ライフサイエンスコーパス: prompt us to

1 These considerations prompted us to address the involvement of VE-cadherin cy

2 an regulate liver damage in diverse contexts prompted us to address the role of IL-17RA signaling in

3 ple causative genes underlie the same locus, prompting us to adopt an alternative approach to testing

4 rie-Tooth disease in three related patients, prompted us to analyse the ALS5/SPG11/KIAA1840 gene in a

5 The high virulence and mortality rate prompted us to analyze aspects of MERS-CoV pathogenesis,

6 his novel anti-inflammatory CRADD-BCL10 axis prompted us to analyze CRADD expression and its potentia

7 A replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations

8 tory and cytoprotective activity of CP-SOCS3 prompted us to analyze its intracellular turnover, as co

9 This prompted us to analyze microarray data from 261 patients

10 This finding prompted us to analyze the formation of the primary cili

11 This prompted us to analyze this scaffold in the context of a

12 This prompted us to ask if X-box-binding protein-1 (XBP1) pla

13 These puzzling results prompted us to ask whether neuroligin-3 mutant phenotype

14 parallel loss of N-cadherin expression in OS prompted us to ask whether these observations are direct

15 not be simply a crystal packing artifact and prompting us to ask if ligand-mediated oligomerization c

16 ence, a pre-requisite for sleep-like states, prompting us to ask whether sleep is present in Cnidaria

17 s of the adiposity-associated microbial OTUs prompted us to assess host genetic-microbe interactions

18 family are involved in oncogenesis and this prompted us to assess whether expression levels of indiv

19 tnership with members of the integrin family prompted us to assume the existence of a direct interact

20 This observation prompted us to characterize a deletion of the gene encod

21 This prompted us to characterize N. udagawae in comparison to

22 ecedes the peak of infected DCs in the lungs prompted us to characterize the role of neutrophils in t

23 xistence of multiple control configurations, prompting us to classify each node in a network based on

24 hibition of nuclear factor kappaB signaling, prompting us to combine AZD8835 with the Bruton's tyrosi

25 This observation prompted us to compare dietary gallstone susceptibility

26 This effect of pre-HCT MRD prompted us to compare outcomes in consecutive patients

27 ells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplan

28 This finding prompted us to compare the gene expression profile of th

29 general intolerability of AAV Rep sequences, prompting us to computationally reengineer the Rep gene

30 ates in copolymerization using this catalyst prompted us to conduct a full mechanistic study on ethyl

31 uld help us rule out specific cell types and prompt us to consider other potential mechanisms of dise

32 independently of haematological progenitors prompted us to consider organ-targeted, cell-specific th

33 This finding prompted us to consider that reduced CVR may play a role

34 cal EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative

35 This variant prompted us to consider this gene as a putative candidat

36 netic factors involved in cellular identity, prompting us to consider how the analyses of 27,578 CpG

37 is important that the development of either prompts us to consider the possibility of the other deve

38 These results prompt us to continue the development of this family of

39 Further analyses of the dataset prompted us to delve into the existing, largely unannota

40 chanistic explanation of this transformation prompted us to demonstrate that the acid-labile and solv

41 of PAC-1 were found to induce neurotoxicity, prompting us to design and assess a novel PAC-1 derivati

42 I W and BamHI Z that disrupts viral latency, prompted us to determine at the nucleotide level all rem

43 These findings prompted us to determine if SNP genotypes at SH3TC2 are

44 4 missense mutation changing Arg 729 to Trp, prompted us to determine the 1.9 A crystal structure of

45 f the disease and intended use in treatment, prompted us to determine the safety of administration of

46 tant mediators of host defense and pathology prompted us to determine their susceptibility to human i

47 our high-throughput chemical screening assay prompted us to determine whether EGF receptor (EGFR) inh

48 These observations prompted us to determine whether IgM-ALA have a role in

49 research shifted to network controllability, prompting us to determine proteins that are important fo

50 erapeutic effects in several disease models, prompting us to determine whether DMF is effective as a

51 sage effects in neurodevelopmental disorders prompted us to develop a computational approach based on

52 This prompted us to develop a high content screening assay (H

53 ion in the fruit fly Drosophila melanogaster prompted us to develop a simpler experimental approach w

54 h palladium- and copper-catalyzed processes, prompted us to develop an alternative method.

