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1 rated to be useful as a Merrifield synthesis protecting group.
2 metrizing, cascade process involving the Boc protecting group.
3 of delta-azaproline can be tuned easily by a protecting group.
4 the chain, carrying an N-terminal carbamate protecting group.
5 ect to comparable systems lacking the cyclic protecting group.
6 acidic removal of the 2-methoxyethoxymethyl protecting group.
7 esized from the corresponding o- and p-nitro protecting group.
8 inert by derivatization with a photochemical protecting group.
9 and dibenzyl acetals depends on the hydroxyl protecting group.
10 application of the methyl group as a useful protecting group.
11 is obtained by removing the diphenylmethane protecting group.
12 was accomplished by switching to the trityl protecting group.
13 based on a lipase catalyzed cleavage of the protecting group.
14 king of the peptide charge with a lipophilic protecting group.
15 G), or tert-butyldisulfanyl (G) as the 5'-S-protecting group.
16 onic characteristics of the ligand's benzoyl protecting group.
17 gly affected by the electronic effects of N3 protecting group.
18 vage reactions that allow for the removal of protecting groups.
19 readily available compound without using any protecting groups.
20 e and S-acyl-2-thioethyl (SATE) phosphate as protecting groups.
21 rs directly from functional monomers without protecting groups.
22 tionalization without the use of specialized protecting groups.
23 ubstrate scope and is tolerant of a range of protecting groups.
24 al quaternary amino acids carrying carbamate protecting groups.
25 of the solvents, acyl groups, or alkylidene protecting groups.
26 ic interplay between acetate and silyl ether protecting groups.
27 only two to four steps without the need for protecting groups.
28 s compound compared with other o-nitrobenzyl protecting groups.
29 ing fragments and cleavage of the ester-type protecting groups.
30 , followed by hydrogenolysis of benzyl ether protecting groups.
31 a Suzuki coupling using tert-butyl thioether protecting groups.
32 nd carboxylic acids without the necessity of protecting groups.
33 ns followed by a one-pot deprotection of all protecting groups.
34 with respect to aziridine substitution and N-protecting groups.
35 ccomplished in nine steps without the use of protecting groups.
36 ables selective oxidation of diols that lack protecting groups.
37 ced by the presence of aromatic rings in the protecting groups.
38 zed by variation of the alpha-amino aldehyde protecting groups.
39 ings in a single operation in the absence of protecting groups.
40 ity, stereoselectivity, or the importance of protecting groups.
41 possible, streamlining or eliminating use of protecting groups.
42 placed by various sulfonyl- or urethane-like protecting groups.
43 has only the 2,4-isomer emerged as a labile protecting group?
44 ed d-glucopyranosyl donors where the racemic protecting group 1-methyl 1'-methylcyclopropylmethyl (MC
45 ng the stability of 2-Pyridinyl Thermolabile Protecting Groups (2-Py TPGs) in the "chemical switch" a
46 lly on (1) effective use of a series alkynyl protecting groups, (2) Sonogashira cross-coupling reacti
48 rine-derived oxazolidines as another type of protecting group), a compound with the presumed structur
49 tablished that para-substituted benzyl ether protecting groups affect the reactivity of glycosyl dono
50 ge and removal of the acid-labile side-chain protecting groups affords the crude peptides containing
51 al repulsion was evaluated for main types of protecting groups (alkyl, silyl, and acyl) usually used
53 Influence of the catalytic system, hydrazine protecting group and alkyne substitution on the cyclizat
57 eophilic strong-base (DBU) labile nucleobase protecting groups and a UV-light cleavable linker were u
58 rate-derived lactones can be mediated by the protecting groups and applied to the total synthesis of
59 of glycosylation stereoselectivity by remote protecting groups and as a control element in enzymic pr
60 with particular emphasis on the influence of protecting groups and conditions on stereoselectivity.
62 eptides, alternative orthogonality regarding protecting groups and ease of producing C-terminal thioe
64 the condition required to remove base labile protecting groups and the ODNs from the solid support.
