ライフサイエンスコーパス: propeptide

1 ound in MGPs (e.g. a putative phosphorylated propeptide).

2 e dimeric MPO and the functional role of the propeptide.

3 e unlike the inherently disordered wild-type propeptide.

4 asmic reticulum (ER)-targeting peptide and a propeptide.

5 intramolecular disulfide bonds involving the propeptide.

6 l properties and interacting with the PC-PLC propeptide.

7 d decrease in the cleavage efficiency of the propeptide.

8 interaction with its transporter, the mutant propeptide.

9 roenzymes containing a 94-96-amino acid-long propeptide.

10 ystal structure of TgCPL in complex with its propeptide.

11 cluding osteocalcin and procollagen type 1 N propeptide.

12 s, suggesting possible interactions with the propeptide.

13 ly by the removal of an approximately 10-kDa propeptide.

14 ly in homozygotes, alters the proalpha2(I) C-propeptide.

15 lagens, since they lack the characteristic C-propeptide.

16 ive renin by trypsin digestion to remove the propeptide.

17 ng via proteolytic removal of the N-terminal propeptide.

18 N-terminal leader sequence and a C-terminal propeptide.

19 the presence or absence of N- and C-terminal propeptides.

20 agenous carboxyl-terminal and amino-terminal propeptides.

21 mbly of collagen fibrils by cleaving off the propeptides.

22 t of fibrillar collagens that have special C-propeptides.

23 wth factor noncovalently associated with two propeptides.

24 residues and are synthesized with N-terminal propeptides.

25 ng in the cleavage of both N- and C-terminal propeptides.

26 d referent controls; collagen III N-terminal propeptide (5.6 [4.3-6.9] ng/mL) was similar to referent

27 motes cleavage and release of the inhibitory propeptide, a mechanistic understanding of how His-69 pr

28 iating the interactions between HNP1 and its propeptide--a finding largely contrasting the commonly h

29 herichia coli, in which the large C-terminal propeptide acts as an autotransporter; certain viral coa

30 ion we investigated how the sequences of the propeptides affected the substrate-enzyme interaction.

31 We found a wide variation in the propeptide affinities for carboxylase.

32 lding and subsequent cleavage of the nascent propeptide, although retention of these N-glycans is not

33 ion of a disulfide bond between C(-7) in the propeptide and C61 in the dimer interface.

34 st cell lysates revealed the presence of the propeptide and catalytic domain in samples treated at pH

35 13 amino acids) is cleaved from a larger pre-propeptide and functions as an extracellular ligand.

36 ized that this could be through release of a propeptide and indeed found that peptide removal abolish

37 t two exons of myostatin gene code for the N-propeptide and its third exon codes for the C-polypeptid

38 Using a battery of analogs of the propeptide and of proHNP1, we identified residues in the

39 We conclude that the effect of propeptide and substrates on carboxylase controls the or

40 of a prokarilysin fragment encompassing the propeptide and the catalytic domain, and found that the

41 olecular interactions between the N-terminal propeptide and the catalytic triad of the enzyme.

42 oproteinase-2 (MMP-2) without removal of the propeptide and to restore enzymatic activity to MMP-2 pr

43 other effect is on folding of the C-terminal propeptide and trimer formation.

44 hey are mediated by different regions of the propeptide and, hence, different modes of interaction wi

45 ilarity to previously characterized protease propeptides and instead wraps intimately around the cata

46 in the proalpha1(I) C-terminal propeptide (C-propeptide), and one, which has a phenotype only in homo

47 signal sequence, a 14 amino acid N-terminal propeptide, and a C-terminal amidation signal.

48 complex consisting of TGF-beta, the TGF-beta propeptide, and a molecule of latent TGF-beta binding pr

49 t complex consisting of TGFbeta, the TGFbeta propeptide, and a molecule of latent TGFbeta binding pro

50 , osteocalcin, procollagen type I N-terminal propeptide, and C-terminal telopeptide of type I collage

51 re we use VEGF-D mutants deficient in either propeptide, and in the capacity to process the remaining

52 f osteocalcin, procollagen type-1 N-terminal propeptide, and tartrate-resistant acid phosphatase 5b w

53 rophobic residues in the central part of the propeptide, and the conserved hydrophobic motif Val(24)V

54 protein is involved in the cleavage of the N-propeptide, and the linker is required for protein foldi

55 unrelated families, we show that eukaryotic propeptides are enriched in histidines compared with pro

56 SBT propeptides are homologous to the I9 family of protease

57 pe III collagen molecules with unprocessed N-propeptides are present in the extracellular matrix of a

58 These propeptides are removed autocatalytically late in assemb

59 n a repeating unit of one D'D3 dimer and two propeptides arranged in a right-handed helix with 4.2 un

60 uces both the thermodynamic stability of the propeptide as well as its affinity for furin at pH 6.0.

