ライフサイエンスコーパス: prone

1 r injuries to which these young athletes are prone.

2 e instability, and Abro1-null mice are tumor-prone.

3 to which traditional subjective methods are prone.

4 ss is subjective, nonquantitative, and error-prone.

5 late-stage installation of the isomerization-prone (2Z,4E,6Z,8E)-tetraenoate motif, and an expedient

6 Monomer- and dimer-prone 5'UTRs displayed equivalent, basal rate of transla

7 plasma of aged senescence-accelerated mouse prone 8 mice, which are known to have deregulated reacti

8 a backup attempt to intercept the more error-prone alternative NHEJ repair pathway by recruiting Ku a

9 weeks then separated by weight gain into DIO-prone and DIO-resistant subgroups.

10 In both genetically prone and experimentally induced mouse models of autoimm

11 OD1, TDP-43, and FUS, are highly aggregation-prone and form a variety of intracellular inclusion bodi

12 of the ASFV virus genome; it is highly error prone and plays an important role during the strategic m

13 Known risk factors for infants include prone and side sleeping, soft bedding, bed sharing, inap

14 chickens were used because they are obesity-prone, and because fatty acids provided to the embryo ca

15 otyping device designs can be tedious, error-prone, and time-consuming.

16 l warming amplifies water deficit in drought-prone areas, tree populations located at the driest and

17 and communities continue to develop in flood-prone areas.

18 s, but the clinical features of exacerbation-prone asthma (EPA) remain incompletely defined.

19 Our results indicate that exacerbation-prone asthma may be a separate asthma endotype and that

20 ); "Late-onset" (n = 105); and "Exacerbation-prone asthma" (n = 13).

21 Treatment of lupus-prone B6.Sle1.Yaa mice with an anti-IL-21 blocking Ab re

22 Finally, in an oxidative stress-prone background, Pml(-/-) animals display a longevity p

23 NHEJ, but also its contribution to the error-prone behavior of Polmu at 2-nt gaps.

24 of checkpoint signaling, resulting in error-prone chromosome segregation.

25 me crop that is resilient to hot and drought-prone climates, and a primary source of protein in sub-S

26 their transition from soluble to aggregation-prone conformations in particular.

27 idually stabilize the dimer-prone or monomer-prone conformations, validated in-solution, and introduc

28 are potential alternatives to the resistance-prone conventional antibiotics.

29 cine-preventable diseases and other outbreak-prone diseases.

30 Proteins disabled in the cancer-prone disorder Fanconi anemia (FA) ensure the maintenanc

31 We link error-prone DNA polymerase activity to the generation of varia

32 e defects promote the participation of error-prone DNA polymerase zeta (Polzeta) in replication of un

33 nt-exposed conformation, which enables error-prone DNA replication past the adduct.

34 the spliceosome "toggles" between such error-prone/efficient and hyperaccurate/inefficient conformati

35 oncogenic process or benefits from the tumor-prone environment to prevail remains an open question.

36 ccount for melanoma risk in <40% of melanoma-prone families, suggesting the existence of additional h

37 cofactor of this cycle, and other oxidation-prone folate derivatives kills human, mouse and chicken

38 of a catalytically competent Cas9, which is prone for catalysis and whose experimental characterizat

39 this tunnel can be transformed into a groove prone for RNA binding by large rearrangements of the C-t

40 azex-Dupre-Christol syndrome (BDCS)-a cancer-prone genodermatosis with an X-linked, dominant inherita

41 Viruses rapidly evolve due to their error-prone genome replication, and identifying which mutation

42 The present data may help identify injury-prone groomers and lead to safer grooming practices.

43 ear: none, few (one to two), or exacerbation prone (>/=3).

44 An aggregation prone Halo-tag mutant (AgHalo) was evolved to sense prot

45 post-treatment protection and more tolerance-prone immunological and epigenetic modifications than OI

46 Transforming error-prone immunosequencing datasets into Ab repertoires is a

47 xacerbations and 173 (24%) were exacerbation prone in the prior year.

48 AC is weak, and chromosome segregation error-prone, in mammalian oocytes.

49 esidue in HEK293T cells was moderately error-prone, inducing a total of approximately 26% single-nucl

50 mble of the molecule, leading to aggregation-prone intermediates.

