ライフサイエンスコーパス: promoter region

1 fferences reside in the "so called JP2" ltxA promoter region.

2 dant changes in DNA methylation at the Fgf21 promoter region.

3 ene SOX9 through interaction of PML with its promoter region.

4 rogressive demethylation within its putative promoter region.

5 e (Mi-2/NuRD) repressor complex to the Il12b promoter region.

6 ctive chromatin that interacts with the KLF5 promoter region.

7 main, bringing the elongation complex to the promoter region.

8 ated in tumors with integrations in the TERT promoter region.

9 ern observed with Bmal1 association with the promoter region.

10 ines presented hypermethylation of the BRCA1 promoter region.

11 often inactivated by hypermethylation of its promoter region.

12 redicted from the nucleotide sequence of the promoter region.

13 cells and the direct binding of Nrf2 to FST promoter region.

14 TFBSs of a gene are likely to locate in the promoter region.

15 Milk EPIT enhanced methylation of the GATA-3 promoter region.

16 ntial CREB-binding sites in the mouse leptin promoter region.

17 3, acts as a repressor upstream of the BECN1 promoter region.

18 n chromatin marks extending from the minimal promoter region.

19 as reflected by the Hmo1 extension and core promoter region.

20 inent hypoxia response elements in the CLDN1 promoter region.

21 escued some deleterious substitutions in the promoter region.

22 tein 1 (AP1), STAT, and Smad DBS in the TSLP promoter region.

23 ze three different binding sites within this promoter region.

24 ated histone 3 lysine 9 (H3K9ac) at the HER2 promoter region.

25 nding of the phosphorylated OmpR to the mcpM promoter region.

26 also revealed DNA methylation changes at its promoter region.

27 response and had methylation sites in their promoter region.

28 883 lies in a PAX2 binding site in the EPHA2 promoter region.

29 redict the nucleosome positioning signals in promoter regions.

30 mark peaks in relevant tissue types and gene promoter regions.

31 sity of epialleles analysed at specific gene promoter regions.

32 genes by binding directly to their putative promoter regions.

33 the 5' upstream regulatory, first intron or promoter regions.

34 ut genomes, and are especially found in gene promoter regions.

35 that Nrf2 binds the Gbe1 and Phka1 upstream promoter regions.

36 explained the elevated translocation risk of promoter regions.

37 ters were further utilized to discover novel promoter regions.

38 y for detecting weak binding signals at gene promoter regions.

39 bidirectional at newly evolved enhancers and promoter regions.

40 studies on RPGs are largely limited to their promoter regions.

41 matin and are found associated with Hox gene promoter regions.

42 idant response elements (AREs) in their gene promoter regions.

43 inding sites include approximately 1700 gene promoter regions.

44 st significantly enriched in hypermethylated promoter regions.

45 understanding the real regulatory content of promoter regions.

46 ased against accessible chromatin located at promoter regions.

47 and MYB at nucleosome-depleted enhancer and promoter regions.

48 well as a quadripartite binding motif in six promoter regions.

49 riction enzyme Hi-C with sequence capture of promoter regions.

50 exhibited hypermethylation, particularly at promoter regions.

51 s to 18S and 28S rRNAs and localizes to rDNA promoter regions.

52 oxidant gene expression by direct binding to promoter regions.

53 thylation in adipose tissue, particularly in promoter regions.

54 were analyzed for methylation alterations at promoter regions.

55 serum response factor binding sites in their promoter regions.

56 by a potential transcriptional terminator in promoter region 298 to 397 with a DeltaG = -7.9 kcal/mol

57 ha, enhance EGFR expression, mediated by the promoter region -856(A) to -226(T).

58 ic G-quadruplex structures formed in the RET promoter region act to repress the transcription of this

59 factor M1BP, which associates with the core promoter region, activates transcription of RP genes.

60 We find that mutations in several promoter regions affect transcription start site (TSS) s

61 tly binding to CACTTTG (+115 to +121) of p53 promoter region and activating p53 transcription, sugges

62 6-binding elements in the Plexin A4 (Plxna4) promoter region and affects Plxna4 expression.

