ライフサイエンスコーパス: promoter element

1 x1 for a C base 5' relative to the core TAAT promoter element.

2 sequence for the human initiator (Inr) core promoter element.

3 leotides at the 3' terminus of the S segment promoter element.

4 e transcription bubble downstream of the -10 promoter element.

5 ransgene driven by a tetracycline-responsive promoter element.

6 of a promoter segment, especially the '-10' promoter element.

7 t-induced genes through binding to the L box promoter element.

8 acting GLUT4-liver X receptor element (LXRE) promoter element.

9 control via phase variation of an invertible promoter element.

10 n but cannot initiate DNA melting at the -10 promoter element.

11 ch does not contain a discernable downstream promoter element.

12 nd A14G) in the most highly conserved 3'-end promoter element.

13 rylation and Csrp2 gene expression via a CRE promoter element.

14 rol of an interferon gamma-inducible H-2K(b) promoter element.

15 , and fimX) phase variation of an invertible promoter element.

16 ment was present immediately upstream of the promoter element.

17 , we have identified a late S-phase-specific promoter element.

18 We have also characterized the K15 promoter element.

19 y represses PLK1 through a canonical CDE/CHR promoter element.

20 of BCL2 transcription via the i-motif in the promoter element.

21 ontrol of a tissue-restricted 3.9kbPeriostin promoter element.

22 cco seeds relative to the soybean fad3C gene promoter element.

23 (NF-YA), binds to the CCAAT motif, a common promoter element.

24 specifically interacts with the -10 and -35 promoter elements.

25 nalyses demonstrate that both are novel core promoter elements.

26 esented DNA motifs and known eukaryotic core promoter elements.

27 tivates CLV3 transcription by binding to its promoter elements.

28 4R), under the control of cell type-specific promoter elements.

29 bp segment in P(shr) that overlaps the core promoter elements.

30 that recruit transcriptional coregulators to promoter elements.

31 nding of transcription factors to regulatory promoter elements.

32 e (HSR) and release of HSF1 from its cognate promoter elements.

33 showed direct binding of HNF3beta to 15-PGDH promoter elements.

34 sigma factors and the presence of additional promoter elements.

35 definition of phylogenetically conserved CHR promoter elements.

36 t lacked similarity to the E. coli sigma(70) promoter elements.

37 duced with the loss of RB harbored different promoter elements.

38 der the control of the Tie2, Runx1, or Prox1 promoter elements.

39 of E2F or pocket proteins p107 and p130 with promoter elements.

40 OTX2) may result from the action of multiple promoter elements.

41 sites (TFBSs) in evolutionary conserved and promoter elements.

42 led the presence of potential wound-response promoter elements.

43 to detect sequences overrepresented in their promoter elements.

44 f LDSS-P as a method to delineate functional promoter elements.

45 SS) at variable distances downstream of core promoter elements.

46 ion can occur in the absence of defined core-promoter elements.

47 ay be driven to increased activation through promoter elements.

48 ivates viral genes by binding exclusively at promoter elements.

49 ter fusions were made to identify regulatory promoter elements.

50 with promoter spacer between the -10 and -35 promoter elements.

51 tion in essentially the same way as proximal promoter elements.

52 ore promoter element, XCPE1 (the X gene core promoter element 1), that drives RNA polymerase II trans

53 tively-regulate gene expression by targeting promoter elements, a phenomenon known as RNA activation

54 d factor (TAF) subunits recognize downstream promoter elements, act as coactivators, and interact wit

55 d that epigenetic signatures at enhancer and promoter elements aligns with transcriptional variation

56 es spatial clustering of MIR335 enhancer and promoter elements along with overexpression of the MIR35

57 We first show here that the '-35' promoter element also can stabilize promoter-proximal pa

58 pment promotes transcription from the distal promoter element and contributes to the overall transcri

59 randed DNA binding affinity for an essential promoter element and diminished interaction with corepre

60 f-function 0.5-Mb deletion, encompassing the promoter element and exons 1, 2 and 3 of phospholipase C

