ライフサイエンスコーパス: promoter

1 under the control of an NF-kappaB-regulated promoter.

2 with lpiA/acvB expression coupled to an RpoN promoter.

3 ence-specific binding of rSaWRKY1 with MYB20 promoter.

4 d an FXR-responsive element on the Tgr5 gene promoter.

5 racts with TRF2 to recruit it to the RP gene promoter.

6 h a fluorophore is expressed under the TRPV1 promoter.

7 and promotes occupancy of BMI1 on the CDKN2A promoter.

8 criptional silencing at the transgenic RD29A promoter.

9 istone H4R3me2a methylation at the PPARgamma promoter.

10 ponding to its binding site in the IL-2 gene promoter.

11 ectly and does not catalyze 5hmC at the gene promoter.

12 volved in HIF-1alpha degradation at the ASS1 promoter.

13 element-binding (CREB) protein on the IL-10 promoter.

14 essed vieSAB transcription by binding to its promoter.

15 eatment activated the acetylation of the p21 promoter.

16 -like4) were identified as binding to OsNHX1 promoter.

17 changes of nucleosome composition at the frq promoter.

18 ne 4 trimethylation (H3K4me3) over the Crhr1 promoter.

19 R2) gene under the control of a 1 kb L7/Pcp2 promoter.

20 unified conceptual understanding of the core promoter.

21 anscriptional interference at the downstream promoter.

22 expressed under the regulation of the Prox1 promoter.

23 rect interaction between DAF-3 and the lag-2 promoter.

24 latory-element binding protein-1c (Srebp-1c) promoter.

25 ncer and the CUPID1 and CUPID2 bidirectional promoter.

26 lls through epigenetic editing of the native promoter.

27 ues and single cells without tissue-specific promoters.

28 he organization of epigenetic states at gene promoters.

29 ) which binds specifically to RpoN consensus promoters.

30 nhanced divergent antisense transcription at promoters.

31 da cI TF against two synthetic bidirectional promoters.

32 mechanisms that interfere with GR binding at promoters.

33 ESR1 binding to Pck-1, G6Pase, Fas and Acc1 promoters.

34 i triggered immediate binding to target gene promoters.

35 tions between distal regulatory elements and promoters.

36 expressed from individual RNA polymerase III promoters.

37 anism that involves CRTC1 recruitment to CRE promoters.

38 cluding p130/p107, still bind to target gene promoters.

39 omatin accessibility at B cell enhancers and promoters.

40 distal CGIs, despite methylation at proximal promoters.

41 1) which cooperatively activate the two LMP1 promoters.

42 FIID alone binds poorly to native p53 target promoters.

43 , than the constitutive MoMuLV 5' LTR (MMLV) promoter (0/25).

44 ry cells when luciferase is driven by a Hes1 promoter (10/19), which has previously been reported to

45 Further, we identify promoters able to drive strong expression in multiple ti

46 e EGR1- and AP-1-binding sites in the CD44v6 promoter account for its responsiveness to TGFbeta1 in l

47 s and measuring their expression to indicate promoter activities at single-mRNA level.

48 s been previously found to increase the IL1B promoter activity and is the most frequent haplotype in

49 nome coverage, allowing us to map autonomous promoter activity genome-wide in K562 cells.

50 ce confirmed increased Cldn14 expression and promoter activity in the TAL of Ksp-cre;Pth1r(fl/fl) mic

51 ecent experiments have shown a heterogeneous promoter activity of autoinducer synthase genes, suggest

52 ITPR2 promoter activity was measured in Huh7 and HepG2 cells.

53 h hydrogen peroxide directly inhibited mmp-3 promoter activity with concomitant nuclear translocation

54 region, the mutation of which increased ULK1 promoter activity, and rendered it unresponsive to mTOR

55 Consistent with their alternative promoter activity, CGI-initiated transcripts are associa

56 hat high miR-375 expression reduced vimentin promoter activity, suggesting that vimentin is an indire

57 cell downwardly tunes CRP-dependent Class II promoter activity, whilst elevating CRP steady state lev

58 e levels, thus indirectly increasing Class I promoter activity.

59 gion is important for the regulation of CAT2 promoter activity.

