ライフサイエンスコーパス: protease

1 leupeptin plus E64 (inhibitors of lysosomal proteases).

2 proteins predicts robust degradation by the protease.

3 n a light-inducible split tobacco etch virus protease.

4 a small protein with high affinity for DENV protease.

5 ct with the invariant catalytic triad of the protease.

6 denotes a tandem cleavage site for the viral protease.

7 C-terminal 77 amino acids of the light chain protease.

8 being removed subsequently using PreScission protease.

9 ous enzymatic activity of Tobacco Etch Virus Protease.

10 however, its removal is mediated by the same protease.

11 interaction of Mpa with the proteasome core protease.

12 we report that PSY is a substrate of the Clp protease.

13 cleavage sites within the catalytic cleft of protease.

14 pecific substrates from an adaptor-dependent protease.

15 otease homologous to other allosteric serine proteases.

16 ed to be cleaved by intracellular macrophage proteases.

17 ent for inhibitors to control the initiating proteases.

18 le by multiple mitochondrial quality control proteases.

19 regulate the proteolytic activity of serine proteases.

20 roteases and inhibition of arginine-specific proteases.

21 inhibits its interaction with SUMO-specific protease 1 (SENP1), which in turn inhibits SENP1-mediate

22 granulation (increased serum mouse mast cell protease 1), increased serum IgG1 anti-EW and IgE levels

23 nnose-binding lectin (MBL)-associated serine protease-1 (MASP-1) and MASP-3 contain zymogenic FD (pro

24 3 by mannan-binding lectin-associated serine protease-2 bound to LP-activation complexes captured on

25 ific mannan-binding lectin-associated serine protease-2.

26 pected diversity in the genes encoding viral proteases (2A(pro)) that help these viruses achieve anti

27 we establish that Toxoplasma gondii aspartyl protease 3 (ASP3) resides in the endosomal-like compartm

28 total of 38 Gag residues correlated with the protease, 32 of which were outside Gag cleavage sites.

29 Among them, the ubiquitin-specific protease 36 (USP36) has been implicated in the regulatio

30 Remarkably, the viral protease 3C directly targets GSDMD and induces its cleav

31 xample, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degradation of the onco

32 on of eIF4G alone by the human rhinovirus 2A protease abrogated this translation strategy.

33 rmeability induced by the thrombin receptor, protease activated receptor 1 (PAR1).

34 Cysteine and serine proteases function via protease-activated and mas-related G-protein-coupled rec

35 ow provide evidence that C4a is a ligand for protease-activated receptor (PAR)1 and PAR4.

36 d receptor 4 in human podocytes, and between protease-activated receptor 1 and protease-activated rec

37 g proinflammatory cytokine secretion through protease-activated receptor 2 (PAR2).

38 Protease-activated receptor 2 activates airway apical me

39 ed injury depended upon interactions between protease-activated receptor 3 and protease-activated rec

40 ns between protease-activated receptor 3 and protease-activated receptor 4 in human podocytes, and be

41 nd between protease-activated receptor 1 and protease-activated receptor 4 in rat podocytes.

42 ncreased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted i

43 ing Gbeta1) in murine megakaryocytes reduced protease-activated receptor 4, activating peptide-induce

44 synthetic peptides and pepducins to describe protease-activated receptor PAR1 and PAR4 signaling.

45 Inhibition of protease-activated receptor-4 (PAR-4), but not PAR-2, bl

46 Protease-activated receptors (PARs) can activate HSCs th

47 f other GPCRs, such as the ADP receptors and protease-activated receptors, can also potentiate CLEC-2

48 ad no effect on the Ca(2+) signals evoked by protease-activated receptors, heterologously expressed m

49 r, C1q targets at these nucleoli to cause C1 protease activation and the cleavage of many nucleolar p

50 y in actinomycetes, exhibits both lipase and protease activities, is secreted into macrophages, and c

51 tural amino acids can be used to investigate protease activities/specificities for peptides containin

52 In vivo, EspL cysteine protease activity contributes to persistent colonization

53 Protease activity of Per a 10 favours Th2 responses by d

54 The protease activity of separase is strictly regulated by t

55 as well as deneddylation, facilitated by the protease activity of the CSN (COP9 signalosome), are req

56 Cathepsin K gene expression and protein and protease activity were detected in LAM-associated fibrob

57 d after FLG knockdown included inflammation, protease activity, cell structure, and stress.