51 ood mononuclear cells (PBMCs) from infection-prone (IP) and non-IP (NIP) children 9-18 months old wer

52 ques and in western diet-fed atherosclerosis-prone Ldlr(-/-) and ApoE(-/-) mice.

53 ted to the inflamed aorta in atherosclerosis-prone low-density lipoprotein receptor deficient (Ldlr(-

54 sion of Tet2-mutant cells in atherosclerosis-prone, low-density lipoprotein receptor-deficient (Ldlr(

55 It can replace expensive and error-prone manual parsing and standardization of scientific n

56 files did, however, discriminate the colitis-prone mdr1a (-/-) genotype from controls.

57 vioural phenotypes and synapse loss in lupus-prone mice that are prevented by blocking type I interfe

58 Hypercholesterolemia-prone mice that were engrafted with bone marrow obtained

59 We immunized non-lupus-prone mice with 11 allotype "a" of IgG2a (IgG2a(a)) and

60 ess this hypothesis by immunizing autoimmune-prone mice with HIV-1 Envelope (Env) and characterizing

61 leukocyte populations in NZM2328 (NZM) lupus-prone mice with spontaneous chronic glomerulonephritis (

62 T cells do not cause tissue damage in lupus-prone mice, as genetic ablation of these cells via beta2

63 Studying glaucoma-prone mice, we show that mitochondrial abnormalities are

64 is family, that-when administered to colitis-prone mice-protected them against colitis-associated dea

65 against M2FA are elevated in atherosclerosis-prone mice.

66 gulf neuronal and synaptic material in lupus-prone mice.

67 n the hematopoietic cells of atherosclerosis-prone mice.

68 ota and attenuated SLE-like disease in lupus-prone mice.

69 es) in Escherichia coli using a highly error-prone microchip-synthesized oligo pool (479 oligos) with

70 rstand how MSCs ameliorate symptoms in lupus-prone MRL.Fas(lpr) mice.

71 ot CD11b-deficient mice, and protected lupus-prone MRL/Lpr mice from end-organ injury.

72 Genetic testing for melanoma-prone mutation in France, a country with low to moderate

73 NA-based data storage system that uses error-prone nanopore sequencers, while still producing error-f

74 , we find that rapid synthesis of misfolding-prone nascent-chain segments increases the fraction of f

75 The error-prone nature of TLS may provide mechanistic understandin

76 celerated tumor formation in medulloblastoma-prone ND2:SmoA1 mice, indicating the disrupting PKM rele

77 lanted subcutaneously in autoimmune diabetes-prone NOD mice, beta-cell-reactive T cells homed to thes

78 ance, and this role is disrupted in diabetes-prone NOD mice.

79 in nonautoimmune B6 mice but not in diabetes-prone NOD mice.

80 ion (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway.

81 ation repair (HR), while counteracting error-prone non-homologous end joining of DNA double-strand br

82 designed to individually stabilize the dimer-prone or monomer-prone conformations, validated in-solut

83 he DNA-damage response (DDR) are often tumor prone owing to genome instability caused by oncogenic ch

84 mology-mediated end joining (MMEJ), an error-prone pathway for DNA double-strand break (DSB) repair,

85 replisome without the need to activate error-prone pathways.

86 inhibitor, we randomly mutagenized by error-prone PCR the E. coli dsbB gene and selected dsbB mutant

87 When mutations are enhanced through error-prone PCR, in vitro M2-seq experimentally resolves 33 of

88 nd behavioral factors associated with a mole-prone phenotype in adolescents.

89 e, 14 years) that are associated with a mole-prone phenotype in late adolescence (age, 17 years).

90 Main Outcome and Measures: Mole-prone phenotype in the 11th grade, defined as total nevu

91 recognizable factors associated with a mole-prone phenotype that may facilitate the identification o

92 -13.25; P = .01) were associated with a mole-prone phenotype.

93 Error-prone polymerases overcome this blockade by synthesizing

94 and function in the presence of aggregation-prone polypeptides.

95 Expression of aggregation-prone polyQ-containing proteins or the Amyloid-beta42 pe

96 very infrequent cause of dysphagia following prone-position ventilation.

