ライフサイエンスコーパス: promiscuous

1 e pocket for the other adenine appears to be promiscuous.

2 A, EZH2 has highest affinity and is somewhat promiscuous.

3 or whether their niche requirements are more promiscuous.

4 ts pore-forming activity is specific and not promiscuous.

5 is clade dependent and ranges from strict to promiscuous.

6 sugar metabolism, whereas others were fairly promiscuous.

7 e a protein's cellular destination are often promiscuous.

8 ence studies demonstrated that both CYPs are promiscuous.

9 odern 1,10-synthases could have evolved from promiscuous 1,11-sesquiterpene synthases.

10 This analysis revealed that such "promiscuous 2-aminothiazoles" (PrATs) behaved as frequen

11 Predictions may be made for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CY

12 re are both serotype-restricted and serotype-promiscuous AAPs in their assembly roles.

13 rther show that the PX-FERM proteins share a promiscuous ability to bind a wide array of putative car

14 ds as substrates, whereas HolE is relatively promiscuous, accepting a range of acyl-CoA and amine sub

15 n the accumulation of ATF2 and RNF20 and the promiscuous accumulation of DDR-associated chromatin mar

16 ificity with the former typically being more promiscuous, acting on a variety of branched DNA substra

17 hosphatases are classically considered to be promiscuous, acting on tens to hundreds of different sub

18 nism for how tRNAs are protected against the promiscuous action of a processing enzyme.

19 Although we found that AmTRP-R is highly promiscuous, activated by various ligands including two

20 Clonal selection initially is promiscuous, activating cells with virtually undetectabl

21 al differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical

22 analysis of thiG to determine its potential promiscuous active site, which we validate experimentall

23 s a permissive PSI-BLAST approach to predict promiscuous activities of metabolic genes.

24 hotriesters were identified, mostly based on promiscuous activities presumed not to be under selectio

25 d evolution are versatile biocatalysts whose promiscuous activities represent potentially attractive

26 on coordination is a plausible way to reduce promiscuous activity of metalloenzymes.

27 ered for higher activity on oligoglycine has promiscuous activity that allows proteins to be tagged u

28 This endogenous E. coli phosphatase has promiscuous activity that, when overexpressed, compensat

29 alled generalists-are characterized by their promiscuous activity with many different substrates.

30 ting different metal ions is related to KpnI promiscuous activity, and tinkering the metal ion coordi

31 ough Mg(2+) ion higher than 500 muM mediates promiscuous activity, Ca(2+) suppresses the promiscuity

32 hese represented by AI4, a T cell clone with promiscuous Ag-recognition characteristics.

33 Furthermore, E. coli CBL (fold type I) is a promiscuous alanine racemase.

34 n common with that of BATs, and as LeuT is a promiscuous amino acid transporter, it does not recapitu

35 The protease is highly promiscuous among diverse N-myristoylated proteins in vi

36 eaves provitamin A carotenoids, BCO2 is more promiscuous and also metabolizes nonprovitamin A caroten

37 Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-pro

38 rneurons in the neocortex often connect in a promiscuous and extensive fashion, extending a "blanket

39 orm contiguous helices that are biologically promiscuous and hemolytic.

40 Thus, based on the promiscuous and high-affinity interactions in fibrin, GF

41 We have previously described promiscuous and immunogenic HLA-DR-restricted peptides d

42 reactive CD4 T cell epitope, which is HLA-DR promiscuous and immunoprevalent in coinfected individual

43 DisA but not YybT (a PDE) whilst TA was more promiscuous and inhibited both DisA and YybT.

44 Moreover, many protein pockets are promiscuous and interact with ligands of diverse scaffol

45 Conversely, many ligands are promiscuous and interact with structurally different poc

46 asis of differences in parental care between promiscuous and monogamous mammal species?

