1 synthetic metabolic pathway gene array as a
proof of principle.
2 after liver transplantation and serves as a
proof of principle.
3 miR-430 in developing zebrafish embryos as a
proof of principle.
4 PIII) and LITTLE ZIPPER (ZPR) interaction as
proof-of-principle.
5 istic 1,000 and 6,000 muatm exposures, and a
proof-of-principle 30,000 muatm exposure.
6 As
proof of principle a CTC panel, immunosuppression panel
7 As
proof of principle,
a range of different shapes, alignme
8 As
proof of principle,
a recombinant BUNV was created that
9 As a
proof of principle,
a selected reaction monitoring (SRM)
10 We highlight a
proof-of-principle and describe the working principle fo
11 Our results establish a
proof-of-principle and provide a framework for improving
12 This is a
proof of principle,
and major hurdles remain before opti
13 We go beyond
proof-of-principle,
and use our system to label and trac
14 By this
proof-of-principle,
another asset was demonstrated to be
15 As a
proof-of-principle application of this ultrafast photode
16 me analysis by nanoLC-MS(2), and demonstrate
proof-of-principle applications of the duplex and triple
17 -dependent Ly6C(low) monocytes, we present a
proof-of-principle approach that addresses these limitat
18 We demonstrate with
proof-of-principle Brownian dynamics simulations that, w
19 tes a hybrid system that we demonstrate as a
proof-of-principle can be utilized in specific DNA seque
20 As
proof-of-principle,
cell viability and immune responses
21 ologic evidence of periodontal regeneration (
proof of principle),
clinical trials, and case reports.
22 We did this
proof-of-principle cohort study at one centre in Canada.
23 A
proof-of-principle CRISPR-UMI negative-selection screen
24 These
proof-of-principle data identify mutp53 as an actionable
25 This
proof-of-principle demonstration illustrates how transie
26 Using this network, we perform a
proof-of-principle demonstration of QDS mediated by MDI-
27 In this issue of JCI, Noh et al. provide a
proof-of-principle demonstration that embryonic stem cel
28 ectively loss-free, color-preserving, and in
proof-of-principle demonstrations have provided 23 dB is
29 y plasmids, but as the field progresses from
proof-of-principle demonstrations to practical applicati
30 As a
proof-of-principle,
deoxynivalenol (DON), an important m
31 By the lithographical design of a
proof of principle device we demonstrate the merits of s
32 Through a
proof-of-principle drug screening using BICA, we found t
33 ied to model MN-degenerative diseases and in
proof-of-principle drug-screening assays.
34 olecules to 2D atomic layers and fabricate a
proof-of-principle dye-sensitized photosensing device.
35 For
proof of principle,
enumeration of the white blood cells
36 r regulating HSV-1 infection, and provides a
proof-of-principle evidence for a novel antiviral mechan
37 Our study provides
proof-of-principle evidence for the development of small
38 These novel compounds provide
proof-of-principle evidence for the possibility of small
39 These data provide
proof-of-principle evidence for the therapeutic potentia
40 Here, we present a
proof-of-principle example of an extreme discordant desi
41 Finally, we provide several
proof-of-principle examples in which we model the effect
42 Here, we report a
proof-of-principle experiment for imaging individual fun
43 In a
proof-of-principle experiment on a university-scale syst
44 Together our data is a
proof-of-principle experiment that demonstrates that cel
45 Here, we report a
proof-of-principle experiment that makes microscopic inv
46 approach to scalable quantum memories with a
proof-of-principle experiment with room temperature atom
47 In this
proof-of-principle experiment, NPRM-bLXA4 dramatically r
48 In a
proof-of-principle experiment, pooled samples of patient
49 In a
proof-of-principle experiment, treatment of these two su
50 In a
proof-of-principle experiment, we used CRISPR-EZ to targ
51 We demonstrate this in a
proof-of-principle experiment.
52 This
proof-of-principle experimental system allowed us to qua
53 e demonstrate the efficacy of our methods in
proof of principle experiments and application to real w
54 Here, we present
proof of principle experiments of an optical gating conc
55 ases of engineered gene drives due to recent
proof of principle experiments with the CRISPR-Cas9 syst
56 Using optimized parameters,
proof-of-principle experiments confirmed the ability of
57 Proof-of-principle experiments demonstrated that in a ce
58 Herein we describe
proof-of-principle experiments for a modular strategy to
59 We demonstrate this in
proof-of-principle experiments for chiral and anisotropi
60 Several platforms have been suggested and
proof-of-principle experiments have been conducted.
