1 rst tested on a three-compartment phantom as
proof-of-concept.
2 enhagen for the years 2016-2030 is used as a
proof-of-concept.
3 ethanol and dimethyl sulfoxide are shown as
proof-of-concept.
4 validated the top 2 candidates in vivo as a
proof-of-concept.
5 In a
proof of concept,
6-week, open-label clinical trial, int
6 As a
proof of concept,
61,913 protein-protein interactions we
7 As
proof of concept,
a photo-cross-linkable derivative of c
8 As a
proof of concept,
a reversible label-free glutathione-S-
9 As a
proof of concept,
a time resolved fluorescence based san
10 Herein, as a
proof-of-concept,
a family of dendrimers displaying inte
11 As
proof-of-concept,
a prototype platform is successfully u
12 As a
proof of concept,
amplification of a gene specific to a
13 This
proof-of-concept analysis demonstrates that unsupervised
14 ry of potent, selective modulators with cell
proof of concept and in vivo activity to the optimizatio
15 Here we present a
proof-of-concept application for the rational design of
16 In a
proof-of-concept application in organocatalysis, the dia
17 As a
proof-of-concept application, the obtained ultrathin COF
18 Conclusion This
proof of concept approach highlights the relative import
19 ative stress mechanisms in TBI and provide a
proof-of-concept approach to improve acute TBI managemen
20 e present experimental results comparing two
proof-of-concept ballast molecules, and show that the ba
21 scharged MnO2 could be recovered, enabling a
proof-of-concept biobattery/supercapacitor hybrid device
22 These observations, made on a
proof-of-concept bioconjugate polymer amphiphile, reveal
23 rst steps have been reported with respect to
proof-of-concept cardiovascular therapeutic applications
24 Proof-of-concept cells display open circuit voltages of
25 n by ultrasound cavitation was assessed in a
proof-of-concept clinical trial in 12 subjects with stab
26 imed to report results of the first-in-human
proof-of-concept clinical trial in healthy adults of a p
27 A phase 2a
proof-of-concept clinical trial in patients with AD is c
28 n silicon and transparent glass surfaces: as
proof of concept,
clusters of either one, two, or three
29 As
proof of concept,
copper(II) in aqueous samples was conv
30 immune system, our results suggest that this
proof-of-concept could potentially be utilized to reduce
31 As
proof of concept,
cultured renal epithelial cells were e
32 We provide
proof of concept data by profiling 60 drugs on 68 acute
33 st this approach in phantoms, and we present
proof-of-concept data in models of AD-like and AS hippoc
34 This pilot study provides not only
proof-of-concept data on the work impairment collected w
35 er, these new findings provide a preclinical
proof of concept defining C1572 as a promising therapeut
36 As a
proof-of-concept demonstration, the PARTI system is appl
37 This
proof of concept developed herein holds immense promise
38 Engineering challenges and
proof-of-concept devices for storing and releasing energ
39 This
proof-of-concept dynamic NA method is an extension of a
40 As a
proof-of-concept example, we conducted theoretical evalu
41 e-shaped gold particles were fabricated as a
proof of concept experiment.
42 formed in model solution were selected for a
proof-of concept experiment.
43 Our
proof-of-concept experiments show that multiple desired
44 atient-derived xenografts (zPDX) and provide
proof-of-concept experiments that compare response to ch
45 The
proof-of-concept finding supports the view that the domi
46 As
proof of concept,
Fogarty et al. (2017) used CRISPR/Cas9
47 riptional complex and provides rationale and
proof of concept for a combinatorial therapeutic attack
48 This work provides a
proof of concept for a general strategy to use nanohoops
49 aken together, our results offer preclinical
proof of concept for a method to enhance delivery of che
50 These experiments provide
proof of concept for a mixed modality approach for treat
51 Therefore, DPM-1001 represents a
proof of concept for a new approach to therapeutic inter
52 Our studies offer a preclinical
proof of concept for a strategy of cotargeting the EGFR
53 We present a
proof of concept for a vector beam polarization state sp
54 As
proof of concept for anti-TRBC immunotherapy, we develop
55 gnosis in TNBC, and they offer a preclinical
proof of concept for combining CDK7 and BCL-2/BCL-XL inh
56 Our results offer a preclinical
proof of concept for CRLX101 as a modality to improve th
57 ollectively, our results offer a preclinical
proof of concept for ERK5 as a target to enhance T-cell
58 This work serves as an extended
