ライフサイエンスコーパス: proper function

1 s must have the right length and pattern for proper function.

2 ncreas, adopt asymmetric positions to ensure proper function.

3 lation of Ca(2+) in neurons is essential for proper function.

4 g Snail1 and Snail2, which are essential for proper function.

5 illus subtilis requires the CheD protein for proper function.

6 ing protein turnover, are also essential for proper function.

7 been shown to require SAM polymerization for proper function.

8 rs a DNA-binding motif, for localization and proper function.

9 whose membrane localization is required for proper function.

10 occur in p16-silenced cells, abrogating its proper function.

11 ine phosphorylation of AQP5 are required for proper function.

12 acids within the protein that are needed for proper function.

13 rting of endocytic ligands and receptors for proper function.

14 uire the complete MMOB C-terminal region for proper function.

15 th thought to be important for the peptide's proper function.

16 endrites and may require neddylation for its proper function.

17 on by the N-terminal proline, is crucial for proper function.

18 e adapted for efficient synthesis as well as proper function.

19 ooperation with adjacent companion cells for proper function.

20 sTALL-1) forms a virus-like assembly for its proper function.

21 at an optimal level of Ege A is required for proper function.

22 oenvironment, including pericytes, for their proper function.

23 less the respective mutations preserve their proper function.

24 rmediates undergo quality-control checks for proper function.

25 ans and embryos and is fundamental for their proper function.

26 re to a stimulus which can be imperative for proper function.

27 perties of alpha-catenin are critical to its proper function.

28 an elongation complex that requires RodZ for proper function.

29 -expressing HSCs but failed to restore their proper function.

30 reprogramming that is necessary to maintain proper function.

31 hannels require the beta subunit barttin for proper function.

32 es that may guide its development and ensure proper function.

33 rtist's intentions toward an artwork and its proper functions.

34 ss that targets them to specific tissues for proper functions.

35 protein and/or sarcomeric components for its proper functioning.

36 important lipid attachments required for the proper function and activation of the small GTP-binding

37 RNase H2C proteins that are all required for proper function and activity.

38 ements of this enzyme that are essential for proper function and also provide supporting evidence tha

39 Guided cell migration is necessary for the proper function and development of many tissues, one of

40 onent of the desmosome, is essential for the proper function and distribution of the gap junction pro

41 has the complex microstructure necessary for proper function and durability.

42 anylgeranyltransferase type-I (GGTase-I) for proper function and for the transforming activity of onc

43 important for most biomaterial applications, proper function and integration also requires biomateria

44 evelopment are used post-developmentally for proper function and maintenance of the nervous system.

45 nd require the accessory subunit barttin for proper function and membrane insertion.

46 Cholesterol is essential for proper function and regulation of eukaryotic membranes,

47 The C-linker/CNBHD is essential for proper function and trafficking of ion channels in the K

48 geometry, are particularly dependent on the proper functioning and distribution of mitochondria.

49 ies demonstrate that AIPL1 is needed for the proper functioning and survival of cone photoreceptors.

50 tiple layers of regulation are essential for proper function, and evolution of this tight control sys

51 de array of mechanisms that facilitate their proper function as modulators and integrators of G-prote

52 he ATPase domain of Vps4 is not required for proper function but plays a role in regulating Vps4 asse

53 ave indicated that each form is required for proper function, but the mechanism of interconversion re

54 The intestinal tract maintains proper function by replacing aged cells with freshly pro

55 aria drives specific T cell dysfunction, and proper function can be restored by inhibitory therapies

56 ritical for calcium entry required for their proper function during immune response.

57 perone to assist their folding and to ensure proper function during viral assembly, maturation, and i

58 f the adult neural stem cell niche to retain proper function even after the removal of major extracel

59 ess: the ability for a system to perform its proper function even as levels of its components change.

60 terminal regions of Rhp26 are needed for its proper function in DNA repair in vivo.

61 ted state of SMN, which is important for its proper function in snRNP assembly.

62 des are extensively modified to ensure their proper function in translation.

63 late in erythrocytes, interfering with their proper function in ways that are not yet fully understoo

64 TPases is of fundamental importance to their proper functioning in cells.

65 its initial recruitment to PICs and for its proper functioning in selecting the translational start

66 case activity of RNase R is required for its proper functioning in vivo and for effective RNA metabol

67 butes to maintain balance of homeostasis and proper functions in the small intestine, and dysregulate

68 Understanding how proper function is achieved at the atomic level is cruci

69 The human placenta is a complex organ whose proper function is crucial for the development of the fe

70 s highly ordered in the atomic structure and proper function is very sensitive to mutation.