66 lytic conditions tolerate common acid-labile protecting groups, and a wide variety of alpha-acyloxy a
67 aqueous media, in the absence of side chain protecting groups, and are tolerant of all proteinogenic
68 tide in solution, cleavage of the side-chain protecting groups, and oxidization of cysteines to yield
69 ction tolerates both acid and base sensitive protecting groups, and products are afforded in 68-96% y
70 proach circumvents the need for conventional protecting groups, and therefore no formal protection an
74 attacks on C1 resulting in departure of the protecting group as 4,4-disubstituted 3-acyloxy-4,5-dihy
77 group, 2) using common functional groups or protecting groups as directing groups, and 3) attaching
78 and C-O pi-bond functionality, as atom-less protecting groups as well as an anomeric directing group
79 utomated multiple on-resin cleavage of Alloc protecting groups as well as the introduction of side ch
80 derivatives can be useful as photocleavable protecting groups, as demonstrated through the synthesis
81 methine, alpha to the carboxy group) and the protecting groups at C17-OH and C18-OH have posed diffic
83 acetyl, and tert-butyldiphenylsilyl (TBDPS) protecting groups at O-3 were prepared from p-methoxyphe
85 ide induces the removal of the boronic ester protecting groups at physiological pH and temperature, r
86 benzyl, benzoyl, or tert-butyldimethylsilyl protecting groups at the C3-O and C4-O positions, were s
87 lated erythropoietin bearing acetamidomethyl protecting groups at the cysteine residues has been synt
88 y been achieved by placing sterically bulky "protecting groups" at the termini, which shield the reac
91 show that the 5'-O-2,7-dimethylpixyl (DMPx) protecting group can be used to limit acid exposure and
97 Key to its success is the use of a new N-protecting group (cinsyl or Cn) bearing an electron-defi
99 excellent stereoselectivity provided by the protecting group combination was found independent of le
101 of the desired alpha products and the silyl protecting groups could be removed in the presence of un
103 charide which was modified by the orthogonal protecting groups diethylisopropylsilyl (DEIPS), 2-napht
105 thogonal on-resin cleavage of Fmoc and Alloc protecting groups during solid-phase synthesis of PAAs w
107 ues is often lengthy and requires the use of protecting groups, enzymes have the potential to synthes
109 l catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup cond
110 ws: if a nonparticipating O-2 racemic chiral protecting group exhibits diastereoselectivity in glycos
111 se synthesis bearing Fmoc/Boc and Fmoc/Alloc protecting groups expanding recently used Fmoc/Boc prote
112 vation by a sulfur atom of a methylthioalkyl protecting group, followed by enzymatic hydrolysis of th
114 utility of the p-(3,4-dimethoxyphenyl)benzyl protecting group for its use at the O-3 position of inos
115 se coupling reactions without the need for a protecting group for the alkyne-functional initiator: (1
116 sclosed herein is that vinyl ethers serve as protecting groups for alcohol-containing molecules and a
120 thenyl group that we name MocVinyl) serve as protecting groups for the above-mentioned heterocyclic C
121 ups to serve for the first time as removable protecting groups for the boron position of 1,2-azaborin
122 spect of this approach is the utilization of protecting groups for the N-terminal Cys in the middle f
127 st and allowing mild reaction conditions and protecting-group free synthesis in addition to being ben
128 on allowed us to identify conditions for the protecting group-free or minimized total synthesis of bi
133 ss to 13 new cis-hydrindanes/cis-decalins, a protecting group-free total synthesis of an insect repel
134 ensuing 2-alkoxyfuran hydrolysis and (ii) a protecting group-free vinylogous Knoevenagel condensatio
137 pivoted on the construction of a late-stage protecting-group-free pentacyclic enol triflate coupling
139 methoxy alkynyl zinc reagents allows for the protecting-group-free syntheses of transtaganolides C an
143 gomers were obtained on solid support from a protecting-group-free two-step iterative protocol, based
144 e progress of efforts that culminated in the protecting-group-free, six-step total synthesis of all o
146 able to rapidly remove propargyloxycarbonyl-protecting group from the N-terminal Cys in a similar ef
147 he presence or not of the trifluoroacetamide protecting group gave either tetrahydroquinolines 18 or
148 nature of the electron-withdrawing nitrogen protecting group has a very limited influence on the cou