55 reviously unidentified MASP-3 G665S mutation prompted us to develop an analytical isoelectric focusin

56 The absence of reliable systems prompted us to develop an assay system based on dual enz

57 This prompted us to develop and evaluate a new class of radio

58 and issue has not been adequately addressed, prompting us to develop StrandScript, a tool that can co

59 This prompted us to directly analyze the transcriptome of dis

60 s exhibited a pH dependence in k(cat), which prompted us to elucidate the role of the new catalytic r

61 nature of its N-terminal domain (Ntd), which prompted us to elucidate the solution structure and acti

62 l is much richer than what so far known, and prompts us to establish striking analogies with the feat

63 is 10 times that of large screening trials, prompting us to estimate the prevalence of these symptom

64 tagenesis screen for T cell-lymphopenic mice prompted us to evaluate a T cell-deficient, B cell-suffi

65 ombencephalosynapsis and aqueductal stenosis prompted us to evaluate brain magnetic resonance images

66 These findings prompted us to evaluate enzyme digests as a way to remov

67 ation of oxidation of a carbon at N(6) in EA prompted us to evaluate N(6)-methyladenine (m6A), an imp

68 texture and the absence of meibomian glands prompted us to evaluate other epidermal appendages: skin

69 usly observed in persistent human infections prompted us to evaluate sequence variation in this anima

70 progestins compromise ARV anti-HIV activity prompted us to evaluate the effects of progestins on ten

71 These data prompted us to evaluate the induction and functionality

72 This prompted us to evaluate the necessity of this SH2bm for

73 concentration of antigen in the chloroplasts prompted us to evaluate the underlying tolerance mechani

74 ntion was no longer apparent after 24 hours, prompting us to evaluate the role of CD24 in lung coloni

75 ha protein up-regulation after MNNG exposure prompted us to examine c-Abl/p73alpha/GADD45alpha signal

76 n of p21 and cell-cycle arrest at G(1)/S and prompted us to examine combinations with the RNR inhibit

77 These properties of BcfA prompted us to examine its utility in inducing a protect

78 This interesting observation has prompted us to examine protein lysine succinylation in d

79 RRE (RRE61) confer RevM10 resistance, which prompted us to examine RRE structure using a novel chemi

80 ays to the development of many human cancers prompted us to examine the associations between single-n

81 both disease aggression and in vitro growth prompted us to examine the effects of a small-molecule i

82 This prompted us to examine the effects of rapamycin on rRNA

83 es to l-DOPA in the striatum, these findings prompted us to examine the impact of CK2 ablation on the

84 AML) among patients with WM treated with NAs prompted us to examine the incidence of such events in a

85 This prompted us to examine the localization, topology, and m

86 red/far-red light ratio on the fibre length prompted us to examine the phenotypic effects of RNA int

87 content of the Plasmodium falciparum genome prompted us to examine the possibility that malarial DNA

88 These data prompted us to examine the possible roles of MetAP2 in c

89 This finding prompted us to examine the relationship between MITF, en

90 ion of BRG1 and that BRG1 complexes with p53 prompted us to examine the role of BRG1 in regulation of

91 normalities in PGC1alpha knock-out (KO) mice prompted us to examine the role of PGC1alpha in CNS myel

92 is inhibited by c-di-AMP and these mutations prompted us to examine the role of TCA cycle enzymes.

93 , resulting in two cases of human infection, prompted us to examine the virulence of this virus (A/Me

94 ut not androgen-sensitive LNCaP cells, which prompted us to examine whether Aurora-A regulates the an

95 This prompted us to examine whether NER attenuation might be

96 ecursor spectinomycin with other antibiotics prompted us to examine whether spectinamides sensitize M

97 appears to be reduced in aging and AMD eyes, prompting us to examine its relationship with AMD.

