ライフサイエンスコーパス: proteasome system

1 y proteins for destruction via the ubiquitin proteasome system.

2 us, where they are targeted by the ubiquitin-proteasome system.

3 K) protein components of the plant ubiquitin/proteasome system.

4 ly dependent on proteolysis by the ubiquitin-proteasome system.

5 ubiquitinated and degraded via the ubiquitin proteasome system.

6 hat its degradation depends on the ubiquitin-proteasome system.

7 evels are tightly regulated by the ubiquitin-proteasome system.

8 dual control via autophagy and the ubiquitin proteasome system.

9 B family repressor potency and the ubiquitin-proteasome system.

10 10 protein degradation through the ubiquitin-proteasome system.

11 tion of wild type channels via the ubiquitin-proteasome system.

12 nhibited protein processing by the ubiquitin-proteasome system.

13 promoting its degradation via the ubiquitin-proteasome system.

14 r stress response that engages the ubiquitin/proteasome system.

15 atrophic genes and proteins of the ubiquitin proteasome system.

16 egradation is a key feature of the ubiquitin proteasome system.

17 pends on the elaborately regulated ubiquitin proteasome system.

18 ne expression through the ubiquitin-mediated proteasome system.

19 ntrol USP33 degradation within the ubiquitin-proteasome system.

20 ancing its degradation via the K48 ubiquitin-proteasome system.

21 he cytosol for degradation via the ubiquitin-proteasome system.

22 been shown to be regulated by the ubiquitin-proteasome system.

23 is a versatile participant in the ubiquitin-proteasome system.

24 gulate protein degradation via the ubiquitin-proteasome system.

25 odulate the dynamic balance of the ubiquitin-proteasome system.

26 a histolytica harbors an extensive ubiquitin-proteasome system.

27 aling extends to regulation of the ubiquitin-proteasome system.

28 roteins for degradation across the ubiquitin proteasome system.

29 are slated for degradation by the ubiquitin-proteasome system.

30 lated by synaptic activity and the ubiquitin-proteasome system.

31 n, followed by degradation via the ubiquitin proteasome system.

32 ause of reduced degradation by the Ubiquitin-proteasome system.

33 its stability is regulated by the ubiquitin-proteasome system.

34 p60 is turned over in cells by the ubiquitin-proteasome system.

35 ation of ELT-2 protein by the host ubiquitin-proteasome system.

36 n stability to be regulated by the ubiquitin-proteasome system.

37 under conditions that stressed the ubiquitin proteasome system.

38 ibrillar proteins primarily by the ubiquitin proteasome system.

39 otential negative regulator of the ubiquitin-proteasome system.

40 ue to its rapid degradation by the ubiquitin-proteasome system.

41 duced clearance of Htt through the ubiquitin-proteasome system.

42 pha3 precursor was degraded by the ubiquitin-proteasome system.

43 scle protein breakdown through the ubiquitin proteasome system.

44 nce of upregulated NEDD4-1 via the ubiquitin-proteasome system.

45 ntribution of the autophagy/vacuole than the proteasome system.

46 t degradation is controlled by the ubiquitin-proteasome system.

47 nduces VPS4B downregulation by the ubiquitin-proteasome system.

48 to the selective inhibition of the ubiquitin proteasome system.

49 y Spg5 as a novel component of the ubiquitin-proteasome system.

50 consistent with dysfunction of the ubiquitin-proteasome system.

51 via SUMO-dependent control of the ubiquitin-proteasome system.

52 orchestrated by ubiquitination and ubiquitin-proteasome system.

53 of intracellular proteins via the ubiquitin-proteasome system.

54 sociated misfolded proteins by the ubiquitin-proteasome system.

55 e of four PIF proteins through the ubiquitin-proteasome system.

56 erial equivalent of the eukaryotic ubiquitin-proteasome system.

57 an reduce buffering effects in the ubiquitin proteasome system.

58 s is primarily accomplished by the ubiquitin-proteasome system.

59 ysregulation and disruption of the ubiquitin proteasome system.

60 conjugation and degradation by the ubiquitin-proteasome system.

61 priming their degradation via the ubiquitin proteasome system.

