ライフサイエンスコーパス: propeller

1 -terminal domain reveals a seven-bladed beta-propeller.

2 Rav1, which can be modeled as a double beta-propeller.

3 g site on blades 2-3 of the SEMA domain beta-propeller.

4 ed that Nup37 folds into a seven-bladed beta-propeller.

5 affold protein that folds into a seven-blade propeller.

6 ntary patches at the center of the beta'-COP propeller.

7 large surface decorations of the Nup82 beta-propeller.

8 nto a deep groove in blade 3 of the PlexinC1 propeller.

9 cluster at the top of the seven-bladed beta-propeller.

10 indicate that it is a D3-symmetric molecular propeller.

11 a strongly pitched, C3-symmetric, molecular propeller.

12 BS9 likely results in misfolding of the beta-propeller.

13 the hydrophobic core that joins the two beta-propellers.

14 is not shielded from other proteins by beta-propellers.

15 anded via tandem duplications to form extant propellers.

16 tion to the small family of five-bladed beta-propellers.

17 t, modern structural designs such as prisms, propellers, 2-solenoid, super-roll, clam, trefoil and bo

18 ncreasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of re

19 Mutant K13-propeller alleles cluster in Cambodian provinces where r

20 iled-bundle proteins, and proteins with beta-propeller and alpha-solenoid secondary structures.

21 We test SMURFLite on all propeller and barrel folds in the mainly-beta class of t

22 hat the enzyme folds into the catalytic beta-propeller and beta-sandwich domains characteristic of GH

23 ts platform formed by the alpha-subunit beta-propeller and beta-subunit betaI domains.

24 eracts through a region near the alphaM beta-propeller and beta2 betaI domain with a region of the C3

25 that binds to the interface between the beta propeller and betaI domains.

26 o a pocket at the interface between the beta-propeller and betaI domains.

27 clustered in short segments within the kelch propeller and BTB domains implicated in substrate and cu

28 elch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, which were associated wit

29 ibrin to multiple sites in the alphaIIb beta-propeller and further indicate that recognition specific

30 We show that Rod's N-terminal beta-propeller and the associated Zwilch subunit bind Spindly

31 The filament functions as a helical propeller and the hook as a flexible universal joint.

32 two loops, one emanating from the Nup82 beta-propeller and the other one from the beta-sandwich fold

33 of the Fab bound to an alpha4 integrin beta-propeller and thigh domain fragment shows that natalizum

34 class-specific antibodies bind to the first propeller and Wnt3a class-specific antibodies bind to th

35 he structure consists of a seven-bladed beta-propeller and, unexpectedly, contains two pseudo-equival

36 eling predicts that WDR-23 folds into a beta-propeller, and we identify the top of this structure and

37 s N-terminal domains of Apaf-1, cognate beta-propellers, and cytochrome c.

38 main architecture consisting of an open beta-propeller appended to an alpha/beta hydrolase domain.

39 l catalytic domain with five-fold alpha/beta-propeller architecture and a C-terminal immunoglobulin-l

40 t is determined by the interplay between the propeller architecture and the intermolecular van der Wa

41 ingly, numerous contacts with the Nup37 beta-propeller are located on this extension of the 6D-7A ins

42 WD40-repeat beta-propellers are found in a wide range of proteins involve

43 Propellers are most well known for their ability to act

44 Due to the propeller arrangement of the p-phenylenes, their rotatio

45 served surface at the side of the Cdc20 beta propeller as a D-box-binding site.

46 ow that Vps18 indeed has a seven-bladed beta-propeller as its N-terminal domain by revealing its stru

47 We define a large subset of WD40 beta-propellers as a class of ubiquitin-binding domains.

48 disordered surface regions of the Nup37 beta-propeller assume structure when bound to Sp-Nup120.

49 We also showed that the Nup82 beta-propeller binds to other yeast Nup116 family members, Nu

50 "K loop," which extends from the N-terminal propeller blade.

51 The flexible propeller blades can adopt distinct conformations, and c

52 are predicted to disrupt the molecule's beta-propeller blades.

53 of C. reinhardtii, that the C-terminal beta-propeller but not the N-terminal domain of CrODA16 is re

54 gand's pyridine rings into a left-handed (M) propeller (circular dichroism spectroscopy).