proof of concept for fast in solution detection methods
59 Overall, our results offer preclinical
proof of concept for H3B-6527 as a candidate therapeutic
60 Proof of concept for human uterine transplantation was d
61 Furthermore, our results offer a preclinical
proof of concept for HuR inhibition as an effective mean
62 Our results offer
proof of concept for identifying novel cancer risk loci
63 , they offer a genetically based preclinical
proof of concept for IGFBP7 as a therapeutic target for
64 ificance: These findings offer a preclinical
proof of concept for immunotherapeutic targeting of an e
65 Our findings offer a preclinical
proof of concept for immunotherapeutic targeting of TEM8
66 tem for drug screening and offer preclinical
proof of concept for KDM4 inhibition as a new strategy t
67 ession in microbial and plant hosts provided
proof of concept for metabolic engineering of pseudolara
68 Our results offer a preclinical
proof of concept for PPARG as a candidate therapeutic ta
69 BM tumors and GSCs and provide a preclinical
proof of concept for repurposing mibefradil as a mechani
70 Our findings provide preclinical
proof of concept for several combination treatments of T
71 Our findings offer a preclinical
proof of concept for small-molecule therapies to target
72 e Golgi organizational states and provides a
proof of concept for the classification of drugs and gen
73 ur results offer a preclinical pharmacologic
proof of concept for the coordinate inhibition of transl
74 Taken together, these results provide
proof of concept for the development of liver-targeted m
75 These findings provide
proof of concept for the development of small molecule i
76 Overall, our results offer preclinical
proof of concept for the effectiveness of PDP to minimiz
77 Together, our results offer a preclinical
proof of concept for the low-dose use of isoform-specifi
78 In this study, we provide preclinical
proof of concept for the role of a proinflammatory CXCL1
79 ollectively, our results offer a preclinical
proof of concept for the use of anti-Jagged1/2 to reprog
80 Here, we provide a preclinical
proof of concept for the use of granzyme B, a downstream
81 ollectively, our results offer a preclinical
proof of concept for the use of protein myristoylation i
82 cer cell migration and provide a preclinical
proof of concept for their candidacy as targets to treat
83 nction for CD44V6 in lung fibrosis and offer
proof of concept for therapeutic targeting of CD44V6 in
84 nes in lentiviruses, in which we demonstrate
proof-of-concept for a 'template-switching' lentiviral v
85 These data provide a
proof-of-concept for a new disease mechanism involving t
86 This study serves as a
proof-of-concept for a new strategy for chemical imaging
87 In this study, we established
proof-of-concept for a novel diagnostic platform (TB-DzT
88 Finally, we provide the
proof-of-concept for a single-chamber microfluidic chip
89 We present here a
proof-of-concept for bisphenol A detection; the device c
90 gene augmentation therapy, thereby providing
proof-of-concept for cone function restoration in BCM pa
91 This study provides
proof-of-concept for direct BAX activation as a treatmen
92 These results contribute to
proof-of-concept for enhanced ethanol ablation as a nove
93 rent design considerations are explored, and
proof-of-concept for highly pathogen-specific cargo rele
94 These results represent a
proof-of-concept for implementing a circadian forecastin
95 calable to microwell formats, and we provide
proof-of-concept for its use in testing entry inhibitors
96 These results provide
proof-of-concept for Mobilan as a tool for antitumor vac
97 Here, we describe a
proof-of-concept for new methodology to detect and quant
98 antitumor efficiency by FF conjugates and a
proof-of-concept for new photosensitizer carriers based
99 on traditional Chinese pastries (TCPs), as a
proof-of-concept for the detection of illegal colorants.
100 Here, we provide
proof-of-concept for the TFT, by showing that introducti
101 tudies with doubly radiolabeled 16 provide a
proof-of-concept for the use of a cathepsin K cleavable
102 Our results constitute a
proof-of-concept for, to our knowledge, a new design pri
103 ade of rationally designed DNA molecules are
proofs of concept for embedding control within complex m
104 A
proof-of-concept gas sensor equipped with the resulting
105 Together these data provide
proof-of-concept genetic evidence that blocking the clat
106 Here, as a
proof of concept,
genetically engineered BLNs, which dis
107 Our
proof-of-concept glaucoma implant shows potential as a l
108 As a
proof-of-concept,
glucose sensing was evaluated.
