ライフサイエンスコーパス: prophylactic

1 cation Study) was designed to assess whether prophylactic ablation of the arrhythmogenic substrate re

2 n help stratify risk and select patients for prophylactic ablation therapy.

3 We assessed the prophylactic activity of DSM265 against controlled human

4 mg DSM265 was well tolerated and had causal prophylactic activity when given 1 day before CHMI.

5 armacokinetics, low projected cost of goods, prophylactic activity, and the potential for a single do

6 These findings suggest that therapeutic or prophylactic administration of defined bacterial consort

7 In mice, prophylactic administration of NAC was effective in prev

8 In conclusion, prophylactic administration of NAC, without concurrent p

9 ound no evidence of benefit or harm with the prophylactic administration of pantoprazole to mechanica

10 Prophylactic administration of WGA-Fc fully protected mi

11 Prophylactic adrenalectomy completely prevented SCI-indu

12 recently, ketamine has also been shown to be prophylactic against stress-induced depressive-like beha

13 eover, it is unknown whether ketamine can be prophylactic against subsequent stressors.

14 tial virus (RSV) F glycoprotein, is the only prophylactic agent approved for use for the treatment of

15 ort routine clinical use of ganciclovir as a prophylactic agent in patients with sepsis.

16 ho developed GVHD while on immunosuppressive prophylactic agents recapitulated the patterns observed

17 differentiation, and fibrotic injury both in prophylactic and early therapeutic settings by about 50%

18 data and variability in patient populations, prophylactic and immunosuppressive strategies, dosing, d

19 of pathogenesis is key to the development of prophylactic and intervention measures.

20 Prevention of OI should include prophylactic and pre-emptive antimicrobials.

21 The requirement of prophylactic and radical cure activities for the next ge

22 of engineered microorganisms with potential prophylactic and therapeutic activities against gut infe

23 The engineered probiotic shows in vivo prophylactic and therapeutic activity against P. aerugin

24 onoclonal antibodies against CHIKV as viable prophylactic and therapeutic agents will be discussed.

25 bs) to HIV delineate vaccine targets and are prophylactic and therapeutic agents.

26 s, and methylated BSA/IL-1 arthritis by both prophylactic and therapeutic anti-G-CSFR mAb treatment,

27 The development of novel prophylactic and therapeutic antiviral drugs against hRS

28 further preclinical/clinical development for prophylactic and therapeutic applications due to their p

29 ates of protection, as well as the safety of prophylactic and therapeutic candidates, are important t

30 with low-molecular-weight heparin (LMWH) for prophylactic and therapeutic indications.

31 eed to be understood to identify targets for prophylactic and therapeutic interventions and develop a

32 interactions as well as assess potential new prophylactic and therapeutic interventions.

33 f the dengue epidemic will require effective prophylactic and therapeutic interventions.

34 To evaluate the effect of C1P, we used a prophylactic and therapeutic LPS-induced ALI model in C5

35 GVHD pathogenesis and as a potentially novel prophylactic and therapeutic option for patients with cG

36 tle or no immune response and provide potent prophylactic and therapeutic protection against influenz

37 tic largely employed as veterinary drugs for prophylactic and therapeutic purposes.

38 e antibiotic overuse in zoothechnics, due to prophylactic and therapeutic treatments, or to their gro

39 d chloroquine or quinine were tested in both prophylactic and treatment models.

40 rface disorders, as well as potential future prophylactic and treatment strategies.

41 bispecific antibodies hold promise as novel prophylactic and/or therapeutic agents in the fight agai

42 ovide an avenue to rapidly generate antibody prophylactics and therapeutics to address disease agents

43 form the development of improved diagnostic, prophylactic, and therapeutic modalities.

44 lock APC anticoagulant activity suppress the prophylactic anti-inflammatory effect of scFv/TM.

45 utic anti-G-CSFR mAb treatment, whereas only prophylactic anti-Ly6G mAb treatment was effective.

46 vidence that moxifloxacin is an effective IC prophylactic antibiotic and suggests that IC antibiotics

47 ch suggest that clindamycin is an inadequate prophylactic antibiotic therapy in the reduction of SSI,

48 tions in mice in the presence and absence of prophylactic antibiotic treatment.

