ライフサイエンスコーパス: prosurvival

1 ss4 (Tss4) possessing anti-inflammatory and prosurvival abilities, as a means for pretransplant gene

2 l-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in v

3 gesting that PcG proteins, consistent with a prosurvival action, may antagonize the action of MG132.

4 vIL-6 are important for proproliferative and prosurvival activities of the viral cytokine in latently

5 ies demonstrate that Dp44mT can overcome the prosurvival activity of autophagy in cancer cells by uti

6 and others have previously demonstrated the prosurvival activity of the PERK pathway in oligodendroc

7 The prosurvival activity of TR3 was due, in part, to formati

8 STAT5A and STAT5B exhibited similar prosurvival activity, but STAT5A attenuation alone was i

9 togenesis, which was evoked by enhanced Mcl1 prosurvival activity.

10 cell MCF7 (P</=0.01), further suggesting its prosurvival activity.

11 g: coadministration of immunosuppressive and prosurvival agents, delivery of cardioprotective factors

12 Mer expression was upregulated, prosurvival Akt and mitogen-activated protein kinase sig

13 king mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking.

14 AFi challenge, and decreased the activity of prosurvival AKT signaling.

15 suppressed GSC growth in part by inhibiting prosurvival AKT/mTOR pathways and stimulating proapoptot

16 ne ventral midbrain, together with its known prosurvival and anti-tumorigenic properties, make it a g

17 y cycle for mitochondrial biogenesis that is prosurvival and counter-inflammatory in sepsis, and desc

18 ative potential with sustained activation of prosurvival and epithelial-mesenchymal transition-signal

19 fied TCTP as a novel mediator of endothelial prosurvival and growth signaling in PAH, possibly contri

20 Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory signaling.

21 Ikzf2 and Tnfrsf9; (iii) consistent with its prosurvival and metabolic role in the liver, Nr4a1 is al

22 Because the balance of prosurvival and proapoptosis signals determines the fate

23 lts in the control of genes clustered around prosurvival and proapoptotic functions among others.

24 More than two dozen prosurvival and progrowth kinases dock a conserved pepti

25 In an attempt to diminish their off-target prosurvival and proinflammatory effects and specific del

26 t mechanisms and exhibits kinase-independent prosurvival and proinflammatory functions.

27 ansition, expressions of NF-kappaB-regulated prosurvival and proinflammatory genes, and in vivo radio

28 c serine/threonine kinase that promotes many prosurvival and proinflammatory signaling pathways, incl

29 as6, a Mer ligand, we observed activation of prosurvival and proliferative signaling pathways, includ

30 ate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes co

31 biologically significant mechanism of vIL-6 prosurvival and proreplication activities via VKORC1v2.

32 e various cytokines to promote angiogenesis, prosurvival, and antiapoptotic effects.

33 t of disc disease must spare osmoprotective, prosurvival, and matrix homeostatic activities.

34 We postulate that immobilization of the prosurvival angiopoietin-1-derived peptide, QHREDGS, to

35 pathways to inhibit apoptosis and stimulate prosurvival autophagy, which was dependent on TSC2/AMPK-

36 glycolytic inhibitor 2-deoxyglucose induced prosurvival autophagy.

37 Our work suggests that prosurvival Bcl proteins normally dampen the beta-cell r

38 translation, CR can reduce expression of the prosurvival Bcl-2 family member Mcl-1 and sensitize lymp

39 Besides the well-known reduction of the prosurvival Bcl-2 family member, Mcl-1, following inhibi

40 epended on NOXA-mediated displacement of the prosurvival BCL-2 family member, MCL-1, from beclin 1, w

41 have identified the essential roles of most prosurvival Bcl-2 family members in normal physiology an

42 hen Bax and Bak were present, inhibiting the prosurvival Bcl-2 family members stimulated autophagy, b

43 eins and closely mimics the structure of the prosurvival Bcl-2 family protein Mcl-1.