71 For proper function, many sRNAs rely on the chaperone Hfq, w

72 similarly essential, interference with their proper functioning may offer novel opportunities for pro

73 n, and synapse elimination are essential for proper function of a circuit that computes directional m

74 Epithelial tubes are essential for the proper function of a diverse array of eukaryotic organs.

75 lational modifications are essential for the proper function of a number of proteins in the cell.

76 ctional protein involved in the assembly and proper function of a number of tight junctions and is al

77 ead to excitotoxicity which necessitates the proper function of active glutamate transporters.

78 get pathways that are also important for the proper function of antitumor lymphocytes, possibly weake

79 ween axons and Schwann cells is required for proper function of both myelinated and nonmyelinated ner

80 TCC life-cycle alterations, facilitating the proper function of cardiac cells.

81 rane protein localization are crucial in the proper function of cardiac myocytes.

82 ity at position 5.39 in CB(1) is crucial for proper function of CB(1).

83 ost-derived IL-7 plays a role in driving the proper function of CD4+ T cells in an ACT setting remain

84 evidence suggests that both development and proper function of central nervous system require intric

85 in fission yeast, which is essential for the proper function of centromeres.

86 traflagellar transport (IFT) is required for proper function of cilia, although many of the mechanist

87 Neuronal survival is necessary for the proper function of cochlear prosthetics, therefore, it i

88 Although proper function of dendritic cells is essential to host

89 lic regulation are highly integrated and the proper function of each is dependent on the other.

90 Proper function of each protein depends on the presence

91 rphase cells, they are also required for the proper function of Ect2 during cytokinesis.

92 ndothelial phenotype and is critical for the proper function of endothelial cells in adult mice.

93 H4B caused by shear is essential in allowing proper function of endothelial NO synthase because GPTCH

94 Proper function of epithelia depends on apically and bas

95 p junction (GJ) organization is critical for proper function of excitable tissues such as heart and b

96 raction partners, which is necessary for the proper function of focal adhesion points.

97 dual actions, vesicular zinc is critical to proper function of hippocampal circuitry in health and d

98 halamic) M(3) receptors are required for the proper function of hypothalamic GHRH neurons.

99 he plasma membrane that was required for its proper function of interacting with F-actin and CD44 as

100 axis that position and are required for the proper function of internal organs.

101 tein required for assembly, maintenance, and proper function of kinetochores during mitosis and meios

102 Photosynthetic light reactions rely on the proper function of large protein complexes (including ph

103 Intraluminal valves are required for the proper function of lymphatic collecting vessels and larg

104 Since the proper function of MADS-box proteins is dependent on spe

105 of G-protein signaling is essential for the proper function of many cells, particularly neurons.

106 n of their target ligand is critical for the proper function of many cellular processes.

107 ar communication (GJIC) is essential for the proper function of many organs, including the lens.

108 lational modifications are essential for the proper function of many proteins in the cell.

109 stinct shapes and sizes are critical for the proper function of many tubular organs.

110 mouse and zebrafish but are dispensable for proper function of mature olfactory neurons.

111 key cellular processes and in particular for proper function of membrane proteins.

112 lar matrix remodeling mechanism required for proper function of mesenchymal cells.

113 The proper function of mitochondria thus depends on folding

114 al for generating cell diversity and for the proper function of most differentiated cell types.

115 ular filtration barrier and required for the proper function of nephrin.

116 The proper function of neural circuits requires spatially an

117 inly postnatally, which is important for the proper function of neural circuits.

118 r glycine levels in the CNS is important for proper function of neural networks.

119 citation and inhibition is essential for the proper function of neuronal networks in the brain.

120 Neuronal polarity is crucial for the proper function of neurons.

121 , androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulat

122 s tightly controlled, which is important for proper function of NF-kappaB.

123 Drosophila melanogaster meiosis requires the proper function of NOD, a nonmotile kinesin-10.

124 We have found that the proper function of NompC, a putative mechanosensitive TR

125 tures, which is critically important for the proper function of on-board automobile fuel cells.

126 portions of the protein that is required for proper function of P1 on the surface of S. mutans.