61 Proof-of-principle experiments on neuronal co-cultures a
62 Our
proof-of-principle experiments show that FSCV is a power
63 These
proof-of-principle experiments show that the combination
64 In this paper, we perform
proof-of-principle experiments that demonstrate the util
65 In
proof-of-principle experiments, the use of gas-phase hyd
66 In
proof-of-principle experiments, we manipulated apterous,
67 As a
proof-of-principle,
fluorophores containing a borinate (
68 telomere-terminal DNA fragments, we provide
proof of principle for a novel method to estimate telome
69 Here we provide a
proof of principle for a novel two-pronged modality refe
70 g of virus-host interactions and establish a
proof of principle for a repurposed, host-targeted appro
71 This provides
proof of principle for a therapeutic approach for allerg
72 velopment of cardiac hypertrophy and provide
proof of principle for a therapeutic approach to treat t
73 This study provides the first
proof of principle for an epigenetics-based therapy for
74 This result constitutes a
proof of principle for collective behavior of macroscopi
75 This study provides a
proof of principle for EMF-based in vivo lineage convers
76 nst the psoriatic inflammation and provide a
proof of principle for future development of agents capa
77 eyond our findings, the analysis serves as a
proof of principle for how upcoming biomedical data sets
78 a, magnetofection, is demonstrated and gives
proof of principle for its translation into corneal gene
79 Proof of principle for local drug delivery with Acoustic
80 al immune-repertoire sequencing data sets as
proof of principle for measuring diversity in large, com
81 ully reconstruct the biliary tree, providing
proof of principle for organ regeneration using human pr
82 This study provides a
proof of principle for the application of metabolomics t
83 This study provides
proof of principle for the application of targeted next-
84 s from SPYRAL HTN-OFF MED provide biological
proof of principle for the blood-pressure-lowering effic
85 to act against intracellular Mtb, providing
proof of principle for the efficacy of a "release and ki
86 nce a key virus-host interaction and provide
proof of principle for the generation of large-scale mut
87 Proof of principle for the potential of scanning LC-FAIM
88 is study render a clinical basis and provide
proof of principle for the use of deformable, motion-coh
89 These findings provide
proof of principle for the use of optimized lupus autoan
90 replacement for type 1 diabetes and provide
proof of principle for therapeutic cloning combined with
91 R243W) were previously discovered, providing
proof of principle for this approach, while the role of
92 As a
proof of principle for this assay, we show that a variet
93 Proof of principle for this therapeutic approach was dem
94 nherited neuropathy mouse model and provides
proof of principle for treating inherited demyelinating
95 Taken together, our results provide a
proof of principle for tumor-targeted, nanoparticle-medi
96 hus, ERK dimerization inhibitors provide the
proof of principle for two understudied concepts in canc
97 These experiments provide a
proof-of-principle for a rational search for pharmacocha
98 This work provides the
proof-of-principle for further application of OSA-TIMS-F
99 This study provides
proof-of-principle for inducing an MET as differentiatio
100 In this article, we establish a
proof-of-principle for methods to initiate and then moni
101 These data constitute a
proof-of-principle for the future usage of sdAbs as PCSK
102 lectron microscopy measurements and serve as
proof-of-principle for the realized GEXRF setup.
103 These data provide
proof-of-principle for the view that newly generated ASC
104 of thin silica gel layers is demonstrated as
proof-of-principle for use in planar chromatography.
105 This study offers a
proof-of-principle for utilizing human neurons to study
106 Meanwhile, recent discoveries provide
proofs of principle for breakthroughs in a family of res
107 We demonstrate here loading and
proof-of-principle four-colour sequence readout of a pol
108 aits and we demonstrate, through ex vivo and
proof of principle genome editing validation, that varia
109 -band electron responses of SmS, we create a
proof-of-principle heavy fermion metamaterial, which is
110 As a
proof-of-principle,
here we tested this approach on the
111 We describe a
proof-of-principle,
immune sandwich assay in which immun
112 Even in the current,
proof-of-principle implementation this architecture is s
113 The compounds identified here provide a key
proof-of-principle in support of further studies identif
114 In
proof-of-principle in vitro experiments of CD4(+) cell i
115 We experimentally demonstrate a
proof-of-principle incandescent emitter with efficiency
116 Proof of principle is demonstrated through the titration
117 Proof of principle is provided that this approach enable
118 nolysis of alpha-pinene has been chosen as a
proof-of-principle model system.
