ライフサイエンスコーパス: pronounced

1 hypermutation (SHM) ranging from minimal to pronounced.

2 is , similar patterns were found albeit less pronounced.

3 r candidates to clinical diagnostics is less pronounced.

4 esting period was moderate after mixing, but pronounced after extrusion.

5 This neurogenic effect was more pronounced after high-thoracic level (Th1) SCI disconnec

6 Humanized mice displayed a more pronounced AHR and bronchial inflammation when challenge

7 enia- and psychosis-related genes, with more pronounced alterations in cerebellar tissue.

8 ome remained largely invariable, we observed pronounced alterations in several proteins linked to aut

9 crophages of the corresponding tumors show a pronounced alternatively activated endotype, which occur

10 The association appeared to be more pronounced among children who were breastfed <6 mo.

11 This observed rate reduction was more pronounced among patients with localized disease at diag

12 Decline in VE was more pronounced among patients with prior season influenza va

13 This improvement was more pronounced among the children with an FMI above the medi

14 t consume rice, and the association was most pronounced among those with <1mug/L arsenic in their hou

15 ctomy is a patient-driven trend that is most pronounced among younger, educated, and well-insured wom

16 at sites where the impact of MWWTPs was less-pronounced and fish showed less of a transcriptome respo

17 ally, we found ReRh lesions to produce (1) a pronounced and long-lasting decrease of place field stab

18 LCx and LAD groups, LA dysfunction was less pronounced and not consistent.

19 in preindustrial farming groups and are most pronounced and reliably directional when the farming cla

20 Dystonia is often more pronounced and severe than choreoathetosis, with a major

21 ng on all measures at both time points, with pronounced and significant unidirectional differences (P

22 ta of male mice, whereas the effect was less pronounced and site-specific in females.

23 Negative effects of prior vaccination were pronounced and statistically significant in 2014-2015 wh

24 odes of the default mode network became more pronounced and widespread.

25 involved different bacterial taxa, was more pronounced, and also involved several fungal taxa.

26 For highly transparent barriers, there is a pronounced Andreev reflection feature providing evidence

27 27 was much less active than AGN 211377, but pronounced anti-inflammatory and angiostatic effects wer

28 Furthermore, it was associated with more pronounced antitumor T-cell immunity via induction of IL

29 ) and 786-O exhibited decreased survival and pronounced apoptosis associated with a decreased GSH/GSS

30 of individual antiandrogens that became more pronounced as the number of components increased from fo

31 The results were more pronounced as the risk of liver-related mortality increa

32 A more pronounced association was identified for patients with

33 The key element is a pronounced asymmetry of surface hopping energies-that is

34 w inactivation, but the effect was much more pronounced at -40 mV, where fast inactivation is complet

35 t 2 h that increased in area and became more pronounced at 10 h.

36 n at higher TC/LDL levels; this risk is more pronounced at a younger age.

37 This sinusoid pattern is more pronounced at higher latitudes (p = 0.023).

38 similatory Fe(III)-reduction, which was most pronounced at intermediate PO4(3-) loadings (i.e., in th

39 ropy is tunable with temperature and is most pronounced at room temperature, which is beneficial for

40 n in species responses and effects were most pronounced at the BENELUX scale.

41 buckling of one of the protomers and is most pronounced at the broadly conserved client-binding regio

42 This effect is even more pronounced at the site of damage.

43 st-MI death among women with MI-CAD was most pronounced at younger ages.

44 nt of variation showed a nonlinear increase, pronounced below 1.5 MBq/kgBW.

45 n fold induction of the HR gene set was most pronounced between grade 0 and grade >/=3 toxicity (P =

46 Differences were most pronounced between groups with no exposure and groups wi

47 phoma lesions and are associated with a more pronounced biologic inflammatory syndrome.

48 the F4 side chain (the "pEF head") confers a pronounced bulky hydrophobic nature to the AbetapE3 N te

49 A pronounced cancer suppressing activity towards at least

50 ed by the acoustic wave, is able to detect a pronounced cationic dynamics in PPy-bonded MT piezosenso

51 and in the developing brain, and causes more pronounced cell death in NPCs and neurons, resulting in

52 r RNAP-ribosome interaction in vitro and for pronounced cell growth defects upon translation inhibiti

53 The most pronounced change in gene expression occurred during the

54 ulatory systems reach maturity, will predict pronounced changes in thalamic development, and thereby

55 tosis in the RPE are mainly characterized by pronounced changes in the protein phosphorylation level.

