ライフサイエンスコーパス: prophase

1 for maintaining Xenopus oocytes arrested in prophase.

2 l enzyme in the progression of early meiotic prophase.

3 ated by programmed cell death during meiotic prophase.

4 ssociate from chromosome arms during mitotic prophase.

5 located from the nucleus to the cytoplasm in prophase.

6 , specifically during meiotic initiation and prophase.

7 lon and its localization to the cytoplasm in prophase.

8 ated density of DSB markers later in meiotic prophase.

9 t reloading of CENP-A during oogenic meiotic prophase.

10 er recombination, which occur during meiotic prophase.

11 sion as a result of accumulation of cells in prophase.

12 tial step for nucleus-centrosome coupling in prophase.

13 otic S phase, followed by entry into meiotic prophase.

14 localize SYCP3 and gammaH2AX during meiotic prophase.

15 into one or two masses during early meiotic prophase.

16 ts are a conserved feature of meiosis I (MI) prophase.

17 expression of SPO11 isoforms in male meiotic prophase.

18 accumulation at the nuclear envelope during prophase.

19 etween homologous chromosomes during meiotic prophase.

20 ligned homologous chromosomes during meiotic prophase.

21 meres as homologues synapse later in meiotic prophase.

22 breakdown, thereby initiating the events of prophase.

23 e of retrotransposition in the early meiotic prophase.

24 s and remodeling chromosome structure during prophase.

25 and phosphoryates p150(Glued) during NEBD at prophase.

26 ions of the horsetail nucleus during meiotic prophase.

27 tene checkpoint, a key step in early meiotic prophase.

28 e critical for bivalent formation in meiotic prophase.

29 in largely unpaired throughout first meiotic prophase.

30 he nucleus that takes place in early meiotic prophase.

31 hosphorylates H3 and chromosomal proteins at prophase.

32 three kinases that phosphorylate Rec8 during prophase.

33 rols chromosome structure throughout meiotic prophase.

34 es only after nucleolar disassembly later in prophase.

35 NDC80 expression is repressed during meiotic prophase.

36 e centromeres and is not incorporated during prophase.

37 no detectable role for chromosomal events of prophase.

38 the leptotene/zygotene transition of meiotic prophase.

39 ase and centrosome separation in the mitotic prophase.

40 ear envelope near centrosomes in late G2 and prophase.

41 he distance centrioles normally reach during prophase.

42 1-activated kinases (Paks) on centrosomes in prophase.

43 a unique role for these proteins in meiotic prophase.

44 t dynein-driven centrosome separation during prophase.

45 ion and activates genes required for meiotic prophase.

46 itment to the PPB occur independently during prophase.

47 er into meiosis and progress through meiotic prophase [1].

48 f chromosome organization established during prophase affect later chromosome behavior during the mei

49 ororin is phosphorylated by Cdk1/cyclin B at prophase and acts as a docking protein to bring Plk1 int

50 esin complex released from chromatin in both prophase and anaphase.

51 partially co-localized with chromatin during prophase and interphase.

52 t pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment.

53 artial loss of centromeric cohesion at early prophase and maintenance of the ability to initiate but

54 During prophase and metaphase activated PSKs are located in the

55 cell cycle regulated-it is inhibited during prophase and metaphase by cyclin-dependent kinase 1 (CDK

56 r sex chromosome inactivation during meiotic prophase and nucleosome removal at postmeiotic stages.

57 centromeric sister-chromatid cohesion during prophase and prevents premature sister-chromatid separat

58 f cohesin is removed from chromosome arms in prophase and prometaphase in a manner that depends on Wa

59 regation during mitosis, occurs via distinct prophase and prometaphase pathways.

60 Tiam1 and Rac localize to centrosomes during prophase and prometaphase, and Tiam1, acting through Rac

61 tMAD2 is associated with kinetochores during prophase and prometaphase, but not metaphase, anaphase a

62 ns, the nuclear envelope (NE) breaks down at prophase and reassembles at telophase.