119 For a
proof-of-principle,
multiplexed detection of three model
120 of a therapy-activated TME, and provides the
proof of principle of co-targeting tumor and the TME to
121 iomarkers, and constitutes the first in vivo
proof of principle of cobalamin treatment in mut-type MM
122 Proof of principle of in vivo targeting of human islets
123 vo In summary, this study provides the first
proof of principle of small-molecule-mediated interferen
124 As a
proof of principle of the method, we separate both Jurka
125 As a
proof of principle of the potential of this technique, c
126 This reaction was chosen to demonstrate the
proof-of-principle of directly monitoring in stillo micr
127 As
proof-of-principle of rTLC, German propolis samples were
128 We show a
proof-of-principle of the fluidized capacitive system wi
129 We have tested our
proof of principle on a currently used immunoanalyzer, t
130 In this
proof-of-principle open-label pilot study, five individu
131 Two
proof-of-principle optical elements were designed, fabri
132 on, gastric inhibitory polypeptide (GIP), as
proof-of-principle peptides to demonstrate the value of
133 We conducted a
proof-of-principle phase II study in patients with p53 t
134 Our approach of a
proof-of-principle platform, which uses isogenic hESCs f
135 As a
proof of principle,
PLSR was used to build soil-bacteriu
136 In summary, these findings provide a
proof-of-principle,
rational strategy to target the MYB
137 These
proof of principle results open a pathway for directing
138 These
proof-of-principle results constitute a significant step
139 Based on these
proof-of-principle results in healthy individuals, we pr
140 aries for genomic regions of interest, and a
proof-of-principle screen that identifies novel cis-regu
141 This
proof-of-principle shows that specific enrichment of ele
142 As
proof-of-principle,
simultaneously using two CRISPR/Cas9
143 ally in the optical domain and demonstrate a
proof-of-principle single-shot coherent diffractive imag
144 We demonstrate
proof-of-principle,
single-shot read-out performance, an
145 for selective targeting of GSCs and offer a
proof of principle strategy to potentially fulfill the s
146 Early
proof of principle studies demonstrated that the adminis
147 , ISRIB promises to be an invaluable tool in
proof-of-principle studies aiming to ameliorate cognitiv
148 Proof-of-principle studies have demonstrated the inducti
149 rve as useful tool compounds for preclinical
proof-of-principle studies in order to validate the syne
150 In the
proof-of-principle studies, iron oxide-labeled autologou
151 In
proof-of-principle studies, our method revealed metaboli
152 In
proof-of-principle studies, the antiadhesion activity of
153 A
proof of principle study using F/R incorporated into lip
154 This
proof-of-principle study demonstrates the feasibility of
155 ne therapy using AAV vectors and showed in a
proof-of-principle study how this virus-host interaction
156 Our
proof-of-principle study illustrates that transcriptome-
157 This
proof-of-principle study introduces a sensing mechanism
158 This
proof-of-principle study investigated the adjuvant prope
159 A
proof-of-principle study on patients recently diagnosed
160 The results of the present
proof-of-principle study showed that proper exploitation
161 This
proof-of-principle study sought to determine whether the
162 This
proof-of-principle study suggests that our protocol is c
163 Here we conducted a
proof-of-principle study to examine the ability of perox
164 In this
proof-of-principle study, IRC-derived morphometric varia
165 In this prospective,
proof-of-principle study, we compared whole-blood RNA-se
166 In this
proof-of-principle study, we demonstrate the potential c
167 In this physiologic
proof-of-principle study, we determined whether transfus
168 In a
proof-of-principle study, we develop an optogenetic Raf
169 In this
proof-of-principle study, we have proposed an approach f
170 In this
proof-of-principle study, we report that macrophages of
171 To test this concept, in this-
proof-of-principle study, we screened for modulators of
172 In our
proof-of-principle study, we used comparative flow cytom
173 In this
proof-of-principle study, we used precise gene editing t
174 of blaKPC-pKpQIL-Klebsiella pneumoniae in a
proof-of-principle study.
175 providing an excellent starting point for a
proof-of-principle study.
176 proved 6-minute-walk distance in this small "
proof-of-principle"
study.
177 Our data provide
proof of principle support for the use of 2DG as a thera
178 These results provide
proof-of-principle support to the suggestion that omic p
179 omo-oligomers from di- to tetramers serve as
proof-of-principle test cases.
