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1 rst tested on a three-compartment phantom as proof-of-concept.
2 enhagen for the years 2016-2030 is used as a proof-of-concept.
3  ethanol and dimethyl sulfoxide are shown as proof-of-concept.
4  validated the top 2 candidates in vivo as a proof-of-concept.
5                                         In a proof of concept, 6-week, open-label clinical trial, int
6                                         As a proof of concept, 61,913 protein-protein interactions we
7                                           As proof of concept, a photo-cross-linkable derivative of c
8                                         As a proof of concept, a reversible label-free glutathione-S-
9                                         As a proof of concept, a time resolved fluorescence based san
10                                 Herein, as a proof-of-concept, a family of dendrimers displaying inte
11                                           As proof-of-concept, a prototype platform is successfully u
12                                         As a proof of concept, amplification of a gene specific to a
13                                         This proof-of-concept analysis demonstrates that unsupervised
14 ry of potent, selective modulators with cell proof of concept and in vivo activity to the optimizatio
15                            Here we present a proof-of-concept application for the rational design of
16                                         In a proof-of-concept application in organocatalysis, the dia
17                                         As a proof-of-concept application, the obtained ultrathin COF
18                              Conclusion This proof of concept approach highlights the relative import
19 ative stress mechanisms in TBI and provide a proof-of-concept approach to improve acute TBI managemen
20 e present experimental results comparing two proof-of-concept ballast molecules, and show that the ba
21 scharged MnO2 could be recovered, enabling a proof-of-concept biobattery/supercapacitor hybrid device
22                These observations, made on a proof-of-concept bioconjugate polymer amphiphile, reveal
23 rst steps have been reported with respect to proof-of-concept cardiovascular therapeutic applications
24                                              Proof-of-concept cells display open circuit voltages of
25 n by ultrasound cavitation was assessed in a proof-of-concept clinical trial in 12 subjects with stab
26 imed to report results of the first-in-human proof-of-concept clinical trial in healthy adults of a p
27                                   A phase 2a proof-of-concept clinical trial in patients with AD is c
28 n silicon and transparent glass surfaces: as proof of concept, clusters of either one, two, or three
29                                           As proof of concept, copper(II) in aqueous samples was conv
30 immune system, our results suggest that this proof-of-concept could potentially be utilized to reduce
31                                           As proof of concept, cultured renal epithelial cells were e
32                                   We provide proof of concept data by profiling 60 drugs on 68 acute
33 st this approach in phantoms, and we present proof-of-concept data in models of AD-like and AS hippoc
34           This pilot study provides not only proof-of-concept data on the work impairment collected w
35 er, these new findings provide a preclinical proof of concept defining C1572 as a promising therapeut
36                                         As a proof-of-concept demonstration, the PARTI system is appl
37                                         This proof of concept developed herein holds immense promise
38                   Engineering challenges and proof-of-concept devices for storing and releasing energ
39                                         This proof-of-concept dynamic NA method is an extension of a
40                                         As a proof-of-concept example, we conducted theoretical evalu
41 e-shaped gold particles were fabricated as a proof of concept experiment.
42 formed in model solution were selected for a proof-of concept experiment.
43                                          Our proof-of-concept experiments show that multiple desired
44 atient-derived xenografts (zPDX) and provide proof-of-concept experiments that compare response to ch
45                                          The proof-of-concept finding supports the view that the domi
46                                           As proof of concept, Fogarty et al. (2017) used CRISPR/Cas9
47 riptional complex and provides rationale and proof of concept for a combinatorial therapeutic attack
48                         This work provides a proof of concept for a general strategy to use nanohoops
49 aken together, our results offer preclinical proof of concept for a method to enhance delivery of che
50                    These experiments provide proof of concept for a mixed modality approach for treat
51             Therefore, DPM-1001 represents a proof of concept for a new approach to therapeutic inter
52              Our studies offer a preclinical proof of concept for a strategy of cotargeting the EGFR