49 age, weight group, risk stratification, and prophylactic antibiotics was used to estimate the impact

50 iver Disease score or diabetes, those taking prophylactic antibiotics, and those with prior HE were m

51 Vaccines and prophylactic antibodies against respiratory syncytial vi

52 ccination for infants, or pregnant women, or prophylactic antibodies for neonates).

53 tivity, which provides a path for developing prophylactic antibodies for use in pregnancy or designin

54 attributable to AF (thromboembolism without prophylactic anticoagulation) was 0.1% per year (n=2 pat

55 nd clean-contaminated procedures, additional prophylactic antimicrobial agent doses should not be adm

56 months (range, 22-80 months), 8 have ceased prophylactic antimicrobials, and 5 have ceased immunoglo

57 This risk may be reduced with prophylactic antimycotic therapy when culture-positive d

58 tion (55% versus 36%), and to have undergone prophylactic aortic root replacement (47% versus 24%), a

59 Prophylactic aortic root replacement and mitral valve su

60 ection was strongly associated with previous prophylactic aortic root replacement.

61 tients, especially in men and after previous prophylactic aortic root replacement.

62 Aortic aneurysms and prophylactic aortic surgery are more common in men.

63 In a murine NCGN model, prophylactic application of E-selectin-targeted immunoli

64 demonstrating potential in agriculture, and prophylactic applications in hospital and community sett

65 ative version, enabling both therapeutic and prophylactic applications.

66 adiated corneas, which may represent a novel prophylactic approach to corneal photodamage.

67 osure prophylaxis (PrEP) program who started prophylactic ART an estimated 10 days (Participant A; 54

68 on of the most effective countermeasures for prophylactic as well as therapeutic treatments of HPAI H

69 less successful applications of these NPs in prophylactic as well as therapeutic vaccination approach

70 Prophylactic augmentation of the abdominal wall with a r

71 interest given the potential therapeutic and prophylactic benefits of omega-3 fatty acids.

72 hology influences Abeta burden and to assess prophylactic benefits, 3xTg and wild-type mice received

73 All were submitted to prophylactic bilateral ureteronephrectomy and annual sur

74 xcellent in patients with AAN, provided that prophylactic bilateral ureteronephrectomy and lifelong s

75 to 2 doses for routine vaccination with the prophylactic bivalent human papillomavirus (HPV) vaccine

76 a fear response when given a week before as prophylactic, but not when given immediately before or a

77 We completed the first prophylactic cancer vaccine clinical trial based on a no

78 ce, use of surrogate cardiac biomarkers, and prophylactic cardioprotective therapy in asymptomatic wo

79 alyses limited to patients likely undergoing prophylactic central neck dissection resulted in three,

80 in humans and support the achievability of a prophylactic CMV vaccine.IMPORTANCE CMV infects the majo

81 mmaya reservoir inserted for the delivery of prophylactic CNS chemotherapy, but were free of their ma

82 te nondetectable CNS leukemia in many cases, prophylactic CNS-directed conventional intrathecal chemo

83 Retrospective data indicate prophylactic CNS-directed therapies may reduce the risk

84 INTERPRETATION: Prophylactic co-trimoxazole seems to offer no survival b

85 lerated the testing of novel therapeutic and prophylactic compounds against gonococcal infection.

86 ty of life, resulting in shortened survival, prophylactic cranial irradiation has been proposed in bo

87 d trials and a meta-analysis have shown that prophylactic cranial irradiation not only reduces the in

88 ne model of radiation-induced proctitis, the prophylactic delivery of a single dose of GAG from a SEL

89 Prophylactic donor lymphocyte infusion (DLI) strategies

90 aban at either a treatment dose (20 mg) or a prophylactic dose (10 mg) than with aspirin, without a s

91 Patients were assigned to receive either a prophylactic dose of low-molecular-weight heparin (for t

92 The median average prophylactic dose of rFIXFc was 58.6 IU/kg (IQR 52.3-64.

93 odels, we previously showed that TMP-SMX, at prophylactic doses, can arrest liver stage development o

94 There is no need for routine prophylactic drainage after pancreatic resection with pa

95 re well suited for development into low-cost prophylactic drugs, due to their relatively easy synthes

96 Among very preterm infants who received prophylactic early high-dose rhEPO for neuroprotection,

97 of kidney transplant recipients treated with prophylactic eculizumab.