55 ed beta-propeller fold with a rare nonvelcro propeller closure.

56 revalent in sub-Saharan Africa, numerous K13-propeller coding polymorphisms circulate in Africa.

57 of a C-terminal coiled-coil segment and beta-propeller combination (Olfm1(coil-Olf)) that reveals a d

58 Tel 23 maintains a characteristic propeller conformation while binding three gold(I) dicar

59 L/ligand interfaces that tightly constrain a propeller conformer of MG.

60 The catalytic domain was a five-bladed beta-propeller consisting of five radially oriented anti-para

61 17 protruding from one end of the BamB beta-propeller contact the face of the POTRA3 beta-sheet in B

62 action of sclerostin with LRP4 (another beta-propeller containing protein in the LRP family).

63 Three tryptophans in the beta-propeller core are important in maintaining structural s

64 ck residues 537-578 or 897-917 from its beta-propeller core diffused faster on the PM and exhibited r

65 tional loop domains that emanate from a beta-propeller core.

66 de-linked coiled coil with a C-terminal beta-propeller dimer at the tips.

67 , or inserting a linker between NLS and beta-propeller, disrupts specificity for importin alpha3, dem

68 sociate mutations in the PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resi

69 XHd3 displays an N-terminal five-bladed beta-propeller domain and a C-terminal beta-sandwich domain.

70 apoER2 surprisingly identified the YWTD beta-propeller domain as the Sepp1 binding site.

71 ions in TRIM32 are clustered in the NHL beta-propeller domain at the C-terminus and are predicted to

72 on in which three copies of a beta'-COP beta-propeller domain converge through their axial ends.

73 Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be importan

74 Trimerization depends on a beta-propeller domain in the carboxy-terminal half of the pro

75 lular functions of coronin and that the beta-propeller domain mediates additional functional interact

76 continuous segments within the alphaIIb beta-propeller domain of alphaIIbbeta3 enriched with negative

77 n with the WD40 repeats-based predicted beta-propeller domain of COP1, whereas COP1 activity is regul

78 of Arp2/3 complex, with the N-terminal beta-propeller domain of Coronin positioned near the p35/ARPC

79 that mediates its interaction with the beta-propeller domain of nidogen.

80 Pal is tethered to the OM and binds the beta-propeller domain of periplasmic TolB, which, as recent e

81 Certain point mutations in the propeller domain of PfKelch13 are associated with resist

82 17E6 Fab bound exclusively to the Propeller domain of the alphaV subunit.

83 that recognize a defined epitope on the beta-propeller domain of the platelet integrin alphaIIb subun

84 uch as colicin E9 (ColE9) also bind the beta-propeller domain of TolB in order to catalyze their tran

85 domains of UVR8 interact with COP1: the beta-propeller domain of UVR8 mediates UV-B-dependent interac

86 end of the inserted (I) domain with the beta-propeller domain on the alpha subunit and is located at

87 pfkelch13 propeller domain polymorphisms previously associated wit

88 rminal domain and a C-terminal 8-bladed beta-propeller domain that are both required for the associat

89 rom Snc1, or deletion of a beta'-COP subunit propeller domain that binds K63-linked polyubiquitin, di

90 ch bind within the confines of the TolB beta-propeller domain tunnel and are known to increase the af

91 Each monomer contains a five-bladed propeller domain with a cavity that could accommodate a

92 Moreover, replacement of the beta'-COP propeller domain with unrelated ubiquitin-binding domain

93 onarily conserved amino acid within the beta-propeller domain, which abrogates almost completely the

94 alysis of surfaces on the yeast coronin beta-propeller domain, which binds to F-actin and is conserve

95 amples carried the C580Y allele in the PfK13 propeller domain, with flanking microsatellite profiles

96 internal cavity through the pore in the beta-propeller domain.

97 differences on the circumference of the beta-propeller domain.

98 omain from its site of insertion in the beta-propeller domain.

99 protein-binding interfaces on the Mdv1 beta-propeller domain.

100 r proteins, that we predict contain a double-propeller domain.

101 examining polymorphisms in the Kelch (PfK13) propeller domain.