53                                 We present a proof of concept for a vector beam polarization state sp
54                                           As proof of concept for anti-TRBC immunotherapy, we develop
55 gnosis in TNBC, and they offer a preclinical proof of concept for combining CDK7 and BCL-2/BCL-XL inh
56              Our results offer a preclinical proof of concept for CRLX101 as a modality to improve th
57 ollectively, our results offer a preclinical proof of concept for ERK5 as a target to enhance T-cell
58              This work serves as an extended proof of concept for fast in solution detection methods
59       Overall, our results offer preclinical proof of concept for H3B-6527 as a candidate therapeutic
60                                              Proof of concept for human uterine transplantation was d
61 Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective mean
62                            Our results offer proof of concept for identifying novel cancer risk loci
63 , they offer a genetically based preclinical proof of concept for IGFBP7 as a therapeutic target for
64 ificance: These findings offer a preclinical proof of concept for immunotherapeutic targeting of an e
65             Our findings offer a preclinical proof of concept for immunotherapeutic targeting of TEM8
66 tem for drug screening and offer preclinical proof of concept for KDM4 inhibition as a new strategy t
67 ession in microbial and plant hosts provided proof of concept for metabolic engineering of pseudolara
68              Our results offer a preclinical proof of concept for PPARG as a candidate therapeutic ta
69 BM tumors and GSCs and provide a preclinical proof of concept for repurposing mibefradil as a mechani
70             Our findings provide preclinical proof of concept for several combination treatments of T
71             Our findings offer a preclinical proof of concept for small-molecule therapies to target
72 e Golgi organizational states and provides a proof of concept for the classification of drugs and gen
73 ur results offer a preclinical pharmacologic proof of concept for the coordinate inhibition of transl
74        Taken together, these results provide proof of concept for the development of liver-targeted m
75                       These findings provide proof of concept for the development of small molecule i
76       Overall, our results offer preclinical proof of concept for the effectiveness of PDP to minimiz
77    Together, our results offer a preclinical proof of concept for the low-dose use of isoform-specifi
78        In this study, we provide preclinical proof of concept for the role of a proinflammatory CXCL1
79 ollectively, our results offer a preclinical proof of concept for the use of anti-Jagged1/2 to reprog
80               Here, we provide a preclinical proof of concept for the use of granzyme B, a downstream
81 ollectively, our results offer a preclinical proof of concept for the use of protein myristoylation i
82 cer cell migration and provide a preclinical proof of concept for their candidacy as targets to treat
83 nction for CD44V6 in lung fibrosis and offer proof of concept for therapeutic targeting of CD44V6 in
84 nes in lentiviruses, in which we demonstrate proof-of-concept for a 'template-switching' lentiviral v
85                         These data provide a proof-of-concept for a new disease mechanism involving t
86                       This study serves as a proof-of-concept for a new strategy for chemical imaging
87                In this study, we established proof-of-concept for a novel diagnostic platform (TB-DzT
88                      Finally, we provide the proof-of-concept for a single-chamber microfluidic chip
89                            We present here a proof-of-concept for bisphenol A detection; the device c
90 gene augmentation therapy, thereby providing proof-of-concept for cone function restoration in BCM pa
91                          This study provides proof-of-concept for direct BAX activation as a treatmen
92                  These results contribute to proof-of-concept for enhanced ethanol ablation as a nove
93 rent design considerations are explored, and proof-of-concept for highly pathogen-specific cargo rele
94                    These results represent a proof-of-concept for implementing a circadian forecastin
95 calable to microwell formats, and we provide proof-of-concept for its use in testing entry inhibitors
96                        These results provide proof-of-concept for Mobilan as a tool for antitumor vac
97                          Here, we describe a proof-of-concept for new methodology to detect and quant
98  antitumor efficiency by FF conjugates and a proof-of-concept for new photosensitizer carriers based
99 on traditional Chinese pastries (TCPs), as a proof-of-concept for the detection of illegal colorants.
100                             Here, we provide proof-of-concept for the TFT, by showing that introducti
101 tudies with doubly radiolabeled 16 provide a proof-of-concept for the use of a cathepsin K cleavable
102                     Our results constitute a proof-of-concept for, to our knowledge, a new design pri
103 ade of rationally designed DNA molecules are proofs of concept for embedding control within complex m