98 risk ratio of olanzapine and its additional, prophylactic effect against relapse in the long term.

99 sions, our findings suggested that LCS has a prophylactic effect against systemic E. coli K1 infectio

100 a longer timescale than accounted for by the prophylactic effect alone.

101 e clinical model of herpes exacerbation, the prophylactic effect of a Ca-SP and microalgae extract co

102 Here we investigate the prophylactic effect of ketamine against neurochemical an

103 S did so after ketamine, suggesting that the prophylactic effect of ketamine is a result of altered f

104 after injury and may be responsible for the prophylactic effect of preinjury transplants.

105 attacks of hereditary angio-oedema, but the prophylactic effect of recombinant human C1 esterase inh

106 tes, used as a measure of the post-treatment prophylactic effect, were significantly lower in the art

107 We evaluated the prophylactic effects of rapamycin, a selective inhibitor

108 In an observational trial the prophylactic effects of topically applied Ca-SP were com

109 Pharmacological xCT blockage counteracts NAC prophylactic effects.

110 order to maximize its antidepressant and/or prophylactic effects.

111 detecting asymptomatic carriage, (2) compare prophylactic efficacy across antimicrobial regimens, and

112 To evaluate prophylactic efficacy, mice were given CR6261 or CR9114

113 cellence guidance were available to estimate prophylactic efficacy.

114 ced myometrial relaxation and that prolonged prophylactic elevation of cAMP alone is unlikely to prev

115 o evaluate the effectiveness of TEG-adjusted prophylactic enoxaparin dosing among trauma and surgical

116 It remains uncertain whether prophylactic exclusion of the LAA is warranted for strok

117 Prophylactic exclusion of the left atrial appendage (LAA

118 Prophylactic filters were defined as VCFs placed before

119 uine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost

120 A prophylactic HCV vaccine boosted with multiple HCV genot

121 A prophylactic HCV vaccine is still needed to control this

122 A prophylactic HIV-1 vaccine is a global health priority.

123 (HIV-1) is a key, as-yet-unachieved goal of prophylactic HIV-1 vaccine strategies.

124 emalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased

125 vestigated the US population-level effect of prophylactic HPV vaccination on the burden of oral HPV i

126 Prophylactic HPV vaccine is available for primary preven

127 Currently, there are three licensed prophylactic HPV vaccines based on virus-like particles

128 ther preclinical and clinical development of prophylactic HSV-2 vaccines that contain appropriate ant

129 Prophylactic human papillomavirus (HPV) vaccination prog

130 e, drug and phototherapy delivered through a prophylactic hydrogel patch leads, in a colon cancer mou

131 In this trial, prophylactic ICD implantation in patients with symptomat

132 n-ischemic dilated cardiomyopathy undergoing prophylactic ICD implantation were prospectively enrolle

133 isk stratification and patient selection for prophylactic ICD therapy.

134 In ICM patients with primary prophylactic ICD, LGE border zone predicted ICD therapy

135 However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failur

136 In addition, other prophylactic immune interventions, such as monoclonal an

137 ursicon subunit forms homodimers that induce prophylactic immunity in Drosophila melanogaster.

138 e hypothesis that bursicon homodimers act in prophylactic immunity in insects, and possibly arthropod

139 of AMP genes via Relish2 in Ae. aegypti, as prophylactic immunity to protect mosquitoes during the v

140 FPR2 signaling as well as for development of prophylactic immunomodulatory therapy.

141 ografting, obviating the need for additional prophylactic immunosuppression.

142 Moreover, prophylactic inactivation of CD11b/CD18, using the ortho

143 rene (Ag-PS) NPs, although effective for the prophylactic induction of tolerance, induce anaphylaxis

144 ds great promise for improving the design of prophylactic influenza vaccines.