127 complex regulation in cells to maintain the proper function of p53.

128 t p300/CBP contribute to the development and proper function of pancreatic islets.

129 hat its phosphorylation is important for the proper function of PELP1 in modulating hormone-driven ce

130 eostasis of the immune system depends on the proper function of regulatory T cells (T(reg) cells).

131 ults suggest that presynaptic plasticity and proper function of RIM1alpha play an important part in a

132 hesis that dimerization is essential for the proper function of sEH, we generated mutations within th

133 RNAs suggests that UBCH7 is required for the proper function of SHR.

134 The proper function of synapses relies on efficient recyclin

135 Proper function of the 26 S proteasome requires assembly

136 We conclude that the proper function of the 5-HT system is particularly impor

137 regulators previously shown to influence the proper function of the actin network.

138 mutant phenotype, but also is sufficient for proper function of the adult heart.

139 maturation of ZTL by HSP90 as essential for proper function of the Arabidopsis circadian clock.

140 Hearing requires proper function of the auditory hair cell, which is crit

141 is thought to ensure correct patterning and proper function of the auditory sensory epithelium.

142 ntrol of neuronal migration is essential for proper function of the brain.

143 n of these receptors is also crucial for the proper function of the cardiovascular, immune, reproduct

144 localization, the C terminus is critical for proper function of the channel sensor and/or gate.

145 priate and defined lengths are necessary for proper function of the cilium.

146 ENCY (FRQ) regulates its degradation and the proper function of the clock.

147 reaction is essential for the integrity and proper function of the CNS.

148 hair cell electromotility is crucial for the proper function of the cochlear amplifier, the active pr

149 The proper function of the craniofacial skeleton requires th

150 f detected reference gene mRNA confirmed the proper function of the device.

151 ion group C protein (Fancc) is necessary for proper function of the DNA damage-induced G2/M checkpoin

152 lar growth, implicating these factors in the proper function of the Dot/Icm complex.

153 In addition, Ift172 is required for proper function of the embryonic node, the early embryon

154 Proper function of the endoplasmic reticulum (ER) and mi

155 ctivity of the RecB subunit is necessary for proper function of the enzyme both in vivo and in vitro.

156 We conclude that NogoA contributes to the proper function of the ER resident chaperone PDI, and is

157 cient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which bin

158 ween these bacteria is a requirement for the proper function of the flagellar motor stators that chan

159 glomerular basement membrane is required for proper function of the glomerular filtration barrier.

160 BD3:PI4KB complex formation is essential for proper function of the Golgi.

161 e and adhesion molecules and is vital to the proper function of the immune system.

162 an epithelial chloride channel required for proper function of the lung, pancreas, and other organs.

163 nctional OAS-TL isoform is essential for the proper function of the male gametophyte, although the sy

164 active MBL in body fluids is an indicator of proper function of the MBL pathway.

165 ial metabolism that is essential to maintain proper function of the mitochondria by regulating energy

166 Proper function of the motor unit is dependent upon the

167 neuron is both necessary and sufficient for proper function of the motor unit.

168 Proper function of the MVB pathway requires reversible m

169 microglia in instructing and regulating the proper function of the neuronal networks in the adult CN

170 The rhythmic expression and the proper function of the Neurospora FREQUENCY (FRQ) protei

171 Proper function of the peroxisome proliferator-activated

172 gradient-dependent regulatory mechanisms for proper function of the photosynthetic machinery.

173 r envelope protein involved in tethering and proper function of the proteasome.

174 d Mei5 and Sae3 as factors necessary for the proper function of the recombinases Dmc1 and Rad51 in DN

175 These results suggest that the proper function of the RING domain, likely to be ubiquit

176 encoded transcripts were induced, confirming proper function of the sensitive phytochrome system.

177 dentified as a virulence factor required for proper function of the T3SS.

178 he importance of membrane composition in the proper function of the Tat protein export pathway.

179 al and glial cells) is often crucial for the proper function of the tissue as a whole, yet assessing

180 ection of Gram-negative LPS depends upon the proper function of the TLR4-MD-2 receptor complex in imm

181 We conclude that PE is required for the proper function of the TOM complex.

182 at the cell surface and consequently for the proper function of the transporter.

183 se in which the essential exons required for proper function of the Trpa1 gene were deleted.

