ライフサイエンスコーパス: proopiomelanocortin

1 ng hormone but not in the cells that express proopiomelanocortin.

2 e of processing of the endogenous prohormone proopiomelanocortin.

3 transmembrane domain, was similar to that of proopiomelanocortin.

4 nitoring 18-kDa fragment-NH2 production from proopiomelanocortin.

5 AgRP and up-regulation of the expression of proopiomelanocortin/alpha-melanocyte-stimulating hormone

6 diminished synthesis and levels of pituitary proopiomelanocortin/alpha-MSH, associated with decreased

7 The corticotropin precursor proopiomelanocortin and corticotropin expression were as

8 ous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous imm

9 ecreased in the Dicer1 mutant mouse, whereas proopiomelanocortin and luteinizing hormone beta-subunit

10 signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related pr

11 tion: increased neuropeptide Y and decreased proopiomelanocortin and neurotensin mRNAs in the arcuate

12 ling-3 (SOCS3) occurs in AgRP neurons before proopiomelanocortin and other hypothalamic neurons.

13 le to slow convertase-mediated processing of proopiomelanocortin and proenkephalin; however, similarl

14 Surprisingly, when proopiomelanocortin and proglucagon were co-expressed in

15 s, while the levels of peptides derived from proopiomelanocortin and provasopressin did not show subs

16 phalin, in vivo production of alpha-MSH from proopiomelanocortin, and in vitro cleavage of a PC2-spec

17 uropeptides, notably agouti-related peptide, proopiomelanocortin, and neuropeptide Y.

18 pothalamic melanin-concentrating hormone and proopiomelanocortin but not hypocretin/orexin neurons; p

19 ed by PUFAs resulted in increased numbers of proopiomelanocortin but not NPY neurons and was accompan

20 the arcuate nucleus, both Neuropeptide Y and proopiomelanocortin cells expressed tdTomato.

21 our studies on the cutaneous expression of a proopiomelanocortin/corticotropin-releasing hormone syst

22 itiated, open-label study, two patients with proopiomelanocortin deficiency were treated with setmela

23 is of peptide hormones, such as glucagon and proopiomelanocortin-derived alpha-melanocyte-stimulating

24 nts the major influence on intermediate lobe proopiomelanocortin-derived peptide secretion, dopamine

25 ing hormone (CRH); arginine vasopressin; the proopiomelanocortin-derived peptides alpha-melanocyte-st

26 ocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulat

27 Using proopiomelanocortin enhanced-green fluorescent protein r

28 teractions of several opioid peptides [e.g., proopiomelanocortin, enkephalin (ENK)] with the stress-r

29 ally in the arcuate nucleus is inhibitory on proopiomelanocortin-expressing (POMC) neurons.

30 Using proopiomelanocortin-expressing cells located in the arcu

31 ells with no concomitant effect on pituitary proopiomelanocortin-expressing corticotrophs in the mous

32 Proopiomelanocortin-expressing intermediate lobe pituita

33 in which insulin expression was targeted to proopiomelanocortin-expressing pituitary cells.

34 ed with increased expression of hypothalamic proopiomelanocortin following leptin stimulation.

35 Null mutations of the proopiomelanocortin gene (Pomc) cause obesity in humans

36 egulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons lo

37 y selectively blocking the expression of the proopiomelanocortin gene (Pomc) in hypothalamic neurons.

38 This chromosomal region contains the proopiomelanocortin gene (POMC).

39 of leukemia inhibitory factor (LIF)-mediated proopiomelanocortin gene expression and adrenocorticotro

40 Additionally, apoE-stimulated hypothalamic proopiomelanocortin gene expression and SHU9119, a melan

41 investigated by targeted mutagenesis of the proopiomelanocortin gene in mouse embryonic stem cells.

42 f five reported receptors, agonists from the proopiomelanocortin gene transcript, and two antagonists

43 The tyrosine codon at position 179 of the proopiomelanocortin gene was converted to a premature tr

44 es is 2-3-fold lower than that of endogenous proopiomelanocortin in AtT-20 cells or prolactin in GH3

45 othalamic neurons express neuropeptide Y and proopiomelanocortin in the arcuate nucleus, melanin-conc

46 n of neuropeptide Y and higher expression of proopiomelanocortin in the hypothalamus.

