ライフサイエンスコーパス: prosaposin

1 e efficient sorting of the lysosomal protein prosaposin.

2 ve and glioprotective factors prosaptide and prosaposin.

3 equential domain-containing proteins such as prosaposin.

4 t through secretion of the signaling protein prosaposin.

5 rolases that derive from a single precursor, prosaposin.

6 roteolytic processing of a common precursor, prosaposin.

7 a putative precursor analogous to vertebrate prosaposins.

8 llular cathepsin D content and impairment of prosaposin activation, a process that is required for me

9 xtracellular cathepsin D to the lysosome for prosaposin activation.

10 ed neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1), we p

11 ted glycoprotein-1), we purified full-length prosaposin and found that it also stimulated GPR37 and G

12 These findings suggest that prosaposin and prosaptides bind to a receptor that initi

13 In C-/- mice, prosaposin and saposins A, B and D proteins were present

14 This partitioning required extracellular prosaposin and was disrupted by lipid raft perturbation

15 derives from the multi-functional precursor, prosaposin, and functions as an activity enhancer for se

16 a show functional association between GPR37, prosaposin, and GM1 in the plasma membrane.

17 cted in the homozygotes (B-/-) mice, whereas prosaposin, and saposins A, C and D were at normal level

18 Prosaposin appears to be a potent neurotrophic factor.

19 Saposins, derived from a common precursor, prosaposin, are small, heat-stable lysosomal glycoprotei

20 After a yeast two-hybrid screen identified prosaposin as a potential interacting protein with the n

21 rolases that derive from a single precursor, prosaposin, by proteolytic cleavage.

22 nd sphingolipid-activator-protein-precursor (prosaposin) deficiency.

23 ts and hepatocytes from PS-/- mice and human prosaposin-deficient fibroblasts.

24 laining the deficiency of myelin observed in prosaposin-deficient mice and humans.

25 Although it has been shown that prosaposin-deficient mice fail to positively select inva

26 romoting lipid binding to CD1d, we expressed prosaposin deletion mutants lacking individual saposins

27 Prosaposin demonstrates diffuse organ of Corti expressio

28 enes (cystatin C, cathepsin C, lysozyme, and prosaposin) did not require de novo protein synthesis fo

29 Human and mouse prosaposin displayed similar temporal and spatial regula

30 ins derived from a common precursor protein (prosaposin) encoded by a single gene.

31 eins, metabolic labeling was done with human prosaposin expressed in insect cells, human fibroblasts,

32 ic sequestration of the activation region of prosaposin for protection of the cell from adverse hydro

33 howed that Sp1 and Sp3 are involved in human prosaposin gene regulation.

34 e 5' region was characterized from the human prosaposin gene.

35 The neurotrophic region of prosaposin has been localized to a 12-amino acid sequenc

36 Together, these results suggest that prosaposin helps maintain normal innervation patterns to

37 -/- mice showed an increase of intracellular prosaposin, impaired prosaposin secretion, deficiencies

38 owed large steady state amounts of uncleaved prosaposin in Purkinje cells, cortical neurons, and othe

39 ha10, studies were performed to characterize prosaposin in the normal rodent inner ear.

40 Prosaposin is a multifunctional protein encoded at a sin

41 Prosaposin is a multifunctional protein that encodes fou

42 Expression of prosaposin is regulated in a temporal and spatial manner

43 Expression of prosaposin is required for efficient lipid binding and r

44 Prosaposin is the precursor of four activator proteins,

45 Prosaposin is the precursor of four low molecular weight

46 n the degradation of glycosphingolipids, and prosaposin itself has neurite outgrowth effects.

47 Subsequent studies in a prosaposin knock-out (KO) (-/-) mouse showed intact but

48 Beginning at P12, the prosaposin KO mice showed histologic organ of Corti chan

49 saposin was observed in ugt1(-/-) cells with prosaposin localized to large juxtanuclear aggresome-lik

50 ons into the saposins A and B domains on the prosaposin locus.

51 on of an essential cysteine in exon 7 of the prosaposin locus.

52 Prosaposin may function as a myelinotrophic factor in vi

53 When secreted, intact prosaposin may function as a neuritogenic factor.

54 nscriptase-PCR and immunohistology localizes prosaposin mRNA to DCs and OHCs, and protein predominant

55 mbinant exogenous saposins were added to the prosaposin-negative cells, saposin B was the most effici

56 etion mutants lacking individual saposins in prosaposin-negative, CD1d-positive cells.

57 Relative to prosaposin null mice ( approximately 30 days), CD-/- mic

58 observed when compared with tissues from the prosaposin null mice, suggesting a compensation in LacCe

59 Our findings suggest that prosaposin, or other agents that stimulate p53 activity

60 These studies indicate that prosaposin processing is highly regulated at a proteolyt

61 In addition, prosaposin promotes neurite outgrowth in vitro via seque

62 hich the recently identified natural ligand, prosaposin, promotes plasma membrane association of GPR3

63 In young Gaucher disease mice (V394Lgba+/+//prosaposin[ps]-null//ps-transgene), which demonstrate ne

64 s with plasma PGRN levels and identified the prosaposin (PSAP) locus as a new locus significantly ass

65 es neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides tha

66 4TO7 cells revealed the direct targeting of prosaposin (PSAP), which encodes a secreted protein foun

67 ed a tumor-secreted inhibitor of metastasis, prosaposin (Psap), which functions in a paracrine and en

68 C and D are derived from a common precursor, prosaposin (psap).

69 Immunoabsorption of extracellular prosaposin reduced GPR37(tGFP) surface density and decre

70 Furthermore, prosaposin's overlapping developmental expression patter

71 tabolism and lysosomal storage diseases, and prosaposin's physiological effects.

72 ins were undetectable in AB-/- mice, whereas prosaposin, saposin C and saposin D were expressed near

73 In both humans and mice, prosaposin/saposin deficiencies lead to severe neurologi

74 The deficiency of prosaposin/saposins (PS-/-) in humans and mice leads to

75 crease of intracellular prosaposin, impaired prosaposin secretion, deficiencies of saposins C and D a

76 Immunofluorescence studies using prosaposin-specific antisera showed large steady state a

77 regulated at a proteolytic level to produce prosaposin, tetrasaposins, or mature monosaposins in spe

78 ast, MSC cultured on a stiff matrix secreted prosaposin that promoted proliferation and survival of m

79 Prosaposin, the precursor of saposins A, B, C, and D, wa

80 Prosaposin, the precursor of saposins A, B, C, and D, wa

81 We report that mice deficient in prosaposin, the precursor to a family of endosomal lipid

82 To explore the proteolytic processing from prosaposin to mature activator proteins, metabolic label

83 Herein prosaposin was found to increase sulfatide concentration

84 Prosaposin was identified as a prominent endogenous UGT1

85 A dramatic decrease in the secretion of prosaposin was observed in ugt1(-/-) cells with prosapos

86 Moreover, both prosaptide and prosaposin were found to protect primary astrocytes agai