61 troponin-T and N-terminal brain natriuretic propeptide, as well as with moderate-to-severe fibrosis

62 lex relied on a pH-dependent cleavage of the propeptide at Asn-38 and Asp-54.

63 In humans, thrombin cleavage of the propeptide at PR(221) downward arrow results in activate

64 lar autocatalytic removal of a 12-amino acid propeptide at the N terminus.

65 into the basic mechanism of proteolysis and propeptide autolysis, as well as the evolutionary pressu

66 with Cys-158 of the very flexible N-terminal propeptide being covalently linked to Cys-319 and thereb

67 revisiae, beta5 (Doa3/Pre2) has a 75-residue propeptide, beta5pro, that is essential for proteasome a

68 Swapping propeptides between furin and PC1 transfers pH-dependent

69 pared with the free protease suggesting that propeptide binding stabilizes the structure of SBT3.

70 these data suggest a mechanism in which the propeptide blocks a key site at the C terminus to preven

71 s; (ii) failure to cleave off the C-terminal propeptide blocks the assembly of fibrillin-1 into micro

72 n by BMP-2, BMP-4 (full-length and shortened propeptides), BMP-10, and GDF-5 allowed us to conclude t

73 demonstrate that subsequent cleavage of the propeptide by chymotrypsin C (CTRC) induces a nearly 10-

74 t Lys33 initiates nucleophilic attack of the propeptide by deprotonating the Thr1 hydroxyl group and

75 we determined that processing of the PC-PLC propeptide by mature Mpl is also pH sensitive.

76 y, we aimed to determine the role of the Mpl propeptide by monitoring the behavior of Mpl synthesized

77 g proMMP-9 and that S-nitrosylation of MMP-9 propeptide by NO-donors is unrelated to their ability to

78 olytic cleavage at the C-terminal end of the propeptide by trypsin.

79 s on mature PDGFs, rationalizing the need of propeptides by PDGFs to cover functionally important hyd

80 ect sequences in the proalpha1(I) C-terminal propeptide (C-propeptide), and one, which has a phenotyp

81 Propeptides can also influence protein compartmentalizat

82 ch CLE domains are largely conserved and pre-propeptides can be aligned.

83 The mature form of VEGF-D, lacking both propeptides, can also promote formation of these recepto

84 d vitamin K hydroquinone both stabilized the propeptide-carboxylase complex.

85 FLEEL, and NaHCO(3), on the stability of the propeptide-carboxylase complexes.

86 Although propeptide cleavage is clearly required for enzymatic ac

87 without resorting to protein sequencing, the propeptide cleavage site in the toxin precursor must be

88 ped an algorithm (SpiderP) for prediction of propeptide cleavage sites in spider toxins.

89 sulted in incomplete gamma-carboxylation and propeptide cleavage where both processes are transmembra

90 The structure of the PDGF-A/propeptide complex reveals this conserved, hydrophobic a

91 re with disulfide bonds that stabilize the C-propeptide conformation and its interaction with other c

92 However, propeptide containing the N528S mutation trafficked norm

93 protease did not mature efficiently from its propeptide-containing precursor.

94 vivo and biochemical assays showed that the propeptide contributes to protein folding and stability.

95 Nodal, Gdf1, and their cleaved propeptides copurified as a heterodimeric low molecular

96 ide-linked multimers, which requires the VWF propeptide (D1D2 domains) and adjacent D'D3 domains.

97 fied an N528S homozygous mutation in the VWF propeptide D2 domain, predicting the introduction of an

98 of FVIII fused to the von Willebrand Factor propeptide-D2 domain that traffics FVIII more effectivel

99 of SBT3 in vivo Secretion was impaired in a propeptide-deletion mutant but could be restored by co-e

100 k organelles and eukaryotic PCs evolved from propeptide-dependent, not propeptide-independent prokary

101 nsfers pH-dependent protease activation in a propeptide-dictated manner in vitro and in cells.