109 As a
proof of concept,
guest binding to one of the helix-shee
110 Proof-of-concept has been established in nonhuman primat
111 ctive for fluorine-18 radiochemistry and, as
proof of concept,
have been used to optimize an otherwis
112 hen deployed on novel experimental data as a
proof of concept,
illustrating the recruitment of LAT to
113 Here, we present a
proof-of-concept immunomodulatory gene circuit platform
114 Data from this
proof-of-concept implementation is fit by a proposed mod
115 In a
proof-of-concept in vivo experiment, blockade of C1q and
116 ctrode assembly (MEA) and tested, as initial
proof-of-concept,
in a non-passive fuel cell operation e
117 is designed and fabricated to demonstrate a
proof-of-concept integrated device, which features wirel
118 Moreover, to move beyond
proof-of-concept into translational applications, we dis
119 The
proof of concept is demonstrated with the apoptosis regu
120 The
proof of concept is shown by using polypyrrole (PPy) fil
121 A
proof-of-concept is demonstrated by an immunospecific de
122 Further, as a
proof of concept,
it is demonstrated that the DNF can de
123 d as the best candidate and to establish the
proof of concept,
its ability to enhance Neph1-CD and ZO
124 As a
proof of concept,
Jurkat cells are enriched to high puri
125 tive ion detectors are used to demonstrate a
proof-of-concept low-cost, amplifier-free, light-emittin
126 This first
proof of concept may ultimately be applicable to geofenc
127 This novel,
proof-of-concept method was proposed for the quick and r
128 This
proof-of-concept mobile DFM device weighs less than 400g
129 Limited
proof-of-concept monotherapy studies to evaluate safety
130 We fabricated and tested a
proof-of-concept NanoThermoMechanical device that has sh
131 As
proof of concept,
Nd/Sm and Nd/Dy are used as binary mod
132 As a
proof of concept,
NiCo coordination polymer spheres are
133 To evaluate the
proof of concept of an intervention to teach surgeons to
134 emristive and superconducting oscillators, a
proof of concept of neuromorphic computing using nanosca
135 These results provide a
proof of concept of systemic antitumor activity after in
136 This work shows a
proof of concept of the use of monodisperse Si and C nan
137 We tested and established the
proof of concept of this approach for 2 serotypes of Str
138 The
proof of concept of utilizing a microfluidic dielectroph
139 This
proof-of-concept of a membrane-free battery has an open
140 Here, we provide a
proof-of-concept of an integrated approach for analysis
141 These data represent
proof-of-concept of efficacy of IL-4 treatment for acute
142 We provide
proof-of-concept of Homo-PROTACs using diverse molecules
143 These results offer
proof-of-concept of how the covalent conjugation of two
144 We thus provide preclinical
proof-of-concept of NKG2D CAR T-cell activity in mouse g
145 We provided a
proof-of-concept of SL-seq in Leishmania donovani, the m
146 These findings represent
proof-of-concept of the efficacy and tolerability of ant
147 Previous reports have demonstrated
proof-of-concept of this approach; however, current comp
148 Thus, we provide preclinical
proof-of-concept of treatment shortening using antibioti
149 Moreover, a
proof-of-concept peptide regulatory circuit was develope
150 We performed a
proof-of-concept phase Ib study of ibrutinib monotherapy
151 To conduct a
proof-of-concept pilot study of a wireless, patient-cent
152 In this
proof-of-concept pilot study, patients wore wristband pe
153 Additionally, a
proof-of-concept prototype system, which integrates an o
154 uclear spins, illuminating a new path toward
proof-of-concept quantum sensors and processors with hig
155 ergen sensitivity in mouse models to provide
proof of concept relating to their use in the clinic.
156 F6P-biosensor is a very promising
proof of concept required for the design of a carbohydra
157 EF-stimulated nucleotide exchange assay in a
proof-of-concept screen, we identified an overlapping se
158 In a
proof-of-concept setting systemic treatment with ustekin
159 This
proof-of-concept shows the feasibility of assembling all
160 As a preclinical
proof of concept,
specific tumor uptake, pharmacokinetic
161 As a
proof-of-concept,
spike-like transients of a stochastic
162 h and small-bandgap ATT-2 in NIR region, the
proof-of-concept STOPVs show the highest PCE of 7.7% so
163 hy human subjects prior to the initiation of
proof of concept studies for the treatment of mood disor
164 Proof of concept studies of tissue phantoms yielded a me
165 Proof of concept studies were performed to detect saliva
166 ts that potentially influence the host, many
proof-of-concept studies have demonstrated causative rol
167 Recently,
proof-of-concept studies have demonstrated genotype-phen
168 In our recent article, we elaborate our
proof-of-concept studies of a mouse/human chimeric IgE a
169 get engagement and assist dose selection for
proof-of-concept studies of PAM compounds.
170 These
proof-of-concept studies support the further optimizatio
171 Proof-of-concept studies with CD3xHER2 BsAb (T-cell recr
172 The first
proof-of-concept studies with the clinically relevant ca
173 For
proof-of-concept studies, two crucial redox enzymes for
174 routine care in non-randomised, exploratory
proof-of-concept studies.