44 revealed collectively high protein levels of prosurvival Bcl-2 members in cell lines and a panel of M

45 ulatory elements commonly found in mammalian prosurvival Bcl-2 members including Bcl-xL and Mcl-1.

46 K(+)(+)DUSP6(-)) and repressed expression of prosurvival Bcl-2 molecules.

47 Myeloid cell leukemia 1 (MCL-1) is a prosurvival BCL-2 protein family member highly expressed

48 bicin from down-regulating the levels of the prosurvival Bcl-2 protein family member Mcl-1.

49 he conserved Bcl-2 fold observed in cellular prosurvival Bcl-2 proteins and closely mimics the struct

50 The prosurvival BCL-2 proteins are attractive yet challengin

51 All 6 human prosurvival Bcl-2 proteins can drive cancer development

52 lineal acute leukemia because of the role of prosurvival BCL-2 proteins in resistance, their imbalanc

53 blish that concurrent inhibition of multiple prosurvival Bcl-2 proteins leads to effective induction

54 t, targeting the ubiquitination machinery of prosurvival Bcl-2 proteins will complement and potential

55 ve cellular interaction profile of all human prosurvival Bcl-2 proteins with all their proapoptotic r

56 olecular strategies including the mimicry of prosurvival Bcl-2 proteins.

57 x activity is controlled in healthy cells by prosurvival Bcl-2 proteins.

58 s inhibition by short-term overexpression of prosurvival BCL-XL, known to block BIM and BMF, is not o

59 ow that the alternative splicing of multiple prosurvival BCL2 family genes promotes malignant transfo

60 suggest that the combinatorial inhibition of prosurvival BCL2 family proteins and BCR-ABL may elimina

61 on, and we define a biochemical cascade from prosurvival Bcl2 family regulators to Caspase-9, then Ca

62 functional TCRbeta gene (Vbeta1(NT)) or the prosurvival BCL2 protein inhibited death and partially r

63 not a preassembled DbetaJbeta complex or the prosurvival BCL2 protein, completely rescues alphabeta T

64 , which then serves as (auto-) antigen for a prosurvival BCR signal.

65 toxic effects of trastuzumab were owing to a prosurvival benefit of Her2 that binds to neuregulin, wh

66 e level of the mitochondria through a common prosurvival binding groove.

67 re, autophagy induction by antiestrogens was prosurvival but did not prevent ERalpha knockdown-mediat

68 ains of ubiquitin, enabling it to serve in a prosurvival capacity.

69 Therefore, TAK1 orchestrates a prosurvival checkpoint in DCs that affects the homeostas

70 d suggest that RhoH plays a critical role in prosurvival CLL cell-cell and cell-microenvironment inte

71 Yet the nature of potential prosurvival cues has remained unclear.

72 ctions are jointly influenced by Fas and the prosurvival cytokine IL-5.

73 This signaling results in secretion of prosurvival cytokines, such as interferon-gamma-inducibl

74 ressed predominantly IgG, and they carried a prosurvival, distinctly mature phenotype, that is, HLA-D

75 est that p10 (protein of 10 kDa) is a unique prosurvival domain in p35, essential for normal CDK5/p35

76 unlike SLPC, CD28 activation in LLPC induces prosurvival downstream Vav signaling.

77 f STAT3 at tyrosine 705 was required for the prosurvival effect because an R26-Stat3(Y705F) allele wa

78 hosphorylation of Akt and suggested that the prosurvival effect can be produced by a cell-autonomous

79 Although S1P possesses a prosurvival effect in beta-cells, an enhanced level of t

80 This was consistent with the loss of CD28's prosurvival effect in LLPC from CD28-AYAA, but not CD28-

81 both promote efferocytosis and override the prosurvival effect of LPS via annexin A1.

