ライフサイエンスコーパス: prostaglandin H synthase

1 hosphate cytochrome P450 oxidoreductase, and prostaglandin H synthase).

2 lational regulation of the inducible form of prostaglandin H synthase.

3 with both native and indomethacin-pretreated prostaglandin H synthase 1 (PGHS-1) were examined by low

4 e monotopic lumenal enzyme cyclooxygenase 1 (prostaglandin H synthase 1) that share this mechanism of

5 peroxidase and cyclooxygenase activities of prostaglandin H synthase-1 (PGHS-1) both become irrevers

6 radical generated in the peroxidase cycle of prostaglandin H synthase-1 (PGHS-1) can serve as the ini

7 cosubstrates for the peroxidase activity of prostaglandin H synthase-1 (PGHS-1) have been reported t

8 Prostaglandin H synthase-1 (PGHS-1) is a bifunctional he

9 Prostaglandin H synthase-1 (PGHS-1) is a constitutively

10 l middle dot)NO is catalytically consumed by prostaglandin H synthase-1 (PGHS-1) through acting as a

11 Prostaglandin H synthase-1 and -2 (PGHS-1 and -2) cataly

12 The method was successfully used to detect prostaglandin H synthase-1 and -2 (PGHS-1 and -2) in nor

13 Cyclooxygenase catalysis by prostaglandin H synthase-1 and -2 (PGHS-1 and -2) requir

14 To investigate the function of prostaglandin H synthase-1 and synthase-2 (PGHS-1 and PG

15 ucible cyclooxygenase (Cox-2), also known as prostaglandin H synthase 2 (PGH-2) is a key enzyme in th

16 d the hypothesis that abnormal expression of prostaglandin H synthase 2 (PHS-2), which can be induced

17 that C. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin

18 Peroxides also induce radical formation in prostaglandin H synthase-2 (PGHS-2) and in PGHS-1 recons

19 t redox characteristics on the modulation of prostaglandin H synthase-2 (PGHS-2) in primary mouse cor

20 We hypothesized that prostaglandin H synthase-2 (PGHS-2) was one of the unide

21 lted in a significant inhibition of monocyte prostaglandin H synthase-2 (PGHS-2), a pivotal enzyme in

22 We compared the expression of prostaglandin H synthase-2 (PGHS-2, cyclooxygenase) mess

23 e drugs block the cyclooxygenase activity of prostaglandin H synthase-2 (PGHS2), but do not affect th

24 The enzyme prostaglandin H synthase-2 (PHS-2) forms one or more tyr

25 gonucleotide or when the early response gene prostaglandin H synthase-2 mRNA was measured over the ti

26 radicals detected in the photosystem II and prostaglandin H synthase-2 systems strongly suggest a me

27 Cyclooxygenase-2 (prostaglandin H synthase-2, PGHS-2, EC 1.14.99.1), an en

28 A similar iminoxyl radical was detected in prostaglandin H synthase-2.

29 cterized endoperoxide biosynthetic enzyme is prostaglandin H synthase, a haem-containing enzyme.

30 sing specific antibodies for human 15-Lox-1, prostaglandin H synthase (also called cyclooxygenase, Co

31 bolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase.

32 nce electron reactions in enzymes, including prostaglandin H synthase, galactose oxidase, ribonucleot

33 ooxygenase (COX)-2, the inducible isoform of prostaglandin H synthase, has been implicated in the gro

34 Significantly, prostaglandin H synthase inhibitors, which block the pro

35 Prostaglandin H synthase isoform-1 (PGHS-1) cyclooxygena

36 Prostaglandin H synthase isoforms 1 and 2 (PGHS-1 and -2

37 Prostaglandin H synthase isoforms 1 and 2 (PGHS-1 and -2

38 Prostaglandins are synthesized by prostaglandin H synthase (PGHS) 1 and 2.

39 Prostaglandin H synthase (PGHS) catalyzes both peroxidas

40 Prostaglandin H synthase (PGHS) catalyzes the conversion

41 mmalian tissues is regulated at the level of prostaglandin H synthase (PGHS) cyclooxygenase catalysis

42 nt techniques to examine the distribution of prostaglandin H synthase (PGHS) in ovine astrocyte-enric

43 Prostaglandin H synthase (PGHS) is a heme protein that c

44 Prostaglandin H synthase (PGHS) is a self-activating and

45 Reaction of prostaglandin H synthase (PGHS) isoforms 1 or 2 with per

46 Both prostaglandin H synthase (PGHS) isoforms utilize a radic

47 Peroxide-generated tyrosyl radicals in both prostaglandin H synthase (PGHS) isozymes have been demon

48 in hours after infection, and is mediated by prostaglandin H synthase (PGHS) products in animal model

49 Prostaglandin H synthase (PGHS), a key enzyme in prostan

50 There are two known isoforms of prostaglandin H synthase (PGHS), a key enzyme in the con

51 ctive substrate for the inducible isoform of prostaglandin H synthase (PGHS), PGHS-2.

52 intermediates in cyclooxygenase catalysis by prostaglandin H synthase (PGHS)-1 and -2.

53 dal antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little e

54 r limit on bioactive prostanoid synthesis by prostaglandin H synthase (PGHS).

55 s associated with slow binding inhibition of prostaglandin H synthase (PGHS).

56 formation of a tyrosyl radical on Tyr385 in prostaglandin H synthase (PGHS).

57 nase intermediate for the "basal" isoform of prostaglandin H synthase (PGHS-1).

58 The prostaglandin H synthases (PGHS) catalyze the conversion

59 ct of oxygenation of arachidonic acid by the prostaglandin H synthases (PGHS), prostaglandin H(2) (PG

60 Prostaglandin H synthases (PGHSs) catalyze the conversio

61 the covalent binding of reactive products of prostaglandin H-synthases (PGHSs) to the enzyme and to o

62 Synthesis of prostaglandin H2 by prostaglandin H synthase (PHS) results in a two-electron

63 pathway promoting growth inhibition in which prostaglandin H synthase plays a significant role.

64 prostanoids is regulated by cyclooxygenases (prostaglandin H synthases), which catalyze the conversio

65 -oxygenase 2 (COX2), an inducible isoform of prostaglandin H synthase, which mediates prostaglandin s