63 e that strain-specific sequences in the cagA promoter region and CagA expression levels influence int

64 lly modulated by both DNA methylation at the promoter region and chromatin accessibility of an upstre

65 by a combination of demethylation of its own promoter region and deficiency in Keap1 instead of gene

66 ntly, such as hypomethylation of the ELF5-2b promoter region and down-regulation of HLA class I antig

67 e nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-

68 Increased abundance is directed by both the promoter region and introns of the G. gynandra gene.

69 and colorectal cancer) by methylation of the promoter region and of a putative enhancer.

70 pendent potassium (Kv) channel subunit Kcna2 promoter region and rescues Kcna2 expression in the inju

71 We found 44% promoter regions and 75% CpG islands were T-47D cell typ

72 The similarity was specific for promoter regions and cerebellum and frontal cortex expre

73 found that nucleosome occupancy increases in promoter regions and decreases in intergenic regions in

74 ch effort in this area has examined proximal promoter regions and epigenetic alterations at other loc

75 ChIP signal is found both in promoter regions and throughout the coding sequences of

76 cellular MTP levels by introducing distinct promoter regions and unique 5'-UTRs, which contain eleme

77 nding sites within the LIF (stemness factor) promoter region, and demonstrate LIF repression by ZEB1.

78 We show that c-Jun directly binds to the GLS promoter region, and is sufficient to increase gene expr

79 upported the recruitment of BRD4 to the BATF promoter region, and p300 inhibition similarly augmented

80 AT2R transcription start site contain a core promoter region, and regions upstream of 70 bp to 3 kbp

81 oximal part of a partner gene, including its promoter region, and the distal part of ALK, including t

82 f1 expression by directly binding to the Sf1 promoter region, and the repressive function was complet

83 ces that influence nucleosome positioning in promoter regions, and their relation to gene regulation,

84 cription factors and DBS present in the TSLP promoter region are differentially used in intestinal ep

85 Eukaryotic promoter regions are frequently divergently transcribed

86 Thus, promoter regions are intrinsically bidirectional and are

87 Fortuitous promoter regions arising during evolution promote bidire

88 Strikingly, fortuitous promoter regions arising in foreign DNA produce equal tr

89 hromatin marks (acetylation) at its proximal promoter region as well as increased cyclic adenosine mo

90 omozygous and heterozygous variations in the promoter region at -550 (L/L) and -221 (X/Y), respective

91 onucleotides containing the G allele of this promoter region bound nuclear extracts more avidly.

92 ncer element and other stem-related genes in promoter regions bound by BRD4.

93 tion of the rRNA operons required the rrn P1 promoter region but not the rrn P2 promoter or the rRNA

94 ed acetylation of histones in the respective promoter regions but also re-expression of APM component

95 t the majority of HREs reside distant to the promoter regions, but the function of these distal HREs

96 eptible, share the identical coding/proximal promoter regions, but vary in the upstream regulatory re

97 s quantified at 7 CpG sites within the SFRP1 promoter region by pyrosequencing.

98 ins were not detected to bind the respective promoter regions by chromatin immunoprecipitation (ChIP)

99 reased association of PRC2 not only with the promoter region chromatin but with HNF4alpha itself.

100 T enhancer sequences), together with the LAT promoter region, comprises a bidirectional promoter requ

101 The TRAV15/DV6 promoter region conferred increased germline transcripti

102 the first intron of the human and mouse PEDF promoter regions, confirmed by binding assays.

103 In the extended BCL2 P1 promoter region containing both Pu39 and P1G4, P1G4 appe

104 The ability of Bmal1 to bind the hGH1 promoter region containing the E-box element was confirm

105 Additionally, the analysis of the HvPAPhy_a promoter region containing the GCN4/Skn1/RY motif highli

106 n did not directly interact with the minimal promoter region containing the TGF-beta response element

107 ATP6V1A, we discovered that the ATP6V1A core promoter region contains three YY1 binding sites.

108 permethylation of CpG islands in the RASSF1A promoter region contribute to epigenetic inactivation.