175 mphasis on mechanistic advances and clinical
proof-of-concept studies.
176 This is a
proof of concept study aiming to quantify neurovascular
177 This
proof of concept study demonstrates that bacterial flora
178 This
proof of concept study demonstrates that pericardial res
179 This
proof of concept study explored using a novel digital-me
180 This is a first
proof of concept study showing that modulating the catab
181 ed, allowing for the initiation of a Phase-2
proof of concept study.
182 Our
proof-of concept study results demonstrate CMLD-2 repres
183 this study was that part 2 was designed as a
proof-of-concept study by contrast with part 1.
184 This
proof-of-concept study demonstrates the feasibility of a
185 This
proof-of-concept study demonstrates the potential of MRI
186 This
proof-of-concept study focused on hip fractures, but use
187 discovery of gammadelta T cells >30 y ago, a
proof-of-concept study has not been done to prove the pr
188 Overall, this
proof-of-concept study illustrates an efficient, general
189 Conclusion This
proof-of-concept study indicates that TA of nonenhanced
190 Collectively, this
proof-of-concept study links urine peptidomics to molecu
191 of the peripheral nervous system in MS, this
proof-of-concept study may offer new insights into the p
192 This
proof-of-concept study provides a new direction for regu
193 This
proof-of-concept study sheds light on genotype-phenotype
194 This
proof-of-concept study shows that the development of bot
195 Results of this
proof-of-concept study suggest that a larger trial, powe
196 This
proof-of-concept study suggests a new multivariable anal
197 We did a nested, case-control,
proof-of-concept study to compare the prevalence of CHIP
198 A
proof-of-concept study was conducted using T2 bacterioph
199 sed on a meta-Lasso regression model and the
proof-of-concept study was performed using a large-scale
200 t this hypothesis clinically, we developed a
proof-of-concept study, in which patients with EGFR-muta
201 In this
proof-of-concept study, Raman microscopy was used to dif
202 In this
proof-of-concept study, Raman microspectroscopy was util
203 In this
proof-of-concept study, stable isotope probing (SIP) was
204 In a
proof-of-concept study, through only external calibratio
205 In a
proof-of-concept study, we defined two groups (1) an acu
206 In a
proof-of-concept study, we enrolled 10 patients with lun
207 In our
proof-of-concept study, we evaluated the capability of t
208 In a
proof-of-concept study, we previously showed that colore
209 percutaneous nephrolithotomy (PCNL) in this
proof-of-concept study.
210 Our findings provide a preclinical
proof of concept supporting the initiation of a clinical
211 In this study, we present a
proof-of-concept technology comprising an on-chip planar
212 n actin polymerization in vitro As a further
proof-of-concept test for cellular effects of these comp
213 Conclusion This study provides
proof of concept that a machine learning model can be ap
214 We have also provided
proof of concept that blocking 12-HETE production is a p
215 These inhibitors provide
proof of concept that both sides of DENV protease active
216 This is a decisive
proof of concept that cancer cells' malignant behaviour
217 Thus, they serve as a
proof of concept that electrical brain stimulation can b
218 These findings provide a
proof of concept that introducing gut bacteria to a herb
219 This study shows
proof of concept that LAIVs boost preexisting, cross-rea
220 Our results provide a
proof of concept that phosphate limitation may be the pr
221 Thus, our study provides
proof of concept that PU.1 inhibition has potential as a
222 Our data provide
proof of concept that single-particle EM can be used to
223 Proof of concept that such proteins can be detected with
224 This study is the first
proof of concept that targeting a lncRNA to transcriptio
225 roughput drug screen, we provide preclinical
proof of concept that targeting the mitochondrial Hsp90
226 Collectively, these data provide
proof of concept that targeting thrombin or fibrin(ogen)
227 Together, this provides
proof-of-concept that a cell-specific and region-specifi
228 We establish a
proof-of-concept that a microtubule motor-cargo interfac
229 till remain uncultured, our work serves as a
proof-of-concept that can be applied to other taxa in or
230 our knowledge, this study provides the first
proof-of-concept that clonotypic analysis may be used as
231 Proof-of-concept that FFLUX's architecture is suitable f
232 Ultimately, our work demonstrates
proof-of-concept that lentiviruses can be used for perma
233 study of a SIRT6 inhibitor and provides the
proof-of-concept that targeting SIRT6 may be a viable st
234 Our data provide
proof-of-concept that this technology can be used to tre
235 As a
proof of concept,