82 The prosurvival effect of shPHD2 on ADSCs is hypoxia-inducib

83 The prosurvival effect of Slug was found to be caused by dir

84 NF-kappaB pathway only played a role in the prosurvival effect of TNFR1.

85 NF, which is necessary for the NMDA-mediated prosurvival effect on neurons.

86 This prosurvival effect was attributed to downregulation of F

87 This prosurvival effect was attributed to the MIF-CXCR7-initi

88 ssed nT(reg) generation independently of its prosurvival effect.

89 buted to the CpG motif-mediated, TLR-induced prosurvival effects and inefficient target modulation in

90 tion 3 (STAT3) is perhaps best known for its prosurvival effects in a wide variety of cancers, but fo

91 ein Hspb8, which, because of its pleiotropic prosurvival effects in other systems, was considered a p

92 o promote tumorigenesis, in part because the prosurvival effects of Akt offset the proapoptotic effec

93 incipal mechanism by which Hunk mediates the prosurvival effects of Akt.

94 erventions with compounds that stimulate the prosurvival effects of autophagy in the vasculature.

95 osis in MM cell lines which can overcome the prosurvival effects of growth factors such as interleuki

96 he Bcl-2 antagonist ABT-199 only reduced the prosurvival effects of HCMV in target monocytes beginnin

97 bling responsiveness of naive T cells to the prosurvival effects of IL-7 and allowing T-cell persiste

98 Whereas bevacizumab failed to inhibit prosurvival effects of VEGFR2-mediated signaling, GSC vi

99 op novel therapeutic approaches based on its prosurvival effects.

100 Shc signaling downstream from TrkB promotes prosurvival effects.

101 um-binding chaperone in the ER; GRP78/BiP, a prosurvival ER chaperone; and Nrf2, a transcription fact

102 ient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin ly

103 alpha-deficient B cells still respond to the prosurvival factor BAFF in culture and require BAFF-R si

104 d Stat5 phosphorylation and induction of the prosurvival factor Bcl-2 and the gut homing integrin alp

105 ured by IL-7, which drives expression of the prosurvival factor Bcl-2.

106 In conclusion, we demonstrate that ABA is a prosurvival factor for Mks in a Tpo-independent manner.

107 These results identify APOBEC3G as a prosurvival factor in lymphoma cells, marking APOBEC3G a

108 a-crystallin domain might act as pleiotropic prosurvival factor in the adult hippocampus.

109 ls is the stabilization of the mitochondrial prosurvival factor Mcl-1, an SCF(Fbw7beta) target in neu

110 sults indicate that Mcl-1 acts as a critical prosurvival factor that protects against apoptosis and a

111 , is also implicated in several cancers as a prosurvival factor.

112 d that NFAT5 regulated the expression of the prosurvival factors A1 and Bcl2 and attenuated the proap

113 red a unique molecular signature enriched in prosurvival factors and tumor suppressors, as well as in

114 th and chemoresistance via downregulation of prosurvival factors Bcl-2 and Bcl-XL that support NF-kap

115 Prosurvival factors of the Bcl-2 family, such as Bcl-xL,

116 as Pd1 and Tim3, and decreased expression of prosurvival factors, including Il7ra.

117 MSC proliferation and production of soluble prosurvival factors, such as CXCL12.

118 y may regulate HSC homeostasis through these prosurvival factors.

119 e not suppressed by transgenic expression of prosurvival factors.

120 st apoptosis during prolonged CS/REW by the "prosurvival" factors XIAP and pAkt.