104                                            A proof-of-concept gas sensor equipped with the resulting
105                  Together these data provide proof-of-concept genetic evidence that blocking the clat
106                                   Here, as a proof of concept, genetically engineered BLNs, which dis
107                                          Our proof-of-concept glaucoma implant shows potential as a l
108                                         As a proof-of-concept, glucose sensing was evaluated.
109                                         As a proof of concept, guest binding to one of the helix-shee
110                                              Proof-of-concept has been established in nonhuman primat
111 ctive for fluorine-18 radiochemistry and, as proof of concept, have been used to optimize an otherwis
112 hen deployed on novel experimental data as a proof of concept, illustrating the recruitment of LAT to
113                           Here, we present a proof-of-concept immunomodulatory gene circuit platform
114                               Data from this proof-of-concept implementation is fit by a proposed mod
115                                         In a proof-of-concept in vivo experiment, blockade of C1q and
116 ctrode assembly (MEA) and tested, as initial proof-of-concept, in a non-passive fuel cell operation e
117  is designed and fabricated to demonstrate a proof-of-concept integrated device, which features wirel
118                     Moreover, to move beyond proof-of-concept into translational applications, we dis
119                                          The proof of concept is demonstrated with the apoptosis regu
120                                          The proof of concept is shown by using polypyrrole (PPy) fil
121                                            A proof-of-concept is demonstrated by an immunospecific de
122                                Further, as a proof of concept, it is demonstrated that the DNF can de
123 d as the best candidate and to establish the proof of concept, its ability to enhance Neph1-CD and ZO
124                                         As a proof of concept, Jurkat cells are enriched to high puri
125 tive ion detectors are used to demonstrate a proof-of-concept low-cost, amplifier-free, light-emittin
126                                   This first proof of concept may ultimately be applicable to geofenc
127                                  This novel, proof-of-concept method was proposed for the quick and r
128                                         This proof-of-concept mobile DFM device weighs less than 400g
129                                      Limited proof-of-concept monotherapy studies to evaluate safety
130                   We fabricated and tested a proof-of-concept NanoThermoMechanical device that has sh
131                                           As proof of concept, Nd/Sm and Nd/Dy are used as binary mod
132                                         As a proof of concept, NiCo coordination polymer spheres are
133                              To evaluate the proof of concept of an intervention to teach surgeons to
134 emristive and superconducting oscillators, a proof of concept of neuromorphic computing using nanosca
135                      These results provide a proof of concept of systemic antitumor activity after in
136                            This work shows a proof of concept of the use of monodisperse Si and C nan
137                We tested and established the proof of concept of this approach for 2 serotypes of Str
138                                          The proof of concept of utilizing a microfluidic dielectroph
139                                         This proof-of-concept of a membrane-free battery has an open
140                           Here, we provide a proof-of-concept of an integrated approach for analysis
141                         These data represent proof-of-concept of efficacy of IL-4 treatment for acute
142                                   We provide proof-of-concept of Homo-PROTACs using diverse molecules
143                          These results offer proof-of-concept of how the covalent conjugation of two
144                  We thus provide preclinical proof-of-concept of NKG2D CAR T-cell activity in mouse g
145                                We provided a proof-of-concept of SL-seq in Leishmania donovani, the m
146                     These findings represent proof-of-concept of the efficacy and tolerability of ant
147           Previous reports have demonstrated proof-of-concept of this approach; however, current comp
148                 Thus, we provide preclinical proof-of-concept of treatment shortening using antibioti
149                                  Moreover, a proof-of-concept peptide regulatory circuit was develope
150                               We performed a proof-of-concept phase Ib study of ibrutinib monotherapy
151                                 To conduct a proof-of-concept pilot study of a wireless, patient-cent
152                                      In this proof-of-concept pilot study, patients wore wristband pe
153                              Additionally, a proof-of-concept prototype system, which integrates an o
154 uclear spins, illuminating a new path toward proof-of-concept quantum sensors and processors with hig
155 ergen sensitivity in mouse models to provide proof of concept relating to their use in the clinic.
156            F6P-biosensor is a very promising proof of concept required for the design of a carbohydra
157 EF-stimulated nucleotide exchange assay in a proof-of-concept screen, we identified an overlapping se
158                                         In a proof-of-concept setting systemic treatment with ustekin
159                                         This proof-of-concept shows the feasibility of assembling all
160                             As a preclinical proof of concept, specific tumor uptake, pharmacokinetic
161                                         As a proof-of-concept, spike-like transients of a stochastic
162 h and small-bandgap ATT-2 in NIR region, the proof-of-concept STOPVs show the highest PCE of 7.7% so
163 hy human subjects prior to the initiation of proof of concept studies for the treatment of mood disor
164                                              Proof of concept studies of tissue phantoms yielded a me
165                                              Proof of concept studies were performed to detect saliva
166 ts that potentially influence the host, many proof-of-concept studies have demonstrated causative rol
167                                    Recently, proof-of-concept studies have demonstrated genotype-phen
168      In our recent article, we elaborate our proof-of-concept studies of a mouse/human chimeric IgE a
169 get engagement and assist dose selection for proof-of-concept studies of PAM compounds.
170                                        These proof-of-concept studies support the further optimizatio
171                                              Proof-of-concept studies with CD3xHER2 BsAb (T-cell recr
172                                    The first proof-of-concept studies with the clinically relevant ca
173                                          For proof-of-concept studies, two crucial redox enzymes for
174  routine care in non-randomised, exploratory proof-of-concept studies.