102 In another study, Piezo1's N-terminal "propeller" domain was proposed to constitute an intrinsi

103 osite ends bound to Fis1 and C-terminal beta-propeller domains (Dnm1-binding sites) extending into th

104 crystal structure of PorZ revealed two beta-propeller domains and a C-terminal beta-sandwich domain,

105 ns predicted to contain four six-bladed beta-propeller domains and both bind the bone-specific Wnt si

106 of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistanc

107 s between the alphaL and alphaX subunit beta-propeller domains concentrate near the binding pocket an

108 itopes that require both the alphaI and beta-propeller domains for full reactivity.

109 brane protein with thioredoxin-like and beta-propeller domains located in the lumen and a haloacid-de

110 ion including only the third and fourth beta-propeller domains of LRP6 (E3E4).

111 the LDLa repeats and the first of four beta-propeller domains, which promotes association between Lr

112 that ubiquitinate substrates bound to kelch propeller domains.

113 a-class proteins interact with distinct LRP6 propeller domains.

114 nteractions involving the axial ends of beta-propeller domains.

115 h could potentially be useful, including the propeller effect, have therefore not yet been demonstrat

116 s to demonstrate the Baranova and Zel'dovich propeller effect: the separation of a racemic mixture by

117 e LRP6 ectodomain comprises four tandem beta-propeller-EGF-like domain (PE) pairs that harbor binding

118 The LRP5/6 ectodomain contains four beta-propeller/EGF-like domain repeats.

119 ed a location for the active site among beta-propeller enzymes cited on the posterior surface of the

120 model, RCC1 does not appear to use the beta-propeller face opposite to its Ran-binding face to inter

121 rod), a universal joint (hook) and a helical propeller (filament).

122 rmational flexibility to wedge the RCC1 beta-propeller flanking the NLS against its lateral surface,

123 es (fanciful ball, puzzle pieces, 3D pixels, propellers, fluidic and multicompartments) with mono-, d

124 find that MojV-G displays a six-bladed beta-propeller fold bearing limited similarity to known param

125 recombinant PLL revealed a seven-bladed beta-propeller fold creating seven putative fucose-binding si

126 wed them to enter the protein vestibule, the propeller fold exceeds the size of the latch region, pro

127 based solution, while it formed the parallel propeller fold in water-depleted potassium-based solutio

128 to recognize blades 2, 3, and 4 of the beta-propeller fold of RON Sema.

129 f62A and PaAbf62A reveals a five-bladed beta-propeller fold that confirms their predicted classificat

130 rotein family, bind via their predicted beta-propeller fold the polyphosphoinositides PtdIns3P and Pt

131 It adopts a seven-bladed beta-propeller fold with a rare nonvelcro propeller closure.

132 ucture of LJM11, revealing a six-bladed beta-propeller fold with a single ligand binding pocket locat

133 f the OLF domain presents a five-bladed beta-propeller fold with unusual geometric properties.

134 The protein has a 6-bladed beta-propeller fold, and it contains a single metal ion.

135 CyRPA has a six-bladed beta-propeller fold, and we identify the region that interact

136 epeat domain, revealing an eight-bladed beta-propeller fold.

137 Sec12 adopts a beta propeller fold.

138 enzyme displayed a type A seven-bladed beta-propeller fold.

139 a G-quadruplex with the parallel-stranded ("propeller") fold, consistent with observations that redu

140 D40 repeat domains, which commonly have beta-propeller folds and often serve as scaffolding proteins

141 lly related but evolutionarily distinct beta-propeller folds.

142 druplexes, including the hybrid, basket, and propeller folds.

143 dues 70-893), folds into a seven-bladed beta-propeller followed by an alpha-helical domain, which tog

144 ral molecules and active matter, or building propellers for microscale transport.

145 1 and Kir6.2 adjacent to the ATP site in the propeller form and is disrupted in the quatrefoil form.

146 and H690Q) in WD domains important for beta propeller formation and protein-protein interaction.