98 these mutations lacked nuclear localization, prompting us to examine the role of nuclear PTEN in regu

99 e NHEJ pathways that are highly error prone, prompting us to examine the role of the alternative NHEJ

100 ation in the hydrophobic pocket of Munc18-2, prompting us to examine the role of this region in the c

101 pends upon cellular mRNA processing factors, prompting us to examine whether MMTV utilizes a similar

102 torneurons to establish orderly connections, prompting us to examine whether the intraspinal circuitr

103 and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method f

104 These findings prompted us to explore a preventive medicine which is or

105 y of boron-containing heteroalkene complexes prompted us to explore the coordination of phosphinobora

106 y in plasma membranes of airway lining cells prompted us to explore the possibility of enriching Clar

107 This unique structure prompted us to explore the possibility of protein bindin

108 he putative bacterial origin of mitochondria prompted us to explore the possible existence of NTR act

109 This prompted us to explore the SAR of the Lactobacillus reut

110 ompounds having multiple phenyl substituents prompted us to explore the use of phenyls as alternative

111 enic mediator of all four of these diseases, prompting us to explore glucocorticoid/TGF-beta signalin

112 nor necessary to control the entire network, prompting us to explore target control: the efficient co

113 dysfunctional fatty acid oxidation and ROS, prompting us to explore the effects of XN on muscle cell

114 LM helicase in meiotic recombination events, prompting us to explore the meiotic phenotype of mice be

115 tonsils of humans naturally exposed to GAS, prompting us to explore whether GAS-specific CD4+ T cell

116 of the electrode, which is also inexpensive, prompts us to explore its use in fabrication of solar-dr

117 tive yeast thiamine (vitamin B1) transporter prompted us to express human SLC35F3 in Escherichia coli

118 This prompted us to express the enzyme heterologously.

119 onsuming immunocytochemistry technique which prompted us to extend further investigation using real p

120 ns of L1 expression with cancer progression, prompted us to further characterize the effect of L1 exp

121 These observations prompted us to further characterize XEEL.

122 These findings prompted us to further investigate the biology and neuro

123 of LANA with centromeric protein F (CENP-F) prompted us to further study whether LANA targets centro

124 This prompted us to generate a high-resolution map of genomic

125 This finding prompted us to generate a series of Mcl-1 deletion mutan

126 ings of pathogenic lung inflammation in mice prompted us to hypothesize a possible role in cancer.

127 These observations prompted us to hypothesize that robust immunotherapy res

128 ved in the regulation of microglia function, prompting us to hypothesize Kv channels may also be invo

129 n A is upregulated in dysplastic epithelium, prompting us to hypothesize that it might be modulated i

130 CUL4B are linked to intellectual disability, prompts us to hypothesize a pathogenic mechanism, in whi

131 This ensemble prompts us to hypothesize that endogenous apoA-II (i) he

132 rs induce high levels of its homologue MDM4, prompt us to identify, through a receptor-based virtual

133 This prompted us to identify a pool of candidate cellular gen

134 ted in nucleoli of serum-starved HepG2 cells prompted us to identify molecules associated with BIG1 i

135 vented by using classic upstream modulators, prompting us to identify more effective approaches to ta

136 rts of regression of localized neuroblastoma prompted us to initiate a prospective cooperative trial

137 IV Nef-mediated CD4 and MHC-I downregulation prompted us to investigate a putative tyrosine motif (Y2

138 protein involved in chloroplast RNA splicing prompted us to investigate a role for APO1 in splicing.

139 high-affinity IL-2R on gammadeltaT-17 cells prompted us to investigate a role for this cytokine.

140 This observation prompted us to investigate a role for ThPOK in the CD8 T

141 This prompted us to investigate an alternative channel, the h

142 other YtxR-regulon members besides ytxAB and prompted us to investigate coregulated genes and gene pr

143 pollen at dosages that cause embryo abortion prompted us to investigate endosperm as a potential sour

144 ylogenetic relationship between RlmN and Cfr prompted us to investigate evolutionary origin of antibi

145 literature concerning c-Fos homodimerization prompted us to investigate Fos homodimerization.

146 ation of transcription and pre-mRNA splicing prompted us to investigate how automethylation is regula

147 tion of hRes expression with cellular stress prompted us to investigate hRes as a possible chaperone.