175 mphasis on mechanistic advances and clinical proof-of-concept studies.
176                                    This is a proof of concept study aiming to quantify neurovascular
177                                         This proof of concept study demonstrates that bacterial flora
178                                         This proof of concept study demonstrates that pericardial res
179                                         This proof of concept study explored using a novel digital-me
180                              This is a first proof of concept study showing that modulating the catab
181 ed, allowing for the initiation of a Phase-2 proof of concept study.
182                                          Our proof-of concept study results demonstrate CMLD-2 repres
183 this study was that part 2 was designed as a proof-of-concept study by contrast with part 1.
184                                         This proof-of-concept study demonstrates the feasibility of a
185                                         This proof-of-concept study demonstrates the potential of MRI
186                                         This proof-of-concept study focused on hip fractures, but use
187 discovery of gammadelta T cells >30 y ago, a proof-of-concept study has not been done to prove the pr
188                                Overall, this proof-of-concept study illustrates an efficient, general
189                              Conclusion This proof-of-concept study indicates that TA of nonenhanced
190                           Collectively, this proof-of-concept study links urine peptidomics to molecu
191 of the peripheral nervous system in MS, this proof-of-concept study may offer new insights into the p
192                                         This proof-of-concept study provides a new direction for regu
193                                         This proof-of-concept study sheds light on genotype-phenotype
194                                         This proof-of-concept study shows that the development of bot
195                              Results of this proof-of-concept study suggest that a larger trial, powe
196                                         This proof-of-concept study suggests a new multivariable anal
197               We did a nested, case-control, proof-of-concept study to compare the prevalence of CHIP
198                                            A proof-of-concept study was conducted using T2 bacterioph
199 sed on a meta-Lasso regression model and the proof-of-concept study was performed using a large-scale
200 t this hypothesis clinically, we developed a proof-of-concept study, in which patients with EGFR-muta
201                                      In this proof-of-concept study, Raman microscopy was used to dif
202                                      In this proof-of-concept study, Raman microspectroscopy was util
203                                      In this proof-of-concept study, stable isotope probing (SIP) was
204                                         In a proof-of-concept study, through only external calibratio
205                                         In a proof-of-concept study, we defined two groups (1) an acu
206                                         In a proof-of-concept study, we enrolled 10 patients with lun
207                                       In our proof-of-concept study, we evaluated the capability of t
208                                         In a proof-of-concept study, we previously showed that colore
209  percutaneous nephrolithotomy (PCNL) in this proof-of-concept study.
210           Our findings provide a preclinical proof of concept supporting the initiation of a clinical
211                  In this study, we present a proof-of-concept technology comprising an on-chip planar
212 n actin polymerization in vitro As a further proof-of-concept test for cellular effects of these comp
213               Conclusion This study provides proof of concept that a machine learning model can be ap
214                        We have also provided proof of concept that blocking 12-HETE production is a p
215                     These inhibitors provide proof of concept that both sides of DENV protease active
216                           This is a decisive proof of concept that cancer cells' malignant behaviour
217                        Thus, they serve as a proof of concept that electrical brain stimulation can b
218                     These findings provide a proof of concept that introducing gut bacteria to a herb
219                             This study shows proof of concept that LAIVs boost preexisting, cross-rea
220                        Our results provide a proof of concept that phosphate limitation may be the pr
221                     Thus, our study provides proof of concept that PU.1 inhibition has potential as a
222                             Our data provide proof of concept that single-particle EM can be used to
223                                              Proof of concept that such proteins can be detected with
224                      This study is the first proof of concept that targeting a lncRNA to transcriptio
225 roughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90
226             Collectively, these data provide proof of concept that targeting thrombin or fibrin(ogen)
227                      Together, this provides proof-of-concept that a cell-specific and region-specifi
228                               We establish a proof-of-concept that a microtubule motor-cargo interfac
229 till remain uncultured, our work serves as a proof-of-concept that can be applied to other taxa in or
230 our knowledge, this study provides the first proof-of-concept that clonotypic analysis may be used as
231                                              Proof-of-concept that FFLUX's architecture is suitable f
232            Ultimately, our work demonstrates proof-of-concept that lentiviruses can be used for perma
233  study of a SIRT6 inhibitor and provides the proof-of-concept that targeting SIRT6 may be a viable st
234                             Our data provide proof-of-concept that this technology can be used to tre
235                                         As a proof of concept, the biodistribution of (89)Zr-Df-pembr
236                                         As a proof of concept, the development of dual-membrane-coate
237                                           As proof of concept, the embryonic region of pearl millet s
238                                           As proof of concept, the fate of 411 target compounds in a