97 To communicate a complication of prone-position ventilation.

98 evere ARDS, the recommendation is strong for prone positioning for more than 12 h/d (moderate confide

99 tients with ARDS, neuromuscular blockade and prone positioning have further reduced mortality, probab

100 n) in a protein that occurs spontaneously in prone primary sequences and leads typically to an equili

101 osphomimetic variants reduce its aggregation-prone/prion-like character, disrupting FUS phase separat

102 the absence of centrosomes, this is an error-prone process that opens up the fly to developmental def

103 the secretion of a destabilized, aggregation-prone protein and increases its accumulation as soluble

104 The concept that certain aggregation-prone proteins can convert other endogenous proteins int

105 Many aggregation-prone proteins enter the mitochondrial intermembrane spa

106 led enrichment for intrinsically aggregation-prone proteins rather than proteins which are affected i

107 al properties of misfolding- and aggregation-prone proteins remain a challenge for diagnostics and th

108 on, storage and release of other aggregation-prone proteins, such as functional antibodies.

109 arge set of highly expressed and aggregation-prone proteins, which make up a metastable subproteome.

110 e recombinantly, like many other aggregation-prone proteins.

111 e rapid proteasomal clearance of aggregation-prone proteins.

112 , we observed addictive-like behavior in DIO-prone rats, including 1) heightened motivation for palat

113 eeking, especially in a subset of "addiction-prone" rats.

114 enome assemblies, but fully exploiting error-prone reads to resolve repeats remains a challenge.

115 reas of high risk were also found in drought-prone regions for beech and in the southern Alps for fir

116 entrations by sequestering their aggregation-prone regions in micellar structures, where the very sol

117 has progressed slowly, especially in drought-prone regions where annual crop production suffers from

118 r endonuclease activity and subsequent error-prone repair have left a mutational footprint on the ins

119 Because apurinic sites are subject to error-prone repair, leading to substitution and short frameshi

120 Owing to their mutation-prone replicase and unique genome organization, IAV popu

121 than that in smaller RNA viruses with error-prone replication, as seen via signatures of selection i

122 eotides are removed by NER followed by error-prone resynthesis with DnaE.

123 s, they often can produce only partial error-prone scaffold assemblies.

124 ze both leak repairs and replacement of leak-prone sections of distribution lines, thus minimizing me

125 amphipathic helix and a soluble degradation-prone segment, providing the first example of a choleste

126 dNTPs specified by the RNA template slippage-prone sequence and its 5' adjacent base.

127 dNTPs specified by the RNA template slippage-prone sequence and its 5' adjacent base.

128 Often, a unique aggregation-prone sequence polymerizes to form regular fibrils.

129 ho experience an exogenous stressor, such as prone/side sleeping or soft bedding, during a critical d

130 stable conditions can contribute to a cancer-prone state and more broadly provides new evidence linki

131 NBS1 (MRN) DNA repair complex lead to cancer-prone syndromes.

132 to the single-strand nick required for error-prone synthesis is an open question.

133 model for population dynamics in disturbance-prone systems.

134 Here, we used an autoimmune-prone T-cell receptor transgenic mouse (2D2) and a mouse

135 In contrast, the population of aggregation-prone tau as induced by the complexation with heparin is

136 tituting a defining signature of aggregation-prone tau, and as such, a possible target for therapeuti

137 strong stimulators for slippage at slippage-prone template motif sequence 3' of such 'slippage-stimu

138 IV transcription is considerably more error-prone than Pols II or V, which may be tolerable in its s

139 rees from lower elevations were more drought prone than trees at higher elevations.

140 But since qubits are noisy and error-prone, they will depend on fault-tolerant quantum error

141 r characterization of protein aggregates are prone to a number of limitations and usually require add

142 This could explain why LIG3 is less prone to abortive ligation than LIG1.

143 on machinery because its DR makes cells more prone to adipogenic differentiation even in the absence

144 pensive spices worldwide, and as such, it is prone to adulteration.