109 on level in whole genome but reduces that in promoter regions CpG sites of CYP2B6 and CYP3A4 genes un

110 Sequencing of a distal IL1RL1 promoter region demonstrated that SNPs rs6543115(C) and

111 ion occurs at different positions within the promoter region, depending on promoter sequence and init

112 ta suggest that ALV integrations in the TERT promoter region drive the overexpression of a novel anti

113 ense transcribing polymerase upstream of the promoter region exhibited an increase in the absence of

114 n and identified a terminator located in the promoter region extending from 298-397 that alters ltxA

115 is study examines polymorphisms in the CRYAA promoter region for association with ARC and elucidates

116 ean offspring of non-HFD-fed dams, essential promoter regions for Pomc expression were enriched with

117 To facilitate selection of promoter regions for transgenic reporters, we assembled

118 quadruplex (G4) formed at the oncogene c-MYC promoter region functions as a gene silencer.

119 5-hmC at distinct genic contexts, including promoter regions, gene bodies, intron-exon boundaries, a

120 Our study shows that promoter regions harbour recurrent mutations in cancer w

121 pression through DNA methylation of the PTEN promoter region has also been reported in a number of ot

122 geneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA exp

123 DNA methylation at a gene promoter region has the potential to regulate gene trans

124 ads to a considerable increase in H3K4me3 at promoter regions; however, these changes in H3K4me3 have

125 Furthermore, functional screening of the Mkx promoter region identified several upstream transcriptio

126 tro, leptospiral PerR could bind to the perR promoter region in a metal-dependent manner.

127 CTCF-binding site interacted with the ORMDL3 promoter region in CD4(+) T cells exclusively from subje

128 e found decreased binding of EGR-1 to the GR promoter region in Fgf2 KO mice.

129 cing confirmed hypermethylation of the APEX1 promoter region in HD cells relative to control, as well

130 ll molecules) can bind to quadruplex-forming promoter regions in a number of genes and down-regulate

131 ysically interacts with the FGF10 and MRPS30 promoter regions in breast cancer cell lines.

132 We found bexarotene increased RXR binding to promoter regions in cortex of APOE3 mice.

133 Promoter regions in foreign environments lose the direct

134 that pCREB enrichment on the C/EBPbeta gene promoter regions in rats with gp120 was higher than that

135 s of all annotated C-phosphate-G islands and promoter regions in the human genome, we report a pilot

136 ling views, they co-occurred within the same promoter region: initiation originating from a focused P

137 allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of dep

138 novel AP-1 site at -1363 bp of the human TF promoter region is highly conserved across multiple spec

139 hether it is also actively excluded from non-promoter regions is not clear.

140 A case study conducted at promoter regions is presented: four out of twelve chroma

141 ing to and inducing transcription on the p27 promoter region leading to a subsequent G1 arrest.

142 D-associated hypermethylation within the TXK promoter region negatively correlates with gene expressi

143 cal nuclease (MNase)-defined nucleosome-free promoter regions (NFRs), where they separate divergent t

144 Intriguingly, DNA methylation in the promoter region of 226 genes was found to be regulated b

145 sulting in increased NICD recruitment to the promoter region of a Notch target gene.

146 delta, we used gene targeting to replace the promoter region of a TRAV12 family member with one from

147 An AP1 binding site was found in the promoter region of A20.

148 se warblers-is perfectly associated with the promoter region of agouti, and genotypes at this locus o

149 The promoter region of APOB bound RAD21 but not RAD21 p.622

150 ch includes a microsatellite (RS3) in the 5' promoter region of Avpr1a.

151 ed the binding of BRD4, but not BRD3, to the promoter region of Bdnf in the NAc, whereas systemic inj

152 lar, we found that 5hmC modifications at the promoter region of brain-derived neurotrophic factor (BD

153 In particular, the promoter region of cardiac transcription factors showed

154 in complex, which then binds to the proximal promoter region of CASP3.

155 repeat transposable element insertion in the promoter region of CitRWP that cosegregated with polyemb

156 y associated with ARC were identified in the promoter region of CRYAA: rs3761382 (P = 0.06, OR (Odds

157 nucleus, Pak1 via C-Fos binds to a specific promoter region of DNA repair kinase ATR (ataxia-telangi

158 anscriptional start site and within the gene promoter region of Egr-1 (early growth response protein

159 related cataract when mutated, the extended promoter region of EPHA2 was screened for variants.