47 the genes encoding the hormones insulin and proopiomelanocortin is potentiated by lineage-specific h

48 ciated with decreased levels of hypothalamic proopiomelanocortin, leading to increased food intake an

49 romogranin A, and on peptides processed from proopiomelanocortin, manifest similar striking sensitivi

50 to detect altered CNS expression levels for proopiomelanocortin, Mc3r, Mc4r, or NPY mRNAs in Agrp(-/

51 The expression of proopiomelanocortin messenger RNA (mRNA) was detected in

52 Three different precursors, mouse proopiomelanocortin (mPOMC), rat proenkephalin (rPE), an

53 ation in plasma corticosterone and pituitary proopiomelanocortin mRNA expression, although the increa

54 Inflammation increased proopiomelanocortin mRNA in cells from noninflamed and i

55 Proopiomelanocortin mRNA was enhanced after 6h with the

56 In normal animals, END and proopiomelanocortin mRNA were less abundant in circulati

57 e were significant decreases in GK, NPY, and proopiomelanocortin mRNA.

58 ricular nucleus (GLP-1RKD(DeltaSim1cre)) and proopiomelanocortin neurons (GLP-1RKD(DeltaPOMCcre)).

59 lus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning

60 PTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced o

61 ition from the AgRP neurons onto neighboring proopiomelanocortin neurons and their common postsynapti

62 alyses in vivo, we found that astrocytes and proopiomelanocortin neurons are responsible for the prod

63 communication with islets, and activation of proopiomelanocortin neurons by leptin enhances insulin s

64 ed protein (AgRP)-expressing neurons precede proopiomelanocortin neurons in developing diet-induced c

65 hetic nerve activity (SNA) via activation of proopiomelanocortin neurons in the arcuate nucleus (ArcN

66 ion of the loss of CEACAM1 from anorexigenic proopiomelanocortin neurons in the arcuate nucleus is un

67 amus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus.

68 odulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate

69 tration of PK2 increased c-fos expression in proopiomelanocortin neurons of the arcuate nucleus (ARC)

70 y the specific nuclei and cell type, such as proopiomelanocortin neurons of the arcuate nucleus, that

71 induction of cilia loss in leptin-responsive proopiomelanocortin neurons results in obesity, implicat

72 Hypothalamic proopiomelanocortin neurons selectively innervate the an

73 n feeding, coexpression with arcuate nucleus proopiomelanocortin neurons, and on limited analysis of

74 sed in the vast majority of leptin-sensitive proopiomelanocortin neurons, highlighting their importan

75 receive input from leptin-responsive arcuate proopiomelanocortin neurons, the physiological functions

76 nt role in maintaining leptin sensitivity in proopiomelanocortin neurons.

77 ceptors in guinea pig and mouse hypothalamic proopiomelanocortin neurons.

78 ostsynaptic currents onto neuropeptide Y and proopiomelanocortin neurons.

79 te-regulating neurons in the arcuate, namely proopiomelanocortin neurons.

80 on neuropeptide Y/agouti-related protein and proopiomelanocortin neurons.

81 on on arcuate NPY/agouti-related protein and proopiomelanocortin neurons.

82 ergy regulatory circuit by stimulating POMC (proopiomelanocortin) neurons of the MBH, oxytocin neuron

83 orexigenic (NPY and AgRP) and anorexigenic (proopiomelanocortin) neuropeptide mRNAs.

84 olically relevant hypothalamic neuropeptides proopiomelanocortin, neuropeptide Y, and agouti-related

85 fects of highly restricted neuronal subsets (proopiomelanocortin, neuropeptide Y/agouti-related pepti

86 retinal ganglion cells and requires the CRF-proopiomelanocortin pathway to exert its effect on camou

87 translation were carried out to produce the proopiomelanocortin peptide.

88 ransmitters, hypothalamic neurons, including proopiomelanocortin (POMC) and agouti-related peptide (A

89 ransmitters, hypothalamic neurons, including proopiomelanocortin (POMC) and agouti-related peptide (A

90 aracterized, selective groups neurons [e.g., proopiomelanocortin (POMC) and agouti-related peptide (A

91 or neuropeptides including those expressing proopiomelanocortin (POMC) and agouti-related peptides (

92 es expression of anorexigenic neuropeptides [proopiomelanocortin (POMC) and cocaine- and amphetamine-

93 utide was internalized in neurons expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-

94 In the anterior pituitary, levels of both proopiomelanocortin (POMC) and CRH-receptor 1 (R1) mRNAs

95 es in mice, we characterized the ontogeny of proopiomelanocortin (POMC) and neuropeptide Y (NPY) cell