61 ning a C-repeat/drought-responsive (CRT/DRE) promoter element and metabolic changes that enhance tole

62 luster is controlled by Twist-1 via an E-Box promoter element and supports a role for these miRNAs as

63 the nonoptimal 19-bp spacer between the -10 promoter element and the -35 promoter element in order t

64 and requires two elements: the extended -10 promoter element and the initial transcribed region from

65 n derepressed expression from wild-type (wt) promoter elements and activation of an additional promot

66 Pol II pausing correlates with distinct core promoter elements and associates a TATA-enriched promote

67 rms of subunit composition and architecture, promoter elements and basal transcription factors requir

68 ine its interactions with a panel of natural promoter elements and consensus-derived sequences.

69 ptional complex that binds in IL-10 and ICOS promoter elements and controls gene expression in human

70 transcription initiation by binding to core promoter elements and directing preinitiation complex as

71 rans-acting factors integrating at conserved promoter elements and epigenetic modifications.

72 er, MCSs impose a necessary distance between promoter elements and genes of interest.

73 t many promoters by binding upstream of core promoter elements and interacting with the C-terminal do

74 which binds to human small nuclear RNA core promoter elements and nucleates pre-initiation complex a

75 ugments recent findings identifying upstream promoter elements and provides further insights into the

76 We show that NSD1 binds near various promoter elements and regulates multiple genes that appe

77 iption with a focus on the identification of promoter elements and regulatory mechanisms.

78 TFIIIC stabilizes binding of TFIIIC to core promoter elements and results in enhanced transcriptiona

79 e combinations: increased activation of ISRE promoter elements and simultaneous activation of both IS

80 In addition to the consensus promoter elements and spacer length, the GC content of t

81 e Cbf1-Met4 complex bound to Cbf1-recruiting promoter elements and that Met31/32 are required for for

82 The organization of the different promoter elements and the activator binding site at the

83 e, which causes variable spacing between the promoter elements and the start site; this in turn cause

84 in the undifferentiated M lineage cells via promoter elements and then the CeTwist activates its own

85 rences in the relative strengths of the core promoter elements and to the presence of active binding

86 ual genes and information about transcripts, promoter elements and transcription factor binding sites

87 ional activators act at a distance from core promoter elements and work by recruiting RNA polymerase

88 acts with a conserved beta-globin downstream promoter element, and ablation of this interaction by be

89 exual reproduction and cyst formation, novel promoter elements, and a microRNA system potentially reg

90 a DNA segment that separates the -10 and -35 promoter elements, and facilitates the formation of stab

91 ough a mechanism involving direct binding at promoter elements, and increases the mutation frequency

92 action between transcriptional machinery and promoter elements, and may be the prominent source of th

93 vary according to the sequence of different promoter elements, and our results are important for und

94 ly independent initiator and downstream core promoter elements, and the conserved NFI-binding sites p

95 All core promoter elements are contacted by subunits of TFIID, wi

96 Alternatively, gene-specific promoter elements are directly fused to the binary facto

97 lds from the cyclin B2 and the canonical UPR promoter elements are upregulated by ELL2 cDNA.

98 Activation sequence-1 (as-1) cognate promoter elements are widespread in the promoters of pla

99 ity required functional vitamin D-responsive promoter elements as well as an intact VDR DNA binding d

100 sequences is consistent with the presence of promoter elements associated with MG428-dependent recA i

101 lta binds to DNA immediately upstream of the promoter element at A-rich sequences on the abrB and rrn

102 in vivo gene targeting to insert an enhancer-promoter element at an imprinted chromosome 12 locus in

103 boxes relative to each other and to the core promoter elements at different genes varies dramatically

104 eagues demonstrate the critical role of core promoter elements at p53 target loci, in that they dicta

105 cy can be altered by the nature of different promoter elements at target promoters.

106 expected, but the model was blind to distal promoter elements between -2871/-750 necessary for gonad

107 oA, IsoC, and IsoD) require Gln3 and UASGATA promoter elements, both requirements typical of NCR-sens

108 nts into close association with the proximal promoter elements bound by CONSTANS (CO).