145 G175R is highly prone to aggregation and has greatly reduced activity.

146 e we show that, in yeast, cytosolic proteins prone to aggregation are imported into mitochondria for

147 We conclude that the hamster prion is prone to aggregation at pH 4.4 because its reconfigurati

148 at are metastable in motor neurons, and thus prone to aggregation upon a disease-related progressive

149 Although such mutant proteins are prone to aggregation, toxicity is also associated with s

150 held assumption that social species are more prone to Allee effects.

151 e the application of this characteristic was prone to ambiguity.

152 ong base, however, N-protected indazoles are prone to an undesirable ring-opening reaction to liberat

153 parameters for subtypes and grading criteria prone to arbitrary judgment.

154 Mutation analysis in single-cell genomes is prone to artifacts associated with cell lysis and whole-

155 onal time-intensive peptide mapping which is prone to artificial oxidation due to extensive sample pr

156 veric donors, suggesting that beta-cells are prone to attract CCR2(+) Treg cells.

157 Some rats [sign-trackers (STs)] are prone to attribute incentive salience to reward cues, wh

158 with upstream regions enriched for SINEs are prone to be reactivated.

159 ry" pathophysiological mechanisms, which are prone to become pharmacological targets for curative str

160 rmally high rates, but are also particularly prone to being recruited to exaggerated beta oscillation

161 ever, conventional observational studies are prone to bias, such as reverse causation and residual co

162 all, this record linkage-based study is less prone to bias.

163 ies show that the dibora[2]ferrocenophane is prone to boron-boron double bond cleavage reactions.

164 Expanded CAG repeats are prone to breakage, and repair of the breaks can cause re

165 to sustain exocytosis, thus making them more prone to Ca(2+)-induced cytotoxicity.SIGNIFICANCE STATEM

166 Furthermore, they are significantly more prone to cancer-associated hypomethylation and mutation.

167 nto those that are stable and those that are prone to change.

168 Ecosystems are increasingly prone to climate extremes, such as drought, with long-la

169 coexisting in the same geographic region are prone to competitively exclude each other.

170 However, observational data are prone to confounding and reverse causation.

171 can make mediation analyses challenging and prone to confounding bias, particularly when conducted a

172 s according to current correction methods is prone to considerable systematic errors even in well-des

173 By using mice genetically prone to CRC, we show that SGG colonization is 1,000-fol

174 id-sensitive moieties, particularly polyenes prone to cyclization.

175 oxygen shortage rendering roots particularly prone to damage.

176 ine (NG) motif in a structural loop, this is prone to deamidation in one of the antibodies but not th

177 arious statin types in hospitalized patients prone to delirium should validate their use in protectio

178 Those with a cancer history may be more prone to develop a recurrent or a new cancer.

179 ted deletion of IL-1R are significantly less prone to develop bone tumors when inoculated in the arte

180 and Native Americans being considerably more prone to develop the disorder.

181 tted to intensive care units with sepsis are prone to developing cardiac dysrhythmias, most commonly

182 tion, why individuals with red hair are more prone to developing melanoma, and whether the activity o

183 Higher severity injuries, which are prone to DIC, are typically seen in younger, otherwise h

184 nal regulation of hepatic Dpp4 in young mice prone to diet-induced obesity.

185 cells induced more severe EAE and were more prone to differentiate into Th17 cells.

186 re species and old-growth specialists may be prone to dispersal limitation, while the dynamics of gen

187 s model expressing low amounts of Spartan is prone to DPC repair defects and spontaneous tumors is un

188 environments of the mitochondrial matrix are prone to dysregulation, prompting the activation of a sp

189 ry that could be targeted in trauma patients prone to early lung dysfunction.

190 translocation fragile DNA sequences are more prone to enzymes or agents that cause longer-lived DNA l

191 TM cells were more prone to ER stress from ECM accumulation compared to oth

192 s making them both time consuming to use and prone to error.

193 once in the endosome, is significantly more prone to escape than its l-counterpart.

194 ronchial/nasal mucosa of neutrophilic asthma prone to exacerbation, suggesting a pathogenic role of I

195 omologies between different plants, they are prone to extensive cross-reactivity among allergen polle

196 istic communities that were previously found prone to extinction in theoretical models.

197 Newer statistical approaches are prone to failure of model convergence, especially in set

198 though the low-resolution basket catheter is prone to false detections and may incorrectly identify r

199 ods for predicting CRM activity, but is also prone to false positive predictions.