147 The overall fold is a six-bladed beta-propeller formed by oligomerization as in the Ralstonia

148 se structures, referred to as quatrefoil and propeller forms, were determined by single-particle cryo

149 We further demonstrate that WD40 beta-propellers from a functionally diverse set of proteins b

150 tivity associated with scaffold protein WD40/Propeller/FYVE (WD40/ProF), which reportedly facilitates

151 ndent FoxO1 phosphorylation occurs on the WD/Propeller/FYVE scaffold in liver and is selectively inhi

152 electron oxidation of dG in chiral hybrid or propeller G-quadruplexes that expose the re or si face t

153 We found two kelch13 propeller gene mutations associated with artemisinin res

154 several polymorphisms in the parasite's K13-propeller gene.

155 allel lines with enhanced reconstruction, or PROPELLER, have resulted in reliable imaging with quiet

156 rms of suprastructures, collinear chains and propellers, have been achieved with various chiral HgS N

157 een blades 4 and 5 of the hemagglutinin beta-propeller head.

158 5 (beta4-beta5 groove) of the H protein beta-propeller head.

159 sistent with agonist-induced rotation of the propeller-head domain of the receptor, sliding of adjace

160 the MELT(P) sequence on the side of the beta-propeller in a previously unknown binding mode.

161 and Nup116 fragments bind to the Nup82 beta-propeller in close vicinity, there are no direct contact

162 llers, which we term a TAPE (tandem atypical propeller in EMLs) domain.

163 alysts in the molecular world and the chiral propellers in the macroscopic world.

164 This revealed four beta propellers, in an assembly markedly similar to those of

165 annel impairments, including: misalignments, propeller-induced airflows, power loss, intermodal cross

166 s, in which the Semaphorin and PlexinC1 beta propellers interact in an edge-on, orthogonal orientatio

167 r PCSK9 binding, processes in which the beta-propeller is critically involved.

168 One propeller is highly atypical, having a discontinuous sub

169 study, we report that Bub3, a 7-bladed beta-propeller, is the MELT(P) reader.

170 Tectonins are a family of beta-propeller lectins conserved from bacteria to mammals tha

171 le domain-domain interactions that lead to a propeller-like construction.

172 SPG11 also has an N-terminal, beta-propeller-like domain, which interacts in vitro with AP-

173 dopt parallel-stranded G-quadruplexes with a propeller-like fold.

174 The protein assembles into a propeller-like homotrimer in which each blade contains a

175 ogy, respectively, with AP site located in a propeller-like loop.

176 The identification of short propeller-like motifs (<50 amino acids) in natural genom

177 Propeller-like nanoscale assemblies with exceptionally i

178 Their propeller-like shape leads these molecules to display mu

179 nbonded P...O interaction, hypervalency, and propeller-like shape of the phosphonium groups in 1a(2+)

180 They possess an inherent chirality due to a propeller-like skeleton.

181 The long lateral-propeller loop is internally very stable but extensively

182 porting the observed instability of the left propeller loop, which extends the rules for G-quadruplex

183 loop region facilitates the formation of the propeller loop.

184 x folding and identify the single-nucleotide propeller loops as the most fragile part of the quadrupl

185 Thus, formation of propeller loops represents a peculiar atomistic aspect o

186 different variants of lateral, diagonal, and propeller loops, and six different loop sequences [d0 (i

187 se interaction between the seven-bladed beta-propeller MEP50 and the N-terminal domain of PRMT5, and

188 Fan, spiral, propellers, moonlets and streamer-channels observed by C

189 rotate with the field and act as microscopic propellers; moreover, owing to their opposite handedness

190 K13 propeller mutation alone was a strong risk factor for re

191 h both multiple Pfmdr1 copy number and a K13 propeller mutation were 14 times more likely to fail tre

192 rall, 371 (39%) of 940 samples carried a K13-propeller mutation.

193 o parasite clearance rates indicate that K13-propeller mutations are important determinants of artemi

194 inated initially but were later overtaken by propeller mutations associated with slower parasite clea

195 recorded P falciparum parasites carrying K13-propeller mutations at high prevalence next to the north

196 tudy provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

197 None of the K13-propeller mutations previously reported in Southeast Asi

198 21 (47%) of 45 parasite samples carried K13-propeller mutations.

199 lence of P falciparum parasites carrying K13-propeller mutations.