63 os exhibit an anterior shifting of nuclei in prophase and reduced anaphase spindle oscillations.

64 at it is distributed to the cytoplasm during prophase and remains excluded from DNA until early telop

65 During oogenesis, oocytes are arrested in prophase and resume meiosis by activating the kinase Cdk

66 d as chromosomes undergo condensation during prophase and separation during anaphase, but the mechani

67 tected nuclear invagination channels at late prophase and telophase, potentially suggesting roles for

68 sferrin uptake is inhibited after entry into prophase and that it resumes in telophase.

69 ia to stop mitosis and transition to meiotic prophase and the spermatocyte state.

70 t dTopors localizes to the nuclear lamina at prophase, and also transiently to intranuclear foci.

71 ure to establish apical cortical polarity at prophase, and lack of cortical Scribble localization thr

72 CCS52B mRNAs are confined to the nucleus at prophase, and the cognate proteins are not translated un

73 Hsp90), LKB1, or AMPKalpha all show similar prophase apical cortical polarity defects (but no Scribb

74 uclear sequestration of these transcripts at prophase appears to protect cyclins from precocious degr

75 Forces that antagonize Eg5 in prophase are unknown.

76 gs to synapse along their lengths, provoking prophase arrest and, ultimately, sterility.

77 ovulatory ovarian follicles of mice, meiotic prophase arrest in the oocyte is maintained by cyclic GM

78 this nucleoporin plays an important role in prophase arrest in wild-type embryos.

79 Notably, anoxia-induced prophase arrest is suppressed in mutant embryos lacking

80 In all vertebrates, release from prophase arrest relies on protein kinase A (PKA) downreg

81 t cohesin declines gradually during the long prophase arrest that precedes MI in female mammals.

82 ar lamina disassembly in the transition from prophase arrest to meiosis I is also impaired in Rab5a-d

83 kinase regulates resumption of meiosis from prophase arrest, chromosome condensation, and kinetochor

84 to phosphorylate Zip1 4S results in meiotic prophase arrest, specifically in the absence of SGS1.

85 nctions into the oocyte, maintaining meiotic prophase arrest.

86 le-strand breaks in meiotically competent G2/prophase-arrested mouse oocytes do not prevent entry int

87 matin (MSUC) occurs during the first meiotic prophase, as chromosomes that fail to pair are sequester

88 nesis in the developing ovary: the events of prophase at the onset of meiosis in the fetal ovary and

89 A subset of the DSBs induced during meiotic prophase become designated to be repaired by a pathway t

90 Its formation begins in early prophase before NEBD when the SAC has not been activated

91 Characteristics of arrested prophase blastomeres and oocytes are the alignment of co

92 ion that NPP-16 and CDK-1 function to arrest prophase blastomeres in C. elegans embryos.

93 se (CDK-1) is detected in wild-type-arrested prophase blastomeres, the inactive state is not detected

94 not affect initial chromosome compaction at prophase but causes anaphase DNA bridge formation and fa

95 ocate throughout the chromatin region during prophase but during anaphase move to surround segregatin

96 at confers a csm4Delta-like delay in meiotic prophase but promotes high spore viability.

97 mately 300 genes coordinately during meiotic prophase, but different mRNAs within the NDT80 regulon a

98 ) is required for the removal of cohesins at prophase, but how Plk1 is recruited to phosphorylate SA2

99 is necessary for arrest of the oocyte at G2-prophase, but it is unclear whether this regulation func

100 cells are exceedingly rare in early meiotic prophase, but they are the only cells that progress into

101 Mammalian oocytes are arrested in meiotic prophase by an inhibitory signal from the surrounding so

102 em that regulates the progression of meiotic prophase by controlling entry of meiotic proteins into t

103 that Cdk1 and Ime2 trigger exit from meiotic prophase by inhibiting the Sum1 transcriptional repressi

104 ver between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks th

105 Crossovers form late in meiosis I prophase, by polo kinase-triggered resolution of Hollida

106 We found that germ cells already in meiotic prophase can nonetheless be sexually transformed from a

107 tope is generated at the nuclear envelope of prophase cells.