200 ive extracellular matrix production that are prone to form in body sites with increased skin tension.

201 rmation propensity, racemic Abeta42 was less prone to form soluble oligomers.

202 (+)-Catechin is the flavanol prone to forming such pigments.

203 tend to populate misfolded species that are prone to forming toxic aggregates, including soluble oli

204 substrates of PRO membranes are particularly prone to fouling because of their direct contact with va

205 ve been asked about which types of cells are prone to fuse and whether other methods may identify a w

206 atients with FEN1-overexpressed cancers were prone to have poor differentiation and poor prognosis.

207 echanisms whereby certain therapies are more prone to HBV reactivation.

208 e and diethylnitrosamine-injected mice, both prone to HCC development.

209 Children with an anxious temperament are prone to heightened shyness and behavioral inhibition (B

210 vitro cultures of P. falciparum, making them prone to high variation.

211 opies or competing interactions, as they are prone to host various domain phases that can be easily a

212 Ziehl-Neelsen is laborious, prone to human error and infection risk, with a limit of

213 peaks manually is a time-consuming task and prone to human error.

214 awareness and increase management in regions prone to human-started wildfires should be a focus of Un

215 Septic patients are especially prone to IIT-induced hypoglycemia, but the mechanism rem

216 oid cells unfit for normal hematopoiesis but prone to immunogenic death, leading to neutrophil extrac

217 Men seem to be more prone to impingement than women.

218 IcmF is prone to inactivation during catalytic turnover, thus se

219 would exceed supply, making the forest more prone to increased tree mortality.

220 ods which are limited to small specimens and prone to inducing artefacts from sample preparation.

221 Rubisco is prone to inhibition by tight-binding sugar phosphates, w

222 H oscillations in the l-alanine spectrum are prone to inhomogeneous broadening in melanoidins prepare

223 Thus, Pb(IV) ions are especially prone to interact with Abeta and affect its aggregation.

224 Cellular communication is prone to interference by neighboring microbes.

225 nuclear magnetic resonance (NMR) data can be prone to interpretational mistakes.

226 DM2 binding, with Apc(min/+) mice, which are prone to intestinal tumor formation.

227 Spinach leaves were particularly prone to losing ascorbate during washing, especially wit

228 per function of ZIP14 and therefore would be prone to manganese-related neurological diseases.

229 A lesions that, if not repaired quickly, are prone to nuclease cleavage, resulting in DSBs.

230 ce can efficiently knockdown RNAs, but it is prone to off-target effects, and visualizing RNAs typica

231 ring ICU rounds at our institution was poor, prone to omissions and inaccuracies, yet largely unrecog

232 stigated in two highly proliferative tissues prone to oncogenic transformation: the hematopoietic lin

233 or suppressor gene, individuals with NF1 are prone to optic gliomas, malignant gliomas, neurofibromas

234 However, PUFA is prone to oxidation.

235 onstitute important therapeutic targets, are prone to oxidative damage.

236 ounter lower inflammation, and are thus less prone to oxidative-stress mediated diseases.

237 Hence, they are prone to participate in the prolongation step of the rad

238 significantly higher morbidity and are more prone to pathogen dissemination and intestinal and syste

239 possess limited mechanical strength and are prone to permanent breakage.

240 high root or shoot Si concentration are less prone to pest attack and exhibit enhanced tolerance to a

241 n producing Pf phage, P. aeruginosa was less prone to phagocytosis by macrophages than bacteria not p

242 YFP) is often used as an acceptor but YFP is prone to photobleaching and pH changes.

243 light and show that younger leaves are less prone to photoinhibition than older leaves.

244 that results in an unfolded protein that is prone to polymerization.

245 arse and the EPA monitoring network could be prone to positive interferences.

246 dities have a short postharvest life and are prone to postharvest fungal decay.

247 imary nonadherence occurs, identify patients prone to primary nonadherence, and simplify medication r

248 than any individual forecast method and less prone to producing a poor forecast.

249 its constitutive activity and making it more prone to Raf-mediated phosphorylation.

250 IV and begin to explain why infants are more prone to rapid disease progression.

251 ical savannas are a globally extensive biome prone to rapid vegetation change in response to changing

252 o display durable antimicrobial activity not prone to rapidly acquired clinical resistance.