109 transcripts shows they originate near known promoter elements but do not usually extend far enough t

110 roides fragilis sigma(ABfr) consensus -33/-7 promoter elements but lacked similarity to the E. coli s

111 -activated receptor-gamma (PPARG)-responsive promoter elements but not through liver X receptor eleme

112 Further study has shown that distinct promoter elements, but comprising the same E2F-recogniti

113 ognition of the TG motif of the extended -10 promoter element by sigma(70).

114 which is regulated by a proximal cis-acting promoter element called fibroblast transcription site-1

115 M1BP binds a core promoter element called Motif 1.

116 was able to bind to and function via a core promoter element called the Initiator (Inr).

117 stable complex that recognizes an snRNA gene promoter element called the PSEA.

118 ontaining a novel cardiac-selective enhancer/promoter element can direct stable cardiac expression of

119 The data also indicate that unmelted -10 promoter element can impair RNAP interactions with promo

120 Our results demonstrate that novel promoter elements can be identified on a genome-wide sca

121 ributions to bursting of the individual core promoter elements-CCAAT, TATAA-like, Sp1BS, and Inr-of a

122 ic repeat structure constitutes a novel core promoter element, coincides with human evolution, and co

123 ediction based deletion analysis of both the promoter elements confirmed the necessary cis-acting reg

124 factor family members to an ERalpha minimal promoter element containing GC/CA-rich boxes.

125 Dorsal gland promoter element-containing effectors are at the front l

126 itu hybridisation and catalogue dorsal gland promoter element-containing effectors from available cys

127 elial growth factor (VEGF) and that the VEGF promoter element contains multiple TTF-1-responsive sequ

128 ising interesting possibilities for how core promoter elements contribute to defining promoters that

129 e-specific transcription factor occupancy of promoter elements contribute to the epigenetic control o

130 rected binding of RNA polymerase to distinct promoter elements controls transcription and promotes ad

131 itiator (Inr) element has been the only core promoter element described in the divergent unicellular

132 ch trans interactions are controlled by core promoter elements describes a general mechanism.

133 We report that core promoter elements determine this promoter specificity; a

134 at are dependent on a TCT or downstream core promoter element (DPE) motif.

135 box or AT-rich region but not the downstream promoter element (DPE) or the motif ten element (MTE).

136 motif ten element (MTE), and downstream core promoter element (DPE) promoter motifs within the TFIID-

137 the TATA box, initiator, and downstream core promoter element (DPE), which confer specific properties

138 initiator, TATA box, and the downstream core promoter element (DPE), which confer specific properties

139 Inr), motif ten element (MTE) and downstream promoter element (DPE)-in a single promoter, and is dist

140 motifs, the TATA box and the downstream core promoter element (DPE).

141 nts such as the TATA box and downstream core promoter element (DPE).

142 TA-box, initiator [Inr], and downstream core promoter element [DPE]) that confer specific properties

143 genome integration, a selectable marker and promoter elements driving a coding gene.

144 e data, we suggest coevolution of epigenetic promoter elements during the establishment of C4 photosy

145 Mutations in this promoter element eliminate the transcription delay and p

146 calization of the uninduced gene depended on promoter elements essential for induction and required t

147 Our data reveal how the TATA and BRE promoter elements facilitate recruitment of the essentia

148 spite the remarkably similar arrangements of promoter elements, FadR predominately regulates fabA exp

149 g regulatory elements as well as the minimal promoter element for optimal expression in each case.

150 required to bind to DNA upstream of the -35 promoter element for transcription activation suggests t

151 ed motifs using microarray data may identify promoter elements for both RpoS and other sigma factors.

152 uences in mammals identified the likely core promoter elements for most genes encoding OXPHOS subunit

153 is work identifies and validates some of the promoter elements for mouse Ogt and Mgea5 genes.