148 This prompted us to investigate in more detail the functional

149 of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pai

150 of ST18 expression in pancreatic beta-cells prompted us to investigate its regulation and its role i

151 s well as in the stomach and small intestine prompted us to investigate its role on appetite control

152 This prompted us to investigate more carefully the effects of

153 at do not fulfill the classical risk factors prompted us to investigate new risk factors of disease.

154 sophate dehydrogenase (IMPDH) inhibitors has prompted us to investigate novel mycophenolic adenine di

155 activation of Wnt/beta-catenin pathway that prompted us to investigate possible interaction among FG

156 This unexpected swing in the response prompted us to investigate the ability of different lymp

157 This prompted us to investigate the aggregation propensity of

158 ed a lymphoma in a patient with Q fever that prompted us to investigate the association between the 2

159 This prompted us to investigate the correlation between semiq

160 This prompted us to investigate the CYP76C subfamily genetic

161 Together, these results prompted us to investigate the downstream consequences o

162 n as longevity assurance homologue 6), which prompted us to investigate the effect of CerS6 modulatio

163 This prompted us to investigate the effect of differential al

164 sustains B9 plasmacytoma cell proliferation prompted us to investigate the effects of p28/CLF on mou

165 This prompted us to investigate the effects of two antidiabet

166 in vitro sulfonamide resistance in Nocardia prompted us to investigate the findings.

167 This prompted us to investigate the immunological impacts med

168 This has prompted us to investigate the importance of IL-15 in S.

169 The high conservation of the Rb cyclin fold prompted us to investigate the link between conformation

170 both therapeutic and nontherapeutic purposes prompted us to investigate the long-term effects of expo

171 This prompted us to investigate the potential connection betw

172 anciclovir in the treatment of EBV lymphomas prompted us to investigate the potential of several HDAC

173 These results prompted us to investigate the potential role of IL-8 si

174 as E. coli CPS acts on sn-2 of phospholipids prompted us to investigate the preferred positions of CP

175 ked to the ability of cells to migrate, this prompted us to investigate the role of AnxA6 in cell mig

176 nt of the DDR in oncogene-induced senescence prompted us to investigate the role of FBXO31 in DNA rep

177 This prompted us to investigate the role of matriptase, a mem

178 This observation prompted us to investigate the role of prohibitin in neu

179 This observation prompted us to investigate the role of RAD51D in cancer

180 OP data than the earlier efforts, but rather prompted us to investigate the statistical limitations o

181 t the role of the heterogeneous catalyst has prompted us to investigate the surface processes occurri

182 majority of HCMV-induced gammadelta T cells prompted us to investigate their cooperation with anti-H

183 heir inevitable seepage into the environment prompted us to investigate their potential toxicity to a

184 oton transfer dynamics of the photoacid HPTS prompted us to investigate these systems with two highly

185 This prompted us to investigate whether activation of MASP-2

186 This prompted us to investigate whether adult hippocampal neu

187 These observations prompted us to investigate whether AhR modulates the epi

188 anied by changes in epigenetic modifications prompted us to investigate whether chemicals known to mo

189 This prompted us to investigate whether CMV infection limits

190 at ERRalpha regulates OPN expression in bone prompted us to investigate whether ERRalpha controls OPN

191 This prompted us to investigate whether IGF signaling is esse

192 This prompted us to investigate whether niclosamide affects t

193 emethylation) in SZ or BP disorder treatment prompted us to investigate whether the beneficial action

194 This contradictory finding prompted us to investigate whether the beneficial effect

195 with ICAP-1, an inhibitor of beta1 integrin, prompted us to investigate whether the CCM complex inter

196 These findings prompted us to investigate whether the expression of onc

197 This action thus prompted us to investigate whether this stage can be a p

198 antigen and an immune response to foreign Ag prompted us to investigate whether VH1-46 B cells may be

199 , AKT, and Wnt/beta-catenin in fibrosis have prompted us to investigate, in a mouse model of ROS-indu

200 s an integral component of cancer metastasis prompting us to investigate a possible role of mda-9/syn

201 MP involved in the synthesis of ATP and GTP, prompting us to investigate ADS lyase in C. neoformans.

202 localization of the cardiac CaValpha2delta1 prompting us to investigate deletions of its hydrophobic

203 R did not significantly impact tumor growth, prompting us to investigate the involvement of IR.

204 ll and underlying mechanisms remain elusive, prompting us to investigate the relevance of CXCR4 in va

205 medically relevant enzymes remains unclear, prompting us to investigate their origin and evolution.