102 ts activity was mapped to the 162-amino-acid propeptide domain (LOX-PP) of the lysyl oxidase precurso

103 In contrast, structural stabilization of the propeptide domain has been proposed to competitively inh

104 MMP-9 or pro-MMP-2, requiring the N-terminal propeptide domain of pro-MMP-9.

105 The propeptide domain of subtilisin BPN' functions as a mole

106 ture form through cleavage of the N-terminal propeptide domain.

107 Furthermore, the novel propeptide domains were shown to possess significantly e

108 sembly in vitro, starting with only pure VWF propeptide (domains D1D2) and disulfide-linked dimers of

109 lytic cleavage of the procollagen C-terminal propeptide during procollagen processing.

110 n domains located within precursor proteins, propeptides, encode histidine-driven pH sensors to regul

111 2) that contains an N-terminal 11-amino acid propeptide ending in a dibasic motif, suggesting cleavag

112 indicating that, although not essential, the propeptide enhances the production of active Mpl.

113 osylation is necessary for maturation of the propeptide, enzymatic deglycosylation of the mature wild

114 the pH sensor that detects transport of the propeptide-enzyme complex to the trans-Golgi network, wh

115 t His-69 does not directly contribute to the propeptide-enzyme interface but, rather, triggers moveme

116 but innate resistance of ADAMTS10 zymogen to propeptide excision by furin was observed, suggesting th

117 These propeptides flank the central VEGF homology domain, that

118 ften remain associated with their respective propeptide following autocatalysis, we aimed at determin

119 rom 57 plant genomes and used the entire pre-propeptide for comprehensive clustering analysis.

120 tension previously proposed to function as a propeptide for regulation of enzyme activity.

121 ibroblasts; and (iii) the requirement of the propeptide for secretion is linked to the presence of do

122 extracellular proteases that depend on their propeptides for zymogen maturation and activation.

123 resulted in the accumulation of the inactive propeptide form of the enzyme.

124 at all, except for BMP-2 and the short BMP-4 propeptides, formed complexes with their growth factors.

125 y enhances this interaction (removal of this propeptide from full-length VEGF-D completely prevents h

126 tumor model, removal of only the C-terminal propeptide from full-length VEGF-D was sufficient to enh

127 o be involved in the displacement of MMP-2's propeptide from the active site and thereby inducing the

128 ter proteolytic removal of N- and C-terminal propeptides from a proform.

129 Even closely related propeptides from other plant SBTs could not substitute f

130 ability to process and release both C- and N-propeptides from type I procollagen in vitro and in vivo

131 Characterization of propeptide function will be important to clarify which f

132 Only three anionic residues in the propeptide, Glu(15), Asp(20) and Glu(23), were modestly

133 oxidized and reduced dimers, showed that the propeptide has a destabilizing effect and that the intra

134 r dimerization, and the beta7 tail and beta5 propeptide have unequal roles in half-mer joining.

135 structures, with sufficient affinity to form propeptide hexamers by binding to other dodecamers, caus

136 e that alter sequences of the proalpha2(I) C-propeptide in individuals with clinical features of a mi

137 tematic assay of both plasma VWF and the VWF propeptide in moderately severe type 1 VWD patients may

138 ut could be restored by co-expression of the propeptide in trans SBT3 was inhibited by SBT3PP with a

139 defect could not be rescued by providing the propeptide in trans to the mplDeltapro mutant.

140 The function of propeptides in plant SBTs is poorly understood and was a

141 c PCs evolved from propeptide-dependent, not propeptide-independent prokaryotic subtilases, our resul

142 ssembly, and explaining why the beta-subunit propeptide inhibits rather than promotes assembly.

143 Ape1 dodecamerization may cluster propeptides into trimeric structures, with sufficient af

144 However, the propeptide is also cleaved by a furin-like proprotein co

145 constructs, we show that (i) the C-terminal propeptide is an essential requirement for the secretion

146 ion of the C-terminal defensin domain by its propeptide is generally thought to be of electrostatic n

147 The NH(2)-propeptide is liberated into the extracellular matrix pr

148 the site of synthesis, and only FD lacking a propeptide is present in blood.

149 ases, N-terminal sequencing implied that the propeptide is removed in the secreted form of VesB.

150 that removal of either the N- or C-terminal propeptide is required for VEGF-D to drive formation of

151 The propeptide is the primary binding site of the vitamin K-

152 r reliable phylogenetic analysis and the pre-propeptide is too variable.