62 accelerated titin turnover by the ubiquitin-proteasome system.

63 ot targeted for degradation by the ubiquitin-proteasome system.

64 s directly ubiquitinated and degraded by the proteasome system.

65 nduction of autophagy-lysosome and ubiquitin-proteasome systems.

66 ions between the transcription and ubiquitin-proteasome systems.

67 the cancer cells, which makes the ubiquitin-proteasome system a potential target to enhance the effi

68 Thus, the ubiquitin-proteasome system acts on plastids to control their deve

69 s were efficiently degraded by the ubiquitin proteasome system, an effect reversed by the aldosterone

70 DPPA3 is partially cleaved by the ubiquitin-proteasome system and an N-terminus fragment remains in

71 se of protein breakdown due to the ubiquitin-proteasome system and autophagy activation.

72 xpression of the components of the ubiquitin-proteasome system and autophagy in LLC-bearing mice.

73 transcripts of muscle proteolytic (ubiquitin proteasome system and autophagy lysosomal pathway) and m

74 mediates the crosstalk between the ubiquitin-proteasome system and autophagy through its binding Nt-A

75 neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy).

76 ule includes genes involved in the ubiquitin-proteasome system and contains SCA genes usually associa

77 Molecular processes such as the ubiquitin proteasome system and DNA methylation are also critical

78 diseases and the link between the ubiquitin-proteasome system and neurodegeneration make this concep

79 somal proteins are degraded by the ubiquitin-proteasome system and not by autophagy.

80 normal protein degradation via the Ubiquitin-proteasome system and partially impaired transcriptional

81 tter is performed primarily by the ubiquitin-proteasome system and perhaps autophagy.

82 of hepatic lipid metabolism by the ubiquitin-proteasome system and suggests COP1 as a potential thera

83 HEV replication requires an active ubiquitin-proteasome system and that proteasome inhibitors affect

84 ysosome pathway, although both the ubiquitin-proteasome system and the autophagy-lysosome pathway are

85 , one can study their roles in the ubiquitin proteasome system and the DNA damage response pathway.

86 ate the degradation of SLBP by the ubiquitin proteasome system and the exosome-mediated degradation o

87 ore measured the activation of the ubiquitin-proteasome system and the lysosomal pathway of intracell

88 ional mitophagy pathways involving ubiquitin-proteasome system and the ubiquitin-binding protein disl

89 to STUbL-mediated targeting to the ubiquitin-proteasome system and thereby implicate this pathway in

90 ates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating

91 r biomedical sciences, such as the ubiquitin-proteasome system and various human disease-associated i

92 lving endo-lysosomal vesicles, the ubiquitin-proteasome system, and autophagy-based or endoplasmic re

93 dependent protease calpain and the ubiquitin-proteasome system, and causes attenuation and biophysica

94 ylation is an integral part of the ubiquitin proteasome system, and expression of the small ubiquitin

95 f the efficient degradation by the ubiquitin-proteasome system, and in response to hypoxia, the degra

96 des are constantly produced by the ubiquitin-proteasome system, and many are probably functional.

97 tion, protein trafficking, and the ubiquitin-proteasome system, and monitored P-gp protein expression

98 regulation of SETD2 protein stability by the proteasome system, and the identification of SPOP, a key

99 , we show that Fbp1 is part of the ubiquitin-proteasome system, and we further investigated the mecha

100 referred to as autophagy) and the ubiquitin-proteasome system are the two major catabolic systems in

101 Autophagy and the ubiquitin-proteasome system are the two major quality control path

102 together, these results reveal the ubiquitin-proteasome system as a novel regulatory mechanism for RI

103 our results not only point to the ubiquitin-proteasome system as an important regulator of presynapt

104 sophila (d) CRY is degraded by the ubiquitin-proteasome system as well.