184 phenotypes such as intestinal colonization, proper function of the type II secretion system, and for

185 us require the translocator protein LcrV for proper function of the type III secretion apparatus, whi

186 the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however

187 o 48 h and this regeneration is dependent on proper function of the VEGF pathway: siRNA-mediated knoc

188 el quickly and efficiently, allowing for the proper function of the vertebrate nervous system.

189 ho-head of membrane lipids necessary for the proper function of the voltage sensor itself?

190 However, the proper function of these neurons remains to be worked ou

191 uired for transport (ESCRT), a requisite for proper function of this pathway.

192 the native conformation is essential for the proper function of tumor suppressor protein p53.

193 rs (Vps39p and Vps41p) were required for the proper function of Vid vesicles.

194 bilize mature protein conformation to ensure proper function of Vif and RUNX1.

195 Proper function of visual arrestin is indispensable for

196 tion factors controlling the development and proper function of vital organs such as liver, pancreas,

197 itry and brain activity depend critically on proper function of voltage-gated calcium channels (VGCCs

198 ining the steady-state level of WC-1 and the proper function of WC-1 and WC-2 in circadian clock and

199 ransmigration, as each step necessitates the proper functioning of a distinct set of integrin molecul

200 It is required for signalling and proper functioning of a range of proteins involved in, f

201 Proper functioning of an organism requires cells and tis

202 The proper functioning of any biological system depends on t

203 The proper functioning of biomolecules in living cells requi

204 Although it is clear that proper functioning of both the IGF-1R and NF-kappaB sign

205 els of polyunsaturated phospholipids for the proper functioning of cell membranes.

206 Protein interactions are fundamental to the proper functioning of cells, and aberrant formation or r

207 n is of central importance to the health and proper functioning of cells, and single-cell studies hav

208 lucosamine) transferase SPINDLY required for proper functioning of DELLAs and acts hypostatically to

209 The proper functioning of eukaryotic organelles is largely d

210 eural circuits or might be necessary for the proper functioning of existing circuits.

211 on of new labels that may interfere with the proper functioning of existing constructs and therefore

212 n important mineral nutrient essential for a proper functioning of human and animal organism.

213 ell is a complex machine that depends on the proper functioning of its numerous parts, including prot

214 ription factors is vitally important for the proper functioning of many intracellular signalling path

215 partment, is believed to be essential to the proper functioning of mitochondria as the powerhouse of

216 lux by the TRPM4 channel is critical for the proper functioning of monocytes/macrophages and the effi

217 ergy, commensal bacteria are crucial for the proper functioning of mucosal immune defenses.

218 The organization and proper functioning of myelin can be understood in terms

219 gulating neuronal activity, cardinal for the proper functioning of nervous systems.

220 ry and inhibitory inputs is critical for the proper functioning of neural circuits.

221 meostatic control systems is fundamental for proper functioning of neural circuits.

222 Because a proper functioning of neural network requires phase cohe

223 vidence that endogenous zinc is required for proper functioning of neuronal circuitry in the brainste

224 the neuronal "milieu," which is required for proper functioning of neuronal circuits, synaptic transm

225 at cellular localization is critical for the proper functioning of nucleolin in this pathway and that

226 Nuclear localization is a prerequisite for proper functioning of p53 and our results confirm that T

227 Thus, proper functioning of polymorphic BAF complexes may cons

228 gulation of chain length is essential to the proper functioning of prokaryotic and eukaryotic polysac

229 Proper functioning of sensory systems requires the gener

230 The proper functioning of striatal neurons relies critically

231 lated SYD-1, a synaptic protein required for proper functioning of SYD-2.

232 inetics of this coupling is critical for the proper functioning of synapses during repetitive action

233 tained release of dopamine necessary for the proper functioning of target structures, such as the str

234 to produce superoxide and thereby alter the proper functioning of the adjacent arterioles.

235 Proper functioning of the adult nervous system is critic

236 S1P(2) receptor expression is essential for proper functioning of the auditory and vestibular system

237 g A-type K(+) currents are essential for the proper functioning of the brain, where they act to delay

238 opriate synaptic connections is critical for proper functioning of the brain.

239 ediated) synapses is a critical step for the proper functioning of the brain.

240 e thylakoid CA is primarily required for the proper functioning of the CCM at low Ci by providing an

241 protein interactions are fundamental for the proper functioning of the cell.

242 s and phosphatases, which are central to the proper functioning of the cell.