153 In them, a portion of the propeptide is visible near the dimer interface, suggesti

154 In contrast, removal of both propeptides is required for high rates of lymph node met

155 roalpha2(I), like that of the proalpha1(I) C-propeptide, is essential for efficient assembly of type

156 complex consisting of TGF-beta, the TGF-beta propeptide [latency associated protein (LAP)], and a lat

157 y, synthesis of PC-PLC in the absence of its propeptide lead to the secretion of a fully active enzym

158 ification and characterization of subtilisin propeptide-like inhibitor 1 (SPI-1) from Arabidopsis tha

159 ed lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX).

160 x roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro-LOX has tumor

161 OX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)).

162 y 30 kDa LOX enzyme and approximately 18 kDa propeptide (LOX-PP).

163 sis, derives the active enzyme (Lox) and the propeptide (Lox-PP).

164 e enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)).

165 Enrichment of histidines in propeptides may therefore be used to predict the presenc

166 of two Mpl single-site mutants with unstable propeptides: Mpl(H75V) and Mpl(H95L).

167 ior of Mpl synthesized in the absence of its propeptide (MplDeltapro) and of two Mpl single-site muta

168 oorly conserved N-terminal half of the beta5 propeptide nonetheless causes substantial defects in pro

169 inantly hydrophobic, and PDGFRs and the PDGF propeptides occupy overlapping positions on mature PDGFs

170 of a conserved histidine residue within the propeptide of a widely studied member, furin.

171 Here we show that in-frame fusion of human C-propeptide of alpha1(I) collagen (Trimer-Tag) to the C-t

172 We show that the propeptide of Ape1 is important for aggregation and vesi

173 lic pressure, left atrial volume, N-terminal propeptide of brain natriuretic peptide, total, collagen

174 ise bout for determination of amino-terminal propeptide of collagen I content.

175 re exercise showed double the amino-terminal propeptide of collagen I in their blood, indicating incr

176 loproteinase (TIMP)-1, TIMP-2 and C-terminal propeptide of collagen type-I with incident AF were exam

177 In addition, it had normal affinity for the propeptide of factor IX.

178 (His69) that functions as a pH sensor in the propeptide of furin (PRO(FUR)), which regulates furin ac

179 The N-terminal propeptide of gp93 was shown to undergo more extensive p

180 These data indicated that the propeptide of Mpl serves to maintain bacterium-associate

181 endent of PrsA2, indicating that neither the propeptide of PC-PLC nor PrsA2 is required for native fo

182 tion status of various histidines within the propeptide of PC1/3 and examined how such alterations ca

183 These findings show that the C-propeptide of proalpha2(I), like that of the proalpha1(I

184 a C-terminal hexapeptide derived from the C-propeptide of procollagen IIalpha1 (i.e. chondrocalcin).

185 lagen (beta=0.22, P<0.001) and aminoterminal propeptide of procollagen III (beta=0.12, P=0.035) at fo

186 eptide of type I collagen, and aminoterminal propeptide of procollagen III.

187 ed at follow-up and included carboxyterminal propeptide of procollagen type I, carboxyterminal telope

188 The level of N-terminal propeptide of procollagen type III (PIIINP) was signific

189 erved histidine-encoded pH sensor within the propeptide of the canonical PC, furin.

190 n the present study, we found that the NH(2)-propeptide of the cartilage-characteristic collagen, typ

191 As in other proplasmepsins, the propeptide of the zymogen interacts with the C-terminal

192 rly understood and was analyzed here for the propeptide of tomato subtilase 3 (SBT3PP).

193 pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women

194 ve to creatinine (fDPD/Cr), serum N-terminal propeptide of type 1 collagen, or beta C-terminal telope

195 Levels of serum C-terminal propeptide of type I procollagen (PICP) were significant

196 N-terminal propeptide of type I procollagen (PINP) and C-telopeptid

197 Patients with HFpEF and higher C-terminal propeptide of type I procollagen values also had higher

198 er matrix metalloproteinase-2 and C-terminal propeptide of type I procollagen values than hypertensiv

199 etalloproteinase inhibitor 1, and C-terminal propeptide of type I procollagen were determined in 28 p

200 (type 1 collagen telopeptide, aminoterminal propeptide of type I procollagen, aminoterminal propepti

201 -propeptide of type IIA collagen (PIIANP), C-propeptide of type II procollagen (CPII), and type II co

202 artilage oligomeric matrix protein (COMP), N-propeptide of type IIA collagen (PIIANP), C-propeptide o

203 issue inhibitor of metalloproteinases-1, and propeptide of type III procollagen and calculated ELF sc