121 romised either by misregulated expression of prosurvival family members or, more frequently, by damag

122 )-a negative regulator of both Rheb and Bcl2 prosurvival family members-as a key downstream target of

123 a key role in autophagy; evidence suggests a prosurvival function for autophagy, but other studies pr

124 Together, our findings establish a prosurvival function for Hunk in tumorigenesis, define a

125 BZ-treated CTCL cells, indicating TGF-beta1 prosurvival function in CTCL cells.

126 uced 100-fold after DNA damage and exerts a prosurvival function in human colorectal cancer cells (C

127 These data identify RnR activity as a prosurvival function inactivated by proteolysis during a

128 Our findings uncover a critical prosurvival function of a p53/PINCR/Matrin 3 axis in res

129 Here, we provide evidence for a novel prosurvival function of Bim in cancer cells.

130 The prosurvival function of IKK centers on activation of the

131 The prosurvival function of the antiapoptotic Bcl-2 proteins

132 In agreement with its prosurvival function, IGF1R inhibition affected the phos

133 based inhibition motifs are required for its prosurvival function.

134 d oxidative stress points to gamma-tubulin-2 prosurvival function.

135 However, the majority of the prosurvival functions of hUTC-conditioned media was spar

136 n-inhibiting cochaperones exerting essential prosurvival functions.

137 ction and spread, some viruses have co-opted prosurvival genes from the host.

138 tor, which was vital for normal induction of prosurvival genes, suppression of proapoptotic genes, nu

139 and promote the expression of progrowth and prosurvival genes.

140 For example, interference of the prosurvival IGF-I/AKT/FOXO3 pathway by redox activation

141 rinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.

142 In contrast, intact GSN (I-GSN) was prosurvival in the presence of CDDP through a FLICE-like

143 atic islet, IL-6 stimulates secretion of the prosurvival incretin hormone glucagon-like peptide 1 (GL

144 Furthermore, inactivation of the prosurvival kinase Akt is a key step in its neurotoxic s

145 These microRNAs activated prosurvival kinases and induced a glycolytic switch in r

146 Once in the cytoskeleton, GBP1 binds to prosurvival kinases such as PIM1 and initiates a signali

147 in the ER compartment.IMPORTANCE HHV-8 vIL-6 prosurvival (latent) and proreplication functions are me

148 PRC2 subunit genes and several prosurvival lymphoma genes were unmethylated and overexp

149 propose p-IRAK-4 as a novel inflammation and prosurvival marker in melanoma with the potential to ser

150 Abundant, sustained expression of prosurvival Mcl-1 is an important determinant of viabili

151 ese results describe a novel, bidirectional, prosurvival mechanism between AML blasts and BM-MSCs.

152 ing LC3 expression; autophagy functions as a prosurvival mechanism to mitigate SAHA-induced apoptotic

153 ndings elucidate YAP binding to dendrin as a prosurvival mechanism.

154 THBS1 and MANF degradation and loss of this prosurvival mechanism.

155 cating that these responses are triggered as prosurvival mechanisms that enable cells to tolerate the

156 stically, ATM mediates crosstalk between the prosurvival MEK/ERK and AKT/mTOR pathways.

157 his process is regulated by proapoptotic and prosurvival members of the B-cell lymphoma 2 (Bcl-2) pro

158 ed by interactions between pro-apoptotic and prosurvival members of the Bcl-2 family.

159 up-regulation of Mcl1 and Bcl2a1, which are prosurvival members of the Bcl-2 family.

160 exocytosis and sustained phosphorylation of prosurvival, metabolic pathways.

161 's effects on caspase-9 activity promote the prosurvival mode.

162 tutively overexpressed Bim may function as a prosurvival molecule in epithelial cancer cells, and pho

163 s, suggesting that MCL-1 may be an essential prosurvival molecule.

164 The upregulated expression of prosurvival molecules in turn inhibited target cell dest

165 vival and NF-kappaB-mediated upregulation of prosurvival molecules is a well-documented protective me

166 for these disorders, and (iii) indicate that prosurvival molecules whose expression is increased in m

167 rgistically promoted the expression of these prosurvival molecules, preventing cellular apoptosis at

168 reasing the translation of proliferative and prosurvival mRNAs.