60 ndicate a functional non-coding SNP in EPHA2 promoter affects PAX2 binding and reduces EPHA2 expressi

61 ntivirus vectors carrying the same enhancers/promoters, an effect not explained solely by foamy virus

62 Promoter analysis revealed an increase in luciferase act

63 Promoter analysis revealed the presence of Zn-deficiency

64 somal rearrangements cause the fusion of the promoter and 5'-UTR of the androgen-regulated TMPRSS2 (t

65 actions indicate the physical proximity of a promoter and an enhancer, we constructed a three-dimensi

66 ell line demonstrated strong allele-specific promoter and enhancer activity and differential binding

67 t several putative Klf5 binding sites in the promoter and first intron of Dmp1 and Dspp genes that ar

68 ith the drug combination exhibited increased promoter and gene body H3K4me3 occupancy at DAC-responsi

69 DNA base OG to guide BER activity in a gene promoter and impact cellular phenotype ascribes an epige

70 manner, resulting in ERG enrichment at Dll4 promoter and multiple enhancers.

71 65, binds to the proximal region of the IL22 promoter and promotes transcriptional activity.

72 egulated by a melanoma-specific BRD2/4-bound promoter and super-enhancer configuration.

73 ion-D6Ertd527e-in which an MT LTR provided a promoter and the 5' exon with a functional start codon w

74 a cell type-specific loop formed between its promoter and the novel DRE.

75 reports showed that LEF1 binds to the MMP13 promoter and transactivates its expression, but we obser

76 rescued by transgenic expression of AtHEMN1 Promoter and transcript analyses indicated that AtHEMN1

77 The use of alternative promoters and alternative splicing at the foraging locus

78 ng reporter genes constructed with inducible promoters and cognate-inducible short hairpin RNA (shRNA

79 n interactions in the nucleus involving gene promoters and distal regulatory elements are currently c

80 We investigated the evolution of liver promoters and enhancers in six primate species using ChI

81 F3 can displace KLF1 from key erythroid gene promoters and enhancers in vivo.

82 Promoters and enhancers share similar architectures and

83 s of Gene Expression (CAGE) demonstrate that promoters and enhancers, based on their expression profi

84 three-dimensional global connectivity map of promoters and enhancers, revealing transcription-activit

85 how enrichment with known cell type markers, promoters and enhancers.

86 mobile gene-remodeling platforms that supply promoters and first exons.

87 ted the interaction of PU.1 with target gene promoters and led to downregulation of canonical PU.1 tr

88 accessible (RAMA) elements were enriched at promoters and may act as gatekeepers of monoallelic mRNA

89 om latency, and they stimulate certain viral promoters and productive infection.

90 ized transcription factor that can bind gene promoters and regulate target gene transcription in resp

91 ark differences in methylation levels within promoters and regulatory regions of genes involved in TL

92 Interactions between transcriptional promoters and their distal regulatory elements play an i

93 comprised de novo synthetic cancer-specific promoters and, to enhance specificity, an RNA-based AND

94 AK4/PPARgamma complex co-recruitment to Nox1 promoter, and increased Nox1 expression and ROS levels a

95 vation of c-jun, which binds to the IFN-beta promoter, and second, p38-mediated inactivation of the m

96 as noncoding, with 24% in intergenic, 12% in promoters, and 28% in introns, with similar statistics o

97 enerated through the use of different genes, promoters, and alternative splicing, but the functional

98 hypermethylation of the PPARgamma2 proximal promoter; and elevated circulating adiponectin.

99 n start-site (TSS) selection and alternative promoter (AP) usage contribute to gene expression comple

100 anscription factors that bind to the insulin promoter are known, relatively little is known about the

101 rial immunomodulatory outputs only when both promoters are mutually active.

102 It has been proposed that many yeast promoters are not nucleosome-free but instead occupied b

103 These newly identified promoters are shown to be transcriptionally active in 29

104 Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabil

105 ent of the activity of thousands of designed promoters at six different levels of TF.