47 nteraction with other proteins appears to be promiscuous and not exclusive, although the major protei

48 ed the residual phosphorylation of glucose a promiscuous and physiologically irrelevant activity, hig

49 Some identified T-cell epitopes are promiscuous and recognizable by the common HLA alleles.

50 The enzyme is relatively promiscuous and reduces a range of disulfide, persulfide

51 We conclude that promiscuous and specific RNA-binding activities of PRC2

52 complexes in which the catalytic subunit is promiscuous and the regulatory subunit confers substrate

53 FADs with promiscuous and unique activities have been identified i

54 d to the construction of a highly efficient, promiscuous, and thermostable artificial enzyme that cat

55 Both enzymes are catalytically promiscuous, and we generated 10 different macroamidines

56 mon binding characteristics that explain the promiscuous, and yet high-affinity, association of E3-19

57 These antibodies acquire promiscuous antigen binding potential post-translational

58 enge of primary CLL cells indicated that the promiscuous antigen-binding activity of subset #8 mAbs c

59 ase in glucocorticoid-sensitive AR L702H and promiscuous AR T878A in patients with prior abiraterone

60 alysis reveals, however, that this agent is "promiscuous" as it binds both dsDNA and protein biomolec

61 Both Polzeta4 and Polzeta5 were most promiscuous at G nucleotides and frequently generated mu

62 NOD mice promotes the differentiation of MHC promiscuous autoreactive CD4(+) clonotypes into antidiab

63 g a naturally occurring constellation of MHC-promiscuous autoreactive T-cell clonotypes, promoting th

64 our results show that loss of Smad2 permits promiscuous Baboon activity, which represses genes subje

65 Many pathogens are considered promiscuous because they cause disease across a range of

66 This promiscuous behavior also extends to its association to

67 via unusual NMR spectra also correlated with promiscuous behavior of molecules in off-target in vitro

68 able aid toward revealing some mechanisms of promiscuous behavior.

69 other CNS receptors, and they resemble known promiscuous binders.

70 and provide a biophysical rationale for how promiscuous binding by GR allows functional substitution

71 inding to two off target proteins to exclude promiscuous binding compounds.

72 ions, defining the importance of disorder in promiscuous binding interactions has proven to be diffic

73 unpaired coiled-coil elements tend to find a promiscuous binding partner.

74 rs encoded in the cognate ligands activate a promiscuous binding pathway that reveals a flexible hydr

75 s were therefore designed to (a) disrupt the promiscuous binding pharmacophore and diminish off-targe

76 1 haplotype is even more permissive than the promiscuous binding shown by the dominantly expressed cl

77 utation selectively alters interactions to a promiscuous binding site that is critical for DNA metabo

78 y in germline gene-encoded antibodies allows promiscuous binding to diverse antigens.

79 h the cell surface and endosomes through its promiscuous binding to lipids.

80 y candidate peptides of Ara h 1 that display promiscuous binding to MHC class II and induce TH2 cytok

81 ss their selectivity and their potential for promiscuous binding to proteins.

82 ne to robustly increase Treg frequencies via promiscuous binding to the glucocorticoid receptor (GR)

83 ighlight how the bromodomain is built toward promiscuous binding with low specificity.

84 are spent unknowingly pursuing artifacts and promiscuous bioactive compounds, while understanding the

85 the human dynein interactome by attaching a promiscuous biotin ligase ('BioID') to seven components

86 oteins were tagged with the Escherichia coli promiscuous biotin ligase (BirA*), expressed in cells, a

87 By fusing a promiscuous biotin ligase to a protein of interest expre

88 The BioID method uses a promiscuous biotin ligase to detect protein-protein asso

89 centered on BioID2, a substantially smaller promiscuous biotin ligase.

90 HmK is potent but promiscuous, blocking KcsA-Shaker, Shaker, Kv1.2, and Kv

91 Aminotransferases can be redundant or promiscuous, but the extent and significance of these pr

92 opeptides combine molecular recognition with promiscuous catalytic activity to allow covalent decorat

93 t to study ion binding and transport of this promiscuous cation channel.

94 er properties may contribute to nonspecific, promiscuous changes in membrane protein and cell functio

95 gnition fundamentally differs from canonical promiscuous chaperone-substrate interactions.

96 crystallin, and HspB5/alphaB-crystallin) are promiscuous chaperones, whereas the chaperone activity o

97 , but not the C57, isoform of Ly49B displays promiscuous cI binding.

98 Thus, promiscuous coexistence of the antagonist regulators in

99 ures paternity certainty in the face of more promiscuous competitors.