149 In addition to these, the removal of the protecting groups has also been carried out in a selecti
152 ion, and an orthogonal cleavage of the N-Boc protecting group in piperidone derivatives was carried o
154 could be controlled by changing the indole N-protecting group in the reductive cyclization precursors
155 been demonstrated in the use of thiazolidine protecting group in the synthesis of over 100 proteins,
156 groups of the carbonyl moiety rather than a protecting group in this type of FeCl3.6H2O-catalyzed co
159 , bromo- and chloroacetates, which are major protecting groups in glycochemistry because they are ort
160 devised for the selective cleavage of benzyl protecting groups in the presence of other easily reduce
161 f, which represent an unprecedent use of the protecting groups in the synthesis of a naturally occurr
163 ycyclization occurred in the presence of the protecting group; in the absence of the protecting group
165 y extended the methodology to regioselective protecting group installation and manipulation toward a
171 monly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation
173 An ortho-alkyloxy side chain on the N-benzyl protecting group is necessary for the macrocyclization t
175 ers and the demand for an N-(o-alkoxybenzyl) protecting group is provided on the basis of DFT calcula
177 ing groups of the o-amino group, the o-nitro protecting group is the only choice to synthesize the o-
179 tonation of 4-amino 2-Pyridinyl Thermolabile Protecting Groups is demonstrated by (1)H-(15)N HMBC and
180 ility of the new removal conditions for both protecting groups is exemplified in the rapid and effici
181 turing the stable trimethylacetyl (pivaloyl) protecting group, is described for their preparation.
182 Variation of this residue and its N-terminal protecting group leads to the conclusion that maximal le
184 ore, which, along with judicial selection of protecting groups, made the current synthesis very effic
185 easy removal of the N-(dipehenylphosphinoyl) protecting groups makes this method practically useful f
186 sing metathesis (RCM), followed by selective protecting group manipulations and a final concomitant -
187 aking it possible to conduct a wide range of protecting group manipulations and install selectively r
188 er Mitsunobu conditions followed by standard protecting group manipulations to provide the desired py
189 Minimizing stereochemical adjustments and protecting group manipulations, diacetone glucose is con
192 ediate 9, which after a series of nontrivial protecting-group manipulations affords key intermediate
193 h features a redox-economic approach free of protecting-group manipulations, assembles all four-ring
197 nzofuran-5-sulfonyl (Pbf), three acid-labile protecting groups mostly adopted in the solution and sol
198 ore trisaccharide modified by the orthogonal protecting groups N(alpha)-9-fluorenylmethyloxycarbonate
201 uoride (HF) is used to remove the side chain protecting groups of the assembled peptide and to releas
203 ion of the hydrogen involved in the IHB by a protecting group (OMe, OAc, OBz, OBn, or OTBDMS), a high
205 ydes, incorporating a methylthiomethyl (MTM) protecting group on nitrogen, are shown to be efficient
206 of cyclization (exo vs endo) depends on the protecting group on nitrogen, the oxidation state of cop
207 at was dependent on both the identity of the protecting group on the beta,delta-oxygen stereocenters
208 hod for synthesizing bpDNA that uses a silyl protecting group on the DNA nucleobases during the solid
209 luorination was achieved using an unorthodox protecting group on the precursor, which could withstand
212 od is demonstrated by the removal of the Nap protecting groups on highly sensitive 2,6-dideoxy-sugar
216 od for the investigation of the influence of protecting groups on the anomeric equilibrium in the sia
218 reactive nucleophiles and electron-donating protecting groups on the donor favor alpha-glycosidic bo
219 s into soluble dyes by introducing transient protecting groups on the secondary amine moieties, follo
221 y chiral tertiary amino acids carrying amide protecting groups or by chiral quaternary amino acids ca
223 to develop triazoles as mechanically labile protecting groups or for use in readily accessible mater
225 the protecting group; in the absence of the protecting group, palladium- and gold-catalyzed benzannu
226 lation strategies, elongation sequences, and protecting group patterns are discussed, but also (semi)
228 rature and solvents; only the delta-nitrogen protecting group plays key role in the isomerization.