105 tal models that impairment of the ubiquitine-proteasome system at specific nodes (E3 ligase parkin, p

106 1 promotes hERG degradation by the ubiquitin-proteasome system at the endoplasmic reticulum to regula

107 to its targeted degradation by the ubiquitin-proteasome system because degradation is blunted by trea

108 osolic antibody recognition to the ubiquitin proteasome system brings this research into sharper focu

109 or degradative route involving the ubiquitin-proteasome system by eliminating 26S proteasomes, a proc

110 The proteasome system cannot degrade aggregated proteins; ho

111 nd found altered levels of several ubiquitin proteasome system components, in particular decreased le

112 The ubiquitin proteasome system controls the concentrations of regulat

113 The ubiquitin-proteasome system degrades viral oncoproteins and other

114 factor, NAC1, that is subjected to ubiquitin-proteasome system-dependent degradation in plant cells.

115 or-1 (FAF1) both have roles in the ubiquitin-proteasome system during NF-kappaB activation, although

116 the cytosolic Hsp70 system and the ubiquitin proteasome system during protein triage are not clear.

117 struction of select targets by the ubiquitin-proteasome system (eg, SCF(Skp2)-directed destruction of

118 s of MCPH1 in association with the ubiquitin-proteasome system ensures mitotic entry independent of c

119 The ubiquitin-proteasome system facilitates the degradation of ubiquit

120 Ubiquitin, and components of the ubiquitin-proteasome system, feature extensively in the regulation

121 ation.Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins,

122 a fungal effector targets the host ubiquitin proteasome system for the suppression of PAMP-triggered

123 dative mechanisms, we found normal ubiquitin-proteasome system function and only modest inefficiency

124 al for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is discussed

125 ubqln KO mice were crossed with a ubiquitin-proteasome system function reporter mouse, the accumulat

126 ms are still unclear, although the ubiquitin-proteasome system has been involved in the degradation o

127 ases are attractive targets in the ubiquitin-proteasome system, however, the development of small-mol

128 ST2L stability is regulated by the ubiquitin-proteasome system; however, its upstream internalization

129 oteins are rapidly degraded by the ubiquitin-proteasome system; however, the relationship of ubiquiti

130 r proteins from degradation by the ubiquitin-proteasome system in conditions of stress.

131 a robust translational reprogramming of the proteasome system in fasted mice.

132 oteins are the main targets of the ubiquitin-proteasome system in growth cones.

133 st time a fine-tuning of FACT by a ubiquitin proteasome system in promoting chromatin reassembly in t

134 her evidence of dysfunction of the ubiquitin-proteasome system in schizophrenia, and suggest that alt

135 (ER) are cleared by the ubiquitin-dependent proteasome system in the cytosol, a series of events col

136 RNA-sequencing data identified the ubiquitin proteasome system in the TNF-alpha signaling pathway as

137 PMI5011-mediated changes in the ubiquitin-proteasome system in vivo correlate with increased phosp

138 nt-resistant fraction by interruption of the proteasome system in vivo.

139 tify an essential function for the ubiquitin-proteasome-system in spermiogenesis and define a novel,

140 hes of the endosomal-lysosomal and ubiquitin-proteasome systems, in maintaining the homeostasis of th

141 se by activating components of the ubiquitin proteasome system, including the E2 ligase LET-70/UBE2D2

142 MuRF-1, a component of the ubiquitin-proteasome system involved in muscle proteolysis, is inc

143 rough this feedback mechanism, the ubiquitin-proteasome system is able to provide an additional layer

144 al of specific proteins by the ubiquitin-26S proteasome system is also likely paramount.

145 Protein degradation by the ubiquitin-proteasome system is central to cell homeostasis and sur

146 The ubiquitin-proteasome system is critical for maintenance of protein

147 ent elimination of misfolded proteins by the proteasome system is critical for proteostasis.

148 ubiquitin (Ub) recognizes enzymes in the Ub proteasome system is crucial for understanding the biolo

149 The ubiquitin-proteasome system is essential for maintaining a functio

150 ontrol of protein abundance by the ubiquitin-proteasome system is essential for normal brain developm

151 If the capacity of the ubiquitin/proteasome system is exceeded, then misfolded proteins a

152 pects of plant lifecycle where the ubiquitin-proteasome system is implicated.

153 The ubiquitin proteasome system is involved in degradation of old or d

154 Recent evidence suggests that the ubiquitin-proteasome system is involved in several aspects of plan

155 tudy, we provide evidence that the ubiquitin proteasome system is involved in the reduced density of

156 between protein ISGylation and the ubiquitin proteasome system is not fully understood.