96 Proopiomelanocortin (POMC) and neuropeptide-Y types of n

97 and neuropeptide expression of anorexigenic proopiomelanocortin (POMC) and orexigenic agouti-related

98 gate changes in the key metabolic regulators proopiomelanocortin (POMC) and the glucocorticoid recept

99 -melanocyte-stimulating hormone derived from proopiomelanocortin (POMC) at the melanocortin 3 recepto

100 Proopiomelanocortin (POMC) can be processed to ACTH and

101 Mouse proopiomelanocortin (POMC) cDNA was cloned into a vector

102 tin innervation of hypothalamic anorexigenic proopiomelanocortin (POMC) cells, coupled with a robust

103 he firing rate of a subpopulation of arcuate proopiomelanocortin (POMC) cells.

104 ve boutons terminate on or near anorexigenic proopiomelanocortin (POMC) cells.

105 ific deletion of Pcdh-gammas in anorexigenic proopiomelanocortin (POMC) expressing neurons also leads

106 ic actions partly by increasing hypothalamic proopiomelanocortin (POMC) expression.

107 y stimulating in vitro and in vivo pituitary proopiomelanocortin (POMC) gene expression and ACTH secr

108 shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypoth

109 Hypothalamic proopiomelanocortin (POMC) gene expression is reduced in

110 ian stress response by stimulating pituitary proopiomelanocortin (POMC) gene expression, and thus adr

111 eptors, endogenous agonists derived from the proopiomelanocortin (POMC) gene transcript, the endogeno

112 e gyrus under the transcriptional control of proopiomelanocortin (POMC) genomic sequences.

113 ients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obes

114 Agouti-related protein (AGRP) and proopiomelanocortin (POMC) have opposing effects on mela

115 asing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic neurons on da

116 tromedial nucleus (VMH) and colocalized with proopiomelanocortin (POMC) in the arcuate nucleus (ARC).

117 Proopiomelanocortin (POMC) is a precursor polypeptide fo

118 Hypothalamic proopiomelanocortin (POMC) is essential for the physiolo

119 It is generally believed that proopiomelanocortin (POMC) is expressed exclusively by n

120 Proopiomelanocortin (POMC) is the precursor for adrenoco

121 TG/securin) targeted to the adenohypophyseal proopiomelanocortin (POMC) lineage, which recapitulated

122 orticotropin-releasing hormone (CRH) induced proopiomelanocortin (POMC) mRNA and ACTH secretion in At

123 /ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalam

124 orticotroph cell differentiation and induces proopiomelanocortin (POMC) mRNA expression and adrenocor

125 n contrast, the number of neurons expressing proopiomelanocortin (POMC) mRNA in the infundibular nucl

126 increased in the Arc during fasting, whereas proopiomelanocortin (POMC) mRNA levels decreased.

127 ARC proOpiomelanocortin (POMC) mRNA levels were significantl

128 u hybridization for neuropeptide Y (NPY) and proopiomelanocortin (POMC) mRNA was performed in section

129 lucocorticoid insufficiency, basal pituitary proopiomelanocortin (POMC) mRNA, adrenocorticotrophic ho

130 There was no difference in proopiomelanocortin (POMC) mRNA, but NPY mRNA was reduce

131 RCA and Arc of the hypothalamus also contain proopiomelanocortin (POMC) mRNA.

132 e Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA.

133 ine vasopressin (AVP) and anterior pituitary proopiomelanocortin (POMC) mRNAs and greater PVN glucoco

134 Here, we have shown that proopiomelanocortin (POMC) neuron-specific deficiency in

135 Arcuate proopiomelanocortin (POMC) neuron-specific deletion of P

136 in the estrogen-mediated changes of arcuate proopiomelanocortin (POMC) neuronal excitability by usin

137 In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived

138 Hypothalamic proopiomelanocortin (POMC) neurons and their peptide pro

139 ntake and energy homeostasis clearly involve proopiomelanocortin (POMC) neurons and their peptide tra

140 Proopiomelanocortin (POMC) neurons are good candidates f

141 Hypothalamic proopiomelanocortin (POMC) neurons are important regulat

142 cused on MOR desensitization in hypothalamic proopiomelanocortin (POMC) neurons as these neurons prod

143 we investigated whether hemorrhage activates proopiomelanocortin (POMC) neurons by measuring Fos immu