200 ur analysis demonstrates that the N-terminal propeller needs to be able to engage the C-terminal tail

201 tagonist Sclerostin interacts with the first propeller of LRP5/6 and preferentially inhibits the Wnt1

202 class-specific antibodies bind to the third propeller of LRP6, suggesting that Wnt1- and Wnt3a-class

203 th projections clamp to the side of the beta-propeller of Rae1, with the finger also contacting Nup98

204 ions between BCL11A and the side of the beta-propeller of RBBP4 that are not seen with histone H3.

205 We thus conclude that the beta-propeller of Vps18 is required for HOPS stability and fu

206 Removing the beta-propeller, or inserting a linker between NLS and beta-pr

207 nose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conf

208 arallel lines with enhanced reconstruction ( PROPELLER periodically rotated overlapping parallel line

209 on CT images (3.49), while findings with the PROPELLER periodically rotated overlapping parallel line

210 erated volume acquisition , 2.52 [P = .002]; PROPELLER periodically rotated overlapping parallel line

211 In distant metastases, the PROPELLER periodically rotated overlapping parallel line

212 panied by an increase in phoD, phoX and beta-propeller phytase genes coding for exoenzymes.

213 Beta-propeller phytase genes were most abundant in bare fallo

214 K13-propeller polymorphism constitutes a useful molecular ma

215 his study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa.

216 test structural models for how the RCC1 beta-propeller protein could bind to the nucleosome.

217 de novo mutations in WDR45, encoding a beta-propeller protein postulated to play a role in autophagy

218 TSSC1 is a predicted WD40/beta-propeller protein that coisolates with both GARP and EAR

219 c diseases: EPG5-related Vici syndrome, beta-propeller protein-associated neurodegeneration due to mu

220 Beta-propeller protein-associated neurodegeneration, the only

221 recently been linked to mutations in the K13 propeller protein.

222 he substrate affinity of USP12, the two beta-propeller proteins potentiate the enzyme through differe

223 election forces underlying emergence of beta-propeller proteins, a globular and symmetric fold group

224 inase, USP12, which is activated by two beta-propeller proteins, UAF1 and WDR20.

225 estimated prevalence of mutations of the K13 propeller region across Myanmar.

226 sis that rs688, which is located in the beta-propeller region of LDLR, has effects on LDLR activity b

227 sociated with single point mutations in the "propeller" region of the P. falciparum kelch protein gen

228 We further proved that the beta-propeller repeat domains of Itgalpha6b are key segments

229 The Propeller residue Asp-150, which normally coordinates Ar

230 aV-Fab interface were interactions involving Propeller residues Lys-203 and Gln-145, with the latter

231 structural variation in the six-bladed beta-propeller scaffold of the GhV-G receptor-binding domain,

232 acts of the amino-terminal seven-bladed beta-propeller (sema) domains of both semaphorin and plexin,

233 We analyzed the K13-propeller sequence polymorphism in 14,037 samples collec

234 ide a conclusive rationale for worldwide K13-propeller sequencing to identify and eliminate artemisin

235 The Nup82 beta propeller serves as a noncooperative binding platform fo

236 s spanning the sequence of the alphaIIb beta-propeller, several sequences were identified as candidat

237 Here, highly complex propeller shape sensing layers were produced, and the re

238 nt-solubilized complex adopts a three-bladed propeller shape with a curved transmembrane region conta

239 he discovery and optimization of a series of propeller shaped PI3Kdelta inhibitors comprising a novel

240 The novel hydrocarbon propeller-shaped D3h-symmetric cyclophane (3), "anthraph

241 parently consistent with a resolution of the propeller-shaped dye molecules by NaClO(3) crystals.

242 GM), given the limited conjugation in these propeller-shaped dyes.

243 ivatives create a very intriguing nonplanar, propeller-shaped geometry.

244 es of Cas1 (Cas2/32:Cas14) into a four-lobed propeller-shaped structure, where the two Cas2 domains f

245 ion pathways, generating compact three-blade propeller-shaped trimers.

246 These compounds are propeller-shaped, and upon precipitation into water, rea

247 d apply it to build recognizers for the beta-propeller shapes.

248 This unexpected feature shows how a propeller structure can be assembled from subdomains wit

249 ted CCD4 form, lacking one blade of the beta-propeller structure conserved in all CCDs.

250 Partial opening of the beta-propeller structure due to thermal relaxation of conform

251 lation variation data, we show that the beta-propeller structure of the ubiquitous WD40 domain provid

252 ng pocket located in the central part of the propeller structure on one face of the molecule.