106 In chimeric BACs, the mTert promoter became strongly repressed in the human genomic

107 al role of the transcription factor Xylanase promoter binding protein 1 (Xpp1) in the regulation of b

108 aled by studying the pre-initiation steps of promoter binding, bending and melting, and abortive RNA

109 d IRF3 binding and increased CTCF binding in promoter-binding assays, and risk allele carriage dimini

110 istic studies on a beta-globin enhancer- and promoter-binding factor, GATA-1, the founding member of

111 TERT regulation by chromatin environment and promoter-bound TFs during ESC differentiation.

112 cleavage-stage genes driven by conventional promoters but did not activate MERVL-promoted genes.

113 We propose that double locking of the vieSAB promoter by H-NS and HapR in the El Tor biotype prior to

114 -activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional activator

115 By integrating promoter capture Hi-C data with genetic associations for

116 atin per se can stimulate efficient enhancer-promoter communication (EPC); however, the role of chrom

117 Moreover, by using mutated promoter constructs, we identified a NF-kappaB site as c

118 or or corepressor, depending on the cell and promoter contexts.

119 ion is under dopamine transporter gene (DAT) promoter control to ablate Cnr2 gene in midbrain DA neur

120 single cells was 20 864 (72.7%), with 12 961 promoters covered.

121 s are enriched in flanking regions of active promoters, CpG island shores, binding sites of the trans

122 ly, elevated expression of H19 lncRNA due to promoter demethylation was observed in cells isolated fr

123 s within the bidirectional histone3-histone4 promoter direct HLB formation in Drosophila In addition,

124 e levels, and IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlation w

125 To determine the mapping between promoter DNA sequence, TF concentration, and gene expres

126 igma(N) fragment in complex with its cognate promoter DNA, revealing the molecular details of promote

127 ymerase (RNAP) holoenzyme and competing with promoter DNA.

128 s catalytically active but unable to bind to promoter DNA.

129 The state of the Re promoter does not change during the FT process.

130 ansgenic mouse model in which the keratin 14 promoter drives expression of the entire HPV8 early regi

131 Moreover, RUNX1 is sufficient for long-range promoter-Ebeta looping, nucleosome clearance, and robust

132 es spatial clustering of MIR335 enhancer and promoter elements along with overexpression of the MIR35

133 d factor (TAF) subunits recognize downstream promoter elements, act as coactivators, and interact wit

134 usters of co-regulated genes with shared cis promoter elements, whose expression can be controlled po

135 Promoters enhance the performance of catalytic active ph

136 not with MLV, suggesting MLV prefers smaller promoter-enhancer loops, whereas PB insertion encompasse

137 which were driven from a strong constitutive promoter ermEp*.

138 ns, and that initiation with them stimulates promoter escape.

139 such genomic regions to genomic annotations (promoters, exons, enhancers, etc.).

140 b) in plants, using a dual RNA polymerase II promoter expression system.

141 at auxin response maxima sites using the DR5 promoter fails to fully rescue lfs plants, suggesting th

142 ine 4 trimethylation (H3K4Me3) at the CDKN2A promoter following LPS-induced senescence.

143 the whole landscape of CRMs, to discriminate promoters from enhancers.

144 thelial growth factor (VEGF) regulates PRKCB promoter function in CLL cells, stimulating PKCbeta gene

145 under the control of the guard-cell-specific promoter, GC1.

146 viral-host co-evolution is imprinted within promoter gene sequences before transcript or protein int

147 monstrate that CRISPR/Cas9 genome editing of promoters generates diverse cis-regulatory alleles that

148 d genetic variants with precise mutations in promoters, genes, and terminators, leading to altered ca

149 with a strain containing the wild-type ACT1 promoter.Genetic isolation of a genetically modified org

150 that 21-nt diRNAs were generated from a 35S promoter::GU-US reporter transgene targeted by CRISPR/Ca

151 cognitive enhancement and MEF2C occupancy at promoters harboring canonical and variant MEF2C motifs.

152 A detailed characterization of the phage promoter has provided a set of constitutive promoters th

153 Drosophila that interact with different core promoters: housekeeping enhancers (hkCP) and development

154 have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the

155 t ChIP-sequencing localized PDX1 to the Atf5 promoter, implicating Atf5 as a PDX1 target.

