ライフサイエンスコーパス: proteasomal

1 ntified Psmd2, a component of the regulatory proteasomal 19S subunit, as an interaction partner for R

2 ed by a dedicated AAA+ ATPase (Mycobacterium proteasomal AAA+ ATPase; ATPase forming ring-shaped comp

3 Collectively, our data show that proteasomal activation is not limited to hexameric ATPas

4 Recruitment of proteasomal activators depended on the extent of active

5 a transpeptidation reaction catalyzed by the proteasomal active sites.

6 substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption

7 Lowering proteasomal activity by loss-of-function manipulations m

8 n age-dependent decrease in the trypsin-like proteasomal activity in REGgamma-/- mice brains, which m

9 in vitro and in vivo; conversely, enhancing proteasomal activity restored and improved self-renewal

10 ipotency of stem cells also relies on normal proteasomal activity that mitigates senescent phenotypes

11 acid analogues into proteins, inhibition of proteasomal activity, expression of the R120G mutated fo

12 ng immunity, apoptosis, IL-1beta production, proteasomal activity, or wound healing.

13 e core particles and substantially increased proteasomal activity, suggesting that the extended carbo

14 Upon inhibition of proteasomal activity, USP14 levels, expression of presyn

15 pletely rescued muscle mass without changing proteasomal activity.

16 A key component of the system is the proteasomal adenosine triphosphatase (ATPase) Mpa, which

17 sitive virus, TRIM5alpha is degraded by both proteasomal and autophagic degradation pathways.

18 provides a mechanism for Akt to control both proteasomal and autophagic degradation.

19 This response is associated with enhanced proteasomal and autophagic proteolytic pathway activitie

20 muscle mass that was linked to increases in proteasomal and autophagy-lysosomal degradation, accompa

21 Notably, MG132 and EerI (proteasomal and endoplasmic reticulum-associated degrada

22 lbeit in different ways, to mark cargoes for proteasomal and lysosomal degradation.

23 or tyrosine kinase EphB3 by targeting it for proteasomal and lysosomal degradation.

24 stored by COX-2 enzyme inhibitors but not by proteasomal and lysosomal inhibitors.

25 ur work reveals the structure of a bacterial proteasomal ATPase in the hexameric form, and the struct

26 uitin receptors, are engaged and unfolded by proteasomal ATPases, and are processively degraded.

27 is domain, which was only found in bacterial proteasomal ATPases, buries the carboxyl terminus of eac

28 l proteostasis network, including ribosomal, proteasomal, chaperone, and endoplasmic reticulum/mitoch

29 accordingly, these conjugates promote rapid proteasomal clearance of aggregation-prone proteins.

30 essing shows that the T210M exchange affects proteasomal cleavage site usage within the mutgp100201-2

31 S1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alp

32 We found different proteasomal components localized to cilia and identified

33 The expression of ribosomal and proteasomal components was significantly up-regulated in

34 egion to facilitate substrate entry into the proteasomal core.

35 lines, the variant SRY exhibited accelerated proteasomal degradation (relative to wild type) associat

36 ding to BET proteins, resulting in decreased proteasomal degradation and accumulation of these protei

37 Akt-regulated USP14 activity modulates both proteasomal degradation and autophagy through controllin

38 rance pathways in the cardiomyocyte, such as proteasomal degradation and autophagy, has proven to be

39 hosphorylation of Numb leads to its enhanced proteasomal degradation and impaired Numb/p53 pathway, t

40 mulation, possibly because of impaired SNAI1 proteasomal degradation and nuclear translocation, might

41 HR23 proteins involved in proteasomal degradation and proteins involved in nucleoc

42 ecific cellular proteins for sumoylation and proteasomal degradation and provide significant insight

43 horylated by Pho85-Pho80, stimulated the 20S proteasomal degradation and reduced its half-life by 2.6

44 ractions protect CCM2 and CCM3 proteins from proteasomal degradation and show that both CCM2 and CCM3

45 supporting a directional preference in NQO1 proteasomal degradation and the use of ligands binding t

46 Proteasomal degradation appears to be mediated by ubiqui

47 able and is regulated via ubiquitin-mediated proteasomal degradation at the base of outer segments.