145 The effectiveness and safety of the prophylactic injection of cefuroxime as measured by the

146 = .001 for trend]) as the use of cefuroxime prophylactic injections increased (11.1%, 14.4%, 32.8%,

147 Our results show that a prophylactic inoculation of prion-infected animals with

148 For patients at high SCD risk, prophylactic insertion of implantable cardioverter defib

149 t for the development of new therapeutic and prophylactic interventions.

150 e underwent uneventful cataract surgery with prophylactic intracameral vancomycin during the procedur

151 ic occlusive retinal vasculitis (HORV) after prophylactic intracameral vancomycin use during an uneve

152 We have shown that prophylactic intranasal administration of our lead fusio

153 een needle type and patient age, sex, use of prophylactic intravenous fluid, needle gauge, patient po

154 Mice administered prophylactic ketamine 1 week, but not 1 month or 1 h bef

155 Mice treated with prophylactic ketamine were protected against the deleter

156 The effectiveness of prophylactic laser or early pars plana vitrectomy (PPV)

157 The role of prophylactic laser retinopexy or early PPV is unknown at

158 Prophylactic levosimendan did not result in a rate of th

159 To assess whether routine prophylactic low-dose oxygen therapy was more effective

160 st useful in the clinic if administered in a prophylactic manner 1 week before a stressor, in order t

161 The use of contralateral prophylactic mastectomies (CPMs) among patients with inv

162 as 75.9% including the cancers discovered at prophylactic mastectomy (95% confidence interval: 69.5%,

163 ienced by patients who undergo contralateral prophylactic mastectomy (CPM) and breast reconstruction.

164 ne national temporal trends in contralateral prophylactic mastectomy (CPM) and determine whether surv

165 Guidelines assert that contralateral prophylactic mastectomy (CPM) should be discouraged in p

166 Contralateral prophylactic mastectomy (CPM) use is increasing among wo

167 e incidental breast cancer was detected in a prophylactic mastectomy specimen.

168 when including and not including cancers in prophylactic mastectomy specimens, respectively).

169 investigated on breast tissues excised from prophylactic mastectomy specimens.

170 BRCA1-mutation carriers) frequently undergo prophylactic mastectomy to minimize their risk of breast

171 Contralateral prophylactic mastectomy use is substantial among patient

172 y high among patients choosing contralateral prophylactic mastectomy, complications and procedure ext

173 Beyond prophylactic mastectomy, there are currently very few op

174 terval cancers, and 25 cancers discovered at prophylactic mastectomy.

175 Contralateral prophylactic mastectomy.

176 e key to achieve this balance; nonantibiotic prophylactic measures such as probiotics, prokinetics, b

177 ka virus (ZIKV) outbreaks or epidemics adopt prophylactic measures to reduce or eliminate mosquito bi

178 understood mechanism and no fully effective prophylactic measures.

179 ncy (66%, 95% CI=57, 75) than those who used prophylactic medication (23%, 95% CI=14, 37).

180 women with bipolar disorder, continuation of prophylactic medication during pregnancy appears highly

181 Prophylactic mesh-augmented reinforcement during laparot

182 -3 and will contribute to the development of prophylactic methods.

183 Prophylactic minocycline and reactive treatment are both

184 as reduced in patients who were treated with prophylactic minocycline or reactive treatment.

185 Use of prophylactic moisturizing compounds.

186 r demonstration in human beings shows that a prophylactic mRNA-based candidate vaccine can induce boo

187 oncept clinical trial in healthy adults of a prophylactic mRNA-based vaccine encoding rabies virus gl

188 The effect of prophylactic negative pressure dressing of closed incisi

189 was undertaken to investigate the effect of prophylactic negative pressure dressings on postoperativ

190 Prophylactic or acute administration of KN93, a CaMKIIal

191 among treatment arms, but patients receiving prophylactic or reactive treatments had a longer OS (7.6

192 These studies demonstrate that prophylactic or therapeutic administration of the polycl

193 When both enzymes were administered in a prophylactic or therapeutic fashion, autoimmune inflamma

194 The effects of prophylactic or therapeutic Syk inhibition on allergic a

195 We found that regardless of the prophylactic or therapeutic treatment, Shenks was able t

196 humoral responses are under development for prophylactic or therapeutic use.