100 Characterization of promiscuous compounds enhances the understanding of comp

101 In PubChem screening assays, 466 highly promiscuous compounds were identified that were examined

102 MR, an industry-developed counter-screen for promiscuous compounds.

103 -cell compartment preferentially accumulates promiscuous constituents with age as a consequence of hi

104 gnature cytokine locus is unable to shed the promiscuous contacts established in the naive T cells, i

105 Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major

106 scherichia coli alanine racemase (ALR), is a promiscuous cystathionine beta-lyase (CBL).

107 A. thaliana. thus provide a first example of promiscuous cytochrome P450 enzymes endowing effective m

108 g proteins and therefore is likely caused by promiscuous dephosphorylation of a variety of substrates

109 ved highly dynamic cellular interactions and promiscuous distribution of leukaemia cells that migrate

110 blic repositories, where proteins containing promiscuous domains could be involved.

111 ing orthologs and paralogs and robustness to promiscuous domains.

112 P-glycoprotein (P-gp), a promiscuous drug efflux pump, has been extensively studi

113 out effects; therefore, our understanding of promiscuous drugs, polypharmacology-related adverse drug

114 uitinates substrates together with UBCH5B, a promiscuous E2 that can function with a broad range of E

115 We find MCV sT to be a promiscuous E3 ligase inhibitor targeting the anaphase-p

116 se, relaxed tRNA specificity leading to semi-promiscuous editing may offer advantages to cells.

117 ulation of CaSR at the systemic level causes promiscuous effects in the parathyroid glands, kidneys,

118 The results document Keap1 as a promiscuous electrophile-responsive sensor able to respo

119 y, we extend these findings to anandamide, a promiscuous endocannabinoid/endovanilloid ligand, which

120 he chemical basis for assay interference and promiscuous enzymatic inhibition for several prominent c

121 These findings contrast with simply promiscuous enzyme activities, which have been described

122 Our results indicate that CPPase, a promiscuous enzyme, is more plastic toward acquiring new

123 mutagenesis and starting with the engineered promiscuous enzyme, MOMT5 (T133L/E165I/F175I/F166W/H169F

124 In contrast, CPPase is an inefficient promiscuous enzyme, which synthesizes the "irregular" mo

125 uperfamily, which includes both specific and promiscuous enzymes active against various phosphorylate

126 nt insights suggest that non-specific and/or promiscuous enzymes are common and active across life.

127 However, pathways that rely on multiple promiscuous enzymes may branch, which might preclude sel

128 Thus, LCP enzymes of S. aureus are promiscuous enzymes that attach secondary cell wall poly

129 aset, by sampling functions of catalytically promiscuous enzymes within the context of the entire met

130 chnological use implicit in the discovery of promiscuous enzymes.

131 P6 showed that P6 antibodies do not detect a promiscuous epitope on NTHi.

132 that recognize unusual, diverse, and highly promiscuous epitopes, including dominant responses to ep

133 Binding was unexpectedly promiscuous, except for Bad and Noxa, and did not explai

134 ls, into the contributions of an exceedingly promiscuous exportin and it provides a new basis for NES

135 Promiscuous expression of a plethora of tissue-restricte

136 sistent with AIRE targeting and inducing the promiscuous expression of genes previously epigeneticall

137 R) signaling strength due to inefficiency in promiscuous expression of self-antigens or presenting a

138 t of self-tolerance in the thymus depends on promiscuous expression of tissue-restricted Ags (TRA) by

139 The promiscuous expression of tissue-restricted antigens in

140 red the molecular analysis of the so-called "promiscuous expression" of tissue-restricted genes, a ke

141 minal RNA recognition motif 1 (RRM1) is more promiscuous for cytosine-containing Py tracts than the C

142 PSI(PsaJF) is promiscuous for its electron donors and can accept elect

143 Here, we demonstrate that POMGNT1 is promiscuous for O-mannosylated peptides, whereas POMGNT2

144 Promiscuous gene expression (PGE) by thymic epithelial c

145 Although the cellular mechanisms by which promiscuous gene expression (pGE) imposes T cell toleran

146 This promiscuous gene expression (pGE) is regulated in part b

147 a crucial role in autoimmunity by regulating promiscuous gene expression (pGE).

148 ed in mTEC differentiation in general and in promiscuous gene expression in particular.