48 ons prevent beta-catenin phosphorylation and proteasomal degradation but promote its nuclear accumula

49 onsensus VP motif of ATGL and targets it for proteasomal degradation by K-48 linked polyubiquitinatio

50 on binding a ubiquitin chain, Usp14 enhances proteasomal degradation by stimulating ATP and peptide d

51 It is targeted for proteasomal degradation by the action of a virus-specifi

52 Proteins are typically targeted for proteasomal degradation by the attachment of a polyubiqu

53 However, the light chain evades proteasomal degradation by the dominant effect of a deub

54 ant RPE65 underwent ubiquitination-dependent proteasomal degradation due to misfolding.

55 mmonly used greenFPs can partially withstand proteasomal degradation due to the stability of the FP f

56 line (T-V) capsid mutants, designed to avoid proteasomal degradation during cellular trafficking, wer

57 on the order of FPs in the timer, incomplete proteasomal degradation either shifts the time range of

58 rgo ubiquitination by the E3 ligase Ltn1 and proteasomal degradation facilitated by the ATPase Cdc48.

59 E3 ubiquitin ligase complex and targeted for proteasomal degradation in a VCP/p97-dependent manner, w

60 he only pathway known to target proteins for proteasomal degradation in bacteria is pupylation, which

61 rtive intramolecular bonds that caused rapid proteasomal degradation in cells.

62 tion status to protect Topo IIalpha from the proteasomal degradation in dose- and catalytically depen

63 Mutations that inactivate proteasomal degradation in Mycobacterium tuberculosis re

64 expression, and it does so by blocking HDAC4 proteasomal degradation in osteoblasts.

65 er hand, targets Dcp2 for ubiquitin-mediated proteasomal degradation in the absence of Hedls associat

66 91W RPE65 undergoes ubiquitination-dependent proteasomal degradation in the knock-in mouse RPE due to

67 elial Akt activity is transiently blocked by proteasomal degradation in the presence of SMCs during t

68 e ubiquitinylated, suggesting that ubiquitin-proteasomal degradation is impaired.

69 nts DNA re-replication by targeting CDC6 for proteasomal degradation late in the cell cycle.

70 s a signal to promote its ubiquitination and proteasomal degradation mediated by FBXL20 (an F-box pro

71 by inhibiting host cell transcription and by proteasomal degradation of a major antiviral IFN effecto

72 rganogenesis, accelerated ubiquitin-directed proteasomal degradation of a master transcription factor

73 tingly, LDAH enhances polyubiquitination and proteasomal degradation of adipose triglyceride lipase (

74 necessary and sufficient for CUL5-dependent proteasomal degradation of all members of the B56 family

75 ated nuclear translocation of AR and induced proteasomal degradation of AR and ARV, suppressing the t

76 p2 and Ubp15 prevent hyperubiquitination and proteasomal degradation of ARTs.

77 SIAH proteins promote the ubiquitination and proteasomal degradation of Axin through interacting with

78 SPOP binds to and induces ubiquitination and proteasomal degradation of BET proteins (BRD2, BRD3 and

79 levant mouse model associated with increased proteasomal degradation of BMPRII.

80 N-methyl-D-aspartate receptors promoted the proteasomal degradation of BRCA1.

81 a key factor that facilitates the ubiquitin-proteasomal degradation of c-Myc protein, as knockdown o

82 p42 for the K48-specific ubiquitin-dependent proteasomal degradation of C/EBPalpha p42.

83 fully reversing EA2 mutant-induced excessive proteasomal degradation of CaV2.1 WT subunits.

84 ge event that is independent of the cellular proteasomal degradation of CIDEB.

85 ease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.

86 Arginylation was not required for proteasomal degradation of CRT, although R-CRT displays

87 nd Ubp3 deubiquitinases are required for the proteasomal degradation of cytosolic misfolded proteins

88 duct inhibition, cholesterol accelerates the proteasomal degradation of DHCR7, resulting in decreased

89 E6AP promotes ubiquitination and proteasomal degradation of ECT2 for which high expressio

90 uces PKA phosphorylation, ubiquitination and proteasomal degradation of eENT1.

91 eat shock protein 90 (HSP90) and followed by proteasomal degradation of EZH2 in drug-resistant cells.

92 We demonstrate that polyubiquitination and proteasomal degradation of ezrin and CUGBP1 require Uba6

93 ptide and ester bond ubiquitination regulate proteasomal degradation of hD4R.