156 MRTF overexpression drove the TAZ promoter in a CC(A/T-rich)6GG (CArG) box-dependent manne

157 Resequencing of the CHGA promoter in an Indian population (n = 769) yielded nine

158 , increased Nrf2 recruitment to the Srebp-1c promoter in livers of BPA-exposed mice was observed.

159 showed that HES1 and NR3C1 bind to the CLDN1 promoter in rat colon crypts.

160 the transcriptional activity from the NtPDR1 promoter in situ with a reporter gene and found that, al

161 recruited to the proximal region of the Ucp1 promoter in subcutaneous inguinal white adipose tissue.

162 e overproduced from the cold-inducible cspD2 promoter in the genetically tractable Haloarchaeon, Halo

163 DNA methylation at gene promoters in a CG context is associated with transcripti

164 nscription of genes with methylated proximal promoters in a tissue-specific fashion.

165 synergistically activated smooth muscle gene promoters in an SRF-dependent manner.

166 the transcription from the Sema3a and Sema3d promoters in cotransfected cells.

167 4) bind the stress-response element in gene promoters in the yeast Saccharomyces cerevisiae However,

168 ressed under control of a hemolymph-specific promoter increased fungal lethality to mosquitoes at spo

169 iation of LXRalpha with Lxralpha and Srebp1c promoters, increased LXRE-LXRalpha binding, and broadly

170 r method is effective in predicting enhancer-promoter interactions as compared to the state-of-the-ar

171 Deletion of CTCF sites compromises enhancer-promoter interactions.

172 ntrol of the cytomegalovirus immediate early promoter into the VC2 vector in place of the HSV-1 thymi

173 n the glial fibrillary acidic protein (GFAP) promoter is used to express cellular toxins that elimina

174 action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying precise

175 DNA methylation at promoters is an important determinant of gene expression

176 ng a transcription factor and the associated promoter it represses.

177 NACbs, and the proteins failed to regulate a promoter lacking a crucial NACbs.

178 antibody under the control of the major late promoter, leading to generation of ICOVIR-15K-cBiTE, whi

179 DNA repair protein counteracting oxidative promoter lesions may modulate gene expression.

180 using cell type-matched epigenomic data and promoter long-range interactions.

181 r depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

182 nced AP-2alpha expression and decreased TACE promoter luciferase activity in DCs.

183 Chromatin immunoprecipitation and NNMT promoter luciferase assays revealed that AURKA's effects

184 vivo lineage tracing revealed that the Krt15 promoter marks a long-lived basal cell population able t

185 s in the DNA methylation status of the PRTN3 promoter may predict the likelihood of stable remission

186 Here we show that dbetah promoter-mediated expression of LMO1 in zebrafish synerg

187 ng that it is coupled to TFIIH's established promoter melting activity.

188 ow that TFAM has 'post-recruitment' roles in promoter melting and RNA synthesis, which were revealed

189 of ovalbumin-specific T cells in rat insulin promoter-membrane-bound ovalbumin transgenic mice after

190 wed significant negative correlation between promoter methylation and expression of an alternative tr

191 l transition, correlating with delayed Nanog promoter methylation and phenocopying loss of Eprn or Li

192 Biological validation showed that PCSK9 promoter methylation is conserved across tissues and pos

193 epigenetic silencing of RAD51C and BRCA1 by promoter methylation is strongly associated with signatu

194 Next, we quantified CDH1 promoter methylation levels in CDH1 mutation-positive fa

195 DNA promoter methylation of cyclin D1 regulators were assess

196 Mechanistically, COX2/PGE2 signaling induced promoter methylation of let-7, resulting in its downregu

197 In addition, promoter methylation of two translationally relevant gen

198 utcomes (P = 0.50), but the presence of TERT promoter methylation, alone or concurrent with promoter

199 3b in liposarcoma cells was downregulated by promoter methylation, resulting at least in part from in

200 mary luminal differentiation marker FoxA1 by promoter-methylation, and that is regulated by the Plk1

201 sing Pd(OAc)2 as the catalyst and AgO as the promoter, mono- and diarylation of anilides were realize

202 TERT promoter mutations alone did not predict adverse outcome

203 Here, we describe the somatic acquisition of promoter mutations in telomerase reverse transcriptase (

204 omoter methylation, alone or concurrent with promoter mutations, correlated with reduced recurrence-f

205 ary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical

206 accessibility and deposition of STAT5 at the promoter of Id2 in response to interleukin (IL)-15.

