ライフサイエンスコーパス: prostaglandin I2

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1 e stable hydrolysis product of prostacyclin (prostaglandin I2).

2 lthough continuous infusion of prostacyclin (prostaglandin I2, a potent vasodilator released by vascu

3 Iloprost (a stable prostaglandin I2 analog) -induced rise in cAMP (mediated

4 llular levels of cAMP induced by iloprost (a prostaglandin I2 analog).

5 ptor antagonists, indicating a role for both prostaglandin I2 and E2 Activation of ERKs and p38, but

6 endothelial cells depressed biosynthesis of prostaglandin I2 and prostaglandin E2, elevated blood pr

7 ein kinases triggers the rapid production of prostaglandins I2 and E2 through cyclooxygenase (COX)-1

8 Prostaglandin E2, prostaglandin I2, and leukotriene C4 are produced by cPL

9 e endothelium of the antithrombotic mediator prostaglandin I2 as a result of inhibition of endothelia

10 production of the counteracting eicosanoids prostaglandin I2, E1, E2, and A2, while in HRGEC only mo

11 vo effects of pharmacological agonism of the prostaglandin I2 (IP) receptor in pancreatic beta-cells

12 of sacrifice revealed significantly elevated prostaglandin I2 levels in the transgenic animals, coupl

13 Prostaglandin I2 levels were elevated 2.15-fold in RIE-R

14 A2 receptors but not anti-inflammatory EP2, prostaglandin I2, or EP3 receptors.

15 f 6-keto-PGF1alpha, the stable metabolite of prostaglandin I2 (PGI2) and thromboxane B2 (TXB2), the s

16 dered resistant to activation by exposure to prostaglandin I2 (PGI2) or forskolin, both of which incr

17 , it remains unknown whether prostacyclin or prostaglandin I2 (PGI2) plays a significant role in modu

18 Transgene expression and prostaglandin I2 (PGI2) synthesis by the injured arterie

19 so observed enhanced autocrine production of prostaglandin I2 (PGI2, also called prostacyclin) in Cav

20 Prostacyclin (prostaglandin I2 [PGI2]) is a key mediator of pulmonary

21 1 receptor, correlating with an increase in prostaglandin I2 production.

22 X-2 expression correlated with inhibition of prostaglandin I2 production.

23 Increased pulmonary production of prostaglandin I2 (prostacyclin) by lung-specific overexp

24 phenotype, including depressed production of prostaglandin I2 (prostacyclin).

25 showed reduced, but not absent, formation of prostaglandin I2 (prostacyclin; control 956 +/- 422 pg/m

26 P4 prostaglandin E2 (PGE2) receptors and the prostaglandin I2 receptor were changed in these cells by

27 xane A2 receptor, prostaglandin D2 receptor, prostaglandin I2 receptor, and one of the PGE2 (EP1) rec

28 ceptor (TP) (11) while sparing EP2, EP3, and prostaglandin I2 receptors (IPs); Kb values (in nanomole

29 s determined by experiments with inhibitors [prostaglandin I2, staurosporine, wortmannin, the endothe

30 ds: prostaglandin E2, prostaglandin F2alpha, prostaglandin I2, thromboxane A2, and prostaglandin D2.

31 I2, E1, E2, and A2, while in HRGEC only more prostaglandin I2 was detected.

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