180 This study provides additional
proof of principle that an apelin receptor agonist may b
181 nzo[c,m]pentaphene moieties not only provide
proof of principle that aromatic belts can be derived by
182 We provide a
proof of principle that BRAINSPAReDT can be used for Cre
183 These results represent an important
proof of principle that can improve the target selection
184 These results provide a
proof of principle that can inform prospective vaccine d
185 Z011 acts as a CB1 PAM and provide the first
proof of principle that CB1 PAMs offer a promising strat
186 Our work provides
proof of principle that chemotherapy paired with an "eco
187 Furthermore, these findings provide
proof of principle that endothelial-derived signaling ca
188 y in mitotically active HD cells and offer a
proof of principle that epigenetic interventions can cur
189 ntiomeric ratio of 70/30 and, thus, provides
proof of principle that iodonium ylides are suitable sub
190 These findings provide a
proof of principle that LMIPs can be used to block QS, t
191 As
proof of principle that MACHETE discovers novel gene fus
192 Overall, our studies represent a clear
proof of principle that MT-Hec1-interacting compounds ma
193 It provides
proof of principle that Skp2 targeting is a promising ap
194 vented the loss of motor function, providing
proof of principle that small molecule chaperones can re
195 We provide
proof of principle that small molecules that target the
196 This also provides a
proof of principle that suboptimal CD8 T cell in old org
197 Our data provide
proof of principle that targeting the BB loop pocket is
198 output of the Ni-Pt materials, establishing
proof of principle that the spin Seebeck effect persists
199 therapy for SMA (nusinersen), and a pivotal
proof of principle that therapeutic antisense oligonucle
200 ells enhanced stress resistance, providing a
proof of principle that TRIC can be used for circuit man
201 CRF-overexpressing (CRF-OE) mice to test the
proof of principle that when CRF is in excess, sex-biase
202 care MCC chemotherapeutic agents and provide
proof-of-principle that ABCB5 blockade can inhibit human
203 valence and clinical data, demonstrating the
proof-of-principle that age seroprevalence predicts tran
204 We aimed to establish definitive
proof-of-principle that circulating microRNAs are differ
205 These results provide
proof-of-principle that clodronate is effective at spari
206 The data provide
proof-of-principle that genetic and environmental factor
207 Notably, we provide
proof-of-principle that inhibiting IP3R3 degradation in
208 matrix derivatives (EMDs) have demonstrated
proof-of-principle that periodontal regeneration can be
209 Additionally, we provide
proof-of-principle that PHH spheroids can reflect liver
210 Here, we provide a
proof-of-principle that the folding deficit is amenable
211 Furthermore, we demonstrate as a
proof-of-principle that the plasmonic nanostructures can
212 at break this paracrine loop, and we provide
proof-of-principle that these drugs could be used to tre
213 odels and human material provide preclinical
proof-of-principle that validates uPA as a novel therape
214 Our studies provide
proof-of-principle that, in the absence of early CMV rea
215 The authors further show, as
proof of principle,
that this model can be used to evalu
216 sease susceptibility gene and demonstrate in
proof of principle the utility of induced neuron-based m
217 fy angiogenin-generating 5'-tRNA halves as a
proof of principle,
the method should be applicable to g
218 n contrast to recklessness and suggest, as a
proof of principle,
the possibility of inferring from br
219 For
proof-of-principle,
the clinically relevant glucagon-lik
220 As
proof-of-principle,
the known binding interaction of Cyc
221 As a
proof-of-principle,
the pancreatic cancer cell line Panc
222 As a
proof-of-principle,
the ssOPM system is also used to acq
223 As a
proof of principle,
these data confirm that in vivo synt
224 For
proof of principle,
this biosensor was used to detect ur
225 As a
proof of principle,
three glycoenzymes acting in series
226 ra-high-field imaging beyond a technological
proof of principle to investigate the intersubject varia
227 These results provide the
proof of principle to support as a strategy for vaccine
228 We conducted a
proof-of-principle trial to evaluate the effect of imati
229 The purpose of this study was to conduct a
proof-of-principle trial to test whether manipulation of
230 We did a
proof-of-principle trial with a novel endovascular baror
231 tis undergoing total knee replacement into a
proof-of-principle trial.