206 ar in activated SAP KO vs wild-type T cells, prompting us to investigate whether SAP is necessary for

207 as impaired by interruption of Hh signaling, prompting us to investigate whether the target of Hh ant

208 ality of this enzyme from different origins, prompted us to isolate and evaluate a high-yielding TG s

209 ression of dissatisfaction with tomato aroma prompted us to lead this study on the impact of domestic

210 lation profile is altered in Clock(-/-) mice prompted us to link the acetylome to the circadian metab

211 This prompted us to look for lysosomal proteins that are invo

212 ate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like virus

213 This prompted us to make a detailed comparative study of the

214 This prompted us to map the origin of the neural crest and do

215 A reported loss of mecA prompted us to monitor 360 cryostocked methicillin-resis

216 of identifying distinct Foxp3 T cell subsets prompted us to more thoroughly characterize Tregs in ope

217 g highly selective for phosphatidylglycerol, prompting us to obtain an X-ray structure in this lipid

218 This low yield prompted us to perform a more quantitative assessment of

219 This prompted us to perform a study aimed at identifying a se

220 (D1R) stimulation is involved in dyskinesias prompted us to perform electrophysiological recordings o

221 ders them notably less sensitive to katanin, prompting us to posit that microtubule disintegration in

222 en together, the existing results and models prompt us to postulate a new structural and functional r

223 These observations prompted us to prepare and evaluate ternary nylon-3 copo

224 Those results prompted us to prepare the Sc(3)N@C(80) trianion, which

225 -C(80), but not dianionic Sc(3)N@I(h)-C(80), prompted us to probe the causes using theoretical calcul

226 of extracellular conversion of NAD(+) to NR prompted us to probe the effects of NAD(+) and NR in pro

227 not conclusive, this initial negative result prompted us to probe unknown regulations, and malate was

228 These data prompt us to propose MG-CA as a new antidandruff drug ta

229 Collectively, these results prompt us to propose these langerin(high) MDLCs as a rel

230 amino acid at the carboxylic terminus, which prompted us to propose a mode of binding based on polar

231 y, we identify that GTP binds to eIF2Bgamma, prompting us to propose a multi-step mechanism for nucle

232 a fluctuating ribosome subpopulation, which prompts us to propose that ribosome dynamics are hierarc

233 nodes do not participate in control equally, prompting us to quantify their participations.

234 This finding prompted us to re-analyze published datasets from a rece

235 This discovery prompted us to re-evaluate the current model for the aut

236 rane proteins, including HIV-1 capsid, which prompted us to re-examine MA-PI(4,5)P2 interactions usin

237 This finding prompted us to re-examine mutants that have been reporte

238 ody Y188 that is highly specific for APP and prompted us to re-examine the expression, localization,

239 This prompted us to redefine the natural product structure by

240 sence of two nested feedback circuits, which prompted us to reexamine the behavior of M. xanthus cell

241 These findings prompted us to reexamine the role of human emerin in sup

242 rtant role for Tom1 in normal physiology and prompt us to refer to this pathway as ERISQ, for excess

243 n of synapses by neurexin/neuroligin binding prompted us to refer to this approach as "SynView." Our

244 This prompted us to refine this model by investigating the dy

245 This unique study prompted us to review current knowledge about SMM and ad

246 These unprecedented tumor responses have prompted us to review how mesothelin was discovered and

247 ole and the echinocandins are of concern and prompted us to review the experience of two large survei

248 This paradox prompted us to revisit the "two-way" hypothesis of trans

249 Caspase-3 but not other "upstream" caspases, prompting us to revisit the role of Caspase-3.

250 rsistence of Ly-6Chi monocytes in allografts prompted us to screen for a Ly-6Chi monocyte-associated

251 These data prompted us to screen MKS patients for mutations in B9D1

252 This finding prompted us to search for an interaction between neprily

253 Lens degeneration in Fpr1(-/-) mice prompted us to search for functional FPR1 expression dir

254 maintaining genomic stability in Drosophila prompted us to search for orthologs in other organisms.

