ライフサイエンスコーパス: protease-activated receptor 2

1 nduces A549 IL-8 secretion via activation of protease-activated receptor 2.

2 against transforming growth factor beta1 and protease-activated receptor 2.

3 ates nociceptors to induce visceral pain via protease-activated receptor-2.

4 ic nociceptors, which required expression of protease-activated receptor-2.

5 Protease-activated receptor 2 activates airway apical me

6 SLIGRL, the protease-activated receptor 2 activating peptide, enhanc

7 Here we show that modulation of protease-activated receptor 2 activation affects melanos

8 Inhibition of protease-activated receptor 2 activation by synthetic se

9 The use of RWJ-50353 to modulate protease-activated receptor 2 activation could lead to a

10 We also provide molecular evidence that protease-activated receptor 2 activation followed by PI3

11 ected protective mechanisms, mediated by the protease activated receptor 2 and heat shock protein 70,

12 sm that was dependent upon the activation of protease activated receptor-2 and adenosine triphosphate

13 Der p1 activates protease-activated receptor 2 and induces the release of

14 nization of the skin could be blocked by the protease-activated receptor 2 antagonist ENMD-1068.

15 -activated receptor is distinct from that of protease-activated receptor-2, because the response to t

16 inhibitor and Bowman-Birk inhibitor inhibit protease-activated receptor 2 cleavage, affect cytoskele

17 also exhibited a dose-dependent increase in protease-activated receptor-2 cleavage activity.

18 s)-coupled receptor Taar1, respectively, and protease-activated receptor-2 could negatively regulate

19 ficantly reduced in STAT6-deficient, but not protease-activated receptor 2-deficient mice.

20 The mechanism involved epithelial protease-activated receptor-2-dependent production of le

21 tors on skin pigmentation and found that the protease-activated receptor 2, expressed on keratinocyte

22 The protease-activated receptor 2, expressed on keratinocyte

23 d human keratinocytes showed upregulation in protease-activated receptor 2 expression as determined b

24 We show that protease-activated receptor 2 expression in human skin i

25 In nonirradiated skin, protease-activated receptor 2 expression was confined to

26 iated skin 24 and 96 h after irradiation and protease-activated receptor 2 expression was detected us

27 After ultraviolet irradiation protease-activated receptor 2 expression was observed in

28 h skin type I showed delayed upregulation of protease-activated receptor 2 expression, however, compa

29 type 2 innate lymphoid cells, which required protease-activated receptor-2 expression.

30 e dependent on subtilisin protease activity, protease-activated receptor-2, IL-33R ST2, and MyD88 sig

31 These results suggest an important role for protease-activated receptor-2 in pigmentation in vivo.

32 onse to activation of the B-cell receptor or protease-activated receptor 2, intracellular dialysis wi

33 Previous studies have shown that the protease-activated receptor 2 is involved in skin pigmen

34 imental arthritis model was not dependent on protease-activated receptor-2, it was dependent on the c

35 ydroxytryptamine [5-HT]), histamine, SLIGRL (protease-activated receptors 2/mas-related G-protein-cou

36 Although in vitro studies suggest protease-activated receptor 2 may be a substrate for TMP

37 se the response to trypsin was unaffected by protease-activated receptor-2 overexpression or knockdow

38 her protease activated receptor-1 (PAR-1) or protease activated receptor-2 (PAR-2) alone did not affe

39 her protease activated receptor-1 (PAR-1) or protease activated receptor-2 (PAR-2) on nonhematopoieti

40 We studied the role of protease-activated receptor 2 (PAR(2)) and its activatin

41 erated during injury and inflammation cleave protease-activated receptor 2 (PAR(2)) on primary sensor

42 Protease-activated receptor 2 (PAR(2)), a receptor for i

43 ubiquitinates the G protein-coupled receptor protease-activated receptor 2 (PAR(2)), which is require

44 The E3 ligase c-Cbl ubiquitinates protease-activated receptor 2 (PAR(2)), which is require

45 n the mechanisms that terminate signaling by protease-activated receptor 2 (PAR(2)), which mediated t

46 st the hypothesis that in vivo activation of protease-activated receptor 2 (PAR-2) in humans would me

47 Protease-activated receptor 2 (PAR-2), a receptor for tr

48 ptase released from these cells can activate protease-activated receptor 2 (PAR-2), which was recentl

49 neutrophils, T lymphocytes, mast cells, and protease-activated receptor 2 (PAR-2).