144 at selective ablation of PPARgamma in murine proopiomelanocortin (POMC) neurons decreases peroxisome

145 e deletion of the aPKC isoform Pkc-lambda in proopiomelanocortin (POMC) neurons disrupts leptin actio

146 Proopiomelanocortin (POMC) neurons have been intensively

147 Hypothalamic proopiomelanocortin (POMC) neurons have traditionally be

148 tin modulates the median eminence-projecting proopiomelanocortin (POMC) neurons identified by selecti

149 imulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered

150 Here, whole-cell recordings were made from proopiomelanocortin (POMC) neurons in mouse brain slices

151 Proopiomelanocortin (POMC) neurons in the arcuate nucleu

152 (LH) together with neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the arcuate nucleu

153 ppa-opioid receptor (KOR), directly inhibits proopiomelanocortin (POMC) neurons in the hypothalamus t

154 important role in driving food intake, while proopiomelanocortin (POMC) neurons inhibit feeding.

155 rons potently stimulate food intake, whereas proopiomelanocortin (POMC) neurons inhibit feeding.

156 c mu-opioid receptors (MORs) in hypothalamic proopiomelanocortin (POMC) neurons leads to the activati

157 ss InsRs in agouti-related protein (AgRP) or proopiomelanocortin (POMC) neurons of L1 mice.

158 mechanism is the activation of anorexigenic proopiomelanocortin (POMC) neurons of the hypothalamic a

159 igh level in white adipose tissue and in the proopiomelanocortin (POMC) neurons of the hypothalamus.

160 Hypothalamic proopiomelanocortin (POMC) neurons play a critical role

161 Here, we demonstrate that hypothalamic proopiomelanocortin (POMC) neurons release endocannabino

162 Hypothalamic proopiomelanocortin (POMC) neurons release peptide produ

163 KEY POINTS: Hypothalamic proopiomelanocortin (POMC) neurons release peptide produ

164 Hypothalamic proopiomelanocortin (POMC) neurons release the endogenou

165 ely suppresses the frequency of IPSCs on ARC proopiomelanocortin (POMC) neurons that are mediated by

166 termine whether exposure to N(2)O stimulates proopiomelanocortin (POMC) neurons to release beta-endor

167 t beta-endorphin-producing neurons, that is, proopiomelanocortin (POMC) neurons, are activated during

168 er full restoration of leptin sensitivity to proopiomelanocortin (POMC) neurons, partial correction o

169 lucose is the primary driver of hypothalamic proopiomelanocortin (POMC) neurons.

170 the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons.

171 input organization and increased activity of proopiomelanocortin (POMC) neurons.

172 ssing effects via activation of hypothalamic proopiomelanocortin (POMC) neurons.

173 of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Ag

174 ansgenic mice overexpressing Socs3 in either proopiomelanocortin (POMC) or leptin receptor-expressing

175 ed by proteolytic processing of their common proopiomelanocortin (POMC) precursor.

176 tide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC) products, and corticotropin-r

177 P-1 shows decreased or increased LIF-induced proopiomelanocortin (POMC) promoter activity, respective

178 lating hormone (MSH) peptides processed from proopiomelanocortin (POMC) regulate energy homeostasis b

179 duced, yet the mRNA of its precursor protein proopiomelanocortin (POMC) remained unaltered.

180 Congenital deficiency of proopiomelanocortin (POMC) results in a syndrome of hypo

181 e lethal yellow (AY/a) mouse has a defect in proopiomelanocortin (POMC) signaling in the brain that l

182 The proopiomelanocortin (POMC) system is the central coordin

183 exposure, epidermal keratinocytes synthesize proopiomelanocortin (POMC) that is processed to melanocy

184 -dependent cytokine family, stimulate murine proopiomelanocortin (POMC) transcription and adrenocorti

185 Expression of melanocortin receptors and proopiomelanocortin (POMC) was analyzed by means of RT-P

186 ric acid (GABA)(+), neuropeptide Y (NPY)(+), proopiomelanocortin (POMC)(+), tyrosine hydroxylase (TH)

187 oglycemia-induced plasma glucagon, pituitary proopiomelanocortin (POMC), and adrenal c-fos, consisten

188 -10, and TNF-alpha, but not IL-4, IFN-gamma, proopiomelanocortin (POMC), and CD95L (Fas L).

