the evolution of n

81 e roles of substrate ambiguity and catalytic promiscuity as drivers of evolution, and the challenges

82 This network displays both specificity and promiscuity, as some bHLH proteins, DNA sequences, and t

83 nd P1 residue types, as well as the relative promiscuity at P3 and on the P' side of the scissile bon

84 tory evolution for the purpose of predicting promiscuity at the genome scale.

85 d biochemical data provide insight into dNTP promiscuity at the secondary allosteric site and how enz

86 demonstrate the plausibility of this second, promiscuity-based model.

87 en ligand and kinase target actually fosters promiscuity because of the high conservation of the part

88 One of these FAPs also exhibits considerable promiscuity, binding with high affinity to several other

89 re, we explore the limits of this remarkable promiscuity by mapping two denatured proteins with very

90 Female promiscuity can generate postcopulatory competition amon

91 arative enzymology and analysis of catalytic promiscuity can provide mechanistic and evolutionary ins

92 Promiscuity cliffs provide immediate access to such modi

93 On the basis of our analysis, we introduce "promiscuity cliffs" as pairs of structural analogs with

94 ecks, we recorded increased levels of female promiscuity compared with noninbred controls, most likel

95 work entropy, a measure of signaling pathway promiscuity, computable from a sample's genome-wide expr

96 This suggests that binding promiscuity confers kinetic advantages to NTF2 by expedi

97 neered variants of GSTA1-1 and the catalytic promiscuity correlates strongly with characteristics of

98 Promiscuity counts allow for a better understanding of a

99 nient or efficient method to obtain in-depth promiscuity counts for compounds.

100 ervices to interact with PubChem and provide promiscuity counts in a variety of categories along with

101 In principle, widespread polyandry (female promiscuity) creates potential for sexual selection in m

102 Levels of promiscuity (defined as the probability of two of an adu

103 ing entropy, a measure of signalling pathway promiscuity derived from a sample's genome-wide gene exp

104 striking feature of this process is the vast promiscuity displayed by PBPs in tolerating entirely unn

105 results indicate that differences in epitope promiscuity do not account for the observed differences

106 line this converged promiscuity and how this promiscuity drove the parallel divergence of organophosp

107 A series of promiscuity, druglike, and ADMET filters were applied to

108 replacements were found to lead to dramatic promiscuity effects.

109 al plasticity appear to contribute to BLIP's promiscuity, enabling it to respond to mutations at the

110 uity is low; and that intermediate levels of promiscuity favour kin discrimination.

111 PubChem promiscuity fills this gap.

112 ly, bank voles (BV) exhibit an unprecedented promiscuity for diverse prion isolates, arguing that ban

113 ure druglike chemical space, consider ligand promiscuity for hit and lead finding, and provide fresh

114 ferent reactions but often exhibit catalytic promiscuity for one another's reactions, consistent with

115 use an unprecedented mechanism of substrate promiscuity for the production of numerous and diverse l

116 acids onto bacterial cell surfaces with vast promiscuity for the side-chain identity.

117 The site-dependent promiscuity forms a foundation to better understand Nav

118 nerations were reintroduced to sociality and promiscuity (free mate choice), they adapted within two

119 ular structures that are predicted by enzyme promiscuity from canonical pathways.

120 principles to infer the roles of functional promiscuity, gene dosage, gene duplication, point mutati

121 c engineering, and a continuing trend of CYP promiscuity generating complex networks in terpenoid bio

122 However, chiral promiscuity has been identified for a number of enzyme f

123 drugs for complex disorders, unintended drug promiscuity has detrimental contribution to side effects

124 ace and physical features of this side chain promiscuity have not been determined systematically.

125 However, the molecular details of this promiscuity have remained elusive.

126 Some insights into this high-promiscuity/high-affinity behavior and its impact on imm

127 t is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to cat

128 activity regulation, feedback, and catalytic promiscuity impede our understanding of context-dependen

129 alism, we have analyzed patterns of compound promiscuity in a publicly available small molecule micro

130 o examine the mechanisms responsible for the promiscuity in AhR ligand binding, we determined the eff

131 acteristics of a primitive enzyme, including promiscuity in binding of substrate and cofactor, format

132 neity, and driven by the degree of signaling promiscuity in cells.

133 ships between physicochemical properties and promiscuity in detail.

134 ere was no consistent difference or trend in promiscuity in epitopes contained in HIV, M. tuberculosi

135 Moreover, the role of catalytic promiscuity in evolution can now be studied by looking a

136 ine the relationship between flexibility and promiscuity in five PDZ domains: the human Dvl2 (Disheve

137 s, which can lead to distinct structures and promiscuity in functions.