253 domain, which potentially folds into a beta-propeller structure resembling the alpha-integrin ligand

254 PfCyRPA adopts a 6-bladed beta-propeller structure with similarity to the classic siali

255 repeat proteins with a circular beta-bladed propeller structure.

256 s with each octameric ring adopting a planar propeller structure.

257 beta-propeller subunits form a remarkable, tryptophan-dominat

258 ecting loops protruding far beyond the lower propeller surface.

259 the ClpB middle domain (MD) is a coiled-coil propeller that binds Hsp70.

260 an extensively decorated, seven-bladed beta-propeller that forms the centerpiece of this heterotrime

261 beta-propellers that bind polyphosphoinositides (PROPPINs), a

262 PROPPINs (beta-propellers that bind polyphosphoinositides) are a family

263 PROPPINs (beta-propellers that bind polyphosphoinositides) are PtdIns3P

264 Flagella, the helical propellers that extend from the bacterial surface, are a

265 created by the junction of two adjacent beta-propellers that form the core structure of Sro7.

266 cted to a carboxyl-terminal three-blade beta-propeller tip domain by flexible loops.

267 ocated near the 2-fold axes, instead of the "propeller tip" as in 135S particles.

268 eature on the external surface known as the "propeller tip." In contrast, our initial 80S-P1 reconstr

269 ts in air cooled as it flows around aircraft propeller tips or over jet aircraft wings.

270 apsids: those with P1 Fabs bound only at the propeller tips, P1 Fabs bound only at the 2-fold axes, o

271 cause a subtle conformational change in the propeller tips, potentially perturbing an interaction si

272 ide-linked dimeric arrangement with the beta-propeller top faces in an outward exposed orientation.

273 al features (i.e., minor groove width, roll, propeller twist and helix twist) for 739 TF datasets fro

274 l features of DNA (minor groove width, roll, propeller twist and helix twist).

275 ts four broad and static DNA shape features, Propeller twist, Helical twist, Minor groove width and R

276 tions (GBshape) provides minor groove width, propeller twist, roll, helix twist and hydroxyl radical

277 Our simulations also indicate that the actin propeller twist-angle and nucleotide cleft-angles are in

278 o-8-oxo-2'-deoxyguanosine with a significant propeller twist.

279 two modes are associated with a buckled and propeller-twisted geometry of the basepair.

280 l strands in their structures by stabilizing propeller type loops, shifting the antiparallel htel-22

281 ution exhibits three G-quartets and flexible propeller-type loops.

282 -quartets, parallel strand orientations, and propeller-type loops.

283 he d(TTGTGGTGGGTGGGTGGGT) sequence reveals a propeller-type parallel-stranded G-quadruplex containing

284 In K(+) solution, this sequence forms a propeller-type parallel-stranded G-quadruplex involving

285 l variability and structural dynamics of the propeller-type topology, we performed molecular dynamics

286 ur repeats can fold into a parallel-stranded propeller-type topology.

287 a large reservoir of naturally occurring K13-propeller variation.

288 ncestral motifs that form five-bladed lectin propellers via oligomeric assembly.

289 trad, or located at the top face of the beta-propeller, where 'hotspot' residues affect the binding o

290 for cytochrome c binding to regulatory beta-propellers, which is dependent on shape and charge compl

291 ealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propel

292 BamB forms an eight-bladed beta-propeller with a central pore and is shaped like a dough

293 A one-step synthesis of a nanographene propeller with a D3-symmetry was obtained starting from

294 Structurally, PON1 is a six-bladed beta-propeller with a flexible loop (residues 70-81) covering

295 Nup120(1-950) also folds into a seven-bladed propeller with a markedly protruding 6D-7A insert and is

296 N-terminal region and a C-terminal WD40 beta propeller with a preformed KEN-box-binding site at its t

297 Each monomer forms a six-blade beta-propeller with a wide "top" and a narrower "bottom" open

298 The enzyme is a seven-bladed beta-propeller with an iron cofactor coordinated by four hist

299 e PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resistance in vitro and in

300 nt in vivo and Spindly binding to a Rod beta-propeller-Zwilch complex in vitro.