154 egree of sequence similarity between -35/-10 promoter elements for RpoS, RpoD, and other sigma factor

155 Here, we identified promoter elements for several transcriptional factors in

156 e similarity searches to matrices of -35/-10 promoter elements found in G. sulfurreducens and in Esch

157 tiple class predictor to separate classes of promoter elements from enhancers or nonfunctional DNA.

158 attern of histone modification distinguished promoter elements from potential enhancer elements acros

159 Core promoter elements function beyond initiation, and when o

160 The downstream core promoter element functionally independent of the initiat

161 or the majority of the 5' genomic regulatory promoter elements fused with ETS genes.

162 SGF-2 binds to promoter elements governing posterior silk gland-specifi

163 However, each mutated core promoter element had a distinct effect on expression: CA

164 1 promoter is CpG rich, no discernable basal promoter elements had been identified.

165 To date, relatively few clock-associated promoter elements have been identified and characterized

166 Several core promoter elements have been previously identified in euk

167 romoter elements in metazoans, but analogous promoter elements have not been identified in Saccharomy

168 1-deficient worms requiring the same UPR(mt) promoter element identified in C. elegans.

169 duced in a reporter-gene system, and a small promoter element immediately upstream of the translation

170 e promoter, identifying for the first time a promoter element important for late promoter function in

171 s later verified E2F1 responsiveness of this promoter element in C(2)C(12) myoblasts and IMR90 fibrob

172 binding of transcription factors to the AP-1 promoter element in macrophages.

173 between the -10 promoter element and the -35 promoter element in order to facilitate productive RNA p

174 a previously unknown liver-specific enhancer-promoter element in the wild-type AAV2 genome that is fo

175 provide evidence that the CHR is the central promoter element in transcriptional regulation of late c

176 he effects of mutations in coding regions or promoter elements in a highly parallel fashion.

177 y, and the holoenzyme releases contacts with promoter elements in a non-sequential fashion during esc

178 hows that RBR1 binds in the proximity of E2F promoter elements in CCS52A1 and CSS52A2 genes, central

179 tions between retinoid X receptors and CYP4F promoter elements in epidermal cells.

180 ss genes, recognizes short sequence-specific promoter elements in metazoans, but analogous promoter e

181 onservation and divergence of the snRNA gene promoter elements in other species of insects.

182 When the nonoptimal spacing between promoter elements in P1 or the coagulase promoter was al

183 The role of core promoter elements in regulating transcription initiation

184 ng HO-1 expression by participation with its promoter elements in renal epithelial cells.

185 nteraction promotes SRF binding to essential promoter elements in SM-specific genes.

186 Active LMO2 promoter elements in T-ALL included a previously unrecog

187 ing a Shn/Smad repression complex on defined promoter elements in the brinker (brk) gene.

188 Unmarked deletions of these promoter elements in the D39 genome also led to signific

189 Among the most highly enriched promoter elements in the induced gene set were heat-shoc

190 reporter system to explore roles of specific promoter elements in this bidirectional initiation of tr

191 ed promoters have identified overrepresented promoter elements in various biosynthetic pathway genes,

192 ption driven by MYC2 using JAZ6 and JAZ8 DNA promoter elements in yeast one hybrid assays.

193 erminal domain of sigma(54) bound to the -24 promoter element, in which the conserved RpoN box motif

194 8 cooperation to be essential for normal p53-promoter element interactions and gene transactivation-a

195 open reading frames, identification of gene promoter elements, intron/exon splicing sites, and SH RN

196 nd of the cis-regulatory element in the BCL2 promoter element is highly dynamic in nature and can for

197 The TCT core promoter element is present in most ribosomal protein (R

198 A single nucleotide change in a conserved promoter element is responsible for both human-selected

199 Binding of endogenous c-Myc to the distal promoter element is significantly enhanced upon interleu

200 his motif, designated the hypoxia-responsive promoter element, is enriched in promoters of hypoxia-re

201 s with expression of EKLF target genes whose promoter elements it no longer binds.

202 stood, since IE62 efficiently transactivates promoter elements lacking this sequence.