138 The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific

139 nclusions will help understand the notion of promiscuity in protein-protein interaction networks.

140 Promiscuity in recruiting TBK1 via independent signals m

141 ich is not expected from currently perceived promiscuity in RNA-RNA interactions.

142 it a high level of catalytic proffciency and promiscuity in structurally similar active sites.

143 ay, representing another example for pathway promiscuity in Sulfolobus species.

144 ibe an approach toward exploring such enzyme promiscuity in the space of a metabolic network.

145 allosteric mechanism of InrS permits greater promiscuity in vitro than CsoR.

146 l, in part, because it has marked functional promiscuity in vitro.

147 phingolipid synthesis and generate catalytic promiscuity, incorporating alanine or glycine into the p

148 the mature protein N terminus affects export promiscuity, independent of the effect of the folding st

149 Some domains appear to have attained promiscuity independently in different lineages, for exa

150 at which a compound was active was used as a promiscuity index.

151 Promiscuity indices also allowed for studies of correlat

152 Promiscuity indices were calculated for three different

153 The promiscuity inherent to minor groove DNA recognition rat

154 and should enable future efforts to engineer promiscuity into other naturally split inteins.

155 A promiscuity investigation of the thymidylyltransferase C

156 an bind other non-native sequences, and this promiscuity invites the possibility for rational design

157 e-magnitude differences in apparent compound promiscuity involving between 50 and 97 unrelated target

158 Substrate promiscuity is a hallmark of P-gp activity, thus a struc

159 The study of compound promiscuity is a hot topic in medicinal chemistry and dr

160 We propose that this promiscuity is a molecular mechanism of adaptation to li

161 However, catalytic promiscuity is a poorly understood property, and no ther

162 Overall, these results suggest that promiscuity is a unifying feature across taxa in explain

163 tionary reconstructions indicate that domain promiscuity is a volatile, relatively fast-changing feat

164 ering substrate specificities; for each, the promiscuity is altered so that d-ribulose 5-phosphate is

165 relationship between protein flexibility and promiscuity is an area of active research and is perhaps

166 Understanding protein promiscuity is becoming increasingly important not only

167 ingly identified, but the molecular basis of promiscuity is currently only little understood.

168 The mechanism underlying this promiscuity is derived from the fact that SRs share comm

169 Surprisingly, this promiscuity is less problematic than one would have imag

170 erative species, helping is more common when promiscuity is low; and that intermediate levels of prom

171 This enhanced substrate promiscuity is not accompanied by significant changes in

172 On the basis of our analysis, promiscuity is not an inherent feature of molecular scaf

173 It is now shown that this enzymatic promiscuity is not exclusive to side chains, but that C-

174 ognition is thought to be essential, whereas promiscuity is often associated with unwanted side effec

175 Enzyme promiscuity is typically studied experimentally using mu

176 A quantitative index of catalytic promiscuity is used to compare engineered variants of GS

177 ry sexual selection (PSS), fuelled by female promiscuity, is credited with the rapid evolution of spe

178 d as NDM-1, represents an example of extreme promiscuity: It hydrolyzes and inactivates nearly all kn

179 ative behaviour is favoured by low levels of promiscuity leading to high within-group relatedness.

180 etabolome databases in addition to an enzyme promiscuity library.

181 roteins, as both high stability and enhanced promiscuity (likely contributors to high evolvability) a

182 of the coexistence of high levels of female promiscuity, low paternity, and costly male care, and em

183 ity assurance: despite high levels of female promiscuity, males of a marine snail provide exclusive,

184 ically irrelevant activity, highlighting how promiscuity may be an evolutionary vestige of ancestral

185 In this regard, drug promiscuity may be leveraged to interfere with multiple

186 ere ineffective sulfatases, and this limited promiscuity may have provided a driving force for foundi

187 ights into the dynamic reaction cascades and promiscuity mechanisms of class I terpene synthases.