108 d state reveals a previously uncharacterized prophase checkpoint in the C. elegans embryo.

109 The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical reg

110 Rec8 is a prominent component of the meiotic prophase chromosome axis that mediates sister chromatid

111 f first division (afd1), required for proper prophase chromosome morphology and for meiotic sister-ch

112 Prophase chromosomes exhibit a highly irregular surface

113 Mitotic prophase chromosomes formed, centrosomes divided, and nu

114 Prophase chromosomes, whose organization was previously

115 specific organizational features of meiotic-prophase chromosomes.

116 huge condensed middle chromosome regions on prophase chromosomes.

117 During late meiotic prophase, COSA-1 localizes to foci that correspond to th

118 These late-prophase defects then lead to aberrant reconfiguring of

119 t antagonist of centrosome separation during prophase, demonstrate its requirement in balancing Eg5-i

120 sms, homolog pairing and synapsis at meiotic prophase depend on interactions between chromosomes and

121 At late prophase, dependent on topoisomerase II and with concomi

122 mice, BPA induces subtle disturbances in the prophase events that set the stage for chromosome segreg

123 with weak recombination defects by blocking prophase exit in a subset of cells in which arrest is no

124 nd show that proper centrosome separation in prophase facilitates subsequent chromosome congression.

125 ed at two steps of DSB repair during meiotic prophase: first by the activity of the MCM-like protein

126 omplexes), facilitates the formation of this prophase form of the CDC20-MAD2 complex but is inactive

127 Our results suggest that Rec8's prophase function, independently of cohesin cleavage, co

128 he central visible characteristic of meiotic prophase, has been a matter of intense interest for deca

129 Cells in meiotic prophase have already replicated their DNA, but they hav

130 During Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linea

131 imination of more than two-thirds of meiotic prophase I (MPI) oocytes before birth.

132 1 in the resection of DSBs in middle meiotic prophase I and in blocking NHEJ.

133 airing at telomeres persists upon entry into prophase I and is most likely important for initiation o

134 molecular assembly that forms during meiotic prophase I and mediates adhesion of paired homologous ch

135 ated P4-induced inhibition of oocyte meiotic prophase I and primordial follicle formation.

136 not commit to finishing meiosis until after prophase I and the realization of such meiosis-specific

137 The chromosome synapsis defects and Prophase I apoptosis of Pol beta-deficient spermatocytes

138 oocytes (in which the nuclei are intact) at prophase I are stimulated to resume meiosis and mature t

139 hat oocytes depleted of BubR1 cannot sustain prophase I arrest and readily undergo germinal vesicle b

140 hypothesized that gene expression during the prophase I arrest is primarily epigenetically regulated.

141 al stages of mammalian oocyte regulation are prophase I arrest, which is important for sustaining the

142 lear because of the long (months to decades) prophase I arrest.

143 We show that during prophase I ASY1 and its interacting partner, ASY3, are e

144 at BLM deficiency does not affect entry into prophase I but causes severe defects in meiotic progress

145 se that Mek1 plays dual roles during meiotic prophase I by phosphorylating targets directly involved

146 min localizations, centriole separation, and prophase I chromatin condensation and also cause anaphas

147 mbination machinery is reactivated following prophase I exit to repair any persisting meiotic DNA dou

148 re arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the hi

149 o confirms the importance of early stages of prophase I for the control of recombination in large gen

150 Chromosome dynamics of prophase I have been studied in budding and fission yeas

151 as a gene involved in key events of meiotic prophase I in Caenorhabditis elegans.

152 Repression of cyclin A translation early in prophase I in Drosophila is important to maintain the oo

153 s failed to be repaired from early to middle prophase I in mre-11(iow1) mutants.