197 in VCF placement and PE rates, filter type (prophylactic or therapeutic), and established predictors

198 persistence and for development of improved prophylactic or treatment strategies.

199 at intrapulmonary application of C1P before (prophylactic) or 24 h after (therapeutic) LPS instillati

200 DA-licensed vaccines, effective postexposure prophylactics, or therapeutics.

201 I among obese women after cesarean delivery, prophylactic oral cephalexin and metronidazole may be wa

202 e rates of SSI among obese women who receive prophylactic oral cephalexin and metronidazole vs placeb

203 However, prophylactic oseltamivir did not prevent H5N1 virus repl

204 d the efficacy of homologous vaccination and prophylactic oseltamivir to prevent H5N1 virus CNS invas

205 Our analyses demonstrate that when prophylactic pasireotide is administered, the cost per P

206 en and treated six of these pregnancies with prophylactic plasma infusions (one pregnancy resulted in

207 Prophylactic platelet transfusion at defined platelet co

208 secondary to bone marrow failure, requiring prophylactic platelet transfusion.

209 donors on the basis of platelet function for prophylactic platelet transfusion.

210 fusions, while the evidence for a benefit of prophylactic platelet transfusions is weak and controver

211 is the optimal platelet count threshold for prophylactic platelet transfusions to minimize bleeding,

212 el, specific and efficacious therapeutic and prophylactic platform for targeted viral genomic ablatio

213 nal supplementation with fish oil might have prophylactic potential for long-term prevention of asthm

214 However, utilization of appropriate prophylactic PPI therapy remains suboptimal, especially

215 cells expressing VHHs can provide prolonged prophylactic protection against bacterial toxins without

216 r, our data support a role for complement in prophylactic protection, as evidenced by intracellular d

217 Prophylactic protocols prevented alloimmunization.

218 Routine use of prophylactic radiotherapy in all patients with mesotheli

219 The use of prophylactic radiotherapy to prevent procedure-tract met

220 We aimed to compare prophylactic radiotherapy with deferred radiotherapy (gi

221 al Endoscopy guidelines recently recommended prophylactic rectal indomethacin for all patients underg

222 The optimal perioperative antibiotic prophylactic regimen in this high-risk population underg

223 ighly complex pathogen which, despite modern prophylactic regimens, continues to affect a high propor

224 Even with extended prophylactic regimens, however, challenges remain.

225 c IgG could be beneficial in tailoring FVIII prophylactic regimens.

226 Current prophylactic replacement therapy, although effective, is

227 Prophylactic retromuscular mesh-augmented reinforcement

228 of bleeding (ie, on demand) or as part of a prophylactic schedule.

229 n = 31) or cataract surgery with concomitant prophylactic sclerostomy (sclerostomy group, n = 29).

230 g and after cataract surgery with or without prophylactic sclerostomy in nanophthalmic eyes with visu

231 Performing a simultaneous prophylactic sclerostomy with cataract surgery reduces c

232 amphiphiles in syngeneic C57BL/6J mice under prophylactic settings.

233 Antiviral prophylactic strategies should be justified according to

234 e reduced efficacy in patients with ESLD and prophylactic strategies to prevent HCV recurrence are st

235 inable and welfare-oriented therapeutics and prophylactic strategies.

236 CNS-directed evaluation and consideration of prophylactic strategies.

237 as well as for the development of effective prophylactic strategies.

238 d the development and validation of targeted prophylactic strategies.

239 d trials are needed to ascertain the optimal prophylactic strategy in lung transplant recipients.

240 is) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios.

241 of parastomal hernia (PH) after placement of prophylactic synthetic mesh using a modified Sugarbaker

242 cally occur below established thresholds for prophylactic TAA repair.

243 o TAA etiology, incidence, and pattern after prophylactic TAA surgery are poorly understood.

244 tion images that fulfilled size criteria for prophylactic TAA surgery at a subsequent AoD site.

245 In summary, prophylactic tau immunization not only prevents tau path

246 ver susceptibility and may open doors to new prophylactic/therapeutic approaches.

247 -extendable framework for the development of prophylactic therapeutics against organophosphate poison

248 the value of detecting subclinical AF and of prophylactic therapies are warranted.