160 on revealed that MYST3 binds to the proximal promoter region of ERalpha gene, and inactivating mutati

161 e, we find that Drosophila SIN3 binds to the promoter region of genes involved in methionine cataboli

162 An SNP in the promoter region of Granule Bound Starch Synthase I was i

163 inding protein 2 (MeCP2) was enriched in the promoter region of Gria1 encoding GluA1 and this enrichm

164 he ER stress response element present in the promoter region of Grp78, the master regulator of ER str

165 cope analyses suggest that Nfic binds to the promoter region of Hhip.

166 F2alpha/VEGF-A expression via binding to the promoter region of HIF2alpha.

167 ups, we found a hypomethylated region at the promoter region of HOXA4 in 55% of the patients.

168 ty of glucocorticoid receptor binding to the promoter region of KLF15 In three independent proteinuri

169 itro identified two p53-binding sites in the promoter region of Krt17.

170 It promoted the association of p53 to the promoter region of miR-128, and enhanced the transcripti

171 DNA methyltransferase-1 was recruited to the promoter region of miR-184, and the CpG sites at the ups

172 analyses indicated the binding of p53 to the promoter region of miR-199a-3p.

173 iR-451a by enhancing H3K9 methylation at the promoter region of miR-451a.

174 ntifies the A-allele of rs1800734 within the promoter region of MLH1 as perturbing the binding of TFA

175 ession decreased the binding of STAT6 to the promoter region of Muc5ac in mice exposed to OVA.

176 ation demonstrated that DDB2 can bind to the promoter region of NEDD4L and recruit enhancer of zeste

177 pressor complex mSin3A-HDAC1 at the proximal promoter region of OGA and correspondingly decreased OGA

178 The promoter region of Os12bglu38 gene of rice has been isol

179 ysis revealed extensive polymorphisms in the promoter region of OsORAP1 between the ozone-susceptible

180 tment stimulates the binding of SMAD3 to the promoter region of S1PR3.

181 hows 16 candidate SMAD3 binding sites in the promoter region of S1PR3.

182 tional modification analysis showed that the promoter region of SHP-1 was enriched with H3K4me1 and H

183 1, which strongly associates with a proximal promoter region of shu1(+) in vivo in response to iron r

184 NA methylation of CpG islands located in the promoter region of some tumor suppressor genes are very

185 ularly as a result of a gene fusion with the promoter region of the androgen-induced TMPRRSS2 gene.

186 sis reveals that PRMT5 binds to the proximal promoter region of the AR gene and contributes mainly to

187 pendent chromatin remodeler, on the proximal promoter region of the AR gene.

188 is shows that both VelB and VosA bind to the promoter region of the beta-glucan synthase gene fksA in

189 A quadruplex sequence from the promoter region of the c-KIT gene forms a stable quadrup

190 probe (DAOTA-M2) and a G-quadruplex from the promoter region of the c-myc oncogene revealed that they

191 KLF10 occupied GC-rich sequences in the promoter region of the EMT-promoting transcription facto

192 studied bind a conserved AT-rich site in the promoter region of the exoY gene from Mesorhizobium loti

193 tified two NFkappaB-binding sites within the promoter region of the human SLICK (KCNT2) and orthologo

194 fected with a reporter construct bearing the promoter region of the kidney-specific Ncx1 gene.

195 Surprisingly, deletion of the core promoter region of the major immediate early promoter (M

196 Mechanistically, FOXM1 bound to the promoter region of the Met gene and transcriptionally in

197 ruct consisting of a portion of the proximal promoter region of the mouse COX-2 gene upstream of luci

198 enes, bind to adjacent sites in the upstream promoter region of the nitrate reductase gene, NIA1, and

199 H3K27me3 was enriched at the promoter region of the Notch ligand Jag1 in podocytes, a

200 atabase search on regulatory elements in the promoter region of the OPG gene, and identified two pote

201 l as validating the importance of a specific promoter region of the PAPhy_a gene which contains three

202 ommon functional polymorphism located in the promoter region of the serotonin transporter gene (SLC6A

203 repeat length polymorphism (5HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A

204 d histone H3K27 trimethylation levels at the promoter region of the Snail2 target E-cadherin.

205 ted that directed DNA methylation of a wider promoter region of the target loci IL6ST and BACH2 decre

206 n cis-acting elements that we observe in the promoter region of the two alleles.