204 peptide of type I procollagen, aminoterminal propeptide of type III procollagen) were measured 1 mont

205 In multivariate analysis, aminoterminal propeptide of type III procollagen/type 1 collagen telop

206 Low aminoterminal propeptide of type III procollagen/type 1 collagen telop

207 brain natriuretic peptide and aminoterminal propeptide of type III procollagen/type 1 collagen telop

208 ng virion maturation, the cleaved N-terminal propeptide of VI is observed, reaching deep into the per

209 universal high affinity docking site for the propeptides of BMP-2, -4, -7, and -10 and GDF-5, but not

210 ured the pKa values of histidines within the propeptides of furin and proprotein convertase 1/3 using

211 The propeptides of proprotein convertases (PCs) regulate act

212 Propeptides of proprotein convertases regulate activatio

213 ound an increase in histidine content within propeptides of secreted eukaryotic proteases compared wi

214 nrichment of the amino acid histidine within propeptides of secreted eukaryotic proteases, our work e

215 The propeptides of subtilisin-like serine proteinases (subti

216 al collagen crosslinks [CTX], and N-terminal propeptides of type I procollagen [P1NP]) markers were m

217 eutralization of all negative charges in the propeptide only partially activated the bactericidal act

218 ted all peptides containing mutations in the propeptide or at nonconserved positions of LctA.

219 r osteocalcin, procollagen type-1 N-terminal propeptide, or tartrate-resistant acid phosphatase 5b; t

220 Serum procollagen type 1 N-terminal propeptide (P1NP) and urine collagen N-telopeptide (NTx)

221 opeptide (betaCTX), and type 1 procollagen-N-propeptide (P1NP).

222 actor (CTGF), procollagen I carboxy-terminal propeptide (PICP), amino-telopeptide of type 1 collagen

223 essed by procollagen type I carboxy-terminal propeptide [PICP]), impaired insulin sensitivity, and in

224 y Luminex, plasma procollagen III N-terminal propeptide (PIIINP) by enzyme-linked immunosorbent assay

225 ne levels of procollagen type III N-terminal propeptide (PIIINP) mark the severity of tubulointerstit

226 Procollagen III N-terminal propeptide (PIIINP) was 3.8-fold higher in induced sputu

227 F-beta), and procollagen type III N-terminal propeptide (PIIINP), with incident heart failure, myocar

228 GF-beta) and procollagen type III N-terminal propeptide (PIIINP), with total and cause-specific morta

229 mation markers procollagen type-I N-terminal propeptide (PINP), osteocalcin, and parathyroid hormone

230 precursors (procollagen I and III N-terminal propeptides [PINP, PIIINP]).

231 lthough this residue is conserved in the PC1 propeptide (PRO(PC1)), PC1 nonetheless activates at pH~5

232 They contain N-terminal propeptides (PRO) that function as dedicated catalysts t

233 on of secretory granules (SG) containing ANP propeptides (pro-ANP), a signature of maladaptive hypert

234 ace, activated extracellularly, and required propeptide processing before cleaving V1 versican at pos

235 inine specificity, yet sharing features like propeptide processing by dipeptidyl peptidase I, storage

236 ts autocatalytic activity does not depend on propeptide processing by furin.

237 Importantly, these high levels of propeptide processing by soluble rFurin did not preempt

238 We report propeptide processing of the ADAMTS15 zymogen by furin a

239 Kinetic binding studies show that VWF propeptide processing of VWF D'D3 fragments is required

240 gulatory roles for ADAMTS ancillary domains, propeptide processing, and glycosylation.

241 The findings reported here show that the propeptides profoundly influence molecular interactions

242 requires proteolytic processing of a 21-kDa propeptide (proSP-C21) in post-Golgi compartments to yie

243 The N-terminal propeptides protecting the active-site threonines are au

244 ctivity that has been shown to depend on the propeptide region (LOX-PP) derived from pro-lysyl oxidas

245 is the most distinct enzyme with a shortened propeptide region and a unique pattern of predicted post

246 nd of proHNP1, we identified residues in the propeptide region important for HNP1 binding and inhibit

247 The propeptide region of the lysyl oxidase proenzyme (LOX-PP

248 for drug binding, and Arg24Cys, found in the propeptide region were found in all resistant clones.

249 ase-like enzyme activity; and more divergent propeptide regions.

