ライフサイエンスコーパス: promiscuously

1 ronizing the annual mating period and mating promiscuously.

2 the need for most chaperones to bind clients promiscuously.

3 deep neural explants cells intercalate more promiscuously.

4 bind divalent cations and accessory proteins promiscuously.

5 nate metabolite N-arachidonyldopamine (NADA) promiscuously activated both CB1 and TRPV1 receptors.

6 biotic receptor pregnane X receptor (PXR) is promiscuously activated by a range of structurally disti

7 40 (SV40) early gene product large T antigen promiscuously activates simple promoters containing a TA

8 alysis of 5'-flanking sequences identified a promiscuously active 172-base pair minimal promoter, whe

9 and DNT1 and DNT2 bind to Toll-6 and Toll-7 promiscuously and are distributed in vivo in domains com

10 n the same community bind to diverse ligands promiscuously and they are also embedded in diverse doma

11 Cop 1 binds promiscuously and very efficiently to living APCs of var

12 Copolymer 1 binds promiscuously and very efficiently to purified HLA-DR mo

13 GEFs can interact with multiple Rho proteins promiscuously, and overexpression of one dominant negati

14 receptors, often called decoy receptors, act promiscuously as molecular sinks to regulate ligand bioa

15 NC promiscuously associates with cellular RNAs, many of whi

16 despite the ability of each ephrin ligand to promiscuously bind many Eph receptors, the two compounds

17 Indeed, all other Eph receptors, which promiscuously bind many ephrins, have a conserved argini

18 and LidA, which were previously reported to promiscuously bind multiple Rab GTPases in vitro.

19 While the PH domains of intersectin and Dbs promiscuously bind several multiphosphorylated phosphoin

20 y a broad ligand selectivity; i.e., they can promiscuously bind to and may be activated by multiple l

21 the fowlpox virus prosurvival protein FPV039 promiscuously binds to cellular proapoptotic Bcl-2 and e

22 inity and specificity: the N37A mutant binds promiscuously both to cognate (C. thermocellum) as well

23 ata show that PMCA "b" splice forms interact promiscuously but also with specificity with different m

24 he V(H) domain of an anti-E2 IgG paired with promiscuously catalytic V(L) domains.

25 onclude that Galphaq, Galpha11, and Galpha14 promiscuously couple several receptors (m3 muscarinic, b

26 activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal

27 ADARs deaminate perfectly base-paired dsRNA promiscuously, deamination is limited to a few, selected

28 and undifferentiated phenotype of C8161 was promiscuously dominant.

29 ) that lack this downstream element were not promiscuously edited in McArdle or HepG2 cells.

30 ode new protein isoforms, and dsRNA-induced, promiscuously edited RNAs that encode nonfunctional, mut

31 Phage Mu transposes promiscuously, employing protein MuB for target capture.

32 how the least range in coupling energies and promiscuously encourage heterodimerization.

33 ls from various nonlymphoid tissues migrated promiscuously, except to the intestinal mucosa, supporti

34 zeable fraction of the overall repertoire of promiscuously expressed self-antigens.

35 mutants of Taq DNA polymerase that not only promiscuously extended mismatches, but had acquired a ge

36 We show here that AID acts promiscuously, generating widespread DNA double-strand b

37 Within a cell, individual glycotransferases promiscuously help to construct dozens of unique glycan

38 se 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, i

39 One major finding was that all of the promiscuously immunodominant gp120 sequences are located

40 Promiscuously immunodominant helper T-cell epitopes in t

41 Promiscuously immunogenic sequences were associated with

42 f a natural heme transport protein, ChuA, to promiscuously import heme derivatives, we have evolved a

43 sely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple envi

44 cells have the capacity to be activated more promiscuously in response to individual cytokines from i

45 most kinase inhibitors that target this site promiscuously inhibit multiple kinases.

46 These aggregates promiscuously inhibit soluble proteins and are a major s

47 possible, this is preferred over the use of promiscuously integrating vectors, which are sometimes a

48 rotein virus assembly systems, coat proteins promiscuously interact to form heterogeneous aberrant st

49 synthesized polypeptide is misfolded and can promiscuously interact with cytosolic factors.

50 r developing polypharmacological agents that promiscuously interact with multiple proteins yet result

51 Strikingly, the same Nup98 groove promiscuously interacts with Nup82 and Nup96 in a mutual

52 Here we show that Ure2p promiscuously interacts with various compositionally sim

53 pus T cells also have hypomethylated DNA and promiscuously kill autologous monocytes/macrophages, we

54 , a photoactivatable, lipophilic probe which promiscuously labels both proteins and lipids within pho

55 ar interest in species in which females mate promiscuously, leading to paternity uncertainty.

56 ty for multiple myeloid or lymphoid programs promiscuously may allow flexibility in fate commitments

57 Although interacting with RNA promiscuously, PRC2 binding is enriched at specific loca

58 inked with low viremia showed the ability to promiscuously present a larger breadth of peptides with

59 lopment of CD8+ cytolytic T lymphocytes that promiscuously recognize MHC class II molecules in associ

60 None of the CTLs promiscuously recognized 16 HLA-B7-binding synthetic pep

61 d repertoire of cytolytic T lymphocytes that promiscuously recognizes major histocompatibility comple

62 that PF1 may act as an architectural factor, promiscuously recognizing a spectrum of AT-containing el

63 the homologous human proteins ABH2 and ABH3 promiscuously repair DNA and RNA bases damaged by S(N)2

64 ic T cells recognizing either selectively or promiscuously restricted epitopes were predominantly T e

65 M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservativ

66 flexible region containing determinants that promiscuously stimulate ParF polymerization.

67 00 microM), some drugs can aggregate and act promiscuously, suggesting that aggregation may be common

68 er, these findings indicate that CtpA rather promiscuously targets polypeptides that lack structurall

69 in cell signaling networks tend to interact promiscuously through low-affinity interactions.

70 monstrate that VDR/RXR heterodimers can bind promiscuously to a wide range of hormone response elemen

71 be location-specifiers, turn out to respond promiscuously to a wide range of stimuli.

72 FR3c in complex with FGF1, an FGF that binds promiscuously to each of the seven principal FGFRs.

73 tational prediction of their ability to bind promiscuously to human major histocompatibility complex

74 dies have proposed that small molecules bind promiscuously to IDPs, causing expansion of their confor

75 In contrast to mouse FcRn, which binds promiscuously to IgGs across species, human FcRn does no

76 g portions of ephrin ligands bind weakly and promiscuously to many Eph receptors.

77 ant mechanism that prevents Gag from binding promiscuously to phosphatidylserine-containing membranes

78 As a chaperone, it binds promiscuously to precursors to maintain them in a non-na

79 nterparts, zebrafish B-ephrins can also bind promiscuously to several Eph receptors.

80 exhibits a potent nickase activity that acts promiscuously upon DNA secondary structures.

81 ion is made deterministically, downstream of promiscuously used-and frequently oncogenic-signalling p

82 ed cysteine residue in free E2 from reacting promiscuously with electron deficient chemical moieties

83 l chemokine-binding proteins, which interact promiscuously with multiple chemokines, pUL21.5 selectiv

84 multiple ligands and receptors that interact promiscuously with one another and typically appear in c

85 s used preferentially or if LMP2A associates promiscuously with other Src family kinase (SFK) members

86 The FG Nups interact promiscuously with various nuclear transport receptors (

87 Cop 1 binds promiscuously, with high affinity and in a peptide-speci

88 Mammalian PRC2 binds RNA promiscuously, with thousands of target transcripts in v

89 In addition, PF1 can bind promiscuously, with varying affinity, to other AT-contai