169 Prosurvival NF-kappaB pathway activation characterized h

170 function was the result of activation of the prosurvival NF-kappaB pathway, which was mediated by RET

171 ta production by repressing IRF7 and amplify prosurvival NF-kappaB signaling by transactivating CARD1

172 B cells by prolonging their residency in the prosurvival niche of peripheral lymphoid organs.

173 ere with the ability of trastuzumab to block prosurvival p-Akt signaling.

174 ha-helical structure and bind to a groove on prosurvival partners Bcl-xL, Bcl-w, Bcl-2, Mcl-1 and Bfl

175 n of these receptors blocks the Akt/GSK3beta prosurvival pathway and activates the apoptotic cascade,

176 ortant Traf2-mediated, NFkappaB-independent, prosurvival pathway in the heart by suppressing necropto

177 oreover, we detected a similarly functioning prosurvival pathway involving phosphorylated CD19 and PI

178 ERK pathway, which frames the conundrum of a prosurvival pathway that kills cells.

179 Proteome analyses revealed a defective prosurvival pathway via PI3K/protein kinase B (Akt1)/Bcl

180 ical utility of agents targeted against this prosurvival pathway.

181 nmutational mechanisms of resistance such as prosurvival pathways and bone marrow signaling may be up

182 RNA target genes are co-regulated members of prosurvival pathways associated with cellular regenerati

183 This in turn down-regulates prosurvival pathways like NF-kappaB, leading to inhibiti

184 at are known to interfere with intracellular prosurvival pathways retained their ability to induce ce

185 een attributed to Akt-induced stimulation of prosurvival pathways that indirectly antagonize the effe

186 tic breast cancer model cell lines inhibited prosurvival pathways, shifted the balance of Bcl-2 famil

187 unique MEK5/ERK5, p90Rsk, and Akt-dependent prosurvival pathways, ultimately leading to enhanced exp

188 and chemokine receptors, which could mediate prosurvival pathways.

189 ncies, leading to constitutive activation of prosurvival pathways.

190 n this study, we present an integrin-binding prosurvival peptide derived from angiopoietin-1, QHREDGS

191 transcription factor Twist1 may explain this prosurvival phenotype in vitro.

192 In contrast, the prosurvival phenotype of patient cells was resistant to

193 hed that FAK inactivation served to unmask a prosurvival phosphoinositide 3-kinase/AKT-dependent sign

194 tor(s) and integrins during induction of the prosurvival PI3K-AKT pathway by heparanase.

195 eby greatly augmenting signaling through the prosurvival PI3K/Akt pathway.

196 T can arise from increased expression of the prosurvival Pim protein kinases.

197 veolar neutrophils display a distinct primed prosurvival profile and transcriptional signature.

198 bility to exhibit both antiproliferative and prosurvival properties by facilitating translation of mR

199 hese results support the notion that HuR has prosurvival properties in PDA cells by enabling them wit

200 Prosurvival protein BCL-2 is overexpressed in estrogen r

201 FKBP38 is a regulator of the prosurvival protein Bcl-2, but in the absence of detaile

202 Our results identify MCL-1 as a critical prosurvival protein for preventing beta-cell death and c

203 Here, we report that the fowlpox virus prosurvival protein FPV039 promiscuously binds to cellul

204 horylation and results in rapid loss of this prosurvival protein in chemoresistant cancer cells.

205 One such viral prosurvival protein is the fowlpox virus protein FPV039,

206 t UPEC abrogates activation of the host cell prosurvival protein kinase B signaling pathway, which re

207 his signal is essential for the induction of prosurvival protein Mcl-1 and precursor cell survival.

208 ulted in rapidly decreased expression of the prosurvival protein Mcl-1, and accordingly, overexpressi

209 tosis was preceded by down-regulation of the prosurvival protein Mcl-1, with proteasomal inhibition p

210 resulting in selective downregulation of the prosurvival protein MCL1.

211 s to demonstrate that GrB cleaves ITSN-1s, a prosurvival protein of lung ECs, and generates two biolo

212 eam, Trib3 interferes with the PD-associated prosurvival protein Parkin to mediate death.

