ライフサイエンスコーパス: promyelocyte

1 cells and an excess of immature cells called promyelocytes.

2 psin G stored in the azurophilic granules of promyelocytes.

3 he normal gene expression pattern of primary promyelocytes.

4 was remarkably similar to that of wild-type promyelocytes.

5 ing RARalpha-PLZF and PLZF-RARalpha in their promyelocytes.

6 at highest levels in cells representative of promyelocytes.

7 t 2 days, corresponding to the appearance of promyelocytes.

8 e stably expressed in undifferentiated HL-60 promyelocytes.

9 rlichia-infected equine neutrophils or HL-60 promyelocytes.

10 e WBC differential showed 64% blasts and 24% promyelocytes.

11 P = .03), and the absolute blood blasts plus promyelocytes (884/microL v 126/microL; P = .019).

12 rogenitor cell line, with characteristics of promyelocytes able to differentiate into granulocytes.

13 , with the strongest expression occurring in promyelocyte and late-myeloblast-like cell lines.

14 ll culture to monitor the oxidative burst of promyelocytes and in vivo to image lung inflammation.

15 sed proliferating myeloid precursors such as promyelocytes and myelocytes, only mature monocytes and

16 reduced endogenous PU.1 mRNA levels in HL60 promyelocytes, and decreased Sfpi1 mRNA levels were also

17 gher variability than healthy CD34(+) cells, promyelocytes, and remission BM cells.

18 erminal granulocytic differentiation of MPRO promyelocytes, and this differentiation is associated wi

19 epsilon mRNA is markedly enhanced as the NB4 promyelocytes are induced by retinoids to differentiate

20 cer of terminal differentiation of malignant promyelocytes, but its effects on more primitive hematop

21 cer of terminal differentiation of malignant promyelocytes, but its effects on more primitive hematop

22 Normal promyelocytes (CD34(-)33(+) and CD34(-)13(+)) expressed

23 a, PKCbeta, PKCbetaI, and PKCbetaII on HL-60 promyelocyte cell differentiation and proliferation were

24 Transient tranfection of a promyelocyte cell line (NB4) with a C/EBP-epsilon expres

25 onstructed from the murine RA-inducible MPRO promyelocyte cell line to identify immediate-early genes

26 HL-60 cells, a myeloblast/promyelocyte cell line, were cultured in the presence or

27 nal granulocytic differentiation of the MPRO promyelocyte cell line.

28 o)) myeloid cells, including myeloblasts and promyelocytes, constitutively expressed the beta-chain o

29 s of ELANE point mutations was the result of promyelocyte death and differentiation arrest, and was a

30 expression in HL-60 and NB4 myeloblasts and promyelocytes decreased their proliferative capacity.

31 ythroid, myeloid, and lymphoid [EML]-derived promyelocytes) derived from EML-ic/ic cells, a myeloid m

32 ned the expression profiles of normal murine promyelocyte-enriched samples, nontransformed murine pro

33 ation and deficient functional maturation of promyelocytes (erythroid, myeloid, and lymphoid [EML]-de

34 yelocytes lack receptor expression, leukemic promyelocytes express both isoforms.

35 cyte-enriched samples, nontransformed murine promyelocytes expressing human promyelocytic leukemia-re

36 d that IFN-gammaR-deficient CDllb(lo)Gr1(lo) promyelocytes from E. muris-infected mice exhibited sign

37 GATA-1 and GATA-2 was detected in eosinophil promyelocyte HL-60 clone 15 cells in response to biochem

38 block in differentiation and accumulation of promyelocytes in the bone marrow and blood.

39 Some of the PR3 synthesized by promyelocytes in the bone marrow escapes the targeting t

40 genic mice and leukemic animals had abundant promyelocytes in the bone marrow, only leukemic mice exh

41 tent EML cells but not in the committed MPRO promyelocytes, indicating that differences in HDAC-conta

42 While normal promyelocytes lack receptor expression, leukemic promyel

43 length human C/EBP-epsilon was cloned from a promyelocyte-late myeloblast-derived lambda gt11 library

44 Accumulation of promyelocytes leads to high levels of the platelet aggre

45 a fraction of the Mre11 complex was bound to promyelocyte leukemia protein bodies in undamaged cells.