232 roach that involved selective removal of the protecting group present at the O-2 position of a single
233 Initial attempts using tert-butyl as thiol protecting group proved problematic, and synthesis was a
236 ) and Ahad into peptides, a truly orthogonal protecting group scheme was developed, encompassing an a
237 droquinolines depends on the choice of the N-protecting group (see scheme; TEA = triethylamine, TMS =
238 )carbamates based on a range of common amine protecting groups serve as preformed nitrogen sources in
241 r the nonparticipating azide group, but this protecting group significantly increased beta-selectivit
246 ting groups expanding recently used Fmoc/Boc protecting group strategy for linear PAAs to an Fmoc/All
247 plished by using a 2'/3'-O-acetyl orthogonal protecting group strategy in which non-nucleophilic stro
248 oligonucleotide building block synthesis, a protecting group strategy was developed for 2'-O-proparg
250 l and amino groups are protected with simple protecting groups such as acetates (Ac, Piv) and carbama
251 ipulations and install selectively removable protecting groups such as levulinoyl (Lev) ester, fluore
253 iodomethyl group over hydrogenolysis-labile protecting groups, such as benzyloxycarbonyl, benzyl est
255 le can be orthogonal to other standard amine protecting groups, such as tert-butyloxycarbonyl (Boc),
257 pend on the steric demands of the hemiaminal protecting group, tetrahydrofuran concentration, and the
258 have designed a nitroaromatic photochemical protecting group that absorbs visible light in the viole
259 an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reactio
260 oligands using cell-adhesive peptides with a protecting group that can be easily removed via transder
262 introduced as esterase-labile phosphodiester protecting groups that additionally are thermolabile.
263 nd characterization of new photolabile amine protecting groups that are active under visible light.
264 ve led to the invention of a large number of protecting groups that temper the reactivity of nitrogen
265 des, the selection of appropriate orthogonal protecting groups, the development of stereoselective gl
266 which the phosphate moiety bears a chemical protecting group, thus eliminating the negative charges
269 ranching positions is modified by orthogonal protecting groups to allow selective attachment of speci
271 agents by (i) incorporating gas phase-labile protecting groups to silence otherwise reactive function
273 benzyl ethers and the efficient and multiple protecting group transformations are applicable in gener
274 reactivity of nitrogen; however, the use of protecting groups typically introduces additional steps
278 This suggested to us that if CPg of the protecting group was a chiral carbon, then diastereosele
279 BRAP with a self-immolative boronic ester protecting group was designed to scavenge H2O2 and relea
280 -step procedure with the triethylsilyl (TES) protecting group was developed to selectively expose the
282 , an L-alanine amino acid derivatized with a protecting group was used to prevent self-polymerization
283 adaption of this approach, introduction of a protecting group was used to synthesize an oligo(3-hexyl
284 ctivity of meso-methyl BODIPY photoremovable protecting groups was accomplished through systematic va
288 substrate scope, and various functional and protecting groups were tolerated under the reaction cond
289 pathway is avoided through use of the benzyl protecting group, which is proposed to stabilize the dio
290 ge of a photolabile nitroveratryloxycarbonyl protecting group, which is widely used as caging group,
291 in up to 96% ee, containing two orthogonal N-protecting groups, which can be deprotected selectively.
292 -chloro (PClB) or p-cyanobenzyl ether (PCNB) protecting groups, which decreased the reactivity of the
293 ctivated analogues by replacing the N-benzyl protecting group with a N-tosyl group, rendering these a
294 olve from the traditional acid-labile trityl protecting group with proper electron-donating substitue
295 carboxylic acids as amides resulted in a new protecting group with significantly improved properties.
296 actions between the aromatic ring of the C-2 protecting group with the exocyclic triple bond and the
297 ngly trivial steps of end-capping to replace protecting groups with N-terminal acetamides and C-termi
298 acidic treatment that removes the polyamide protecting groups with no harm to the cycloadduct, in co
299 ydrolyzing acetals and constitute orthogonal protecting groups with traditional 1,3-dioxane/1,3-dioxo
300 biomimetic conditions, without the need for protecting groups, yielding powerful synthons in previou
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