56 d to a rise in lactate and concurrently with pronounced changes in the spectral profile of LFP-relate

57 lectron microscopy of the dermis also showed pronounced changes in the structure and organization of

58 ll saturation states, and the effect is most pronounced close to equilibrium.

59 Reoxidation of Co((0)) is more pronounced close to the outlet of the reactor, where hig

60 onal and interannual timescales, including a pronounced cold period from October 2011 to May 2013.

61 for GluN2C-containing NMDA receptors is more pronounced compared with DCS, suggesting that AICP can b

62 talloproteinase-3 release, and was even more pronounced compared with supplementation of single GFs.

63 nes (e.g. IL-6, MCP-1, IL-22, TNF-alpha) and pronounced complement consumption, resembling changes se

64 or post-hydrolytic state was required for a pronounced conformational shift.

65 cular N...S interaction, resulting in a less pronounced conjugation of the TAPP core and the thiophen

66 pecies, many with preserved soft tissues, in pronounced contrast to normal survival and early recover

67 We observed a pronounced correlation between weakened predicted SD-aSD

68 sory dendrite contains a ciliary root with a pronounced cross-banding of electron-dense material that

69 reduction in SR calcium content and its more pronounced decline after calcium release.

70 tion of exponential growth results in a more pronounced decline in VieA specific activity compared to

71 nnually during the study period, with a more pronounced decrease among those diagnosed in an inpatien

72 estion and the colonic fermentation caused a pronounced decrease in 3,5-O-dicaffeoylquinic acid and 5

73 However, slightly more pronounced decreases were seen in virulence via intrahem

74 phiphysin, and Rvs (BAR) proteins leads to a pronounced defect in CI-MPR endosome-to-TGN transport.

75 led-up diamond tubular microcavities exhibit pronounced defect-related photoluminescence with whisper

76 ings show that OFD Type I patient cells have pronounced defects in the DSB-induced histone modificati

77 Notably, we identified a pronounced deficit in neuronal adaptation to repetitive

78 smission of neural communications, undergoes pronounced development during the first years of life, w

79 esented here show that this is not the case; pronounced deviations of the local order from that obser

80 re transformations are well-characterized by pronounced difference in SPR spectral band position (shi

81 arge changes in expression through life with pronounced differences between the foetal and adult huma

82 such that middle-aged mice showed much more pronounced differences compared with young mice.

83 phaS fibrils, which is also indicated by the pronounced differences in the 1D-IR (FTIR), 2D-IR, and v

84 1,500 promoter variants in yeast, we reveal pronounced differences in the dependency of TF activity

85 Pronounced differences in the HERFD XAS pre-edge energie

86 The most pronounced differences were higher anxiety in cervical a

87 udied scenes for the two test types revealed pronounced differences; that is, autobiographical retrie

88 MrNV particles have pronounced dimeric blade-shaped spikes extending up to 6

89 grades of fibrosis are associated with more pronounced disease manifestations, adverse mutation prof

90 n a fully eclipsed stacking arrangement with pronounced disorder in the stacking direction.

91 These patterns were more pronounced during autumn migration, especially within ur

92 Interestingly, this contribution is less pronounced during fine dexterous finger movements.

93 buted to synaptic depression, which was more pronounced during stronger stimulation.

94 we find persistent stratification, including pronounced educational inheritance and disparities in pa

95 Coincidental to these findings was more pronounced EEG theta activity over frontal, temporal and

96 luenced by ageing temperature, with the most pronounced effect at 30 degrees C ( approximately 256 fo

97 ing BMI over the 10-year period, with a more pronounced effect observed in women for individual-level

98 The most pronounced effect of seeds microwaving was noted for can

99 fected by the BMP antagonist Gremlin-1 but a pronounced effect on matrix fibrillar organisation was r

100 Many of the mutations had a pronounced effect on the balance between the open and cl

101 ement to investigate the neural basis of the pronounced effects of cocaine-associated conditioned sti

102 ate that proximal nonionic polar groups have pronounced effects on hydrophobic interactions generated

103 sity and offspring obesity leads to the most pronounced effects on offspring metabolism.