58 uces its cleavage, which is dependent on the protease activity.

59 uctural homology modeling predicts that this protease adopts a fold and a catalytic site characterist

60 rgo reciprocal proteolytic conversion to the proteases alphaFXIIa and alpha-kallikrein by a process c

61 is associated with remarkable expansions of protease and cell wall gene families, while divergent in

62 s of the foot-and-mouth disease virus leader protease and coronavirus PLPs, which act as deubiquitina

63 trienzyme treatment combining alpha-amylase, protease and gamma-carboxy peptidase allowing complete s

64 veals a novel biological role for a rhomboid protease and highlights new avenues for defining mechani

65 Matriptase-2 (MT2) is a protease and key suppressor of hepatic hepcidin expressi

66 show that TMPRSS13 is a glycosylated, active protease and that its own proteolytic activity mediates

67 on of specialists correlated with phylogeny, protease and trichomes.

68 inhibitor of hepatitis C virus (HCV) NS3/4A protease and was developed for treating chronic HCV infe

69 ocyte damage indicated activation of caspase proteases and inhibition of arginine-specific proteases.

70 kinase, triggers egress, activating malarial proteases and other effectors.

71 ecificity of the assay with respect to other proteases and proteins granted the measurement of thromb

72 AAA+ proteases and remodeling machines couple hydrolysis of A

73 mass spectrometry after digestion with three proteases and sequencing de novo defined the complete pr

74 by expression of heat shock protein 60, Clp protease, and Lon peptidase 1.

75 tidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity.

76 ernal stressors, including organic solvents, proteases, and ethylene oxide gas sterilization.

77 ecretion of 40 proteins including cytokines, proteases, and other inflammation agonists as well as 14

78 related cysteine protease cathepsins, other proteases, and receptors.

79 Dau c 1 was incubated with endolysosomal proteases, and the resulting fragments were identified b

80 In this study, we explored the diversity of protease- and IgG subclass-restricted AHAs and their pot

81 sses-serine, cysteine, aspartyl, and metallo-proteases-and develop a discriminatory scoring function

82 Very few proteases are able to withstand such harsh conditions, w

83 is crucial for protein homeostasis, and ClpP proteases are conserved between eubacteria and the organ

84 Although serine proteases are found ubiquitously in both eukaryotes and

85 The caspase family of cysteine proteases are highly sought-after drug targets owing to

86 he ADAM (adisintegrin and metalloproteinase) proteases are involved in ectodomain cleavage of transme

87 proteins, including perforins, adhesins, and proteases, are extensively proteolytically processed bot

88 Our data identify Gag-protease as a major determinant of subtype differences i

89 s a novel role for a secreted staphylococcal protease as a requirement for the development of a biofi

90 gen challenge, whereas mice sensitized using proteases as adjuvants developed predominantly eosinophi

91 Proteins are targeted to the protease at the center of this system, the proteasome, b

92 n autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membr

93 Proteomic analysis reveals that two proteases belonging to the calpain family (SmCalp1 and S

94 rate-enzyme complexes for each of five model proteases belonging to the four major protease mechanist

95 prime side also significantly modulates DENV protease binding affinity, as revealed by engineering th

96 inding states, and for two highly homologous proteases, calpain-1 and calpain-2.

97 sly added proteinase K, suggesting that this protease can access the DTM occupied by a small PEX5 pro

98 mice and in vitro suggests that coagulation proteases can directly cleave complement proteins.

99 icity would also aid in the design of custom proteases capable of selectively and controllably cleavi

100 e IL-1beta in the extracellular space by the protease caspase-1.

101 hway is normally halted by the pro-apoptotic protease caspase-8 and the IAP ubiquitin ligases, how an

102 The secretion of IL-1beta requires a unique protease, caspase-1, which is activated by various prote

103 We identified the activity of the lysosomal protease cathepsin B in macrophages as a rate-limiting f

104 sm involving the derepression of the lysomal protease cathepsin B.

