1 tly, how the phenotypic features could be so
protean.
2 ights into the still enigmatic phenomenon of
protean agonism and a rationale for the design of such c
3 y the concepts of functional selectivity and
protean agonism and begin to define the first postrecept
4 ents within dualsteric compounds that elicit
protean agonism at the muscarinic M2 acetylcholine recep
5 In addition,
protean agonism is described, whereby a ligand produces
6 gand binding may be the mechanism underlying
protean agonism of dualsteric ligands.
7 r, may represent a novel approach to achieve
protean agonism.
8 ne the first postreceptor step in actions of
protean agonist ligands.
9 gonist at the 5-HT3A receptor, it becomes a "
protean agonist" (functioning as an agonist and an inver
10 nsistent with the former's designation as a "
protean"
agonist.
11 ant interest both in inverse agonists and in
protean agonists (i.e., compounds with functional select
12 Protean agonists are of great pharmacological interest a
13 e and inverse agonists on the same receptor (
protean agonists), and differ in the stimulus pattern th
14 w appreciation that lymphoid progenitors are
protean and able to alter their differentiation potentia
15 sions of corneal immunoglobulin deposits are
protean and present a diagnostic challenge.
16 Inverse,
protean,
and ligand-selective agonism: matters of recept
17 iggers of vasovagal syncope are likely to be
protean,
and many potential central and peripheral trigg
18 delayed due to its infrequent occurrence and
protean appearances.
19 e upon TA binding, generating a fluctuating "
protean clamp" that stably traps the substrate.
20 Coeliac disease (CD), due to its
protean clinical manifestation, is still very under diag
21 ndrome is difficult, however, because of the
protean clinical manifestations and associations, limita
22 a fascinating and perplexing infection, with
protean clinical manifestations and both diagnostic and
23 Given the
protean clinical manifestations and the lack of a consen
24 Protean clinical manifestations characterize this disord
25 hey are often considered rare disorders with
protean clinical manifestations, considerable advances i
26 bital inflammatory syndrome (IOIS), may have
protean clinical manifestations.
27 The
protean clinical presentation requires individualized tr
28 IgG4-related disease is a
protean condition that mimics many malignant, infectious
29 levels of analysis are required to probe the
protean consequences of early-life adversity on the deve
30 HCMV has evolved
protean countermeasures for anti-HCMV cellular immunity
31 odel system for characterizing the elusively
protean cross-beta conformation.
32 TGF-beta is long considered a "
protean"
cytokine in cancer, changing its role from anti
33 se symptoms are nonspecific, subjective, and
protean,
diagnosis of drug-induced lupus (DIL) requires
34 h the pathogenesis and the treatment of this
protean disorder.
35 ve in similar subsets of patients with other
protean disorders.
36 , a nonreceptor protein tyrosine kinase with
protean downstream influences on cell cycle regulation,
37 Finally, given the rapid and
protean effects of statins on determinants of platelet r
38 oxygen species, signaling pathways that have
protean effects on smooth muscle cell physiology.
39 WIST2 mutations cause AMS or BSS by inducing
protean effects on the transcription factor's DNA bindin
40 ct) and cardiac fibrosis, the prototypic but
protean features of HCM histopathology, are presumed tri
41 Symptoms are
protean (
flushing, sweating, diarrhea, bronchospasm), us
42 ies, including pathologic data, has led to a
protean handling of IS in LT.
43 e, yet the clinical manifestations are often
protean in nature and the etiology, elusive.
44 linical manifestations of celiac disease are
protean in nature and vary markedly with the age of the
45 The clinical manifestations of CD are
protean in nature and vary markedly with the age of the
46 management of the multiple, progressive, and
protean lesions associated with the disorder.
47 rst century's challenges to human being with
protean manifestation affecting nearly all organs of our
48 It has
protean manifestations and can affect any organ, includi
49 Thus, this important liver disease has
protean manifestations but is often insidious and can le
50 celiac disease, add to our knowledge of the
protean manifestations of MBP.
51 In addition, the multiorgan
protean manifestations of mycoplasma infection are discu
52 Assertions about "
protean manifestations" of B burgdorferi infection shoul
53 The various presentations,
protean manifestations, variable natural history, and at
54 he complexity of this molecular disease with
protean manifestations.
55 isease) is often said to be associated with "
protean"
manifestations, a reference to the ancient god
56 (HCMV) infection, but the virus has evolved
protean mechanisms to inhibit MHC-based Ag presentation
57 The essay concludes with observations on the
protean nature of physical organic chemistry.
58 The
protean nature of speech and language disorders requires
59 Given the
protean nature of the clinical presentation of celiac di
60 payment structures are equipped to meet the
protean needs of this important population of children.
61 herpesviruses, EBV and VZV produce the most
protean neurological syndromes.
62 and a specific diagnosis for a disease with
protean nonspecific findings.
63 In addition to
protean roles in embryonic development, germ-line specif
64 In this study we review the
protean roles of glutamine in cancer, both in the direct
65 in nonhematopoietic cells and dissecting the
protean roles of STAT3 is limited by the lethality assoc
66 We propose that balanol is a
protean structure that may be modified to produce select
67 osed precisely because of their scarcity and
protean symptoms.
68 APFs result in a
protean syndrome variously combining portal hypertension
69 wn as "the internist's tumor" because it has
protean systemic manifestations, suggesting that it util
70 Because these interactions are
protean,
there can be no health without mental health.