149 A distinct feature of promiscuous gene expression is its mosaic pattern (i.e.,

150 The results highlight that important promiscuous gene function may be missed when annotation

151 and that proteins can evolve from substrate-promiscuous generalists into specialists during the cour

152 uencing of all patients allowed exclusion of promiscuous genotype-induced methylation calls.

153 CCP4 behaves as a promiscuous glutamase, with little preference for chain

154 These two lipids are synthesized by a single promiscuous glycosyltransferase encoded by the ORF atu22

155 ssay interference compounds (PAINS) or other promiscuous groups.

156 ted dsDNA binding and unwinding activity and promiscuous guide RNA specificity.

157 direct attention toward the contribution of promiscuous halogenating enzymes in further expanding th

158 Despite being a promiscuous heterodimer partner, this nuclear receptor i

159 n-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain.

160 region between amino acids 43 and 67 showed promiscuous HLA-binding capacity and induced memory CD4(

161 l paradox: if phosphatases are indeed highly promiscuous, how do cells insulate themselves against un

162 nt ERK1/2 inhibitors reported along with the promiscuous hypothemycin (and related analogues) that ac

163 One remarkably promiscuous immunodominant peptide (P9) could be present

164 It is ubiquitous in distribution and promiscuous in function, with >50 putative peptide subst

165 We found that NAO is promiscuous in its binding and has photophysical propert

166 M during tissue repair, also could be highly promiscuous in its GF-binding capacity.

167 that the glycosyltransferase is surprisingly promiscuous in its substrate preferences.

168 sids do not necessarily colocalize; AAPs are promiscuous in promoting capsid assembly of other seroty

169 Although individual molecules can be promiscuous in terms of their contribution to function,

170 vestigated which domains could be considered promiscuous in the different organisms.

171 CcrA and CcrB are promiscuous in their substrate choice: they act on many

172 These promiscuous inhibitors are worse than useless because th

173 The third type consists of promiscuous inhibitory folds which resemble mouse traps

174 The promiscuous inteins reported here thus improve the appli

175 The resulting "promiscuous" inteins are shown to be superior reagents f

176 tive pockets in native proteins implies that promiscuous interactions are inherent to proteins.

177 However, promiscuous interactions between MET and ERBB family mem

178 nterventions should target the migration and promiscuous interactions of cancer cells with the surrou

179 e the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thu

180 ands, where their diffusion is restricted by promiscuous interactions with other OMPs.

181 id-like aggregation but rather involves many promiscuous interactions.

182 ion characterized by long-range epistasis, a promiscuous intermediate, and few gain-of-function mutat

183 s contradicts our model of evolution through promiscuous intermediates.

184 Harnessing promiscuous intermolecular reactions of carbenoid compou

185 conserved among SULT1 family members and is promiscuous-it binds catechins, a naturally occurring fa

186 Compounds were derived from the promiscuous kinase inhibitor PP1 to search for analogs t

187 lysine in a hydrophobic pocket to accelerate promiscuous Knoevenagel condensations of electron-rich a

188 unctions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics.

189 lopment of strong and selective binders from promiscuous lead compounds represents one of the most ex

190 ith human PXR (hPXR) by interacting with its promiscuous ligand binding domain.

191 ding underlines the highly collaborative and promiscuous ligand binding mechanism.

192 FABP5, like its family members, displays a promiscuous ligand binding profile, capable of interacti

193 Fibronectin (Fn) is a promiscuous ligand for numerous cell adhesion receptors

194 from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode.

195 LPA1 binding pocket raise the possibility of promiscuous ligand recognition of phosphorylated endocan

196 akin to those of alphabetaTCRs but with more promiscuous ligand specificity trigger calcium flux.

197 We engineered a promiscuous ligase based on the NEDD8 conjugating enzyme

198 Promiscuous-line males had deficits in viability, but a

199 Promiscuous-line males inherit higher MUP expression tha

200 Fitness assessments between this promiscuous lineage and a monogamous laboratory lineage

201 s in human cortical neurons, suggesting that promiscuous lipase inhibitors have the potential to caus

202 moLac is a native, proficient lactonase with promiscuous, low phosphotriesterase activity.