105 oma viral oncogene homolog 1 (AKT1), and the protease cathepsin H (CTSH), for which we establish a ro

106 ith high selectivity versus related cysteine protease cathepsins, other proteases, and receptors.

107 Here, we examine the effect of the protease-cleavable valine-citrulline [VC(S)] linker on A

108 g length, termed Proteomic Identification of protease Cleavage Sites (PICS).

109 n donor exhibited restricted specificity for protease-cleaved F(ab')2 fragments and did not bind the

110 Our previous studies showed that HIV protease cleaves the host protein procaspase 8 to genera

111 Here, we report that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP-AMP

112 ed in the absence of the Bre5-Ubp3 ubiquitin protease complex.

113 orm of predatory behaviour in a community of protease-containing coacervate microdroplets and protein

114 Such defects result in protease deficiency in lysosomes and impaired lysosomal

115 they were slowly degraded by the periplasmic protease DegP.

116 rapeutic strategies aimed at inhibiting this protease-dependent cleavage of Akt may prove beneficial

117 We conclude that serine proteases derived from commensal bacteria can directly i

118 We used chronoamperometry to measure protease-digested GA samples.

119 developed sensor strips were able to measure protease-digested samples containing GA in very small sa

120 et al. (2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving th

121 nical model entails a C1r2s2 with its serine protease domains tightly packed together in the center o

122 is essential for HIV-1 replication, and Gag-protease-driven replication capacity has previously been

123 were found to have a significantly lower Gag-protease-driven replication capacity than that of viruse

124 To determine the impact of Gag-protease-driven viral replication capacity on mother-to-

125 isms to fine-tune the activity of a cysteine protease dubbed RD21 (RESPONSIVE TO DESICCATION-21).

126 ency between Gag structural proteins and the protease during the development of resistance of HIV-1 t

127 ty of EspL defines a family of T3SS cysteine protease effectors found in a range of bacteria and reve

128 Proteases enzymatically hydrolyze peptide bonds in subst

129 ion (ADPL), to serine hydrolase and cysteine protease enzymes enables quantification of differential

130 Characterizing the substrate specificity of protease enzymes is critical for illuminating the molecu

131 ure-based approach is generalizable to other protease enzymes with known or modeled structures, and c

132 s and suggest a general strategy for mapping protease exosite interactions.

133 s are known to play a key role in regulating protease expression in cancer.

134 The impact of galectin-3 and protease expression on S. aureus virulence was studied i

135 fferentiation and inhibitor concentration on protease expression.

136 d preproteins conjugated with the artificial protease FeBABE and cysteine-cysteine cross-linking.

137 The recognition motifs for these processing proteases, first published more than 10 years ago, inclu

138 ombinant viruses encoding plasma-derived Gag-protease from 53 nontransmitter mothers, 48 transmitter

139 An aspartic protease from Salpichroa origanifolia fruits was success

140 ication of a neurotoxin precursor processing protease from the venom of the spider Cupiennius salei T

141 Cysteine and serine proteases function via protease-activated and mas-relate

142 Modulation of flap opening through protease-Gag interactions fine-tunes the lifetime of the

143 in rice by combining Brassica napus cysteine-protease gene (BnCysP1) with anther-specific P12 promote

144 e substrates that are efficiently cleaved by proteases gives insights into substrate recognition and

145 Although trypsin-like serine proteases have flexible surface-exposed loops and are kn

146 ered by exploiting allosterism in plasmin, a protease homologous to other allosteric serine proteases

147 ing TGFbeta1 signalling through the secreted protease HTRA1.

148 data support the clinical relevance of this protease in human influenza pathogenesis.

149 , we confirm the biochemical activity of the protease in propeptide removal from neurotoxin precursor

150 mitochondrial membrane AAA+ quality control protease in yeast, YME1.

151 l flexibility of uPA and trypsin-like serine proteases in general.

152 th, and negative regulation of extracellular proteases in late stage regeneration.

153 escribes a novel role for Giardia's cysteine proteases in pathogenesis and how Giardia's disruptions

154 determine whether generation of coagulation proteases in vivo can activate the complement cascade in

155 ave various types of self-compartmentalizing proteases; in addition to the proteasome itself, these i

156 ndergoes sequential degradation by different proteases, including cathepsin S (CatS) and the intramem

157 id proteolysis of apelin-derived peptides by proteases, including neprilysin (NEP).