46 mphoma (Baf3), differentiation of the murine promyelocyte line 32D, and activation of MAP kinase in C

47 leukemias, especially those that were at the promyelocyte (M3) and myeloblast (M2) stages of developm

48 results in a clinical remission by inducing promyelocyte maturation, a significant number of patient

49 = .009), the percentage of blood blasts plus promyelocytes (median 29% v 8.5%; P = .03), and the abso

50 s gene was maximally expressed in cells with promyelocyte morphology.

51 he multipotent progenitor (EML) or committed promyelocyte (MPRO) stages.

52 Transcription was restricted to promyelocyte, myelocyte, and very early metamyelocyte st

53 ish the requirement for C/EBPepsilon for the promyelocyte-myelocyte transition in myeloid differentia

54 4(-)MPO(++)) cell population, which includes promyelocytes, myelocytes and metamyelocytes; mean (+/-

55 ressed primarily in myeloid cells, including promyelocytes, myelomonocytes, and their differentiated

56 RA is indeed expressed at high levels in the promyelocytes of Ctsg-PML-RARA mice and alters the trans

57 The splenic promyelocytes of mice with both the nonleukemic and leuk

58 ar or identical to structures containing the promyelocyte (PML) protein.

59 mRNA levels were observed in myeloblasts and promyelocytes, similar to myeloperoxidase, a marker of a

60 In contrast, a targeted mutation of the promyelocyte-specific cathepsin G gene (which lies just

61 e have found a novel C/EBP-epsilon-dependent promyelocyte-specific gene, mXCP1.

62 While many promyelocyte-specific genes were highly expressed in all

63 o cause APML in an animal model, we used the promyelocyte-specific targeting sequences of the human c

64 iptionally activated at the beginning of the promyelocyte stage and are transcriptionally repressed a

65 racteristic myeloid maturation arrest at the promyelocyte stage and demonstrated an increased AMP/ADP

66 development in the bone marrow niche at the promyelocyte stage independently of microbes.

67 or azurophil granules are synthesized at the promyelocyte stage of development.

68 These genes are transcribed after the promyelocyte stage of differentiation, and transcription

69 ML-RARalpha or are at the late myeloblast or promyelocyte stage of myeloid development.

70 ine protease that is highly expressed at the promyelocyte stage of myeloid development.

71 CYBB is transcriptionally inactive until the promyelocyte stage of myelopoiesis, and in mature phagoc

72 opmentally regulated pattern, peaking at the promyelocyte stage, or in cell model systems, appearing

73 Furthermore, promyelocyte stage-specific expression of genes coding f

74 nulocytic differentiation is arrested at the promyelocyte stage.

75 ckade of granulocytic differentiation at the promyelocyte stage.

76 id cells that have differentiated beyond the promyelocyte stage.

77 d to myeloid cells differentiated beyond the promyelocyte stage.

78 id cells that have differentiated beyond the promyelocyte stage.

79 OX-2 expression in the myelocyte rather than promyelocyte stages of differentiation.

80 tain leukemias blocked at the myeloblast and promyelocyte stages of differentiation.

81 ssion of CEBPA, but not CEBPB; and promoting promyelocyte survival and differentiation.

82 R had greater percentages of myeloblasts and promyelocytes than controls (53% +/- 13% versus 3% +/- 2

83 pment, resulting an accumulation of leukemic promyelocytes that are often highly sensitive to retinoi

84 Since NE is maximally produced in promyelocytes, this protease may play a role in APL path

85 gin is a committed myeloid precursor (e.g. a promyelocyte) versus an hematopoietic stem/progenitor ce

86 n of EML cells that increased in EML-derived promyelocytes, whereas cells lacking Lbr exhibited compl

87 nal granulocytic differentiation of the MPRO promyelocytes while potentiating interleukin-3 (IL-3)-in

88 rentiation, is severely impaired in leukemic promyelocytes with the t(11;17) translocation compared w