154 versus homoeologous chromosomes during early prophase I in two representative B. napus accessions tha

155 rompt disassembly of the SC during exit from prophase I is a landmark event of meiosis, the underlyin

156 CID assembly in prophase I is also conserved in female meiosis.

157 e interactions during premeiotic S phase and prophase I is central to establishing the unique meiosis

158 e interactions during premeiotic S phase and prophase I is essential for establishing the meiosis I c

159 Meanwhile, no replicative PGCs or prophase I meiocytes could be found.

160 splantation, as evidenced by the presence of prophase I meiocytes displaying homologous pairing.

161 sed Aurora B kinase (AIR-2) signals in early prophase I nuclei, coupled with a parallel decrease in s

162 rate that embryonic exposure to ATZ disrupts prophase I of meiosis and affects normal follicle format

163 rsistent histone H2AX phosphorylation during prophase I of meiosis and deficient sister chromatid coh

164 affect spindle nucleation or progression of prophase I of meiosis but does inhibit maturation of Ser

165 izes to the synaptonemal complex (SC) during Prophase I of meiosis in mice.

166 During prophase I of meiosis, a high proportion of Parp-1((-/-)

167 s to be maintained from its establishment in prophase I oocytes before birth until continuation of me

168 ouble-strand breaks (DSBs) introduced during prophase I precede and are required for efficient homolo

169 d, events: oocyte maturation (release of the prophase I primary arrest) and egg activation (release f

170 1beta cohesin needs only be expressed during prophase I prior to the primordial follicle stage to ens

171 through the RAS-ERK pathway to drive meiotic prophase I progression and oogenesis; in the absence of

172 meiotic time course revealed a 12-h delay in prophase I progression to the first labeled tetrads.

173 motes efficient SC destruction at the end of prophase I to ensure faithful inheritance of the genome.

174 about sixfold during meiotic maturation from prophase I to metaphase II and then increases approximat

175 colocalize to meiotic centromeres from early prophase I until anaphase II in wild-type males, but bot

176 Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce th

177 and then binds to chromatin in early meiotic prophase I when it regulates the leptotene-zygotene prog

178 the prophase of the first meiotic division (prophase I).

179 es are deficient in progression through late prophase I, a time point when expression of the X-linked

180 cripts can be detected in oocytes throughout prophase I, arguing against a male-specific function for

181 epletion of the germ cell pool at the end of prophase I, as in males.

182 ks (DSBs) by the Spo11 endonuclease early in prophase I, at discrete regions in the genome coined "ho

183 Upon exit from prophase I, Dbf4, the regulatory subunit of DDK, directl

184 arrested as early as the leptotene stage of prophase I, demonstrating that cohesin plays an essentia

185 t the onset of leptotene, the first stage of prophase I, frequently occurred earlier in fst-1 than in

186 In meiotic prophase I, homologous chromosome pairing is promoted th

187 tants exhibit severe meiotic defects in late prophase I, including improper disassembly of the SC and

188 nd their fetal oocytes are arrested at early prophase I, leading to oocyte depletion at 1 week of age

189 is highly enriched at the rDNA region during prophase I, released at the prophase I/metaphase I trans

190 alizes to spermatocyte nuclei during meiotic prophase I, specifically at sites of asynapsis and the t

191 fter a long period of quiescence at dictyate prophase I, termed the germinal vesicle (GV) stage, mamm

192 spermatocytes at the early stages of meiotic prophase I, the limited period when PRDM9 is expressed.

193 spontaneous DSBs ( approximately 10) in late prophase I, the repair of which is inhibited by the pres

194 n is essential for chromosome pairing during prophase I, the resulting crossovers are critical for ma

195 During prophase I, the sex body assembles incorrectly in Ago4(-

196 defective in chromosome synapsis at meiotic prophase I, which provokes an arrest at the pachytene-li

197 iation of AtRECQ4A with the telomeres during prophase I, which we propose enables dissolution of reco

198 s regulating transcriptional activity in the prophase I-arrested oocyte are still not entirely unders

199 formation, suggesting a role during meiotic prophase I.

200 osomal fragmentation and aggregation in late prophase I.

201 (synapsis) of homologous chromosomes during prophase I.

202 stablishment of sister chromatid cohesion in prophase I.

203 sely associate with the nuclear periphery at prophase I.