94 Under calcification-inducing conditions, proteasomal degradation of HDAC1 precedes VC and it is m

95 anistically, PYK2 inhibition facilitated the proteasomal degradation of HER3 while inducing upregulat

96 in Absentia Homolog1 (SIAH1), which mediates proteasomal degradation of HIPK2, was decreased in the g

97 tor of the Cul4A ubiquitin ligase to trigger proteasomal degradation of HLTF.

98 Proteasomal degradation of HOIP leads to irreversible in

99 his ubiquitin-editing process results in the proteasomal degradation of Imd, which we propose functio

100 quitylation, a process that does not lead to proteasomal degradation of its substrates.

101 of Vpr to MCM10 enhanced ubiquitination and proteasomal degradation of MCM10.

102 out selectively inhibited ubiquitination and proteasomal degradation of MiD49, a mitochondrial recept

103 A or arsenic trioxide synergistically induce proteasomal degradation of mutant NPM1 in AML cell lines

104 rate that gigaxonin is crucial for ubiquitin-proteasomal degradation of neuronal IF.

105 pon induction by phospho-Ser64-Skp2-mediated proteasomal degradation of Nkx3-1, participated in ER tr

106 otein, which mediates the ubiquitination and proteasomal degradation of Nrf2, has a strong protective

107 tion in cancer cells leads to SIRT1-mediated proteasomal degradation of oncogenic transcription facto

108 riggers ubiquitination, internalization, and proteasomal degradation of P-gp.

109 quitin ligase well known for its role in the proteasomal degradation of p53 in human papillomavirus (

110 Here, Mid1 regulates the ubiquitination and proteasomal degradation of Pax6 protein.

111 the 148M variant disrupts ubiquitylation and proteasomal degradation of PNPLA3, resulting in accumula

112 es posttranslational mechanisms that prevent proteasomal degradation of proto-oncogene beta-catenin (

113 stone H4 knockdown cells was associated with proteasomal degradation of RIP1, accumulation of cellula

114 ity was required to promote the K48-mediated proteasomal degradation of Rsp5 HS-induced substrates.

115 rentiation by suppressing the AMPK-dependent proteasomal degradation of Runx2 and promotes bone forma

116 of the virus into the cytoplasm, induce the proteasomal degradation of SAMHD1.

117 the functions of gigaxonin is to facilitate proteasomal degradation of several IF proteins, we sough

118 other species of phytoplasma can trigger the proteasomal degradation of several MADS box transcriptio

119 lphabeta regulatory particle, which enhances proteasomal degradation of small peptides and unfolded p

120 nation of SMN has a mild effect on promoting proteasomal degradation of SMN.

121 of multiple cellular proteins and subsequent proteasomal degradation of some of them, but the detaile

122 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin by interacting with

123 mechanistically by showing that Plk1 induces proteasomal degradation of SUZ12 and ZNF198 by site-spec

124 Ubiquitination-directed proteasomal degradation of synaptic proteins, presumably

125 peat-containing proteins (betaTRCP) mediated proteasomal degradation of TAZ, as well as a correspondi

126 thelial cells lacking PCBP2 exhibit impaired proteasomal degradation of TAZ.

127 A major virulence mechanism is the proteasomal degradation of the antiviral kinase PKR by t

128 s susceptibility in macrophages by promoting proteasomal degradation of the cell survival protein Bcl

129 ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcripti

130 ion led to elevated ubiquitination and rapid proteasomal degradation of the PAX3-FOXO1 chimeric oncop

131 protein, PROTACs promote ubiquitination and proteasomal degradation of the target protein.

132 ently enhanced ubiquitination and subsequent proteasomal degradation of the wild-type CaV1.2 channels

133 ave been described, the mechanism leading to proteasomal degradation of these defective translation p

134 ) E3 ubiquitin ligases leading to subsequent proteasomal degradation of these substrates.

135 Subsequent proteasomal degradation of these transcription factors k

136 F box E3 ligase subunit, thereby alleviating proteasomal degradation of TRF1, leading to a stable ass

137 lized Twist protein expression by preventing proteasomal degradation of Twist by beta-TrCP.

138 ere cyclin F mediates the ubiquitination and proteasomal degradation of Vif through physical interact

139 in complexes into the cytosol, and increased proteasomal degradation of wild-type cavin1 but not muta

140 with KIN10 abrogates this effect by inducing proteasomal degradation of WRI1.

141 se to TGF-beta treatment is mediated via the proteasomal degradation pathway.

142 ual regulation of protein levels through the proteasomal degradation pathway.