104 uces prey size and prey abundance, with more pronounced effects where the macaque population size is

105 reas especially age but also shift work have pronounced effects, specifically on decline rates and ul

106 ons suggest that the thermal diffusivity has pronounced electronic as well as phononic character.

107 The pronounced elevation in AUD risk following divorce or wi

108 Pronounced elevations in trough levels of nitric oxide m

109 title compounds are highly fluorescent with pronounced emission solvatochromicity and protochromic f

110 ial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)-FL (leading t

111 y of two basal breast cancer cell lines with pronounced endogenous overexpression of TRPV4, MDA-MB-46

112 ocytes in Nr4a1(-/-) apoE(-/-) mice leads to pronounced endothelial apoptosis.

113 t with FA-Tg(+) mice, the SHS-Tg(+) mice had pronounced epithelial necrosis, alveolar space consolida

114 Patients with AD showed pronounced evidence of inflammation compared with health

115 ofile of non-phosphorylatable AGO2 reveals a pronounced expansion of the target repertoire bound at s

116 s environment leads these species to exhibit pronounced exploration and exploitation phases but diffe

117 nder disease conditions, cortical areas with pronounced expression of risk genes implicated in SCZ fo

118 esolved metal-free 819 knot enantiomers have pronounced features in their circular dichroism spectra

119 These results confirmed the pronounced foaming and interfacial properties of acid ca

120 These differences become more pronounced for autism genes (p = 1.8 x 10(-3), OR = 2.2)

121 an in white persons; the difference was more pronounced for cancer of the distal colon and rectum and

122 This inhibition was also more pronounced for CD4 T cells than for CD8 T cell subsets,

123 that impacts on bumblebee colonies are more pronounced for colonies at an earlier stage in the repro

124 Increases were more pronounced for generic candesartan, which is the studied

125 icular significance, these changes were more pronounced for male mice than for female mice.

126 This effect was most pronounced for patients with an extended ICU stay who we

127 The protective effect was more pronounced for PB than LC-DG treatment.

128 e effects of radiation on survival were more pronounced for seedlings existing at high understory lig

129 Declines in abundance after 2005 were more pronounced for species of all sizes having equilibrium l

130 These effects were more pronounced for the cisplatin resistant subline Cal27CisR

131 perimental temperatures, this trend was more pronounced for the lipase than the cutinase.

132 This increase is most pronounced for the single-channel LZ complexity measure,

133 Risks were more pronounced for those who lost a noninfant sibling (i.e.,

134 the very end of T2, and was characterized by pronounced formation of deep waters in the NW Atlantic.

135 ermal layer), dominant at short times, and a pronounced free-energy barrier at the transition from th

136 the task, and that information flow was more pronounced from mothers toward offspring than the revers

137 These deficits were accompanied by pronounced hippocampal atrophy, including subfields corn

138 rovement in survival that is associated with pronounced host antiviral response and inflammasome acti

139 est interaction in polymer micelles and such pronounced host-guest specificities in polymer micelles

140 on supplied by glacial weathering results in pronounced hotspots of biological production in an other

141 in atmospheric samples were generally not as pronounced however.

142 the epilepsy configuration resulted in more pronounced HR acceleration and reduced HR deceleration d

143 Mexico - habitats that routinely experience pronounced hypoxic events.

144 Remarkably, the blockage is not pronounced if transcription is performed in the presence

145 The most pronounced ILC2 recruitment was observed in subjects wit

146 Further, we demonstrated a pronounced impact of deterministic assembly in all micro

147 Microscopic chemical images revealed a pronounced impact of geochemical heterogeneities concern

148 eir respective editing sites and have a more pronounced impact on RNA secondary structure.

149 inhibited and defensive gene expression more pronounced in 1 SL than in 2 SL.