232 Meta-analyses based on small
proof-of-principle trials suggest efficacy of repetitive
233 We provide
proof-of-principle under seminatural conditions for two
234 We also demonstrate successful
proof-of-principle use of multiplexed ribozyme flanked g
235 The
proof-of-principle use of the MAB technique with the cir
236 ith concentration mass balances, providing a
proof-of-principle validation for assessing micropolluta
237 The experimental
proof of principle was achieved by in situ detection of
238 As
proof of principle we studied the kinetochore, a multipr
239 As a
proof of principle we study the response of dendritic ce
240 As
proof of principle we use this system to evaluate base s
241 ges in mitochondrial H2S levels in vivo As a
proof of principle we used MitoA to show that H2S levels
242 As our first
proof-of-principle we employed the bacterial chemotaxis
243 As
proof of principle,
we achieved light-triggered chemokin
244 As a
proof of principle,
we acquired 4D (H)COCANH, (H)CACONH,
245 As a
proof of principle,
we adapted this strategy for the det
246 As
proof of principle,
we analyse CD4+ T-cell responses to
247 As a
proof of principle,
we analyze CMC values determined by
248 For
proof of principle,
we applied our assay to 0.5 mL blood
249 As a
proof of principle,
we applied our automated annotation
250 As
proof of principle,
we apply HiHiMap to measure the leve
251 As
proof of principle,
we apply this approach to interrogat
252 As
proof of principle,
we assembled genomes of the pigeon (
253 As
proof of principle,
we demonstrate an electrochemical re
254 As a
proof of principle,
we demonstrate that a micro-thermal
255 As
proof of principle,
we demonstrate that we can manipulat
256 As a
proof of principle,
we demonstrate the capability of thi
257 As a
proof of principle,
we demonstrated correlation of the h
258 nting with symptoms of long-QT syndrome as a
proof of principle,
we demonstrated that commercially av
259 As
proof of principle,
we demonstrated that inactivation of
260 As
proof of principle,
we developed an eight-miRNA classifi
261 Using MEMOIR as a
proof of principle,
we engineered mouse embryonic stem c
262 As
proof of principle,
we examined hepatocellular carcinoma
263 As a
proof of principle,
we experimentally implement the prop
264 As
proof of principle,
we focused on TGFbeta because of its
265 As a
proof of principle,
we generated DNA aptamers that exhib
266 e dip coating of strawberries and bananas as
proof of principle,
we have shown that the formation of
267 In a
proof of principle,
we identified a compound that preven
268 As a
proof of principle,
we investigate such a structure comp
269 As a
proof of principle,
we mapped connectivity quantitative
270 As a
proof of principle,
we predict and measure the gap openi
271 As a
proof of principle,
we present results of analysis on Co
272 As a
proof of principle,
we profiled the muscle transcriptome
273 As a
proof of principle,
we show that fish deficient for the
274 As
proof of principle,
we showed that one compound enhanced
275 As
proof of principle,
we successfully isolated a high-qual
276 Asa
proof of principle,
we tracked the bacterial population
277 As a
proof of principle,
we used SRS microscopy to analyze th
278 As a
proof of principle,
we used the catalytic domain of matr
279 As a
proof of principle,
we used the coupled microfluidic lam
280 As a
proof of principle,
we used this new "nanomapping" metho
281 As a
proof of principle,
we validated our method using 28 sgR
282 As a
proof of principle,
we were able to simultaneously inact
283 For a first
proof-of-principle,
we concentrated on the transcription
284 As
proof-of-principle,
we conducted large-scale cell cycle
285 Finally, as a
proof-of-principle,
we demonstrate the ability of the la
286 As
proof-of-principle,
we developed a small, selective, pep
287 As
proof-of-principle,
we evaluated treatment of one tetra-
288 As a
proof-of-principle,
we explore the interactions of S. ce
289 As a
proof-of-principle,
we investigated two CD-based supramo
290 To establish this
proof-of-principle,
we performed virtual screening on a
291 As
proof-of-principle,
we targeted the low-density lipoprot
292 As
proof-of-principle,
we use PALM to image silica beads wi
293 As
proof-of-principle,
we used a multidisciplinary strategy
294 To demonstrate
proof-of-principle,
we used the TRBO-sgRNA delivery plat
295 As a
proof-of-principle,
we utilized PAC-seq to explore the p
296 rise from NMDAR hypofunction and establish a
proof of principle whereby experimental modelling of a d
297 In all, this work provides a
proof of principle which paves the way to the developmen
298 in recent years from theoretical to clinical
proof of principle with the publication of a first-in-ma
299 detection of cocaine and methamphetamine as
proof-of-principle with 0.25 and 0.75 mg/mL limits of de
300 r the determination of rate constants in the
proof-of-principle works on KSEC-MS.