50 tivation of two Galpha(q)-coupled receptors, protease-activated receptor-2 (PAR(2)) and neurokinin-1

51 Proteases that cleave protease-activated receptor-2 (PAR(2)) at Arg(36) downwa

52 Protease-activated receptor-2 (PAR(2)) is a G-protein co

53 Protease-activated receptor-2 (PAR(2)) is one of four pr

54 Protease-activated receptor-2 (PAR-2) is a G-protein-cou

55 Protease-activated receptor-2 (PAR-2) is activated by tr

56 Protease-activated receptor-2 (PAR-2) mediates pro-infla

57 Evidence is growing that protease-activated receptor-2 (PAR-2) plays a key role i

58 The G protein-coupled receptor protease-activated receptor-2 (PAR-2) plays a key role i

59 tumor and developmental angiogenesis through protease-activated receptor-2 (PAR-2) signaling.

60 re we show that a serine protease acting via protease-activated receptor-2 (PAR-2) stimulates the dev

61 Protease-activated receptor-2 (PAR-2), a Galpha(q/11)-co

62 We have reported previously that protease-activated receptor-2 (PAR-2), a proinflammatory

63 rthermore, matriptase elicited signaling via protease-activated receptor-2 (PAR-2), and promoted fibr

64 ombosis and activates cell signaling through protease-activated receptor-2 (PAR-2).

65 include serotonin (5-HT) and agonists of the protease-activated receptor-2 (PAR-2).

66 activated by trypsin-like proteases, termed protease-activated receptor-2 (PAR-2).

67 odels, we identified the interaction between protease-activated receptor 2 (PAR2) and serine protease

68 Protease-activated receptor 2 (PAR2) and single-chain ur

69 A protease-activated receptor 2 (PAR2) antagonist and PAR2

70 lation, and the EPCR-dependent activation of protease-activated receptor 2 (PAR2) by the ternary TF-V

71 Protease-activated receptor 2 (PAR2) is a G protein-coup

72 Protease-activated receptor 2 (PAR2) is expressed by vas

73 which regulates liver TICs through the CTSS/protease-activated receptor 2 (PAR2) loop.

74 rated during inflammation and disease cleave protease-activated receptor 2 (PAR2) on afferent nerves

75 hypothesized that mast cell tryptase cleaves protease-activated receptor 2 (PAR2) on colonocytes to i

76 leased during inflammation and injury cleave protease-activated receptor 2 (PAR2) on primary afferent

77 ses (mast cell tryptase and trypsins) cleave protease-activated receptor 2 (PAR2) on spinal afferent

78 The G-protein-coupled protease-activated receptor 2 (PAR2) plays an important

79 ger signaling through the G protein-coupled, protease-activated receptor 2 (PAR2) relevant to inflamm

80 Protease-activated receptor 2 (PAR2) signaling and downs

81 d scaffold of coagulation proteases cleaving protease-activated receptor 2 (PAR2) that plays pivotal

82 Neutrophils from aPL-treated mice expressed protease-activated receptor 2 (PAR2), and stimulation of

83 F) conditions induced KLK5 and activated the protease-activated receptor 2 (PAR2), resulting in thymi

84 g proinflammatory cytokine secretion through protease-activated receptor 2 (PAR2).

85 gulation factor VIIa-dependent activation of protease-activated receptor 2 (PAR2).

86 avage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2).

87 y was carried out to determine the effect of protease-activated receptor-2 (PAR2) activation on the p

88 The irreversible proteolytic nature of protease-activated receptor-2 (PAR2) activation suggests

89 in turn cleaved the pericellular substrates protease-activated receptor-2 (PAR2) and pro-urokinase.

90 uch as trypsin and mast cell tryptase cleave protease-activated receptor-2 (PAR2) at R(36) downward a

91 This study sought to evaluate the role of protease-activated receptor-2 (PAR2) in coxsackievirus B

92 Protease-activated receptor-2 (PAR2) is a 7-transmembran

93 Protease-activated receptor-2 (PAR2) is an emerging new

94 at degrades elastic fibers and activates the protease-activated receptor-2 (PAR2) on endothelial cell

95 Protease-activated receptor-2 (PAR2) traffics to lysosom

96 Protease-activated receptor-2 (PAR2), a cell surface rec

97 on of beta2-adrenergic receptor (beta2AR) or Protease-activated-receptor-2 (PAR2) results in relief f

98 keratinocyte-melanocyte interactions via the protease-activated receptor 2 pathway affects melanosome

99 These results imply that inhibition of the protease-activated receptor 2 pathway by soymilk may be

100 agents that could exert their effect via the protease-activated receptor 2 pathway.

101 regulate PKA activity in cardiomyocytes via protease-activated receptor 2 proteolysis.

102 Differences in protease-activated receptor 2 regulation in type I skin

103 onditions induced kallikrein 5 and activated protease-activated receptor 2, resulting in thymic strom

104 Furthermore, we show that protease-activated receptor 2 signaling is involved in m

105 er dysfunction, itch, and dermatitis via the protease-activated receptor 2-thymic stromal lymphopoiet