203 polymerase (RNAP) binding to a conserved -10 promoter element located at the upstream edge of the tra

204 ction of two or more features such as active promoter elements, location and connectivity.

205 approaches or the use of highly active viral promoter elements may overwhelm a cell's post-transcript

206 We identify a dorsal gland promoter element motif (termed DOG Box) present upstream

207 Additional, as-yet-unidentified core promoter elements must be present in eukaryotic genomes.

208 ssion, RNA interference underexpression, and promoter element mutation studies.

209 the ferric uptake regulator (Fur); however, promoter elements necessary for regulated expression of

210 es 18 to 22 and 27 to 29), a downstream core promoter element (nucleotides 27 to 29 and 30 to 33), an

211 nding domain in complex with a high affinity promoter element of another MODY gene, HNF1alpha, which

212 clude the binding of sigma(70) R4 to the -35 promoter element of class II promoters.

213 The promoter element of the KRAS gene contains a GC-rich nuc

214 transcription factor that binds to the core promoter element of the rDNA.

215 To define the core promoter elements of bidirectional promoters in human, w

216 rect binding of NF-kappaB p65 subunit to the promoter elements of mir-17-92, mir-125b-1, mir-21, mir-

217 MUC1 occupies the promoter elements of multiple genes directly involved in

218 Further, we show that MP binds to distinct promoter elements of multiple genetically defined PIN ge

219 This study aimed to characterize the basic promoter elements of PRPF31 and TFPT.

220 Promoter elements of similar size from zebrafish and Tet

221 a transgenic vector expressing mpl from the promoter elements of the 2-kb region of DNA just proxima

222 ne factor 3 complex (ISGF3) does not bind to promoter elements of the affected genes.

223 when juxtaposed with additional far-upstream promoter elements of the gene.

224 inding sites were identified in the putative promoter elements of their corresponding genes.

225 ites by core clock transcription factors and promoter elements of these effector genes provided a fun

226 al transcription factors/coregulators at the promoter elements of various genes.

227 .2 regulates NeuroD1 through two independent promoter elements, one that is bound and activated direc

228 Expression of Rv0081 initiates from two promoter elements; one promoter located downstream of th

229 irectly by the position of a particular core promoter element or the first nucleosome.

230 induction of the HSR is independent of these promoter elements or E2F/DP and instead requires a disti

231 ne promoters is not due to conventional core promoter elements or splicing signals.

232 atoma cells to elucidate how a conserved DR1 promoter element present in the promoters of L-FABP and

233 en on the basis of identified cis-regulatory promoter elements, presented considerable differences in

234 tween upstream activation sequence (UAS) and promoter elements, promoter and terminator regions, and

235 es, but also this unexpected complexity in a promoter element provides additional justification for t

236 ng site lies immediately upstream of the -35 promoter element recognized by Region 4 of the sigma sub

237 ated that the hdrRM system utilizes the same promoter elements recognized by ComE and thus appears to

238 rrence of a base pair at a given position of promoter elements reflects its contribution to intrinsic

239 The weak P1 promoter elements remain relaxed in the three genetic ba

240 We identify a conserved promoter element required for TamA activation, and show

241 his study was undertaken to identify the MIF promoter elements responsible for regulating gene expres

242 We identify 3 critical promoter elements responsible for transcriptional activa

243 DNA binding domains (DBDs) bound to IFN-beta promoter elements revealed flexibility in the loops (L1-

244 In search of another core promoter element(s), a nonredundant database containing

245 omain mediates Hamp suppression via proximal promoter element(s).

246 2) and sigma(4) matches the distance between promoter elements separated by approximately 17 bp.