143 e we report that tagging Cas9 with ubiquitin-proteasomal degradation signals can facilitate the degra

144 the N-terminal domain (NTD) and accelerating proteasomal degradation through dynamic effects on the C

145 ts the partially synthesized polypeptide for proteasomal degradation through the action of the ubiqui

146 yltransferase, CHROMOMETHYLASE 3 (CMT3), for proteasomal degradation to initiate destabilization of t

147 pVHL (von Hippel-Lindau protein) followed by proteasomal degradation under normal conditions.

148 ation of its triphosphohydrolase activity or proteasomal degradation using specialized, virus-like pa

149 at Nrf2 is regulated at the protein level by proteasomal degradation via Kelch-like ECH-associated pr

150 use its N-terminal tryptophan targets it for proteasomal degradation via the N-end rule pathway.

151 The 20S proteasomal degradation was conserved for human lipin 1

152 in the absence of CaVbeta subunits even when proteasomal degradation was inhibited with MG132 or ubiq

153 , the path from the CUL3 complex to ultimate proteasomal degradation was previously unknown.

154 Proteasomal degradation was quantified by measuring chym

155 SM undergoes cholesterol-dependent proteasomal degradation when cholesterol is in excess.

156 ting the human CaV2.1 subunit from excessive proteasomal degradation with specific interruption of en

157 al isopeptide bond is not a prerequisite for proteasomal degradation, (2) by overcoming trimming at t

158 an antizyme inhibitor, ubiquitin-independent proteasomal degradation, a complex bi-directional membra

159 Formaldehyde selectively depletes BRCA2 via proteasomal degradation, a mechanism of toxicity that af

160 ction, protein aggregate formation, enhanced proteasomal degradation, altered subcellular localizatio

161 MAX2, to target SMXL/D53 family proteins for proteasomal degradation, and genetic data suggest that K

162 nhibition destabilized AR-FL and induced its proteasomal degradation, AR-V7 protein exhibited higher

163 , K301, do not only target podocin/MEC-2 for proteasomal degradation, but may also affect stability a

164 exes that stabilize and protect Lyn from its proteasomal degradation, contributing to toxic Lyn accum

165 eage packaged into virions target SAMHD1 for proteasomal degradation, increase intracellular dNTP poo

166 sor, which targets the HIF-alpha subunit for proteasomal degradation, led to rapid development of hyp

167 ed Parkin in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading t

168 tion, reduce PEX5 abundance by promoting its proteasomal degradation, thereby impairing its functions

169 misfolded collagen X by either autophagy or proteasomal degradation, thereby reducing intracellular

170 eat-induced Rsp5 substrates are destined for proteasomal degradation, whereas other Rsp5 quality cont

171 utophagy inactivation redirects HIF2alpha to proteasomal degradation, whereas proteasome inhibition i

172 fenib down-regulated total FAK, inducing its proteasomal degradation, while Ln-332 and HSC-CM promote

173 in gene transcription coupled with impaired proteasomal degradation, yet this hypothesis remains unt

174 lated A/Archipelago E3 ligase and subsequent proteasomal degradation.

175 ld-type (WT) protein expression via aberrant proteasomal degradation.

176 r 152, enhancing its stability by inhibiting proteasomal degradation.

177 bosomes and targets nascent polypeptides for proteasomal degradation.

178 alpha (HIF1alpha), targeting it for eventual proteasomal degradation.

179 dependent fashion without being targeted for proteasomal degradation.

180 its enzymatic activity and targeting JAK for proteasomal degradation.

181 lycomb repressive complex2 (PRC2), undergoes proteasomal degradation.

182 tinated phosphorylated TFEB, targeting it to proteasomal degradation.

183 ound and target WBP2 for ubiquitin-dependent proteasomal degradation.

184 g the removal of toxic misfolded proteins by proteasomal degradation.

185 minute 2 homolog (Mdm2), which marks p53 for proteasomal degradation.

186 ase that targets CAS for ubiquitin-dependent proteasomal degradation.

187 filament protein Lamin A/C protects RB from proteasomal degradation.

188 by chymotrypsin C before being directed for proteasomal degradation.

189 to protein instability of Xbp1 secondary to proteasomal degradation.

190 ase, leading to RBM39 polyubiquitination and proteasomal degradation.

191 iated Mig6 ubiquitination and the subsequent proteasomal degradation.

192 tination in addition to serving as a tag for proteasomal degradation.