158 TLR ligands, but not proteases, induced TNF during allergic sensitization.

159 ribution of CXCL10 to the described cytokine/protease inflammatory loop associated with disease outco

160 SBT propeptides with respect to its mode of protease inhibition.

161 omly assigned to receive a ritonavir-boosted protease inhibitor (lopinavir 400 mg with ritonavir 100

162 enofovir disoproxil fumarate (TDF) without a protease inhibitor (PI) (0.18 [interquartile range {IQR}

163 rmation) were randomly assigned to a boosted protease inhibitor (standardised to ritonavir-boosted lo

164 The function of serine protease inhibitor 2A (Spi2A) was studied in mouse TH2 c

165 n stored baseline samples in patients in the protease inhibitor and NRTI group and calculated the pre

166 s studied in mouse TH2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 genes were

167 servational Study of the Consequences of the Protease Inhibitor Era) cohort, a clinic-based cohort of

168 biquitously-expressed member of the cysteine protease inhibitor family that is present at notably hig

169 tage antiplasmodial activity of the aspartic protease inhibitor hydroxyl-ethyl-amine-based scaffold c

170 e testing); or with raltegravir; or alone as protease inhibitor monotherapy (discontinued after week

171 otease inhibitor plus raltegravir group), or protease inhibitor monotherapy (plus raltegravir inducti

172 sified to combination therapy after week 96; protease inhibitor monotherapy group).

173 In the protease inhibitor monotherapy group, 292 (78%) of 375 h

174 s than 400 copies per mL; p=0.003 versus the protease inhibitor plus NRTI group at 144 weeks.

175 alysis at 144 weeks, 317 (86%) of 367 in the protease inhibitor plus NRTI group had viral loads of le

176 plus two or three clinician-selected NRTIs (protease inhibitor plus NRTI group), protease inhibitor

177 r plus raltegravir offered no advantage over protease inhibitor plus NRTI in virological efficacy or

178 NRTIs (protease inhibitor plus NRTI group), protease inhibitor plus raltegravir (400 mg twice per da

179 per mL compared with 312 (81%) of 383 in the protease inhibitor plus raltegravir group (p=0.07; lower

180 itor plus raltegravir (400 mg twice per day; protease inhibitor plus raltegravir group), or protease

181 INTERPRETATION: Protease inhibitor plus raltegravir offered no advantage

182 ption offers any advantage over the standard protease inhibitor plus two nucleoside reverse-transcrip

183 reduced use of expensive second-line boosted protease inhibitor regimens, this policy option is also

184 a-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT deficie

185 and velpatasvir plus the pangenotypic NS3/4A protease inhibitor voxilaprevir (sofosbuvir-velpatasvir-

186 TMPRSS2, but Zhou et al. found that a serine protease inhibitor was more protective than a cathepsin

187 A regimen of protease inhibitor with NRTIs remains the best standardi

188 way and alpha1-antitrypsin protein (a serine protease inhibitor) expression and downregulation of neu

189 ng minimally discussed, including vicilin, a protease inhibitor, and a flavonol synthase/flavanone 3-

190 alities similar to that seen with a cysteine protease inhibitor, E-64 (I-1).

191 amide versus continuing a regimen of boosted protease inhibitor, emtricitabine, and tenofovir disopro

192 ight not accurately predict NRTI activity in protease inhibitor-based second-line ART.

193 adhesion molecule, and HAI-2, a cell surface protease inhibitor.

194 e peptide from the alpha1-antitrypsin serine protease inhibitor.

195 cleoside polymerase-inhibitor (GS-9669) or a protease-inhibitor (GS-9451) and after 12 weeks with sof

196 ral therapy (ART) based on ritonavir-boosted protease inhibitors (bPIs) represents the only available

197 iptase Inhibitors (EFV) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucle

198 HIV-1 protease inhibitors are crucial for treatment of HIV-1/A

199 The enriched protease inhibitors CER-based protein extract resulted i

200 assessed in the presence/absence of specific protease inhibitors.

201 proving the resistance profile of HCV NS3/4A protease inhibitors.