207 taining this polymorphism and located in the promoter region of this gene with attention-deficit/hype

208 flammatory responses by directly binding the promoter region of Tnfaip3, a deubiquitinating enzyme in

209 CHD4 directly binds the proximal promoter region of Ucp1, which is displaced upon treatme

210 ng analysis confirmed that AbrB bound to the promoter region of yloA.

211 After sequencing 2-kb promoter regions of 472 genes in 410 healthy adults, we

212 blood DNA methylation levels of 384 CpGs in promoter regions of 82 addiction-related genes in 256 Af

213 demonstrated that VtlR binds directly to the promoter regions of abcR2 and the three hypothetical pro

214 The promoter regions of active genes in the eukaryotic genom

215 Promoter regions of active NL genes are often excluded f

216 and the protein globally associates with the promoter regions of actively expressed genes in a heat-d

217 thylation (H3K4me3) mark frequently found at promoter regions of actively transcribed genes and is th

218 In addition, the promoter regions of CDKN2A, CDKN2B, and of RASSF1A were

219 )-rich chromosomal loci, associates with the promoter regions of cell cycle-regulated genes, and shar

220 2 (polycomb repressive complex-2) binding to promoter regions of claudin-5, VE-PTP, and vWf.

221 esulting in increased binding of BRG1 to the promoter regions of Ctnnb1, Mef2d, and Dbn1.

222 ique) for the first time to characterize the promoter regions of differentially expressed brain genes

223 were associated with motifs enriched in the promoter regions of differentially expressed genes (DEGs

224 ChIP-seq assays identify ELAV in the promoter regions of extended genes.

225 s-specific changes to DNA methylation at the promoter regions of genes aberrantly transcribed followi

226 er-order DNA structures typically present at promoter regions of genes and telomeres.

227 ting histone H3 lysine 27 methylation at the promoter regions of genes involved in cardiac hypertroph

228 differential transcription factor binding of promoter regions of genes involved in lipid oxidation in

229 that TRB1 is preferentially associated with promoter regions of genes involved in ribosome biogenesi

230 ferase 2A (KAT2A, also known as GCN5) in the promoter regions of genes.

231 riched at ribosomal protein genes and in the promoter regions of rRNA genes.

232 recipitation revealed that SUB1 binds to the promoter regions of several oncogenes such as PLK1 (Polo

233 1 elements, and hypermethylation in specific promoter regions of single-copy genes in NPC1-deficient

234 s Hey1 and Hey2, which bound directly to the promoter regions of Snail2 and Twist1 and repressed gene

235 that SUMO-1 marks chromatin at the proximal promoter regions of some of the most active housekeeping

236 several mechanisms: chromatin remodeling in promoter regions of specific genes, blockade of NF-kappa

237 rvation triggers lncRNA transcription across promoter regions of stress-responsive genes including fb

238 d assays; and 5) disrupts CAR binding to the promoter regions of target genes in chromatin immunoprec

239 eling and facilitate the binding of SMAD3 to promoter regions of target genes.

240 he methylation status of CpG loci within the promoter regions of Th1/2 lineage commitment genes (GATA

241 to an 11-bp inverted repeat sequence in the promoter regions of the identified target genes and that

242 te that endogenous Osr2 protein binds to the promoter regions of the Sema3a and Sema3d genes in the e

243 ly, PRDM16 represses ISGs through binding to promoter regions of these genes and blocking the activat

244 FOXF2 bound to promoter regions of these genes indicating direct transc

245 Binding occurred mainly in the 500-bp promoter regions of these genes.

246 to five cis-acting elements enriched in the promoter regions of these transcription factors.

247 teracting the action of GATA3 at the ERalpha promoter region, overexpression of FOXC1 hinders recruit

248 tween genotypes of the serotonin transporter promoter region polymorphism and serum 5-HT level.

249 the full mtrR sequence and a portion of its promoter region; portions of ponA, porB, gyrA, and parC;

250 RNA polymerase II is engaged with promoter regions prior to this transcriptional burst, su

251 ies were mostly restricted to CpG islands or promoter regions, recent findings indicate that many of

252 crRNAs targeting the promoter region reduced transcript levels down to 8%.