249 ong participants who had previously received prophylactic therapy decreased from 16 events before the

250 of cell wall beta-1,3-glucan and is used for prophylactic therapy in immune-suppressed individuals.

251 The risk of prophylactic therapy must be weighed against the inciden

252 dotracheal intubation, might be considered a prophylactic therapy, rather than just a supportive ther

253 ibute to immunogen design and antibody-based prophylactic therapy.

254 of up to 70%, prompting a recommendation for prophylactic total gastrectomy.

255 etween two such groups as one group with the prophylactic treatment and another with the authentic tr

256 Efficacy of prophylactic treatment by leukotoriene receptor antagoni

257 groud: It has already been reported that the prophylactic treatment by leukotoriene receptor antagoni

258 Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but tr

259 kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1

260 containing Spirulina species extract for the prophylactic treatment of herpes labialis and suggest po

261 should be a consideration when contemplating prophylactic treatment protocols.

262 A prophylactic treatment that protects the gastrointestina

263 These Abs could be of interest in prophylactic treatment to block HIV-1 penetration in muc

264 This study about the prophylactic treatment was planned to focus on the effec

265 Prophylactic treatment with AMA0825 inhibited myofibrobl

266 er experimental infection with H. pylori, or prophylactic treatment with H. pylori-derived immunomodu

267 Prophylactic treatment with H. pylori-derived immunomodu

268 randomized clinical study to assess whether prophylactic treatment with metoprolol or losartan, init

269 Prophylactic treatment with minocycline significantly le

270 9%) patients, malaria was contracted despite prophylactic treatment.

271 Comparing efficacies of phage-curative and prophylactic treatments in healthy immunocompetent, MyD8

272 Prophylactic ureteric stenting in renal transplantation

273 In patients with hereditary angioedema, the prophylactic use of a subcutaneous C1 inhibitor twice we

274 The early prophylactic use of antibiotics in AP remains controvers

275 INTERPRETATION: Prophylactic use of dexamethasone oral solution substant

276 g nonhypoxic patients with acute stroke, the prophylactic use of low-dose oxygen supplementation did

277 cal to effective vaccine development and the prophylactic use of monoclonal antibodies.

278 Prophylactic use of negative pressure dressings for clos

279 Without considering pasireotide cost, prophylactic use of the drug saved an average of $8,109

280 ostinjury abdominal compartment syndrome and prophylactic use of the open abdomen to prevent intra-ab

281 These results suggest a secondary prophylactic use of these antibiotics by A. echinatior b

282 y use of steroids is suggested because their prophylactic use to prevent full-blown PML-IRIS seems to

283 icable not only for therapeutic but also for prophylactic vaccination.

284 The volunteers were given a prophylactic vaccine candidate (n = 7) or placebo (n = 5

285 s of virus pathogenesis, immune control, and prophylactic vaccine development.

286 A prophylactic vaccine exists and currently available anti

287 pment of a simple, recombinant protein-based prophylactic vaccine for HCV with potential for universa

288 virus 2 (HSV-2), and to date, an efficacious prophylactic vaccine has not met the rigors of clinical

289 congenital viral infection, and developing a prophylactic vaccine is of high priority to public healt

290 Vesiculovirus vectors as therapeutic and/or prophylactic vaccine vectors to combat emerging viral di

291 A prophylactic vaccine with high efficacy and low cost is

292 rabbits and mice, our study has identified a prophylactic vaccine with the potential to target a wide

293 trates evidence of high effectiveness of HPV prophylactic vaccines at an individual level, supporting

294 While prophylactic vaccines have been developed, uptake is low

295 Although prophylactic vaccines provide protective humoral immunit

296 Although prophylactic vaccines targeting a subset of HPV types ar

297 Several prophylactic vaccines targeting herpes simplex virus 2 (

298 efforts to develop antiviral treatments and prophylactic vaccines.

299 pump inhibitor stewardship, and prescribing prophylactic vancomycin and/or probiotics to colonized p

300 the NTDB, and 189957 in the NIS), most were prophylactic VCFs (93.6% in the PTOS, 93.5% in the NTDB,