250 Instead, its propeptide remains complexed with the catalytic domain,

251 the biochemical activity of the protease in propeptide removal from neurotoxin precursors by cleavag

252 The interaction of TGF-beta and its cleaved propeptide renders the growth factor latent, and the lib

253 cell lines, the mutated residues in the BMP6 propeptide resulted in defective secretion of BMP6; redu

254 tation in the procollagen III amino terminal propeptide segment (PIIINP) of collagen, type III, alpha

255 omparable to current tools for prediction of propeptide sequences in spider toxins.

256 rial membrane as inactive proproteins, whose propeptides serve in part to maintain them in associatio

257 In related proteases, the propeptide serves as a folding catalyst and can act eith

258 EGF-D binds heparin, and that the C-terminal propeptide significantly enhances this interaction (remo

259 However, in contrast to SBT propeptides, SPI-1 could not substitute as a folding ass

260 nce as protease inhibitors raises doubt that propeptide stability alone is sufficient for effective i

261 sign, we have redesigned the subtilisin BPN' propeptide structure to generate synthetic peptide seque

262 kably, this interface is largely composed of propeptides, suggesting that proteolytic maturation woul

263 In contrast, the propeptides tested had similar effects on carboxylase ca

264 r, triggers movement of a loop region in the propeptide that modulates access to the cleavage site an

265 proteins are synthesized as precursors with propeptides that must be cleaved to yield the mature fun

266 GGT is synthesized as a single polypeptide (propeptide) that undergoes autocatalytic cleavage, which

267 nsus MMP prodomain, it features a 14-residue propeptide, the shortest reported for a metallopeptidase

268 d the proline-rich regions of the C-terminal propeptide to allow proalpha chain association and sugge

269 that fine-tunes the sensitivity of the PC1/3 propeptide to facilitate the release inhibition at highe

270 ed mice in which the cysteines that link the propeptide to LTBP were mutated to serines, thereby bloc

271 In contrast, VWF propeptide to VWF:Ag ratios >3 were observed in only 6%

272 t that histidine enrichment may have enabled propeptides to evolve to exploit pH gradients to activat

273 ns evolved to enrich histidines within their propeptides to exploit the tightly controlled pH gradien

274 tructural analyses revealed cleavage of ESF1 propeptides to form biologically active mature peptides.

275 We also measured the ability of several propeptides to increase carboxylase catalytic activity.

276 ndogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity.

277 questions we employed fluorescently labeled propeptides to measure affinity for the carboxylase.

278 and in the capacity to process the remaining propeptide, to monitor the functions of these domains.

279 of this peptide (termed N-AgrD) beyond AgrD propeptide trafficking has never been described before.

280 equires binding of PCPE to the procollagen C-propeptide trimer, identification of the precise binding

281 nds to the stalk region of the procollagen C-propeptide trimer, where the three polypeptide chains as

282 tion between the von Willebrand factor (VWF) propeptide (VWFpp) and mature VWF aids N-terminal multim

283 at the ratio of plasma levels of VWF and its propeptide (VWFpp) can be used to identify patients with

284 ions of von Willebrand factor (VWF), the VWF propeptide (VWFpp) is cleaved.

285 The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity ( FVIII: C) a

286 by using the ratios of von Willebrand factor propeptide (VWFpp) or factor VIII activity to VWF antige

287 VWF is synthesized with a very large propeptide (VWFpp) that is critical for intracellular pr

288 VWF propeptide (VWFpp) was elevated with an infinitely high

289 illebrand factor mature protein (VWF:Ag) and propeptide (VWFpp), P-selectin, and platelet factor 4.

290 Human pro-FD containing an APPRGR propeptide was produced in insect cells.

291 directly and thereby clarify the role of the propeptide, we identified mutations and solution conditi

292 lloproteinase-2, and collagen III N-terminal propeptide were measured in the Prospective Comparison o

293 binding affinities between fibrillin and all propeptides were determined.

294 ndent upon the NH2-terminal cytoplasmic SP-C propeptide, which contains a conserved PPDY motif.

295 s intranuclear localization of lysyl oxidase propeptide, which interferes with NF-kappaB RelA signali

296 he parvulin and the NC domain with secretion propeptides, which have been implicated in substrate tar

297 rophobic, cysteine-containing amino-terminal propeptide whose presence correlates with physical, sero

298 ng experiments comparing the wild-type furin propeptide with a nonprotonatable His-69 --> Leu mutant

299 e of Arabidopsis SBTs at the junction of the propeptide with the catalytic domain.

300 SPI-1 thus resembles SBT propeptides with respect to its mode of protease inhibit