213 protein 4 (BRD4)-dependent expression of the prosurvival protein survivin (BIRC5) and attenuation of

214 at Trib3 physically interacts with Parkin, a prosurvival protein whose loss of function is associated

215 protein, and 22 peptides bound at least one prosurvival protein with a dissociation constant between

216 em and D443rVem, increased activation of the prosurvival protein, AKT, and the MAPKs, ERK, JNK, and P

217 ed evidence of interaction with at least one prosurvival protein, and 22 peptides bound at least one

218 Bcl-2, a prosurvival protein, regulates programmed cell death dur

219 ncreased apoptosis through downregulation of prosurvival proteins Bcl-2 and Mcl-1.

220 37, a BH3 mimetic compound that inhibits the prosurvival proteins Bcl-2, Bcl-x(L), and Bcl-w resulted

221 We observed up-regulation of prosurvival proteins Bcl-xL and Mcl-1, which sequester B

222 ides for interaction with one or more of the prosurvival proteins Bcl-xL, Bcl-w, Bcl-2, Mcl-1 and Bfl

223 hondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability

224 AT3-dependent mRNA and protein expression of prosurvival proteins in the selectively vulnerable CA1.

225 l-2 can mediate interactions between Bax and prosurvival proteins inside the membrane in the absence

226 We investigated the importance of the prosurvival proteins myeloid cell leukemia-1 (MCL-1) and

227 P) increases proliferation and expression of prosurvival proteins relative to BMCs expressing green f

228 therapeutic potential of directly inhibiting prosurvival proteins was unveiled with the development o

229 This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward th

230 odulation, intracellular signaling pathways, prosurvival proteins, and the tumor microenvironment.

231 of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the proc

232 apoptosis resistance induced by the upstream prosurvival proteins.

233 karyocytes, suggesting redundancy with other prosurvival proteins.

234 m the BIM protein, which inactivates all its prosurvival relatives.

235 ated in mutant BRAF melanoma as an adaptive, prosurvival response to FDA-approved RAF inhibitors.

236 he one hand, autophagy might be induced as a prosurvival response to therapy, thereby reducing treatm

237 s required for key roles in phagocytosis and prosurvival responses of macrophages.

238 , and CCL20 expression) without compromising prosurvival responses.

239 ind RAIDD or activate caspase-2, and engages prosurvival RIP1 instead.

240 Our study unveiled an unexpected prosurvival role for RUNX1 in myeloid leukemogenesis.

241 ate degradation of AML1-ETO but rather has a prosurvival role in AML cells, as inhibition of autophag

242 This prosurvival role of BAP1 depends on its de-ubiquitinatin

243 The prosurvival role of enhanced Stat3 activity was validate

244 a cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons.

245 ssed whether cAMP signaling converges on the prosurvival role of MEF2D in Sprague Dawley rat embryoni

246 neuronal cell death and also antagonizes the prosurvival role of MEF2D.

247 ymocytes and as a downstream effector of the prosurvival role of the pre-T-cell receptor.

248 Critical prosurvival roles for inhibitor of NF-kappaB kinase (IKK

249 nction of p53 metabolic genes, others reveal prosurvival roles of those targets in both tumor and nor

250 c-Abl plays both proapoptotic and prosurvival roles, and our findings suggest that c-Abl's

251 Caspase-8 has both prodeath and prosurvival roles, mediating apoptosis and/or preventing

252 We show that ERAS expression elicits a prosurvival signal associated with phosphorylation/inact

253 Thus, LGP2 promotes an essential prosurvival signal in response to antigen stimulation to

254 F-alpha secretion which, in turn, provided a prosurvival signal.

255 NMDAR-mediated, bidirectional regulation of prosurvival signaling (i.e. the cAMP response element-bi

256 Prosurvival signaling activates Pin1, a peptidyl-prolyl

257 TRAF1, a prosurvival signaling adaptor required for 4-1BB-mediate

258 ous factor that controls the balance between prosurvival signaling and apoptosis in hepatocytes in AP

259 or-1 (IGF-1), which activates IGF-1 receptor prosurvival signaling and improves cardiac left ventricu

260 n NMDAR-mediated bidirectional regulation of prosurvival signaling and neuronal death.