157 e that the overall activity of the ubiquitin-proteasome system is preserved in SBMA models.

158 The ubiquitin proteasome system is required for the rapid and precise

159 The eukaryotic ubiquitin-proteasome system is responsible for most aspects of reg

160 The ubiquitin-proteasome system is responsible for removing most abnor

161 The ubiquitin-proteasome system is targeted by many viruses that have

162 The ubiquitin-proteasome system is the major pathway for protein degra

163 The ubiquitin-proteasome system is the major pathway for selective deg

164 The ubiquitin-proteasome system is the major pathway for selective pro

165 The ubiquitin-proteasome system is the major pathway of non-lysosomal

166 SGylation negatively regulates the ubiquitin-proteasome system, leading to increased production of IF

167 Pinto et al. show that the axonal ubiquitin-proteasome system locally regulates the accumulation of

168 omains in proteins not part of the ubiquitin proteasome system may bind the proteasome more tightly t

169 rganelle biogenesis factors by the ubiquitin-proteasome system may constitute an important regulatory

170 cy disrupts their folding, and the ubiquitin-proteasome system may help manage this stress.

171 Our findings indicate that the ubiquitin-proteasome system may play a role in the pathogenesis of

172 (aa261-270) that was required for ubiquitin-proteasome system-mediated degradation, among which two

173 that the SlNAC1 is subject to the ubiquitin-proteasome system-mediated degradation.

174 Compared with Day 7, increased ubiquitin-proteasome system-mediated muscle proteolysis, inflammat

175 The ubiquitin-proteasome system mediates a cellular stress response ca

176 The proteasome system of Mycobacterium tuberculosis is requi

177 gase that functions to promote the ubiquitin-proteasome system of protein degradation and also in mit

178 maged proteins are degraded by the ubiquitin-proteasome system or through autophagy-lysosome, key com

179 rgeted protein removal through the ubiquitin-proteasome system, or selective, whole-chloroplast degra

180 volved in cytokinin signaling, the ubiquitin-proteasome system pathway, DNA repair and Cu transportat

181 t that protein degradation via the ubiquitin proteasome system plays a fundamental role in the develo

182 The ubiquitin proteasome system plays a pivotal role in controlling th

183 The ubiquitin (Ub)-proteasome system plays a pivotal role in the regulation

184 The ubiquitin-proteasome system plays a pivotal role in the sequence o

185 of fertilization and wherever the ubiquitin-proteasome system plays a role in cellular function or p

186 the ATP- and ubiquitin-independent REGgamma-proteasome system plays a role in maintaining energy hom

187 The ubiquitin proteasome system plays a significant role in protein tu

188 tients), and one patient with FTLD-ubiquitin proteasome system positive inclusions (FTLD-UPS) that st

189 the prokaryotic ubiquitin-like protein (Pup)-proteasome system (PPS), the bacterial equivalent of the

190 ts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-p

191 In the ubiquitin-proteasome system, protein substrates are degraded via c

192 aded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the

193 in-like modifier)-modification and ubiquitin-proteasome systems regulate the major events of meiotic

194 polycomb-repressive complex 1.The ubiquitin-proteasome system regulates cellular reprogramming by de

195 Among its many functions, the ubiquitin-proteasome system regulates substrate-specific proteolys

196 of the ubiquitin ligase SYVN1, the ubiquitin/proteasome system regulator NEDD8, or the F-box protein

197 The ubiquitin-proteasome system represents the major pathway of select

198 Protein elimination by the ubiquitin-proteasome system requires the presence of a cis-acting

199 atment with MG132, an inhibitor of ubiquitin proteasome system, rescues the expression level and memb

200 at EXO1 is rapidly degraded by the ubiquitin-proteasome system soon after DSB induction in human cell

201 We further show that the blockers of the Ub-proteasome system such as ubistatin and fullerenol inhib

202 The ubiquitin-proteasome system targets many cellular proteins for deg

203 r E3 enzymes are components of the ubiquitin proteasome system that function during the transfer of t

204 Mycobacterium tuberculosis (Mtb) has a proteasome system that is essential for its ability to c

205 To identify components of the ubiquitin/proteasome system that protect against aggregation, we a

206 tilation-induced activation of the ubiquitin-proteasome system, the autophagy/lysosomal system, and c

207 ver via the anaphase promoting complex (APC)-proteasome system, thereby ensuring temporal control of

208 lity of Atoh1 was regulated by the ubiquitin proteasome system through the action of Huwe1, a HECT-do

209 ocesses utilize chaperones and the ubiquitin-proteasome system to aid in protein elimination.