150 y confined to non-allergic rhinitis and more pronounced in adolescents than in young children, highli

151 The CV(2) was pronounced in amblyopic neurons for high-contrast stimul

152 This cost is particularly pronounced in Andean maize, which has experienced a more

153 tissue disorganization phenotypes were most pronounced in animals undergoing brain regeneration and

154 Climate changes are pronounced in Arctic regions and increase the vulnerabil

155 nbred mouse strains, this difference is most pronounced in BALB/cJ mice, which have dramatically low

156 Decreased disparity tuning was most pronounced in binocular and ipsilaterally biased neurons

157 all racial/ethnic groups, and this was most pronounced in black persons (by 5.7% per year among men

158 robiota composition (P = 0.002) and was more pronounced in breastfed infants.

159 of HOFox-mediated reactions is particularly pronounced in case of unreactive glycosyl donors and/or

160 patients than CVID 21norm patients and most pronounced in CD21(low) B cells.

161 Selection on start codons is most pronounced in evolutionarily conserved, highly expressed

162 tion between child PFAS and HOMA-IR was more pronounced in females [e.g., PFOA: -15.6% (95% CI: -25.4

163 These effects were most pronounced in first episode and adult-onset patients (>2

164 gynous species show greater V k*, especially pronounced in haremic species, resulting in an overall r

165 the point of uncapping, causing defects most pronounced in high-turnover tissues including intestinal

166 Risk was more pronounced in Hispanics (OR=5.90, CI=1.89-25.96) than in

167 The proexcitatory changes were more pronounced in homozygous mice than in heterozygotes, con

168 This cross-reactivity was more pronounced in ImmunoCAP measurements with venom extracts

169 These effects were especially pronounced in individuals with more robust illusory perc

170 tations comparable to nocturnal animals, but pronounced in lateral regions of the eye where images mo

171 associated microbial community and are more pronounced in macro-aggregate compared with micro-aggreg

172 cial behaviors, and this difference was more pronounced in male than female rats.

173 tinct age-related inflections that were more pronounced in males for AFA-for-age than in females.

174 cal AL progression, and this effect was more pronounced in males.

175 e organoleptic impact of P. viticola is more pronounced in Merlot wines compared to Cabernet Sauvigno

176 nceptional or gestational weight may be most pronounced in more undernourished and vulnerable women.

177 In spoonbills, this effect is most pronounced in older male birds, while young individuals

178 The loss of TKI sensitivity was most pronounced in patient samples harboring FLT3 or PDGFRB a

179 The effect was most pronounced in patients with 3-vessel disease and noninfa

180 iameter stenosis >/=90% and was particularly pronounced in patients with both of these angiographic c

181 es in the last years of life is particularly pronounced in patients with cardiovascular disease.

182 h an endovascular revascularization was more pronounced in patients with congestive heart failure or

183 bscores (2.1 +/- 3.5, P < .001) and was most pronounced in patients with severe CSU (2.5 +/- 5.6, P <

184 the increase in NVTs, excluding 6C, was more pronounced in PCV13 counties.

185 onfidence interval [CI], 1.33-1.55) and more pronounced in people with recurrences (2.02; 95% CI, 1.4

186 The shift from glucose to lipid usage was pronounced in Pten(-/-) mice and correlated with the dis

187 of gradual warming on decomposition was more pronounced in recalcitrant and nutrient-limited soils.

188 es (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipola

189 That translational suppression was more pronounced in terminal effector cells than in memory pre

190 attern was specific to the hippocampus, most pronounced in the gamma band, and not explained by spati

191 Development of ischemic MR was more pronounced in the LAI group than in the LCx group.

192 This effect is markedly more pronounced in the organophosphatase activity than the la

193 ormalized neuromelanin volume in PD was most pronounced in the posterior SNpc (median, -83%; P < .001

194 te LPE The above-mentioned effects were less pronounced in the single lpeat1 mutant.

195 These decreases are particularly pronounced in the spring and summer in the Gulf of Maine

196 Activation was more pronounced in the tibialis anterior than in the diaphrag

197 These effects are more pronounced in visual areas anterior to V1-V3.

198 growth and these responses may be especially pronounced in water limited areas.

199 en advanced age and greater torsion was more pronounced in women than in men (both interaction P<0.05

200 This finding was even more pronounced in women, in whom 184 (63%) were not eligible

201 , a significant increase of torsion was more pronounced in women.

202 uals, and these disparities are particularly pronounced in young and middle age.

