ライフサイエンスコーパス: prostaglandin-endoperoxide synthase

1 n G2 by the cyclooxygenase (COX) activity of prostaglandin endoperoxide synthases.

2 nic acid substrate was also not available to prostaglandin endoperoxide synthase 1 in the immediate p

3 chanisms of damage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxy

4 se domain mutations, but only a single gene, prostaglandin-endoperoxide synthase 1/cyclooxgenase 1 (P

5 r F2-isoprostanes, is a minor product of the prostaglandin endoperoxide synthase-1 (PG G/H S-1) expre

6 m of action of this drug, we expressed human prostaglandin endoperoxide synthase-1 (PGHS-1) and PGHS-

7 nation of the crystal structure of the ovine prostaglandin endoperoxide synthase-1 (PGHS-1)/S- flurbi

8 orted to inhibit arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and

9 enhanced ovarian expression of PLA(2)G4A and prostaglandin endoperoxide synthase 2 (PTGS2) in wild-ty

10 volves the activation-dependent induction of prostaglandin endoperoxide synthase 2 and the supply of

11 imental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also know

12 teraction) = 0.02) with a genetic variant in prostaglandin-endoperoxide synthase 2 (PTGS2) (rs1204276

13 Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key r

14 s that constitutively express high levels of prostaglandin-endoperoxide synthase 2 (Ptgs2, also known

15 es a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxyge

16 ionship between levels of MIC1 and levels of prostaglandin-endoperoxide synthase 2 expression (PTGS2

17 ted Myd88(-/-) (TLR signaling-deficient) and prostaglandin-endoperoxide synthase 2(-/-) (Ptgs2(-/-))

18 of transfected A549 cells showed that PTGS2 (prostaglandin-endoperoxide synthase 2) was one of the hi

19 TGS2 (also known as COX2), the gene encoding prostaglandin-endoperoxide synthase 2, allowing activate

20 Alternatively, celecoxib, an inhibitor of prostaglandin-endoperoxide synthase 2, reduced polyp num

21 The gene expressions of prostaglandin-endoperoxide synthase 2, tissue inhibitor

22 al hypoperfusion increases the expression of prostaglandin endoperoxide synthase-2 (PGHS-2) in ovine

23 The prostaglandin endoperoxide synthase-2 (PGS-2) gene encod

24 sly, we have shown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclo

25 t the cyclooxygenase-2 (COX-2, also known as prostaglandin endoperoxide synthase-2) signaling cascade

26 Site-directed mutants of prostaglandin-endoperoxide synthase-2 (PGHS-2) with chan

27 Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2)

28 rleukin-8, toll-like receptor 4, cryropyrin, prostaglandin-endoperoxide synthase-2, and heparinase ge

29 din E(2) (PGE(2)) and its processing enzyme, prostaglandin-endoperoxide-synthase-2/ cyclooxygenase-2

30 One common target for these drugs is prostaglandin endoperoxide synthase, also referred to as

31 with its primary mode of action in mammals (prostaglandin-endoperoxide synthases) but modulated gene

32 ase activities of constitutive and inducible prostaglandin endoperoxide synthases by serving as a sub

33 s as a neuroendocrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox

34 duction of prostaglandin G/H synthase (PGHS; prostaglandin endoperoxide synthase, cyclooxygenase) by

35 repressed the mRNA and protein expression of prostaglandin endoperoxide synthase/cyclooxygenase-2 (CO

36 Cyclooxygenase (COX), also referred to as prostaglandin endoperoxide synthase, is the rate-limitin

37 Reaction of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hy

38 thout affecting the levels of NO synthase or prostaglandin endoperoxide synthase or by inhibiting the

39 (PG) D2 through utilization of constitutive prostaglandin endoperoxide synthase (PGHS) -1 and induce

40 dal antiinflammatory agents (NSAIDs) bind to prostaglandin endoperoxide synthase (PGHS) and induce a

41 Prostaglandin endoperoxide synthase (PGHS) is a heme pro

42 Prostaglandin H(2) synthesis by prostaglandin endoperoxide synthase (PGHS) requires the

43 Prostaglandin endoperoxide synthase (PGHS)-2, the induci

44 gh levels of nitric oxide synthase (NOS) and prostaglandin endoperoxide synthase (PGHS).

45 apid as well as time-dependent inhibitors of prostaglandin endoperoxide synthase (PGHS).

46 Ca2+]i) elevation in regulating ET-1-induced prostaglandin endoperoxide synthase, prostaglandin G/H s

47 Prostaglandin endoperoxide synthases (PTGS), commonly re

48 BACKGROUND & AIMS: Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme

49 p-regulation of the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nu

50 umatoid arthritis to inhibit cyclooxygenase (prostaglandin-endoperoxide synthase), thereby decreasing