202 xperimental results suggesting that NS5A- or protease-inhibitors can generate non-infectious virus, w

203 reover, specific APP isoforms contain Kunitz protease-inhibitory domains, which regulate the proteoly

204 of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory processes,

205 upiennius salei The chymotrypsin-like serine protease is a 28-kDa heterodimer with optimum activity a

206 The AAA+ Lon protease is conserved from bacteria to humans, performs

207 Gag-protease is essential for HIV-1 replication, and Gag-pro

208 However, how this protease is post-translationally regulated remains uncle

209 The protease is required to select specific substrates for d

210 Production of secreted proteases is stimulated by secreted signals that convey

211 pin A12 of the serpin family, and its target protease kallikrein 7 (KLK7) are heparin-binding protein

212 A secreted cysteine protease known as streptococcal pyrogenic exotoxin B (Sp

213 is aminopeptidase N (APN), a multifunctional protease known to cleave biologically active peptides an

214 njugation through manipulating specific SUMO protease levels.

215 s specifically degraded by the mitochondrial protease Lon.

216 ease, these findings suggest that intestinal proteases may enhance NanI activity, which in turn could

217 approaches using mice deficient in mast cell protease (MCPT) 4, the mouse functional homologue of hum

218 model proteases belonging to the four major protease mechanistic classes-serine, cysteine, aspartyl,

219 as a novel therapeutic strategy to activate protease-mediated degradation of extracellular matrix an

220 red and sufficient for protection against V8 protease-mediated integrity damage, and exogenous applic

221 We show that the cold protease method provides a great reduction in gene expre

222 , comparing the results of the psychrophilic protease method with procedures using 37 degrees C incub

223 S. sanguinis strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/c

224 R, EGFRvIII, and abrogated gains in secreted proteases, MMP-2 and MMP-9, following radiation.

225 Determination of preferential protease motifs during podocyte damage indicated activat

226 Infant-derived Gag-protease NL4-3 recombinant viruses (n = 41) were found t

227 nders against infection, express four serine proteases (NSPs) that play roles in the control of cell-

228 ntimicrobial peptides, and neutrophil serine proteases (NSPs).

229 very of new chemical matter for this pivotal protease of the complement system: in silico active site

230 ve towards thrombin than to the other serine proteases of the coagulation cascade.

231 nhibit C1s, MASP1, and MASP2, the activating proteases of the complement cascade.

232 S. aureus toxins and virulence proteases often circulate in host blood vessels leading

233 gh activity for the bacterial outer-membrane protease (OmpT).

234 and regulate vaspin interaction with target proteases or other proteins and may play an important ro

235 n this study, we reveal the role of the SUMO protease, OsOTS1 in mediating tolerance to drought in ri

236 s (GAS) and subsequent hPg activation to the protease plasmin generate a proteolytic surface that GAS

237 acid identity to torovirus (ToV) papain-like protease (PLP) (ToV-PLP).

238 little is known about the role of bacterial proteases, possibly released in the bloodstream during i

239 strong hydrogen-bond-interactions with HIV-1 protease (PR) active-site amino acids and is bulkier wit

240 Using the dimeric protease (Pr) from Kaposi's sarcoma-associated herpesvir

241 olytic system comprising the periplasmic PDZ-protease Prc and the lipoprotein adaptor NlpI contribute

242 Furthermore, the protease Prd1, misannotated as intermembrane space prote

243 ion also encode a sequence-specific cysteine protease, Prp, which carries out this cleavage.

244 In addition, we demonstrated that this protease rapidly hydrolyzes Staphylococcus aureus protei

245 cells depends on endosomal acid pH-dependent proteases rather than on the cell surface acid pH-indepe

246 lts establish connections between chirality, protease resistance, cellular penetration, and intracell

247 slocated to target cells into heterogeneous, protease-resistant, antibody-inaccessible compartments.

248 TACE is a major shedding protease, responsible for the liberation of the inflamma

249 HAs specifically recognize IgG subclass- and protease-restricted hinge neoepitopes.

250 Here we show that the inactive rhomboid protease RHBDF2 (iRHOM2) regulates thickening of the foo

251 sequence for the inhibition of the cysteine proteases rhodesain of Trypanosoma brucei rhodesiense an

252 ate, directing it toward the flat, symmetric protease ring.