203 llenges this claim, however, contending that promiscuous male competitors and the risk of cuckoldry l

204 ested to function via frequently encountered promiscuous mechanisms of action including inhibition of

205 rk, we model the selectivity of two multiply promiscuous members of this superfamily, namely the phos

206 e (corresponding to human CMV US11), and the promiscuous MHC class I- and class II-restricted CD8(+)

207 were created by computational prediction of promiscuous MHC-II CD4(+) T cell derived from the top 50

208 esion, whereas N3-EtdT and O(2)-EtdT display promiscuous miscoding properties during transcription.

209 osphate groups binding to BRCT to understand promiscuous molecular recognition and guide inhibitor de

210 e of entropy in allosteric signaling between promiscuous molecular recognition sites and can inform t

211 Hub proteins are proteins that maintain promiscuous molecular recognition.

212 The A138T promiscuous mutant protein binds more tightly to the cog

213 protein-DNA interactions, we have exploited "promiscuous" mutants of EcoRI endonuclease to study the

214 we addressed this challenge by converting a promiscuous natural human IgG-binding domain, the hypert

215 This promiscuous nature of Arg helps explain the increased pr

216 the bound ligand population, reflecting the promiscuous nature of ligand binding by multidrug efflux

217 val cell lineage polarity, and highlight the promiscuous nature of Wnts and the importance of Wnt gra

218 d participate in functional and all possible promiscuous non-functional PPIs.

219 y and characterization of AmbO5 protein as a promiscuous non-heme iron aliphatic halogenase.

220 The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor

221 the alkyl group, and these lesions directed promiscuous nucleotide misincorporation in E. coli cells

222 obodies selectively blocking CXCR2, the most promiscuous of all chemokine receptors.

223 thracis and C. tetani epitopes were the most promiscuous of the group that we analyzed.

224 terase-like lactonase (PLL) family that show promiscuous organophosphate-degrading activity.

225 The shuffling experiments demonstrate that promiscuous pairing of heavy and light chains is possibl

226 for allergen specificity and to test whether promiscuous pairing of heavy and light chains with diffe

227 allow TrkA selectivity over TrkB and TrkC or promiscuous, pan-Trk inhibition.

228 ar cells pulsed with 6 HER2-derived class II-promiscuous peptides via interferon-gamma (IFN-gamma) en

229 odominant peptides and were part of the best promiscuous peptides.

230 These results highlight promiscuous pharmacological influences on the serotonerg

231 drophilic group to interrupt the lipophilic, promiscuous pharmacophore and promote interaction with h

232 here metabolite profiling identified NudB, a promiscuous phosphatase, as a likely pathway bottleneck.

233 e-phosphorylate free d-ribulose generated by promiscuous phosphatases from d-ribulose 5-phosphate.

234 SsoPox exhibits promiscuous phosphotriesterase activity for the degradat

235 tructures of the MOBV relaxase MobM from the promiscuous plasmid pMV158 in complex with several origi

236 tion of MOBV histidine relaxases among small promiscuous plasmids and their preference toward Gram-po

237 Starting from a weakly promiscuous PLL scaffold (Dr0930 from Deinococcus radiod

238 Second, we design "promiscuous", polyspecific proteins against all binding

239 rtaining to mechanistic details of how these promiscuous proteins function remain outstanding, and th

240 rmation of the relative ion activity of this promiscuous pump.

241 lex and includes, in addition to KNOLLE, the promiscuous Qb,c-SNARE SNAP33 and the R-SNARE vesicle-as

242 e metabolic networks that lack annotation of promiscuous reactions.

243 Their high-energy, promiscuous reactivity profiles have hampered applicatio

244 provide a direct signal-processing role for promiscuous receptor-ligand interactions and establish o

245 specific iterative algorithm to account for promiscuous recognition by calculation of OR values for

246 indicate that, in contrast to murine NAIPs, promiscuous recognition of multiple bacterial ligands is

247 network-based identification of an indirect promiscuous replacement of a key metabolic enzyme, which

248 h genome-scale metabolic modeling to predict promiscuous replacements via alternative metabolic pathw

249 y suppression, in which over-expression of a promiscuous 'replacer' gene rescues lethality caused by

250 itope in CFP-10 was identified but exhibited promiscuous restriction.