210 Mycobacterium tuberculosis (Mtb) requires a proteasome system to cause lethal infections in mice.

211 rves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and org

212 nge of plant pathogens subvert the ubiquitin-proteasome system to enhance their virulence.

213 ention on E3 ligases.Targeting the ubiquitin proteasome system to modulate protein homeostasis using

214 at reiterate the importance of the ubiquitin-proteasome system to plants.

215 ular quality-control machinery-the ubiquitin-proteasome system-to remove specific cancer-causing prot

216 In the ubiquitin-proteasome system, ubiquitin-conjugating enzymes and ubi

217 ated cMLCK protein turnover by the ubiquitin-proteasome system underlies the transition from compensa

218 dation of maternal proteins by the ubiquitin-proteasome system (UPS) accompanies the maternal-to-zygo

219 The ubiquitin-proteasome system (UPS) also plays an important role in

220 The ubiquitin-proteasome system (UPS) and autophagy are two major intr

221 folded protein response (UPR), the ubiquitin-proteasome system (UPS) and autophagy, appear indispensa

222 nhibitors to selectively block the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway,

223 te proteostasis is mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system an

224 understood alternative arm of the ubiquitin proteasome system (UPS) and is required for mouse embryo

225 prominent proteolytic systems, the ubiquitin proteasome system (UPS) and the autophagosomal/lysosomal

226 ns that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via

227 is DISC1 turnover elicited by the ubiquitin proteasome system (UPS) but that it is orchestrated by t

228 The ubiquitin proteasome system (UPS) controls many cellular processes

229 The ubiquitin proteasome system (UPS) degrades misfolded proteins incl

230 The ubiquitin proteasome system (UPS) directs programmed destruction o

231 The ubiquitin-proteasome system (UPS) for protein degradation has been

232 involved in mitochondrial (MT) or ubiquitin-proteasome system (UPS) functions were markedly downregu

233 The ubiquitin-proteasome system (UPS) has been implicated in the retri

234 Ubiquitin-26S proteasome system (UPS) has been shown to play central r

235 The ubiquitin proteasome system (UPS) has emerged as a drug target for

236 The ubiquitin-proteasome system (UPS) has emerged as a therapeutic foc

237 In Drosophila, ubiquitin proteasome system (UPS) impairment led to enhancement of

238 TOC apparatus is regulated by the ubiquitin-proteasome system (UPS) in a process controlled by the e

239 Based on the central role of the ubiquitin-proteasome system (UPS) in the degradation of cellular p

240 nteraction is the role of the host ubiquitin/proteasome system (UPS) in the infection process.

241 implicating the involvement of the ubiquitin proteasome system (UPS) in their pathogenesis.

242 The ubiquitin-proteasome system (UPS) influences gene transcription in

243 The ubiquitin proteasome system (UPS) is a major regulator of protein

244 Degradation of proteins by the ubiquitin-proteasome system (UPS) is an essential biological proce

245 The ubiquitin proteasome system (UPS) is an essential metabolic consti

246 rotein degradation mediated by the ubiquitin-proteasome system (UPS) is critical to eukaryotic protei

247 ed that protein regulation via the ubiquitin proteasome system (UPS) is crucial for normal HSC functi

248 The ubiquitin proteasome system (UPS) is known to regulate expression

249 The ubiquitin proteasome system (UPS) is primarily responsible for cel

250 In eukaryotic cells, the ubiquitin-proteasome system (UPS) is responsible for the regulated

251 of protein homeostasis, including ubiquitin-proteasome system (UPS) mediated protein degradation, en

252 The ubiquitin-proteasome system (UPS) plays a critical role in removin

253 p53 and its E3 ligase MDM2 by the ubiquitin-proteasome system (UPS) promotes carcinogenesis and mali