253 Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION F

254 ion of subtilisin (50 nm to 2 mum), a serine protease secreted by the non-pathogenic bacterium Bacill

255 omponent that is sensitive to digestion with proteases (senPrP(Sc)) and to a lesser extent the resist

256 tion, which was reversed by sentrin-specific proteases (SENPs) 1, 2, and 5.

257 The heat-stable protease Ser2 is secreted by the species Serratia liquef

258 he androgen-regulated TMPRSS2 (transmembrane protease, serine 2) gene to the open reading frame of ER

259 e prevalence of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with the erythroblast

260 ing cathepsin S (CatS) and the intramembrane protease signal peptide peptidase-like 2a (SPPL2a).

261 volution under the pressure of PIs using Gag-protease single genome sequencing and coevolution analys

262 ed and primary keratinocytes, that S. aureus protease SspA/V8 is the dominant secreted factor (in lab

263 umulation of proteins that represent genuine protease substrates) from secondary effects (proteins ov

264 Here, we present how the broad-specificity protease subtilisin enables mapping of previously hidden

265 to encoding housekeeping genes as well as a protease subunit (clpP)-like and acetyl-CoA carboxylase

266 ered to physically interact with various Clp protease subunits (i.e., ClpS1, ClpC1, and ClpD).

267 Knockout mutants of genes for protease subunits are of limited value, due to their oft

268 ory granules, including mast cell-restricted proteases such as tryptase.

269 on allows them to be modified to incorporate protease susceptibility and biological-recognition motif

270 mass of M. charruana contains a trypsin-like protease that can generate peptides from casein that hav

271 e (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (AP

272 gene encoding cathepsin S (Ctss), a cysteine protease that cleaves invariant chains and produces anti

273 cessive amounts of Dipeptidyl peptidase-4, a protease that is a target of diabetes therapies.

274 metalloproteinases (MMPs) are extracellular proteases that can cleave extracellular matrix and alter

275 es, which are sometimes covalently linked to proteases that cleave signaling proteins.

276 age of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C

277 nd sufficient to target the substrate to the protease through recognition of a short phenylalanine-ri

278 the cell surface acid pH-independent serine protease TMPRSS2, but Zhou et al. found that a serine pr

279 a3 protector protein is degraded by cellular proteases to generate infectious subviral particles (ISV

280 oV) S protein requires cleavage by host cell proteases to mediate virus-cell and cell-cell fusion.

281 ed mixture of 2 recombinant gluten-targeting proteases, to reduce mucosal morphometric measures in bi

282 l retromer toward the soma and thus enhances protease transport to lysosomes, thereby restoring lysos

283 lasmic autophagic vacuoles and activation of proteases (trypsin, chymotrypsin).

284 a member of the type II transmembrane serine protease (TTSP) family.

285 le is known about the different roles of IgA protease variants in NTHi infection.

286 N-termini of several proteases were downregulated in prt6, including RD21A.

287 -assisted continuous evolution (PACE) of TEV protease, which canonically cleaves ENLYFQS, to cleave a

288 /T, collagenase NB1, and thermolysin/neutral protease, which was significantly enhanced in the presen

289 -40-mer length range are rapidly degraded by proteases, which may limit their biomedical utility.

290 kably, the switch is shared with proteasomal proteases, which we identify as evolutionary and structu

291 ial to selectively perturb interactions with proteases while preserving interactions with other prote

292 ion Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in activated

293 Calpains are ubiquitous pro-inflammatory proteases, whose activity is controlled by calpastatin,

294 This insertion encodes a predicted protease with 54 to 68% amino acid identity to torovirus

295 Factor D is a trypsin-like serine protease with a narrow specificity for arginine in the P

296 Our studies show that mast cells release a protease with chymotrypsin-like cleavage specificity in

297 Thus CAPN14 is a unique protease with distinct tissue-specific expression and fu

298 e describe a dissociation method that uses a protease with high activity in the cold, purified from a

299 ctions together with the AAA+ HslU; the ClpP protease with its partner AAA+ ClpX; and Anbu, a recentl

300 Deubiquitinases are proteases with a wide functional diversity that profound