247 We identify and experimentally validate a promoter element sequence motif that is enriched upstrea

248 Nestin antibodies and GFP driven by nestin promoter elements serve as excellent markers for the rea

249 The majority of identified Flavobacterium promoter elements show homology to those of other member

250 eover, although the host genomic copy of the promoter element showed no CpG methylation, the same seq

251 Unlike previously defined promoter elements shown to affect alternative splicing,

252 e clusters exhibited little gene homology or promoter element similarity, and largely overlapped with

253 Novel promoter elements such as the E box in Spga-specific gen

254 ovides a genome-wide background for specific promoter elements, such as transcription-factor binding

255 The sequences of predicted promoter elements suggest that the alternative sigma fac

256 l promoter opening is recognition of the -10 promoter element (T(-12)A(-11)T(-10)A(-9)A(-8)T(-7) cons

257 No promoter element (TATA or CAAT box) was observed for eit

258 s a methodology to identify and characterize promoter elements that affect the distribution of stocha

259 Furthermore, several core promoter elements that are absent in the slob57 promoter

260 l transcription factors and for the DNA core promoter elements that are located close to transcriptio

261 s driven from both initiator (Inr) and novel promoter elements that are tightly developmentally regul

262 s were infected with rOka mutants lacking gI promoter elements that bind cellular transactivators, sp

263 Promoter elements that contribute to high light (HL) ind

264 in the ChIP-Seq screen and characterize the promoter elements that facilitate PSPTO_1203-dependent r

265 Furthermore, we identified critical promoter elements that mediate the inductive effects of

266 We investigated the signals and promoter elements that regulate CTSK gene expression in

267 e C terminus of sigma(70) and binds to a DNA promoter element, the MotA box.

268 This complex binds to an essential promoter element, the proximal sequence element, centere

269 amily of sigma factors contact two conserved promoter elements, the -10 and -35 elements, which are s

270 artial interactions with the -10, -35 and UP promoter elements; the TG motif of the extended -10 elem

271 ectional promoters utilize a variety of core promoter elements to initiate transcription.

272 The ability of core promoter elements to modulate transcriptional bursting i

273 ncy, but the contribution of individual core promoter elements to transcriptional bursting is not kno

274 hat lower c-MYC to direct targeting of these promoter elements unless this assay, or similar ones, de

275 tory sequence with similarity to an upstream promoter element (UP) was identified upstream of the oxd

276 data demonstrate the significance of the 5' promoter element upstream of the conventional KIR promot

277 We find that a promoter element upstream of the TSS, the "discriminator

278 ulated operons identified likely -35 and -10 promoter elements upstream of a number of functionally i

279 We found that, while Pfim3 promoter elements upstream of the +1 transcriptional sta

280 majority of locations contain the four core promoter elements- upstream TFIIB recognition element (B

281 the inductive signal is absent, and another promoter element, VPCact, which is required for activati

282 A 3-kb human ROBO4 promoter element was able to drive reporter expression i

283 Moreover, CREB binding to this promoter element was confirmed by chromatin immunoprecip

284 The LMP1-regulated promoter element was mapped to a region containing two E

285 ontaining the bb0729-cdr operon and upstream promoter element was used to complement the cdr mutant.

286 e deletion or mutation of ZmHyPRP regulatory promoter elements we conclude that the promoter expressi

287 ifferent configurations relative to the core promoter elements, we constructed promoter-lacZ fusions

288 Putative -35/-10 promoter elements were also identified in the G. sulfurr

289 Spatially distinct promoter elements were found to be required for post-ger

290 For this purpose, TAPNAC promoter elements were fused to the beta-glucuronidase (

291 their ability to bind and amplify identified promoter elements when present in a genomic DNA context

292 The HLA-E CGI functions as an active promoter element which is dramatically repressed by DNA

293 rase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the

294 usters of co-regulated genes with shared cis promoter elements, whose expression can be controlled po

295 zed that the mutation identified a candidate promoter element with a more widespread role in gene reg

296 ontext of the holoenzyme, recognizes the -10 promoter element with the same efficiency and specificit

297 c leukaemia, human T-ALL samples largely use promoter elements with little influence from distal enha

298 NA sequences of BvgA-binding motifs and core promoter elements would indicate the opposite.

299 tivity in skeletal and cardiac myocytes (MCK Promoter Element X [MPEX]).

300 X gene promoter, here we identify a new core promoter element, XCPE1 (the X gene core promoter elemen