193 SOX9 and prevents it from ubiquitin-mediated proteasomal degradation.

194 innate immune system by targeting STAT2 for proteasomal degradation.

195 rects a variety of substrate fates including proteasomal degradation.

196 amma stability through the inhibition of its proteasomal degradation.

197 ets both IRF3 species for ubiquitination and proteasomal degradation.

198 , involves NFkappaB, and may be regulated by proteasomal degradation.

199 ligase Hrd1 that targets BLIMP-1 protein for proteasomal degradation.

200 sor promyelocytic leukemia protein (PML) for proteasomal degradation.

201 nteraction with Rpn8 C terminus mediates its proteasomal degradation.

202 arget IRF3 for ubiquitination and subsequent proteasomal degradation.

203 is maintained by San1 via ubiquitylation and proteasomal degradation.

204 proteins are then ubiquitinated, followed by proteasomal degradation.

205 -thereby preventing their ubiquitination and proteasomal degradation.

206 and PA polymerase proteins, leading to their proteasomal degradation.

207 alanine protected SNAT2 against LOA-induced proteasomal degradation.

208 CRL4-DCAF1 E3 ligase for ubiquitin-dependent proteasomal degradation.

209 he tertiary stability and directly caused by proteasomal degradation.

210 eta-TrCP) E3-ligase activity in blunting Taz proteasomal degradation.

211 llin-4 ubiquitin ligase to target SAMHD1 for proteasomal degradation.

212 ream events of substrate deglycosylation and proteasomal degradation.

213 tes misfolded ER proteins to the cytosol for proteasomal degradation.

214 ate recruitment, an important step in CYP3A4 proteasomal degradation.

215 DGT catalytic sequence, was resistant to the proteasomal degradation.

216 n of lysines within this site leads to rapid proteasomal degradation.

217 ated regulation of polyamine homeostasis and proteasomal degradation.

218 iques while the protein itself is subject to proteasomal degradation.

219 E3 ligase that targets specific proteins for proteasomal degradation.

220 nd that these proteins are indeed subject to proteasomal degradation.

221 y modified substrates for ubiquitination and proteasomal degradation.

222 uently through processes that do not involve proteasomal degradation.

223 eta-catenin escapes ubiquitylation-dependent proteasomal degradation.

224 nd to SOX9 to inhibit its ubiquitination and proteasomal degradation.

225 b modulates MCL-1 stability by affecting its proteasomal degradation.

226 ligase CRL4(COP1/DET1) that targets Etv5 for proteasomal degradation.

227 HIV-1 Vif protein binds A3H and mediates its proteasomal degradation.

228 bilization of GABARAP, but not LC3B, through proteasomal degradation.

229 is kinase is that it is tightly regulated by proteasomal degradation.

230 -UBX-containing protein UBXN7, for efficient proteasomal degradation.

231 and (c) promoted RelA polyubiquitination and proteasomal degradation.

232 ng the inhibition exerted on alpha-synuclein proteasomal degradation.

233 vels, phosphorylating HSF1 and promoting its proteasomal degradation.

234 hat targets, e.g., the steroid receptors for proteasomal degradation.

235 in normoxia enables arginylation followed by proteasomal degradation.

236 ullin4-associated-factor 1 (DCAF1)-dependent proteasomal degradation.

237 s to the APOBEC3 proteins and leads to their proteasomal degradation.

238 t the transcriptional and mRNA levels and by proteasomal degradation.

239 ediated PARylation marks protein targets for proteasomal degradation.

240 on the CaV2.1 wild-type subunit via aberrant proteasomal degradation.

241 ltransferase Tip60, which targeted Foxp3 for proteasomal degradation.

242 ors (HIFs) for ubiquitination and subsequent proteasomal degradation.

243 iquitination of proteins, targeting them for proteasomal degradation.

244 2 while decreased polyubiquitination and its proteasomal degradation.

245 duces their K48-poly-ubiquitination mediated proteasomal degradation.

246 or macromolecular complexes to enable their proteasomal degradation; however, the complex nature of

247 hat targets the HIF transcription factor for proteasomal degradation; inappropriate expression of HIF

248 dent PPARgamma activation is associated with proteasomal degradation; therefore, regulation of PPARga

249 Ets-1 deubiquitination blocks its proteasomal destruction and enhances tumorigenicity, whi

250 nition, dislocation, and ubiquitin-dependent proteasomal destruction.