239                                         As a proof of concept, the Janus particle-derived catalyst ca
240                                         As a proof of concept, the method was applied to the rapid an
241                                         As a proof-of-concept, the ability of niosomes to prevent phy
242                                         As a proof-of-concept, the machine learning model trained on
243 clinical studies have demonstrated promising proofs-of-concept, the performance of human clinical BCI
244                                   To provide proof-of-concept, these 3D printed electrode architectur
245                                         As a proof-of-concept, these materials were fabricated into t
246                                         As a proof of concept, this approach shows that stochastic mo
247                                         As a proof of concept, this work is accompanied by 22 ready t
248                                          For proof-of-concept, this sensor was used to detect Plasmod
249                                         As a proof-of-concept, this study demonstrates the successful
250 e laws of physics and has rapidly grown from proof-of-concept to robust demonstrations and deployment
251 ous targets, the progress on translating the proof-of-concepts to commercially viable and environment
252                  This work was designed as a proof of concept, to demonstrate the successful use of t
253 otency and pharmacokinetics produced in vivo proof-of-concept tool molecule 20 (AM-1488), which rever
254                          In conclusion, this proof-of-concept trial provides initial evidence that ke
255 , single-blind, randomised, sham-controlled, proof-of-concept trial.
256 d timing studies when rushing from promising proof-of-concept trials with surrogate end points such a
257 sing a highly silver-selective membrane as a proof-of-concept under different conditions (variation o
258                          In addition to this proof-of-concept, use of PR scaffolds with differing phy
259 ancies have demonstrated compelling clinical proof-of-concept, validating the biology and drug discov
260                  In this paper, we present a proof-of-concept validation experiment on top-view image
261 peutic mechanisms were undefined and in vivo proof of concept was limited.
262                                              Proof-of-concept was extended to a patient-derived xenog
263                                         As a proof of concept we demonstrate the sensitivity of the r
264                                         As a proof of concept we determined gamma of trans-stilbene a
265                                         As a proof of concept we exposed growing colonies of Escheric
266                                           As proof-of-concept we investigated proteome-wide protein i
267                                           As proof of concept, we apply the theory for the investigat
268                                           As proof of concept, we converted existing, single-emission
269                                           As proof of concept, we demonstrate that our mouse model pe
270                                As an initial proof of concept, we developed stepwise multiple linear
271         METHODS AND To establish preclinical proof of concept, we developed two independent rat model
272                                         As a proof of concept, we employed sUHR to determine the lipi
273                                         As a proof of concept, we engineered the vaccine DEKnull to a
274                                         As a proof of concept, we focus on combinations with the anti
275                                      In this proof of concept, we generate and sequence six sciHi-C l
276                                           As proof of concept, we have applied the VEPART method to s
277                               Moreover, as a proof of concept, we include the experimental validation
278                                           As proof of concept, we mutagenized a selected region withi
279                                         As a proof of concept, we performed a biochemical characteriz
280 sing optical sensing of chloramphenicol as a proof of concept, we show here that a GFP variant engine
281                                         As a proof of concept, we show that key predictions of the cr
282                                         As a proof of concept, we target the ACT1 promoter of the mod
283                                         As a proof of concept, we translated our murine data to the t
284                                   Here, as a proof of concept, we use downshifting CdSe/CdS quantum d
285                                           As proof-of-concept, we carry out field demonstrations wher
286                                         As a proof-of-concept, we delivered short guide RNAs targetin
287                                         As a proof-of-concept, we demonstrate the application of the
288                  Using ABO blood typing as a proof-of-concept, we developed i) an integrated biologic
289                                         As a proof-of-concept, we generated D1-dopamine receptor (D1)
290                                         As a proof-of-concept, we have subjected the fourth generatio
291                                           As proof-of-concept, we present simulation results for stan
292                                          For proof-of-concept, we propose an oxide-semiconductor-oxid
293                                         As a proof-of-concept, we show that labile substrates generat
294                                As an initial proof-of-concept, we used antibody-peptide fusions and f
295                                         As a proof-of-concept, we used MegaSTAR to identify pairs of
296                                         As a proof-of-concept, we used these advances to rapidly muta
297                                           As proof-of-concept, we used this technology to treat mouse
298                                         As a proof of concept, wild-type (ATCC 29212) and vancomycin-
299                                         This proof of concept with regard to a microfluidic dielectro
300                               This promising proof of concept work can lead to a revolutionizing way

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