188 UGGT may therefore endow the enzyme with the promiscuity needed to recognize and reglucosylate its ma

189 ncies for correct dNMPs (leading to relative promiscuity) not because of a more open NBP but because

190 Recent experimental evidence suggests that promiscuity, not only in interactions but also in the ac

191 uences and derived peptides revealed agonist promiscuity, not only within, but also between aGPCR sub

192 s, these break new ground in sequence space: promiscuity now connects enzymes with only distantly rel

193 sporter, adopt a canonical binding mode with promiscuity obtained via differential packing in the bin

194 ool to explore the sequence requirements and promiscuities of orthogonal CRISPR-Cas systems in rapidl

195 a split reporter protein, we have tested the promiscuity of a panel of reported kinase inhibitors aga

196 genesis, for altering the proficiency and/or promiscuity of a secondary metabolite glycosyltransferas

197 ing studies reveal that the superb substrate promiscuity of AMEs allows the resistant bacteria to cop

198 We exploited the promiscuity of bacterial transpeptidases to develop a no

199 ed for exhaustive mass spectra matching, the promiscuity of binding of cisplatin to ubiquitin is reve

200 Our hypothesis accounts for the Na(+)/H(+) promiscuity of bioenergetic proteins, as well as the dee

201 Given the binding promiscuity of C1q's globular region (gC1q), we hypothes

202 These data demonstrated the broad substrate promiscuity of Cps2L, with kcat/Km changes for monofluor

203 o unravel the structural basis for substrate promiscuity of dCK at both the nucleoside acceptor and n

204 The promiscuity of DNA repair enzymes is particularly import

205 rely on the inherent or engineered substrate promiscuity of each amide synthetase.

206 The promiscuity of EcRppH differentiates it from its Bacillu

207 New insights were gained into the binding promiscuity of enzymes within the prokaryotic L-rhamnose

208 We then analyzed binding promiscuity of epitopes derived from HIV and M. tubercul

209 We also analyzed promiscuity of epitopes from Streptococcus pyogenes, whi

210 10 of the complexes provide evidence of the promiscuity of ExBox(4+) for the various PAHs.

211 Anion promiscuity of FbpA in the diverse composition of the pe

212 ator of the receptor binding specificity and promiscuity of FGFs.

213 oration of timely wound healing, rather than promiscuity of IL-6 with an alternate receptor.

214 These data highlight the promiscuity of influenza viruses and the need for dilige

215 The actions of TIRAP depend on the promiscuity of its phosphoinositide-binding domain.

216 The innate promiscuity of kinase inhibitors largely results from AT

217 Because of the inherent promiscuity of kinase inhibitors, our results suggest th

218 ACKR2 displays promiscuity of ligand binding and is capable of interact

219 41 was achieved to investigate the substrate promiscuity of MarG.

220 kinetic traps, providing a rationale for the promiscuity of Mia40.

221 of redundancy among miRNAs, coupled with the promiscuity of miRNA binding sites in the transcriptome,

222 and molecular modeling has suggested reduced promiscuity of ML351 compared with ML127.

223 Given the promiscuity of most tyrosine kinases, it is remarkable t

224 In order to study the promiscuity of MtTPS5, (2Z,6E)-FDP, an analogue of presu

225 4-Me-7-NO2-L-Trp uncovered remarkable regio-promiscuity of nitration biocatalysts.

226 Promiscuity of pattern recognition receptors, such as re

227 rgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous protein

228 ounterparts but can show specific off-target promiscuity of potential clinical importance.

229 NA was strain dependent, showing a different promiscuity of prion strains in cofactor utilization.

230 To investigate the catalytic promiscuity of ProcM, we chose four prochlorosins previo

231 The promiscuity of respiratory electron transfer reactions c

232 similar between aGPCRs allowing for agonist promiscuity of several Stachel-derived peptides.

233 To determine potential functional promiscuity of similar DNA binding domains, we replaced

234 inding affinity between GAS6 and AXL and the promiscuity of small molecule inhibitors represent impor

235 eet such as face inversion by exploiting the promiscuity of strand-strand interactions.

236 stion, we compared the in silico HLA binding promiscuity of T cell epitopes from pathogens with disti

237 Substrate promiscuity of terpene synthases provides organism acces

238 Promiscuity of terpene synthases results in the enormous

239 rom several directions including the binding promiscuity of TFs and the intrinsically disordered natu

240 in nature and also demonstrates the receptor promiscuity of the A. orientalis sulphur-delivery system

241 ism and raising questions about the reported promiscuity of the AHR.

242 The promiscuity of the amide synthase of S. hygroscopicus wa

243 gp120 demonstrated that the antigen-binding promiscuity of the antibody compensates for the molecula

244 The promiscuity of the aptamer can also be used to distingui

245 Studies focused on the inherent promiscuity of the biosynthetic machinery elucidated a m

246 ue specificity, departing from the ancestral promiscuity of the bone morphogenetic protein subfamily,

247 artificial metalloenzymes that exploits the promiscuity of the central hydrophobic cavity of the tra

248 the incompatibility is due to the functional promiscuity of the DNA-binding protein ParRpB171, which

249 In this work we took advantage of this promiscuity of the enzyme to gain insight into the mecha

250 Given the promiscuity of the enzymes involved, it has not yet been

251 e benzoyl-CoA pathway, apparently due to the promiscuity of the enzymes involved.