251 promotes targeting of the SnRK1 protein for proteasomal destruction.

252 rgets SOX9 for subsequent ubiquitination and proteasomal destruction.

253 ese proteins to target them for lysosomal or proteasomal destruction.

254 complex as an effective inhibitor of the 19S proteasomal DUBs and suggests a potentially new strategy

255 DUB inhibitors, especially the inhibitors of proteasomal DUBs are becoming a research hotspot in targ

256 Therefore, Nrf1 must be cleaved by a non-proteasomal endoprotease that we show requires ubiquitin

257 at the ALS-associated UBQLN4 variant impairs proteasomal function, and identify the Wnt signaling pat

258 Proteasomal inhibition prolonged IRS-2 tyrosine phosphor

259 over, we demonstrate for the first time that proteasomal inhibition restores the apoptosis sensitivit

260 Through global transcriptome analyses, proteasomal inhibition showed conserved overlap in downr

261 induced loss of SNAT2 could be attenuated by proteasomal inhibition, the functional increase in Syste

262 es and increased in the embryos treated with proteasomal inhibitor MG132, in which intact sperm mitoc

263 MG132, a proteasomal inhibitor, rescued PC-1 knockdown-dependent

264 L3 has a rapid turnover and is stabilized by proteasomal inhibitors.

265 ning 21 (TRIM21), which rapidly recruits the proteasomal machinery and triggers induction of immune s

266 h these elements predominantly degraded in a proteasomal manner.

267 Ubiquitinated alpha-synuclein is targeted to proteasomal or lysosomal degradation.

268 16 is polyubiquitinated and degraded via the proteasomal pathway.

269 tion of hTDO through the ubiquitin-dependent proteasomal pathway.

270 1(VI) and alpha3(VI) and are degraded by the proteasomal pathway.

271 lerating STAT3 degradation via the ubiquitin-proteasomal pathway.

272 is can be arrested by blocking lysosomal and proteasomal pathways.

273 nvolved in NFkappaB2 p100 ubiquitination and proteasomal processing to p52, as upregulated.

274 After proteasomal processing, the PRAME300-309 peptide ALYVDSL

275 ted by cullin-RING E3 ligases for subsequent proteasomal processing.

276 ubiquitin ligase, Ube3c/Hul5, which enhances proteasomal processivity.

277 Remarkably, the switch is shared with proteasomal proteases, which we identify as evolutionary

278 a direct link between the lipid droplet and proteasomal protein degradation and suggest that dynamic

279 nverged on ribosomal protein translation and proteasomal protein degradation as critical nononcogene

280 tics of the proteasome and HslV, a classical proteasomal reaction mechanism could be inferred from th

281 rates in the cytoplasm that are destined for proteasomal recycling.

282 nts for cancer, offer mechanistic insight on proteasomal regulation of tumor-associated peptide/HLA a

283 s and examine their roles in stress-mediated proteasomal remodeling.

284 ted CSB and results in an increase of UBXD7, proteasomal RPN2, and Sug1 in the chromatin compartment.

285 We further show that the proteasomal shuttle proteins DDI1 and DDI2 are required

286 omes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

287 not genetically encoded and the rules behind proteasomal splicing are unknown, it is difficult to pre

288 which removes ubiquitin chains en bloc from proteasomal substrates prior to their degradation, requi

289 likely to be important for coordinating the proteasomal subunits during substrate processing.

290 issense variant, L344P, that largely escapes proteasomal surveillance and shows subtle but clear chan

291 Interestingly, degradation via the proteasomal system was not involved in the reduction of

292 subsequent degradation through the ubiquitin proteasomal system, leading to the suppression of cell m

293 urnover and homeostasis are regulated by the proteasomal system, which is critical for cell function

294 aggregates by basal autophagy but not by the proteasomal system.

295 e NRF2 inhibitor KEAP1, resulting in reduced proteasomal turnover of NRF2.

296 complex protects both RB and Lamin A/C from proteasomal turnover.

297 e function of parkin, we have identified the proteasomal ubiquitin receptor Rpn13/ADRM1 as a parkin-i

298 t are consistent with the role of RPN13 as a proteasomal ubiquitin receptor, and have major implicati

299 Here, we found that the five known proteasomal ubiquitin receptors in yeast are collectivel

300 Agrobacterium, which presumably facilitates proteasomal uncoating of the invading T-DNA from its ass