243 biological process that is essential to the proper functioning of the central nervous system.

244 Proper functioning of the centrosome relies on assembly

245 Myelination is essential for proper functioning of the CNS.

246 ropy that is believed to be critical for the proper functioning of the cochlea.

247 nd chloride ions are necessary cofactors for proper functioning of the complex.

248 Our results suggest that proper functioning of the ESX-1 pathway requires the int

249 eta2 (LAMB2) is a GBM component required for proper functioning of the glomerular filtration barrier.

250 ut they provide a robust source that permits proper functioning of the gradient in heterozygous embry

251 n the theta range (3-12 Hz) is important for proper functioning of the hippocampus, a brain area esse

252 scriptional regulators are indispensable for proper functioning of the immune system.

253 Proper functioning of the innate immune response depends

254 ion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.

255 Proper functioning of the mitochondrion requires the orc

256 e conserved kinase Mps1 is necessary for the proper functioning of the mitotic and meiotic spindle ch

257 NA, binding of centromere protein C, and the proper functioning of the mitotic kinetochore.

258 s1 was recently shown to be required for the proper functioning of the MSC, but it did not appear to

259 tterning during development is essential for proper functioning of the musculoskeletal system.

260 autophagosome content is crucial to maintain proper functioning of the nervous system.

261 Correct wiring is crucial for the proper functioning of the nervous system.

262 neuronal reactions are important factors for proper functioning of the nervous system.

263 asparagine-linked protein glycosylation for proper functioning of the neuromuscular junction.

264 rtance of N-linked protein glycosylation for proper functioning of the neuromuscular junction.

265 rol the distribution and storage of iron for proper functioning of the photosynthetic machinery.

266 These cognitive constructs depend on proper functioning of the prefrontal cortex (PFC).

267 s the second zinc finger is essential to the proper functioning of the protein while the remaining zi

268 positive potentials at the pore that enables proper functioning of the protein.

269 eins have been shown to be essential for the proper functioning of the secretion system, and one of t

270 lls, PERK is highly abundant and crucial for proper functioning of the secretory pathway.

271 important role in regulating development and proper functioning of the skin.

272 and 141 affect ubiquinone reduction and the proper functioning of the sodium pump.

273 one of the two salt bridges is critical for proper functioning of the Tol-Pal system.

274 requisite for subunit joining and may ensure proper functioning of the translocation process.

275 ated wastewater reuse, but also for ensuring proper functioning of the treatment plant.

276 Proper functioning of the vertebrate central nervous sys

277 ional information to contractile arrays, and proper functioning of these gradients is dependent on bo

278 pt their interaction, which is necessary for proper functioning of these two enzymes.

279 % of human cancers, which indicates that the proper functioning of this complex is necessary to preve

280 domain within NEMO/IKK gamma is required for proper functioning of this IKK subunit.

281 expression of wild-type WIPI49 disrupts the proper functioning of this MPR pathway, whereas expressi

282 hat this amino acid residue is essential for proper functioning of this NES.

283 ol in the mitochondrion is essential for the proper functioning of this organelle.

284 cterium-specific components are required for proper functioning of this regulatory circuit.

285 Oscillatory behaviour is essential for proper functioning of various physical and biological pr

286 t as it forms a local signalling centre, the proper functioning of which is essential for the formati

287 ient transport in plants is dependent on the proper functioning of xylem networks, a series of interc

288 in early development and imperative for the proper functions of the liver, pancreas, and intestines

289 related to efficient synthesis, rather than proper function, of proteins may act globally on the ami

290 Spindle formation and proper function require that microtubules with opposite

291 SarR, which require homodimer formation for proper function, SarS is unusual within the SarA protein

292 ignin-specific channel is more important for proper functioning than the S lignin-specific channel.

293 mplex" (IMAC) at distal tips is required for proper function, the mechanism driving tip accumulation

294 For proper function, these ion channels have to be anchored

295 s, contact inhibition is associated with the proper functioning tissues, whereas abnormal regulation

296 se tissue, enhancing its ability to maintain proper function under metabolically challenging conditio

297 n even wider range of proteins can maintain 'proper' function while immobilized.

298 family of having large domain movements for proper function with the ribosome.

299 racellular asparaginase that is required for proper functioning within the cell.

300 This N-terminal tail is indispensable for proper function, yet its solution structure and role in