252 teristics of peptide binding specificity and promiscuity of the five PDZ domains.

253 otype is probably attributable to functional promiscuity of the HNF1beta transcription factor, involv

254 usly characterized and is likely a result of promiscuity of the HPr binding interface.

255 ceL-TerL intein, indicating a high degree of promiscuity of the Int(C) fragment of the GOS-TerL intei

256 Substrate promiscuity of the most active chimera was further asses

257 y demonstrated the substrate and cosubstrate promiscuity of the wild-type human ChAT (hChAT).

258 esign highly specific siRNAs by limiting the promiscuity of their seed sequences (positions 2-8 of th

259 atform accounts for the remarkable substrate promiscuity of these domains.

260 d activation barriers suggest that the broad promiscuity of these enzymes arises from cooperative ele

261 On the basis of the substrate promiscuity of this enzymatic assembly line, several pac

262 Results presented herein demonstrate the promiscuity of this last step by means of a set of "comp

263 he first example of exploiting the catalytic promiscuity of transaminases as a tool for novel transfo

264 requirements and explore the differences in promiscuity of two pyridine synthases, TclM and TbtD, ul

265 l genetic mutations that reveal the rampant "promiscuity" of genotype-phenotype relationships.

266 The origin of the selectivity (or promiscuity) of the metal-ion-mediated base pairing is d

267 be approximated by computing the signalling promiscuity, or entropy, of a cell's transcriptome in th

268 isplays both enhanced activity and substrate promiscuity over a chemical library of 313 ncAAs.

269 Domain promiscuity positively correlates with the number of exp

270 ation often occurs between non-relatives and promiscuity rates are among the highest recorded.

271 These data establish how promiscuity, rather than specificity, can be a beneficia

272 To characterize this potential promiscuity, reactivity of the T cell clones against 400

273 As a result of this promiscuity, reassignment of the CUN codon box from leuc

274 thermore, these findings suggest that T-cell promiscuity reflects a novel form of T-cell avidity matu

275 which predicts that overlapping patterns of promiscuity result from sharing a common multifunctional

276 hibits extraordinary substrate and inhibitor promiscuity, resulting in a wide range of possible drug-

277 ther possibility fosters selection for queen promiscuity, revealing a novel benefit of it for eusocia

278 be aided by enzymes that practice catalytic promiscuity, such as these two unrelated DNA glycosylase

279 esults showed a considerably lower degree of promiscuity than initially expected, even for those memb

280 osa PAO1 K648 (pvd-, pch-) exhibited greater promiscuity than that of E. coli for the uptake and util

281 eae family and their bioactivity, functional promiscuity that could be exploited as leads in developi

282 we describe a method for achieving catalytic promiscuity that uses the photoexcited state of nicotina

283 cooperative breeding is associated with low promiscuity; that in cooperative species, helping is mor

284 With this higher promiscuity there is a shift in nucleotide occupation of

285 a surrogate Valpha domain, fostering ligand promiscuity to favor development of beta chains with sel

286 tectures are limited, we harnessed enzymatic promiscuity to generate a focused library of chartreusin

287 How such a transition from promiscuity to pair-bonding could be achieved is puzzlin

288 dicts a compound's high throughput screening promiscuity, to a higher degree than the original data m

289 Enzyme promiscuity toward substrates has been discussed in evol

290 the structural origins of PXR's recognition promiscuity using computational solvent mapping, a techn

291 In this study, TOMM enzymatic promiscuity was assessed using a currently uncharacteriz

292 ter in its own right, an index of biological promiscuity was developed.

293 zzle, because females can sustain costs from promiscuity, whereas full fertility can be provided by a

294 active site to achieve remarkable catalytic promiscuity wherein the substrate-free conformational en

295 andscapes showing a high level of functional promiscuity, which are frequently regulated through post

296 rved detection mechanism combines structural promiscuity with high specificity and enables discrimina

297 Chemokines display considerable promiscuity with multiple ligands and receptors shared i

298 we also find evidence of unanticipated MTase promiscuity with some enzymes apparently also modifying

299 biosynthetic enzymes can display unexpected promiscuity, with human glycosyltransferase pp-alpha-Gan

300 generalized feature driving selectivity and promiscuity within this superfamily and can be in turn u

301 Selection for promiscuity would be especially strong if productivity i