189 transcriptional events in hypothalamic GABA, proopiomelanocortin (POMC), and dopamine neurons.

190 cotropin-releasing hormone (CRH), urocortin, proopiomelanocortin (POMC), and POMC-derived peptides.

191 ofluorescent staining for ACTH, a product of proopiomelanocortin (POMC), and prohormone convertase 1

192 tide Y (NPY), agouti-related protein (AGRP), proopiomelanocortin (POMC), cocaine- and amphetamine-reg

193 ons that express hypothalamic neuron markers proopiomelanocortin (POMC), neuropeptide Y (NPY), agouti

194 vels and fat stores and altered hypothalamic proopiomelanocortin (POMC), neuropeptide Y (NPY), and ag

195 fect arcuate mRNA levels of proEnkephalin or proOpiomelanocortin (POMC), or PVN levels of Met-Enkepha

196 neuropeptides, such as neuropeptide Y (NPY), proopiomelanocortin (POMC), orexin/hypocretin, melanin-c

197 to analyze a number of peptides derived from proopiomelanocortin (POMC), provasopressin, prooxytocin,

198 timulating hormone (alpha-MSH), a product of proopiomelanocortin (POMC), reduce food intake, whereas

199 mors, blocking EGFR suppressed expression of proopiomelanocortin (POMC), the ACTH precursor.

200 Pituitary expression of proopiomelanocortin (POMC), the common precursor for adr

201 Immunolabeling for proopiomelanocortin (POMC), the precursor to beta-endorp

202 ed peptide (Agrp), neuropeptide Y (Npy), and proopiomelanocortin (Pomc), was fully normalized in dual

203 s RIIbeta in agouti-related peptide (AgRP)-, proopiomelanocortin (POMC)-, single-minded 1 (Sim1)-, or

204 The proopiomelanocortin (POMC)-derived neuropeptide alpha-me

205 Neurons containing proopiomelanocortin (POMC)-derived peptides, known to co

206 the capacity for autocrine processing of the proopiomelanocortin (POMC)-derived peptides.

207 neuronal system, including the anorexigenic proopiomelanocortin (POMC)-expressing cells of the arcua

208 For comparison, we also analyzed Proopiomelanocortin (POMC)-expressing neurons, an interm

209 lts in inhibition of downstream anorexigenic proopiomelanocortin (POMC)-positive neurons in a GABA-de

210 Proopiomelanocortin (POMC)-producing cells are present i

211 Proopiomelanocortin (POMC)-producing cells comprise near

212 produced BEP and its precursor gene product, proopiomelanocortin (POMC).

213 eptide derived from the N-terminal region of proopiomelanocortin (POMC).

214 f the hypothalamic anorexigenic neuropeptide proopiomelanocortin (POMC).

215 R), neuronal growth regulator 1 (NEGR1), and proopiomelanocortin (POMC)] by PUFAs, only 125 genes [e.

216 Despite a severe defect in pituitary proopiomelanocortin processing to mature adrenocorticotr

217 nd kappa, but not delta, opioid receptor and proopiomelanocortin, proenkephalin, and prodynorphin tra

218 y pathway proteins, including proenkephalin, proopiomelanocortin, protachykinins A and B, chromograni

219 nd adrenocorticotropic hormone, a product of proopiomelanocortin proteolysis.

220 amic neuropeptide Y RNA levels and increased proopiomelanocortin RNA levels, a set of effects opposit

221 ments of the corticotropin-releasing hormone/proopiomelanocortin system human keratinocytes show high

222 we show that TR4 transcriptionally activates proopiomelanocortin through binding of a direct repeat 1

223 d blunted the effect of insulin or leptin on proopiomelanocortin, thyroid-releasing hormone, melanin-

224 hormone-releasing hormone (GHRH), pituitary proopiomelanocortin to adrenocorticotropic hormone, isle

225 both human and murine tumor cells increased proopiomelanocortin transcription, ACTH secretion, cellu

226 s lower and expression of the anorexic gene, proopiomelanocortin, was higher.

227 na pellucida glycoprotein 3 (ZP3) and bovine proopiomelanocortin were reported to be LacdiNAc-modifie

228 e had a decreased hypothalamic expression of proopiomelanocortin, which suggests that BBS genes play

229 ohistochemistry showed a marked reduction in proopiomelanocortin with an increase in neuropeptide Y a

230 ulated (amphetamine-regulated transcript and proopiomelanocortin) with fasting were also found to be