254 The ubiquitin-proteasome system (UPS) regulates diverse cellular pathw

255 The ubiquitin proteasome system (UPS) regulates many biological pathwa

256 The ubiquitin proteasome system (UPS) regulates the ubiquitination, an

257 was undertaken to characterize the ubiquitin proteasome system (UPS) response to varied dietary prote

258 ious proteolytic processes such as ubiquitin-proteasome system (UPS) to avoid a build-up of misfolded

259 uling paint biocides, inhibits the ubiquitin-proteasome system (UPS) via targeting both 19S proteasom

260 egradation of proteins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquit

261 ecular level, an activation of the ubiquitin-proteasome system (UPS) was detected which resulted in a

262 anisms of protein homeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease.

263 as dendrite pruning-depends on the ubiquitin-proteasome system (UPS), but the specific processes regu

264 Targeting the ubiquitin-proteasome system (UPS), therefore, is an attractive ave

265 unclear whether proteolysis by the ubiquitin proteasome system (UPS), which catalyzes most protein de

266 quitination is orchestrated by the ubiquitin proteasome system (UPS), which constitutes a cascade of

267 We also demonstrated that the ubiquitin-proteasome system (UPS), which is known to influence syn

268 eport the rapid ubiquitination and ubiquitin proteasome system (UPS)-mediated degradation of FMRP in

269 cellular survival and the rate of ubiquitin-proteasome system (UPS)-mediated proteolysis following h

270 evealed a broad down-regulation of ubiquitin proteasome system (UPS)-related genes, in particular, co

271 eratin-derived AMPs (KAMPs) by the ubiquitin-proteasome system (UPS).

272 karyotic cells is performed by the Ubiquitin-Proteasome System (UPS).

273 synaptic proteostasis requires the ubiquitin-proteasome system (UPS).

274 is, is known to be degraded by the ubiquitin-proteasome system (UPS).

275 st subunit of RNAPII, Rpb1, by the ubiquitin proteasome system (UPS).

276 C) pathway and are degraded by the ubiquitin-proteasome system (UPS).

277 ssential role in autophagy and the ubiquitin proteasome system (UPS).

278 uitinated and degraded through the ubiquitin proteasome system (UPS).

279 d nonproteolytic activities of the ubiquitin-proteasome system (UPS).

280 for subsequent degradation by the ubiquitin-proteasome system (UPS).

281 e-mediated degradation through the Ubiquitin-Proteasome System (UPS).

282 ification is ubiquitination by the ubiquitin-proteasome system (UPS).

283 membrane fusion apparatus, and the ubiquitin-proteasome system (UPS).

284 ein interactions abound within the ubiquitin-proteasome system (UPS).

285 FDH abundance is regulated by the ubiquitin proteasome system (UPS).

286 ich is functionally related to the ubiquitin proteasome system via its ubiquitin binding domain.

287 mitogens, Tiam1 is degraded by the ubiquitin-proteasome system via the SCF(betaTrCP) ubiquitin ligase

288 uitinated proteins, suggesting the ubiquitin-proteasome system was not impaired.

289 bona fide native substrates of the ubiquitin-proteasome system was observed from PKG manipulation in

290 isphosphatase are degraded via the ubiquitin proteasome system when cells are replenished with glucos

291 and thereby regulates its level through the proteasome system, whereas clinically relevant parkin mu

292 removes GKAP from synapses via the ubiquitin-proteasome system, whereas inactivity induces synaptic a

293 ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of p

294 ulation that is independent of the ubiquitin proteasome system, which can become occupied with damage

295 maritoclax induces Mcl-1 degradation via the proteasome system, which is associated with the pro-apop

296 n accumulation is regulated by the ubiquitin proteasome system, which is highly dysregulated in oculo

297 SlGLK2 is degraded by the ubiquitin-proteasome system, which is mainly determined by two lys

298 FLI1 protein as a substrate of the ubiquitin-proteasome system with a characteristic polyubiquitinati

299 impact RB function, including the ubiquitin-proteasome system with deregulated RB destruction freque

300 the roles of the components of the ubiquitin-proteasome system with emphasis on areas where future re