204 infertile associated with meiotic arrest at prophase I.

205 mosome synapsis and undergo apoptosis during Prophase I.

206 in the context of the important landmarks of prophase I.

207 c chromatin for subsequent functions in late prophase I.

208 NA region during prophase I, released at the prophase I/metaphase I transition, and reassociates with

209 round the late pachytene-diplotene stages of prophase I; surprisingly, without any obvious defect in

210 Hormonal stimulation breaks this prophase-I arrest and induces re-entry into MI.

211 centers (MTOCs) in mouse oocytes arrested at prophase-I.

212 located at the pericentromere during meiotic prophase II but is restricted to the inner centromere at

213 During meiotic prophase in Drosophila males, transcript for the core ce

214 review the critical events in early meiotic prophase in Drosophila melanogaster oocytes.

215 s been shown to activate condensin II during prophase in human cells, and facilitate further phosphor

216 To study the nuclear dynamics during meiotic prophase in maize, we established a system to observe li

217 affect chromosome motility in early meiotic prophase in maize.

218 gression through the early stages of meiotic prophase in maize.

219 During meiotic prophase in males, the sex chromosomes partially synapse

220 mologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the a

221 systems regulate the major events of meiotic prophase in mouse.

222 During meiotic prophase in Saccharomyces cerevisiae, expression of the

223 During meiotic prophase, in a conserved chromosomal configuration calle

224 tration that oxidative stress during meiotic prophase induces chromosome segregation errors and suppo

225 rmatocytes and prohibits the transition from prophase into metaphase of the first meiotic division, r

226 n-dependent PHF8 dismissal from chromatin in prophase is apparently required for the accumulation of

227 e and from neuroblast chromosome arms during prophase is blocked by translational fusion of Smc3's C-

228 ciation of telomeres with centrosomes during prophase is crucial for efficient spindle formation.

229 lk1 is recruited to phosphorylate SA2 during prophase is currently not known.

230 is is initiated by retinoic acid and meiotic prophase is the first and most complex stage of meiosis

231 h accumulates at the centromeres earlier, in prophase, is not dependent on Ska3.

232 The protracted arrest in meiotic prophase makes oocytes particularly susceptible to the a

233 haromyces cerevisiae that controls exit from prophase, meiosis, and spore formation.

234 hosphorylation upon cycling that suggested a prophase/metaphase block; germ cells were almost entirel

235 utant neuroblasts showed a striking delay in prophase/metaphase transition by live imaging and increa

236 mid undergoes Csm4- and Ndj1-dependent rapid prophase movements with speeds comparable to those of te

237 otein quantification in juvenile mice and in prophase mutants indicates that early spermatocytes synt

238 eakdown (NEBD) and impaired the formation of prophase NE invaginations (PNEIs), similar to microtubul

239 rm cells appear to execute events of meiotic prophase normally, and many proteins characteristic of t

240 Sa15 forms linear structures in meiotic prophase nuclei to which Zhp3 localizes.

241 , was localized with 5-methylcytosine in the prophase nucleus of a subset of KIT(+) progenitors durin

242 m cell samples, especially in females, where prophase occurs in the embryonic ovary.

243 Vertebrate immature oocytes are arrested at prophase of meiosis I (MI).

244 tinct cell cycle phases during male meiosis: prophase of meiosis I and after exit from meiosis II, in

245 embryonic gonocytes results in arrest during prophase of meiosis I.

246 a complete block of spermatogenesis at early prophase of meiosis I.

247 asun spermatocytes arrest during prophase of meiosis I.

248 meres and anchors chromosome movement in the prophase of meiosis.

249 on causes reduction of perinuclear dynein in prophase of mitosis.

250 are arrested for long periods of time in the prophase of the first meiotic division (prophase I).

251 differentiation does not proceed beyond the prophase of the first meiotic division due to massive ap

252 holds together homologous chromosomes during prophase of the first meiotic division.