207 PRC1-independent recruitment of OCT4 to the promoter of Kdm2b, a histone demethylase gene that promo

208 ease gene (BnCysP1) with anther-specific P12 promoter of rice for facilitating production of hybrid v

209 The putative promoter of Ss-riok-2 contains a number of conserved ele

210 hylation localized to a 600 bp region in the promoter of the Ifitm3 gene.

211 ichment of O-GlcNAc-modified proteins at the promoter of the transcription factor MYBL1, which was al

212 f RNAPII, but no changes in H3K27me3, at the promoters of affected endocrine genes.

213 The GACTTTT motif is enriched in the promoters of both these gene sets, and conserved in SARD

214 ion towards transcription start sites in the promoters of co-expressed genes.

215 ranscription factor DNA-binding sites in the promoters of differentially expressed genes was used to

216 TD) RNA polymerase (Pol) II formation on the promoters of IRF1, IRF7, and RIG-I, producing their enha

217 bind to and activate transcription from the promoters of its gluconeogenic targets, and the effects

218 at may act as cis-regulatory elements in the promoters of LEC1 target genes suggest that LEC1 may int

219 ecruitment to canonical binding-sites in the promoters of Nanog, Oct4 and Sox2.

220 ing motifs of TFAP2 (which was identified in promoters of T, NANOS3, and SOX17) and the RREB-1 cell a

221 trong evidence for positive selection within promoters of this species.

222 toolkit includes 23 Cas9-sgRNA plasmids, 37 promoters of various strengths and temporal expression p

223 cription initiation from host RNAP-dependent promoters on the phage genome via a mechanism that invol

224 duces structural changes in mtRNAP to enable promoter opening and trapping of the DNA non-template st

225 tisense transcripts originate either at gene promoters or within the gene body, and they show differe

226 better interpreted as a switching off of the promoter, or where an increase in bioluminescence would

227 ngation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human

228 AC-seq) data, we found that the latent HIV-1 promoter phenotypically resembles endogenous long termin

229 We found that strong viral enhancers/promoters placed in foamy viral vectors caused extremely

230 h cDNA sequencing, revealed four independent promoters, pr1-4, that produce 21 transcripts with nine

231 II in transcriptional elongation, leading to promoter-proximal accumulation of Pol II.

232 tion and restriction of gene activity to the promoter-proximal approximately 25 kb is observed.

233 Finally, we find a higher percentage of promoter-proximal GR binding for genes regulated by GR a

234 I) recruitment levels tend to display Pol II promoter-proximal pausing, while Pol II recruitment and

235 Promoter-proximal Ser2 phosphorylation is associated wit

236 oter DNA, revealing the molecular details of promoter recognition by sigma(N) The structure allowed u

237 Thus, gp226 is required for promoter recognition by the AR9 nvRNAP and may represent

238 We describe here the promoter reference technique (PRT), an assay for protein

239 s quantified at 7 CpG sites within the SFRP1 promoter region by pyrosequencing.

240 Additionally, the analysis of the HvPAPhy_a promoter region containing the GCN4/Skn1/RY motif highli

241 tro, leptospiral PerR could bind to the perR promoter region in a metal-dependent manner.

242 studied bind a conserved AT-rich site in the promoter region of the exoY gene from Mesorhizobium loti

243 h analysis of the functional consequences of promoter region variation within the classical HLA class

244 thylation at multiple CpG sites in the HOXA4 promoter region was associated with height in a cohort o

245 nding sites within the LIF (stemness factor) promoter region, and demonstrate LIF repression by ZEB1.

246 Thus, promoter regions are intrinsically bidirectional and are

247 ed acetylation of histones in the respective promoter regions but also re-expression of APM component

248 Our study shows that promoter regions harbour recurrent mutations in cancer w

249 several mechanisms: chromatin remodeling in promoter regions of specific genes, blockade of NF-kappa

250 he methylation status of CpG loci within the promoter regions of Th1/2 lineage commitment genes (GATA

251 me capture, we included genome-wide proximal promoter regions that contain sequences that regulate ge

252 itative RT-PCR, and DNA methylation of their promoter regions was analyzed by PCR and pyrosequencing.