253 4 di-methylation (H3K4me2), to the AHR gene promoter region, resulting in repression of AHR expressi

254 Analysis of the yloA promoter region revealed the presence of AT-rich direct

255 Computational prediction of promoter regions revealed the presence of several putati

256 We identified a functional TOLLIP promoter region single-nucleotide polymorphism, rs574385

257 To understand whether the TRAV15/DV6 promoter region specifies TRAV15/DV6 as a Vdelta, we use

258 ng contacts identified in certain well-known promoter regions, such as the -35 and -10 elements, do n

259 interacting with the putative NACbs in their promoter region, suggesting their direct role in plant s

260 nd polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have

261 We identified the promoter region that regulates miR-143/145 microRNA expr

262 me capture, we included genome-wide proximal promoter regions that contain sequences that regulate ge

263 nity and that its binding sites include 1700 promoter regions that include genes associated with neur

264 RRN3 and GPR15, have DNA methylation loci in promoter regions that were recently reported to be hypom

265 ly, MYC is shown to be recruited to the IRF7 promoter region through interaction with nuclear recepto

266 H3K27 and H3K56 acetylation levels at their promoter regions, thus enhancing de novo lipid synthesis

267 ically, FOXC1 can bind directly to the WNT5A promoter region to activate its expression.

268 binding protein HuR (ELAVL1) binds the CD133 promoter region to regulate its expression.

269 nt for the NR4A1/Sp4 complex to bind GC-rich promoter regions to elevate transcription of the PAX3-FO

270 by which microRNAs could interact with gene promoter regions to modify gene transcription.

271 binds distinct motifs in nucleosome-depleted promoter regions to regulate heat shock genes and genes

272 manner to bind sequence-specific DNA within promoter regions to regulate lineage-specific gene expre

273 ely excised approximately 44 kb DNA spanning promoter region, transcription start site, and the CAG e

274 g luciferase assays, we demonstrate that the promoter region upstream of exon 1B is quite adequate to

275 A 6-kb promoter region upstream of the distal TSS is highly act

276 The HLA-C promoter region variant, rs2395471, 800 bp upstream of t

277 esults confirm the relationship between cagA promoter region variation and protein expression origina

278 h analysis of the functional consequences of promoter region variation within the classical HLA class

279 thylation at multiple CpG sites in the HOXA4 promoter region was associated with height in a cohort o

280 Hypomethylation of the promoter region was observed in mineralized aortic valve

281 itative RT-PCR, and DNA methylation of their promoter regions was analyzed by PCR and pyrosequencing.

282 well as its binding to SMAD3 and target gene promoter regions, was evaluated in the nucleus accumbens

283 Within the MIR122 promoter region we identified a nuclear factor-kappaB bi

284 In detailed studies of the EpCAM promoter region, we observed that ERK2 suppresses EpCAM

285 Ppd-A1 genomic sequences from the 5' UTR and promoter region were analysed in 104 accessions of six t

286 Various regions of the HABP2 promoter region were cloned into reporter constructs, an

287 DE genes with a NKD binding motif in the 5' promoter region were considered as likely direct targets

288 and H3K4me2, two active gene markers, at FST promoter region were significantly increased during SiO2

289 ivator-Like Element (TALE) locating an Ascl1 promoter region, were designed for site specific epigene

290 inhibit chromatin remodeling in the fbp1(+) promoter region where the Atf1 and Rst2 transcriptional

291 translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate gener

292 es increased methylation of CpG sites in its promoter region, which is associated with gene silencing

293 d increased H3K27 dimethylation at the Il12b promoter region, which might contribute to Il12b trans-s

294 of LanFTc1 revealed a 1.4-kb deletion in the promoter region, which was perfectly predictive of verna

295 ion is more likely to result from binding to promoter regions, which are often accessible regardless

296 ble regions of Dmp1 gene were located in the promoter region while effect of Klf5 on Dspp activity wa

297 ed by pairwise nucleotide differences in the promoter regions with estimated differences in mRNA expr

298 These genes share common promoter regions with pre-mir-21; as the miR-21 matures

299 Androgen recruits AR to Aire promoter regions, with consequent enhancement of Aire tr

300 Targeting promoter regions yielded the strongest repression, where