261 longevity results from a balance between the prosurvival signaling and the toxicity of superoxide.

262 TBK1 reportedly mediates prosurvival signaling by activating NF-kappaB and AKT.

263 We specifically found that TRAIL induces prosurvival signaling by increasing the phosphorylation

264 e (Hunk), which serves as an effector of Akt prosurvival signaling by suppressing c-myc expression in

265 end-joining DNA repair pathway and provides prosurvival signaling during DNA damage.

266 VEGF-A or FGF2, attributable to the loss of prosurvival signaling from endogenous VEGF.

267 herapeutic resistance through a compensatory prosurvival signaling mechanism.

268 identified Yes-associated protein (YAP) as a prosurvival signaling molecule, the in vitro silencing o

269 Gal-I levels exhibit increased activation of prosurvival signaling molecules, including pAkt, p-p70S6

270 CK1alpha suppression inhibits the NF-kappaB prosurvival signaling pathway.

271 and the ability to induce both apoptotic and prosurvival signaling pathways has suggested that TRAIL

272 Although NF-kappaB initiates prosurvival signaling pathways post-IR, the molecular fu

273 f extracellular glutamate and an increase of prosurvival signaling pathways.

274 ecent studies link KLF4 and KLF5 to adaptive prosurvival signaling responses induced by HER2-targeted

275 2A or GluN2B attenuated the up-regulation of prosurvival signaling triggered by the activation of eit

276 luN2B also attenuated the down-regulation of prosurvival signaling triggered by the coactivation of s

277 sis in breast cancer cells but also elicited prosurvival signaling via an EGF receptor/phosphoinositi

278 esponse to oxidative stress, which activates prosurvival signaling via regulation of gene expression

279 nhanced EPC proliferation, angiogenesis, and prosurvival signaling while inhibiting EPC senescence.

280 In addition to deactivation of prosurvival signaling, cetuximab-mediated EGFR targeting

281 her, these data indicate that in addition to prosurvival signaling, insulin action in early life medi

282 Janus kinase 1 supported a role for IL-10 in prosurvival signaling.

283 n FADD-mediated cell death and IL-5-mediated prosurvival signaling.

284 fate by participating in either prodeath or prosurvival signaling.

285 ut may also initiate transcription-dependent prosurvival signaling.

286 rutinib to dually target BTK to suppress its prosurvival signaling.

287 nd EGFR/EGFRvIII suppressed their downstream prosurvival signaling.

288 mplex 2 (mTORC2), resulting in activation of prosurvival signaling.

289 CD8 T cell immunity in the mucosa when other prosurvival signals are limiting.

290 se results indicate that BPTF transduces key prosurvival signals driven by MITF, further supporting i

291 -145, antagonizes BCR crosslinking activated prosurvival signals in primary CLL cells.

292 we show that integrin alphavbeta3 transduces prosurvival signals into TCL nuclei, suggesting a novel

293 que effectors of K-Ras4B that antagonize the prosurvival signals of other K-Ras effectors.

294 ignals, we show that GSK3 inhibition induces prosurvival signals through increased activity of the au

295 These cells provide prosurvival signals to tumors; however, little is known

296 he cellular balance between proapoptotic and prosurvival sphingolipids.

297 XBP1 mRNA, which is ligated to code for the prosurvival transcription factor.

298 in immunoregulatory proteins is modulated by prosurvival transcription factors, such as NFkappaB and

299 stine, epithelial HuR promotes expression of prosurvival transcripts that support Wnt-dependent tumor

300 of transcriptionally active ATF6, improving prosurvival UPR function in striatal neurons.