the biodistribution of (89)Zr-Df-pembr
236 As a
proof of concept,
the development of dual-membrane-coate
237 As
proof of concept,
the embryonic region of pearl millet s
238 As
proof of concept,
the fate of 411 target compounds in a
239 As a
proof of concept,
the Janus particle-derived catalyst ca
240 As a
proof of concept,
the method was applied to the rapid an
241 As a
proof-of-concept,
the ability of niosomes to prevent phy
242 As a
proof-of-concept,
the machine learning model trained on
243 clinical studies have demonstrated promising
proofs-of-concept,
the performance of human clinical BCI
244 To provide
proof-of-concept,
these 3D printed electrode architectur
245 As a
proof-of-concept,
these materials were fabricated into t
246 As a
proof of concept,
this approach shows that stochastic mo
247 As a
proof of concept,
this work is accompanied by 22 ready t
248 For
proof-of-concept,
this sensor was used to detect Plasmod
249 As a
proof-of-concept,
this study demonstrates the successful
250 e laws of physics and has rapidly grown from
proof-of-concept to robust demonstrations and deployment
251 ous targets, the progress on translating the
proof-of-concepts to commercially viable and environment
252 This work was designed as a
proof of concept,
to demonstrate the successful use of t
253 otency and pharmacokinetics produced in vivo
proof-of-concept tool molecule 20 (AM-1488), which rever
254 In conclusion, this
proof-of-concept trial provides initial evidence that ke
255 , single-blind, randomised, sham-controlled,
proof-of-concept trial.
256 d timing studies when rushing from promising
proof-of-concept trials with surrogate end points such a
257 sing a highly silver-selective membrane as a
proof-of-concept under different conditions (variation o
258 In addition to this
proof-of-concept,
use of PR scaffolds with differing phy
259 ancies have demonstrated compelling clinical
proof-of-concept,
validating the biology and drug discov
260 In this paper, we present a
proof-of-concept validation experiment on top-view image
261 peutic mechanisms were undefined and in vivo
proof of concept was limited.
262 Proof-of-concept was extended to a patient-derived xenog
263 As a
proof of concept we demonstrate the sensitivity of the r
264 As a
proof of concept we determined gamma of trans-stilbene a
265 As a
proof of concept we exposed growing colonies of Escheric
266 As
proof-of-concept we investigated proteome-wide protein i
267 As
proof of concept,
we apply the theory for the investigat
268 As
proof of concept,
we converted existing, single-emission
269 As
proof of concept,
we demonstrate that our mouse model pe
270 As an initial
proof of concept,
we developed stepwise multiple linear
271 METHODS AND To establish preclinical
proof of concept,
we developed two independent rat model
272 As a
proof of concept,
we employed sUHR to determine the lipi
273 As a
proof of concept,
we engineered the vaccine DEKnull to a
274 As a
proof of concept,
we focus on combinations with the anti
275 In this
proof of concept,
we generate and sequence six sciHi-C l
276 As
proof of concept,
we have applied the VEPART method to s
277 Moreover, as a
proof of concept,
we include the experimental validation
278 As
proof of concept,
we mutagenized a selected region withi
279 As a
proof of concept,
we performed a biochemical characteriz
280 sing optical sensing of chloramphenicol as a
proof of concept,
we show here that a GFP variant engine
281 As a
proof of concept,
we show that key predictions of the cr
282 As a
proof of concept,
we target the ACT1 promoter of the mod
283 As a
proof of concept,
we translated our murine data to the t
284 Here, as a
proof of concept,
we use downshifting CdSe/CdS quantum d
285 As
proof-of-concept,
we carry out field demonstrations wher
286 As a
proof-of-concept,
we delivered short guide RNAs targetin
287 As a
proof-of-concept,
we demonstrate the application of the
288 Using ABO blood typing as a
proof-of-concept,
we developed i) an integrated biologic
289 As a
proof-of-concept,
we generated D1-dopamine receptor (D1)
290 As a
proof-of-concept,
we have subjected the fourth generatio
291 As
proof-of-concept,
we present simulation results for stan
292 For
proof-of-concept,
we propose an oxide-semiconductor-oxid
293 As a
proof-of-concept,
we show that labile substrates generat
294 As an initial
proof-of-concept,
we used antibody-peptide fusions and f
295 As a
proof-of-concept,
we used MegaSTAR to identify pairs of
296 As a
proof-of-concept,
we used these advances to rapidly muta
297 As
proof-of-concept,
we used this technology to treat mouse
298 As a
proof of concept,
wild-type (ATCC 29212) and vancomycin-
299 This
proof of concept with regard to a microfluidic dielectro
300 This promising
proof of concept work can lead to a revolutionizing way