253 During the entire meiotic prophase of the yeast Saccharomyces cerevisiae, chromoso

254 Upon prophase onset, constraints are relaxed, and PCs initiat

255 The mechanisms regulating interphase, prophase, or metaphase arrest in response to anoxia are

256 ibition of Plk1, a kinase essential for the "prophase pathway" of cohesin release from chromosomes, o

257 horylation accumulates at centrosomes during prophase, peaks at metaphase, and decreases through telo

258 upport a role for SPO11alpha in mid- to late prophase, presumably acting as a topoisomerase, that wou

259 presenting at least 35 genes that affect key prophase processes such as pairing, synapsis, and homolo

260 with a single dramatic exception: the normal prophase program of recombination and synapsis between h

261 These observations imply that the prophase program senses absence of karyogamy and/or abse

262 howed evidence that DSB numbers increased as prophase progressed.

263 ysis of protein abundance remodeling between prophase, prometaphase and anaphase.

264 sis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger for the

265 sites in which replication was delayed until prophase, regardless of FA pathway activation.

266 e inactive X chromosome is unknown; however, prophase release of human XIST RNA provides a clue.

267 ent of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand

268 unction mutant in chicken cells; it disrupts prophase, results in a dramatic shortening of the mitoti

269 Here, we explore the prophase roles of Rec8.

270 ning GLFG bodies are disassembled in mitotic prophase, significantly ahead of nuclear pore disassembl

271 ession, disturbs ribosome biogenesis in late-prophase spermatocytes and prohibits the transition from

272 tected in the cytoplasm of spermatogonia and prophase spermatocytes.

273 ribution of crossover-associated proteins in prophase-stage oocytes.

274 nd persistent activity of PP4 during meiotic prophase suggest a model whereby Zip1-S75 phosphorylatio

275 e detachment in untreated cells increases at prophase suggesting that it is a regulated cellular proc

276 observations, we propose that during meiotic prophase the presence of occasional fast moving chromoso

277 Instead of continuing through meiotic prophase, the cells attempt an abnormal mitotic-like div

278 n of middle genes controls exit from meiotic prophase, the completion of the nuclear divisions, and s

279 ex, localizes in the nuclear envelope during prophase, the exact role of p150(Glued) and its regulati

280 ase 1 (cdk1)/cyclinB complex, primarily from prophase through early anaphase, subsequent to global ac

281 We show here that both meiotic prophase timing and germ-line apoptosis, one output of c

282 primarily localizes to spindle poles during prophase to metaphase but gradually diminishes after ana

283 omatin and chromosome individualization from prophase to metaphase transition.

284 that the successful transition from meiotic prophase to mitosis requires the modulation of Cdk1 acti

285 integrity during the transition from meiotic prophase to mitosis.

286 rane fragments, defining the transition from prophase to prometaphase and resulting in complete mixin

287 analogous to sister individualization at the prophase to prometaphase transition of the eukaryotic ce

288 lly, and many proteins characteristic of the prophase-to-metaphase transition are not obviously deple

289 vestigate how the somatic cells regulate the prophase-to-metaphase transition in the oocyte, and show

290 re removed from sister chromatid arms during prophase via phosphorylation, whereas centromeric cohesi

291 ith failure of spermatocytes to exit meiotic prophase via the G2/MI transition.

292 ages of the cell cycle, in particular during prophase when most cohesin dissociates from chromosome a

293 hat maximal phosphorylation of Nuf occurs at prophase, when centrosome-associated Nuf disperses throu

294 We find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the

295 efore rapidly accumulating in the nucleus at prophase, which promotes disassembly of the nuclear lami

296 and p150 dynactin on the nuclear envelope at prophase, which results in inefficient dynein-driven cen

297 endent recruitment of POK1 to the PPB during prophase, while POK1 retention at the cortical division

298 in is stripped from chromosome arms by early prophase, while the remaining cohesin at kinetochores is

299 Cdk1 (sum1-ci) blocks meiotic development in prophase with an ndt80Delta-like phenotype.

300 ed at mid to late pachytene stage of meiotic prophase with defective synapsis of the homologous chrom