203 The variation was most pronounced in, but not exclusive to, platelets.

204 24-h pattern of CT-1 was characterized by a pronounced increase during the night (from 02:00 to 08:0

205 Moreover, these samples exhibit a pronounced increase in creep, and stress relaxation as a

206 ng all C-terminal lysines underwent the most pronounced increase in processing, leading to accumulati

207 This was due to a pronounced increase in the frequency of repopulating cel

208 gly modifies the interaction as indicated by pronounced increase in the indentation, hysteresis and w

209 e enhancement of aromatic carbonates is more pronounced indicates that the negative hyperconjugation

210 ns at later stages of infection, with a more pronounced inflammatory infiltrate and increased specifi

211 with a CB2-specific antagonist that caused a pronounced inhibition of HDM-induced airway inflammation

212 Also, pronounced inhibition of herpesvirus replication was obs

213 lantic ocean/atmosphere environment exhibits pronounced interdecadal variability that is known to str

214 fuse pattern of atrophy with relatively less pronounced involvement of the medial temporal lobe, abno

215 mals developed larger infarct scars and more pronounced left ventricular remodeling compared with wil

216 ssis can cause severe disease, manifested as pronounced leukocytosis, pulmonary hypertension, and eve

217 Pronounced ligand rotation during muH binding seems to e

218 fically focus on aged HSCs presenting with a pronounced lineage skewing, a hallmark of HSC ageing.

219 Artichokes and carrots suffered pronounced losses of antioxidant activity during boiling

220 ost degenerate chiral Landau bands, implying pronounced magneto-transport signals.

221 find that the lac induction curve exhibits a pronounced maximum at intermediate lactose concentration

222 and a subsequent decrease in pH with a more pronounced metabolic output of S. mutans.

223 Pdr5p and Can1p were selected because of the pronounced mother-bud asymmetry for these proteins distr

224 ibition, on top of GDF8 inhibition, leads to pronounced muscle hypertrophy and force production in mi

225 reasing plant species richness leads to more pronounced N gradients as indicated by higher K N -value

226 transfer effects, the IDEAL fitting revealed pronounced negative contrasts of tumors in the fitted CE

227 increasing deltaCFmin thresholds revealed a pronounced negative correlation (Spearman rho = -0.99, P

228 Two of the girls had pronounced neonatal progeroid features and were initiall

229 ffective than SG, likely related to its more pronounced neurohormonal effects.

230 severe muscular dystrophies associated with pronounced neurological defects.

231 ltic Sea, an estuarine-like environment with pronounced north to south gradients in salinity and nutr

232 However, the data show a pronounced nucleobase bias with a preference for binding

233 ange in Mg/Ca suggests this event was not as pronounced on the western North American coast as anomal

234 salt and surfactant additives and that more pronounced order is obtained by centrifugation than sedi

235 Furthermore, all defect types feature a pronounced orientational disorder of the OH groups, whic

236 lly, continue postmenopausally, and are most pronounced over the menopausal transition.

237 .96%; P<0.001) and showed age-dependent more pronounced peak atrial longitudinal systolic strain func

238 DOC production and export display a pronounced peak in the oligotrophic subtropical oceans,

239 S-causative human PFN1 mutants causes a less pronounced phenotype, suggesting a loss of function of t

240 An enhanced Dbf4-Cdc5 interaction pronounced phosphorylation of Dbf4 and accelerated SC de

241 that cry1L407F can still bind ATP, has less pronounced photoreduction and formation of FADH degrees

242 mSiO2-Dopa nanoplatform is able to produce a pronounced photothermal effect, that elevates water temp

243 er, 14-3-3 epsilon members were required for pronounced polar distribution of PIN-FORMED auxin efflux

244 of inflammatory cytokines and MDSC were more pronounced post-cART.

245 The proteasome has pronounced preferences for the initiation site, and its

246 cellular legumain activity were nevertheless pronounced, probably because the cells lacked this inhib

247 Subgroup analyses identified more pronounced protective effects of residential density amo

248 One of the most pronounced realisations of this heterogeneity is seen in

249 This pi-conjugated anion displayed pronounced redox activity, undergoing facile one-electro

250 Mice lacking both genes show the most pronounced reduction in astrogliosis and microglial accu

251 no longer actively replicating resulted in a pronounced reduction in lesion severity, with markedly d

252 WTI induced a pronounced reduction of alveolar macrophages in both str

253 oligodendrocyte progenitors, SPNs displayed pronounced resistance to early or delayed cell death fro

254 ntrary to a common assumption, we found that pronounced rhythms in metabolic pathways are often favor

255 ows outer leaflet phospholipids to bind to a pronounced ridge surrounding the channel, followed by di

256 s of cloned Ntcp from all species revealed a pronounced role of the human homologue to support HBV an

257 many infectious diseases, however, there is pronounced seasonal variation in incidence.