255 This unexpected result prompted us to search for the factors controlling these

256 ies from the family Isididae (bamboo corals) prompted us to sequence the complete mt genome of a deep

257 oncordance of antibody status among siblings prompt us to speculate that both genetics and family env

258 ce of single-agent melphalan in this setting prompted us to study a new high-dose combination of infu

259 weak neutralizing activities of anti-V2 MAbs prompted us to study Fc-mediated activities.

260 K to crystallize in the absence of inositide prompted us to study putative conformational changes upo

261 mited to known Smad2/3-dependent ones, which prompted us to study TGF-beta1-induced signaling in macr

262 This finding prompted us to study the effects of fibrinogen and its g

263 inactive G-protein coupled receptors (GPCRs) prompted us to study the extent to which these crystal s

264 nigrostriatal dopaminergic (DAergic) neurons prompted us to study the impact of neuroinflammation and

265 ryotic cell nucleoplasm and nuclear membrane prompted us to study the putative interaction of chromat

266 n and lung cancer cells in situ This finding prompted us to study the role of HD5 in infection and sp

267 s and a role in de novo telomere biogenesis, prompting us to study the activities of Dna2 on G4 DNA-c

268 acizumab is administered every 2 to 3 weeks, prompting us to study ways to reduce the frequency of ad

269 This prompted us to subject 1a to an elaborate structure-acti

270 branches arising from the aortic arch, which prompted us to subsequently search for 3 branches in suc

271 Overall, these findings prompted us to suggest a new, to our knowledge, model fo

272 This has prompted us to suggest that HIV infection alters the end

273 y of this tethered RCM variant but have also prompted us to suggest that the originally assigned abso

274 These observations prompted us to survey the evolution of ycf1.

275 red the concept of "lethal mutagenesis" that prompted us to synthesize pyrimidine nucleoside analogue

276 irement for C-terminal exposure of the motif prompted us to term the phenomenon the C-end rule (CendR

277 tor antagonist anakinra in the first patient prompted us to test for the presence of mutations and ch

278 diverse genetic backgrounds of MRSA strains prompted us to test the accuracy of the BD GeneOhm MRSA

279 The latter finding prompted us to test the efficacy of a Shp2 inhibitor tar

280 e in other lymphomas with 9p24.1 alterations prompted us to test the efficacy of the anti-PD1 antibod

281 This observation prompted us to test the hypothesis that a substantial pr

282 This in vitro finding prompted us to test the hypothesis that blockade of EP3

283 intain secondary and tertiary VSG structure, prompted us to test the hypothesis that Th cells may pre

284 This finding prompted us to test the hypothesis that vaccination with

285 tion of infrared signals in the optic tectum prompted us to test the implementation of spatiotopicall

286 ns expressing alpha-synuclein, and therefore prompted us to test the possibility that Nurr1 can be ph

287 mall-vessel vasculitis, and this association prompted us to test whether the peculiar structure of NE

288 activate its cognate G protein, transducin, prompted us to test whether the same monomeric state is

289 e potential to be utilized in other formats, prompting us to test the efficacy of rPIV5-H5, which enc

290 the known lifespan-regulating protein SIRT1, prompting us to test whether a pharmacological activatio

291 thers to regulate endothelial cell invasion, prompting us to test whether calpain acted upstream of M

292 D8(+) T cells were also expanded in RF mice, prompting us to test whether CD8(+) T cell activity migh

293 A-type lamins anchor TAN lines, prompting us to test whether emerin, a nuclear membrane

294 shown that Snapin interacts with Dysbindin, prompting us to test whether Snapin might be involved in

295 ization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4]tr

296 These difficulties prompted us to undertake a metaanalysis of PET studies o

297 This case prompted us to unravel the role of M. pneumoniae in GBS

298 This challenge prompted us to use a long short-term memory (LSTM) langu

299 otic-induced model of autoimmune cholangitis prompted us to use these reagents and the model to addre

300 SI-MS in culture-negative cases of infection prompted us to use this approach over other diagnostic m