253 thylation in adipose tissue, particularly in promoter regions.

254 ut genomes, and are especially found in gene promoter regions.

255 ave a high enrichment of CTCF binding sites, promoter-related marks, and enhancer-related histone mod

256 However, promoter release was inhibited in the presence of dUTP o

257 Promoter reporter and gel shift assays determined that t

258 gulate alpha-SYN expression; while exogenous promoter-reporter assays failed to reproduce the similar

259 nce of H3K4me3 and H3K27me3 at developmental promoters represents a poised transcriptional state.

260 ce expressing Cre from the Lyz2 or the BGLAP promoter, respectively.

261 blies, BAF and PBAF complexes, enhancers and promoters, respectively, suggesting that each complex ha

262 In vivo, promoter responses to TAF mutations correlate with the l

263 g to SBE DNA in TGF-beta-responsive SMC gene promoters, resulting in suppression of SMC marker gene t

264 iability in RNA and protein numbers are both promoter sequence-dependent and subject to regulation.

265 Here we compare viral and human promoter sequences and expression to test whether geneti

266 and microscopic tools to characterize plant promoter sequences and the discovery of two root hair re

267 Our results identify promoter shape as a molecular trait that can evolve inde

268 e and negative regulatory influences at each promoter site are integrated to modify pqsR expression.

269 Moreover, we find that the lncRNA and promoter-spanning transcript interaction are based on a

270 RNAs interact first with a 5' UTR-containing promoter-spanning transcript, which is then followed by

271 cular trait that can evolve independently of promoter strength.

272 istone H3 Lys27 acetylation at enhancers and promoters, suggesting a cross-talk between these chromat

273 ally active histone modifications at M2 gene promoters than did macrophages from male mice.

274 silencer factor) to position 509 of the KCC2 promoter that leads to downregulation of KCC2 transcript

275 promoter has provided a set of constitutive promoters that span over four logs of strength without d

276 ancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression, NFkappaB a

277 entation by enhancing H3K9me2/3 at the CIITA promoter, thereby repressing its expression through NO a

278 under the control of the endogenous fly tau promoter, thus avoiding potential toxicity due to geneti

279 at uses a mannose receptor, C type 1 (mrc1a) promoter to drive strong EGFP expression in lymphatic ve

280 se p300 is normally associated with the ASS1 promoter to maintain acetylated H3K14ac and H3K27ac for

281 to three E-boxes present in the human 4E-BP1 promoter to repress transcription of 4E-BP1.

282 phosphorylation mutants from a constitutive promoter to uncouple Atf1 activity from endogenous, stre

283 ing site-specifically integrated single-copy promoter transgenes and measuring their expression to in

284 uclear factor-kappaB to the PTPRZ1 and Wnt8a promoters, ultimately decreasing Wnt/beta-catenin signal

285 By applying this assay to over 1,500 promoter variants in yeast, we reveal pronounced differe

286 vation domain of FoxM1 to the cyclin B1 gene promoter via clustered regularly interspaced short palin

287 rdingly, the activity of the wild type RUNX2 promoter was decreased upon methylation treatment in vit

288 utative dioxin response elements in the EBF1 promoter was demonstrated by EMSAs and chromatin immunop

289 The EGR1 promoter was engineered to enhance trans-activation capa

290 in the human genomic context, but the hTERT promoter was highly active in the mouse genomic context.

291 Hypermethylation of the ANO1 promoter was strongly correlated with but not sufficient

292 No enhancers of the APIP promoter were found.

293 enriched for cell migration genes, and their promoters were enriched for the binding motifs of TFAP2

294 n of mtRNAP to recruit the polymerase to the promoter whereas TFB2M induces structural changes in mtR

295 neage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription fa

296 lent in the other tend to share demethylated promoters, while methylation differences between alpha-

297 , and that it is regulated by an alternative promoter whose activity is repressed by the liganded est

298 transcription factors, particularly in SDHD promoter wild-type samples.

299 veals predominant R-loop formation near gene promoters with strong G/C skew and propensity to form G-

300 cally activating the two EBV immediate early promoters (Zp and Rp).