251 n as C2c2) exhibits a "collateral effect" of promiscuous ribonuclease activity upon target recognitio

252 of PRC2-binding RNA motifs rationalizes the promiscuous RNA binding of PRC2, and their enrichment at

253 at enhancers may be a frequent by-product of promiscuous RNA polymerase initiation at accessible chro

254 vation loop show decreased specific Xbp1 and promiscuous RNase splicing activity relative to wild-typ

255 tN) transferase, EptC (Cj0256), that plays a promiscuous role in modifying the flagellar rod protein,

256 ples of the intentional preorganization of a promiscuous scaffold along an atropisomeric axis to incr

257 phopantetheinyl transferase (rather than the promiscuous Sfp transferase required to modify the L. la

258 Similar principles could apply to other promiscuous signaling pathways.

259 he active site of PIM1, and also at a second promiscuous site.

260 ial clades evolve from within a broader host-promiscuous species and sometimes target different niche

261 We find that the promiscuous species produces sperm with longer midpiece

262 Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh

263 howing that R-M systems are more abundant in promiscuous species, wherein they establish preferential

264 These findings point towards promiscuous spread of the mcr-1 gene by efficient horizo

265 , Srs2 dislodges Rad51 from ssDNA preventing promiscuous strand invasions.

266 ctivity assays that hybrid CDN-producing and promiscuous substrate-binding (Hypr) GGDEF enzymes are f

267 esters are the cognate substrates for AP but promiscuous substrates for NPP.

268 at transcription in 1-cell embryos is highly promiscuous, such that intergenic regions are extensivel

269 ition of BRG1 ATPase/remodeling activity are promiscuous, suggesting that context is a crucial factor

270 ted nutrient milieus, which may underlie the promiscuous survival of T. gondii tachyzoites in diverse

271 Our group has previously defined several promiscuous T helper epitopes within the PvMSP1 protein,

272 diabetogenic and I-A(g7)-restricted, but MHC-promiscuous T-cell receptor (4.1).

273 XAV939 is a promiscuous tankyrase inhibitor and a potent inhibitor o

274 ldihydropyrimidine (HAP) binding pocket is a promiscuous target for inducing assembly.

275 Recent discoveries indicate a significant promiscuous targeting of this B-cell mutator enzyme geno

276 argeting in vitro compared with Gbetagamma's promiscuous targeting of various effectors.

277 tate the design of new enzymes from existing promiscuous templates.

278 ects have shown that DNA binding is far more promiscuous than DNA cleavage, yet the molecular cues th

279 Moreover, kinase inhibitors are less promiscuous than often thought.

280 xplains why the poxvirus resolvases are more promiscuous than RuvC, cleaving a variety of branched, b

281 ctories via "intermediate" proteins that are promiscuous, thus avoiding transitions via non-interacti

282 The promiscuous TLR binders were human SIGLEC-5/9 and mouse

283 Exploiting the promiscuous TP activity of PBP4, we developed a simple,

284 ICP0 also functions as a promiscuous transactivator, and it blocks repressor comp

285 ome-wide surveys have uncovered evidence for promiscuous transcription across the entirety of the Kap

286 sion, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechan

287 rectal cancer (CRC), as compared to the more promiscuous transformation of small intestinal organoids

288 sequence of this finding is an exceptionally promiscuous transporter: not only can EmrE export divers

289 ion for horizontal uptake and maintenance of promiscuous type III interference modules that supplemen

290 high tRNA charging fidelity to the otherwise promiscuous, unmodified enzyme.

291 R5 relative to T/F Envs argues that the more promiscuous use of CCR5 by these Env proteins is selecte

292 s indicate that the ability of CXCR6 to make promiscuous use of the available Gi/o proteins is exquis

293 ts, with the high-affinity population having promiscuous Valpha-chain pairing and the low-affinity su

294 ngs of HLA-DP2-expressing CBD patients using promiscuous Valpha-chain pairing to recognize an identic

295 We propose that the abundance of promiscuous variants promotes the expansion and diversif

296 equently connected in sequence space to more promiscuous variants that can serve as intermediates dur

297 e studies provide evidence that VP16 and the promiscuous viral trans-activator (bICP0) are expressed

298 of various species, including monogamous and promiscuous voles.

299 karyotes, but eukaryotes tend to be far less promiscuous with their genetic information.

300 The structures rationalize the mechanism of promiscuous, yet specific, drug recognition: (i) a four-