258 eginning at 3 days postinfection led to more pronounced sensitivity than depletion beginning prior to

259 potent monoamine-releaser with particularly pronounced serotonin- releasing properties, has unique s

260 anufactured tools of distinctive shape, with pronounced shaft curvature and hooks of intermediate dep

261 ts in the nonlinear regime, which exhibits a pronounced shift in its circular dichroism spectrum unde

262 An even more pronounced shift in maximal beta-HB production was obser

263 xidase-deficient (Mpo(-/-)) mice showed less pronounced slowing and decreased heterogeneity of electr

264 rties include large Stokes shifts (>100 nm), pronounced solvatofluorochromic effects arising from int

265 major changes in puberty and typically more pronounced species differences than other body parts.

266 Pronounced spectral changes are observed at the Cu K-edg

267 Degradation studies revealed a pronounced stability in both the solid state and in solu

268 ring more enclosed microhabitats have a less pronounced streak (or its absence in Hypsignathus monstr

269 pecies roosting in open microhabitats have a pronounced streak of high retinal ganglion cell density,

270 lectrode materials as they exhibit - besides pronounced structural stability - exceptionally high ion

271 on in the crystal lattice during lithiation, pronounced structural transformations occur in Li4/3Ti5/

272 esions, double-strand DNA strand breaks, and pronounced susceptibility to single-strand breakage.

273 Pronounced tau and Abeta pathologies were primarily dete

274 rest and highly weathered Ultisols, and more pronounced temporal changes in soil C:N, N:P, and C:P ra

275 Patients with Lyme disease often develop pronounced TH17 immune responses that may help control e

276 ative and gram-positive bacteria may be less pronounced than formerly assumed.

277 he anion exclusion effect in HM is thus more pronounced than that in OPA, even at high ionic strength

278 g key structural units responsible for their pronounced therapeutic activities.

279 In summary, we find a pronounced thickness dependence of the glass transition

280 We report on a pronounced thickness dependence of the parasitic channel

281 Furthermore, investigation of samples with pronounced topographical features is complicated by syst

282 in AlaRS editing-defective background causes pronounced toxicity in Escherichia coli even at low-glyc

283 strated that hMSC-mediated effects were most pronounced under PS-only conditions, where developed for

284 The blockage also becomes less pronounced upon reduced RNA polymerase concentration.

285 , and pulmonary vascular resistance and more pronounced ventilatory responses to exercise, lower pulm

286 ed to intrathecal injection of G-CSF exhibit pronounced visceral hypersensitivity, an effect that is

287 scenario (RCP 8.5) corresponding to the most pronounced warming (+1.4 to 4.8 degrees C) forecasted me

288 Each of these changes was more pronounced when cocoa flavanols and methylxanthines were

289 the dissolved inorganic carbon pool and most pronounced when poorly reactive iron minerals such as ma

290 genic peptide, and the effect was especially pronounced when presentation was restricted to the defec

291 volume exclusion and that the effect is more pronounced when the crowder's size is closer to that of

292 Earthworm population responses were more pronounced when the soil had been under reduced tillage

293 1 effects on scratch wound healing were more pronounced when TJs could form.

294 d fatty acids, and these effects become more pronounced with age.

295 This lateralization was more pronounced with higher anxiety.

296 L dislocation surgery that seemed to be more pronounced with IOL exchange.

297 ns, but such clustering is on the whole less pronounced with mutations often spread throughout the ge

298 The impact was most pronounced with pericarp-enriched bran.

299 nodes without plateau, with the effect most pronounced with up to four LNs (HR, 1.34; 95% CI, 1.29 t

300 icrowave-heated (MWH) reaction displays very pronounced zero-order kinetics, displaying a much higher