253 concentration, which makes ferrihydrite more prone to reductive dissolution by the 2,6-DMBQ/2,6-DMHQ

254 ereating or drug taking, might be especially prone to relapse following treatment.

255 s, which may explain why rare forms are more prone to replacement than common ones.

256 back on synaptic weight changes, making them prone to runaway dynamics.

257 are destabilized and the plasma membrane is prone to rupture.

258 These individuals are prone to seizures and have high brain levels of the infl

259 ippocampus, a region sensitive to stress and prone to seizures.

260 or counterintuitive testimony, children are prone to set aside their own prior convictions, but they

261 e induction involve the use of viral vectors prone to silencing and insertional mutagenesis or the us

262 recent sequencing technologies that are less prone to single-base errors should confirm these results

263 crobial communities and show that it is less prone to some of the biases found in sequencing-based me

264 more maladaptive substitutions and are more prone to splicing errors.

265 these shorter isoforms, full-length MAVS is prone to spontaneous aggregation and Nix-mediated mitoph

266 However, haESCs are prone to spontaneous diploidization through unknown mech

267 Mdm2(SNP309G/G) mice are more prone to spontaneous tumor formation than Mdm2(SNP309T/T

268 ygous in Fdxr had a short life span and were prone to spontaneous tumors and liver abnormalities, inc

269 t the device without constraint structure is prone to spurious trigger, while the designed constraint

270 1/2, whereas STEAP1 expression appeared less prone to such dynamic regulation.

271 How a system that is prone to such instabilities can rveliably drive morphoge

272 ether all pneumococcal serotypes are equally prone to such interaction.

273 with antibiotic-resistant bacteria (ARB) are prone to systemic infections that are difficult to treat

274 ditional labor-intensive approaches that are prone to taxonomic and enumeration mistakes.

275 hat repair is local, polarity sensitive, and prone to template switching, characteristics that are co

276 , naive OT2 cells without Pam3Cys4 cargo are prone to TGF-beta-dependent inducible regulatory Foxp3(+

277 strate that intertemporal decision making is prone to the attraction effect in humans.

278 rs in which affected children and adults are prone to the development of benign and malignant tumors

279 e 1 (NF1) cancer predisposition syndrome are prone to the development of low-grade brain tumors (glio

280 vascular risk factors are disproportionately prone to these cardiac diseases in the setting of alcoho

281 bservation, we find that people who are more prone to think that they predicted an event that they ac

282 fluorescence measurement techniques that are prone to toxicity in chronic settings, sophisticated tim

283 nonical fork convergence in fission yeast is prone to trigger deletions between repetitive DNA sequen

284 y, these results suggest that skeletal sites prone to tumor cell dissemination contain less-mature HA

285 Apart from being prone to tumor development, Arf-null mice are blind, and

286 e to flagging and build models that are less prone to uncertain expected versus observed outcomes.

287 ghly clonogenic cells that are nonmotile and prone to undergo apoptosis.

288 re with high levels of enantiopurity and are prone to undergo deleterious acid-base side-reactions un

289 at secretory granules and rendered them more prone to undergo exocytosis.

290 ant OGT bearing the p.Arg284Pro mutation was prone to unfolding and exhibited reduced glycosylation a

291 sources and their markets, both of which are prone to unpredictable shifts.

292 nually, a process that is time consuming and prone to user input error.

293 ta on assay and sample levels), is much less prone to user input errors, improves compliance with min

294 s with homozygous p.Ser267Phe in SLC10A1 are prone to vitamin D deficiency, deviated sex hormones and

295 n into primary tumors of the prostate cancer-prone transgenic adenocarcinoma of the mouse prostate (T

296 ing untimely tRNA and mRNA binding and error prone translation.

297 d with Pten deletion to produce a metastasis-prone tumor.

298 Hpsefl/fl NKp46-iCre mice) were highly tumor prone when challenged with the carcinogen methylcholanth

299 guingly, FUS's nearly uncharged, aggregation-prone, yeast prion-like, low sequence-complexity domain

300 n of Tg(mitfa:BRAF(V600E)); p53(lf) melanoma-prone zebrafish.