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1 he phenylalanine clamp identified in anthrax protective antigen.
2 at lipopolysaccharide (LPS) is the major OMV protective antigen.
3 o predict the likelihood that a protein is a protective antigen.
4 a major surface antigen of sporozoites, is a protective antigen.
5 s a membrane-anchored glycoprotein and major protective antigen.
6 ce in the lungs and that rPsrP(SRR1-BR) is a protective antigen.
7 GAS esterase and determining whether it is a protective antigen.
8 es and a poor understanding of its role as a protective antigen.
9 ed in sporozoites and EEFs, CS is a dominant protective antigen.
10 sed by furin-dependent processing of anthrax protective antigen.
11 lethal toxin, a mixture of lethal factor and protective antigen.
12 in the endosomal membrane formed by anthrax protective antigen.
13 esses lethal factor and the receptor-binding protective antigen.
14 is considered both a virulence factor and a protective antigen.
15 s a virulence factor, YopE can function as a protective antigen.
16 flagellar proteins are virulence factors and protective antigens.
17 sis system that curates, stores and analyzes protective antigens.
18 ed methods will fail to discover truly novel protective antigens.
19 al polysaccharides are often immunodominant, protective antigens.
20 d the screening and characterization of tick protective antigens.
21 on empirical evidence that these function as protective antigens.
22 e lack of broad-spectrum fungal vaccines and protective antigens.
23 unity to mice was used to identify potential protective antigens.
24 xin (LT) are important virulence factors and protective antigens.
25 t are attenuated yet capable of synthesizing protective antigens.
26 e nucleus for efficient synthesis of encoded protective antigens.
27 dence that fimbrial tip adhesins function as protective antigens.
30 ctor (LF) and/or Oedema Factor (EF) bound to Protective Antigen 63 (PA63) which functions as both the
31 1lambda monoclonal antibody directed against protective antigen, a component of the anthrax toxin.
33 protein (F1-V) has shown great promise as a protective antigen against aerosol challenge with Y. pes
35 U2/FP59, composed of the urokinase-activated protective antigen and a fusion protein of Pseudomonas e
36 been well characterized as a surface-exposed protective antigen and a virulence factor of S. pneumoni
37 llus anthracis edema toxin (ET), composed of protective antigen and an adenylate cyclase edema factor
38 emonstrated that detection of the biomarkers protective antigen and capsule correlated with bacterial
40 rrA bound to the promoters of genes for both protective antigen and cytochrome aa3, demonstrating tha
41 aracterized the levels of antibodies against protective antigen and found that over half of anthrax v
42 ered recently in Ixodes scapularis as a tick protective antigen and has a role in tick blood digestio
43 vaginal IgA titers against the heterologous protective antigen and higher levels of antigen-specific
44 s to two complex antigens-Bacillus anthracis protective antigen and influenza hemagglutinin-in which
45 ve developed a multiplex biomarker assay for protective antigen and lethal factor of the Bacillus ant
48 ndopeptidase essential for the activation of protective antigen and the formation of anthrax lethal t
49 he increasing structural characterization of protective antigens and epitopes provide the molecular a
51 limited by incomplete information regarding protective antigens and the requirement for multiple boo
52 B-type toxins, edema toxin (edema factor and protective antigen) and lethal toxin (lethal factor and
53 antigen) and lethal toxin (lethal factor and protective antigen), and a poly-d-glutamic acid capsule.
54 the genes for anthrax toxins (lethal factor, protective antigen, and edema factor) where expressed 4-
56 ings are consistent with the ability of anti-protective antigen antibodies to prevent anthrax and sug
59 ether, these data demonstrate that different protective antigens are required based on the route of v
61 CXO1 encodes pagA1, the homologue of anthrax protective antigen, as well as hasACB, providing for hya
63 (EF), a key anthrax exotoxin, has an anthrax protective antigen-binding domain (PABD) and a calmoduli
64 and IgG2b variants of the Bacillus anthracis protective antigen-binding IgG1 monoclonal antibody (mAb
65 ial cell surface and is a well-characterized protective antigen but is not essential for virulence.
66 proteins are independent neutralization and protective antigens, but the contribution by F is greate
67 -reactive VHHs block binding of EF/LF to the protective antigen C-terminal binding interface, prevent
68 mposed of phenylalanine (Phe)427 residues of protective antigen catalyses protein translocation via a
71 sed lethal toxin receptor protein, bound the protective antigen component of lethal toxin, and were s
73 tibody fragments engineered to recognize the protective antigen component of the B. anthracis exotoxi
74 abbits and monkeys, the time to detection of protective antigen correlated with the time to bacteremi
75 d GPI-linked parasite protein, Cysteine-rich protective antigen (CyRPA) as an interacting partner of
76 These results provide in vivo evidence of protective antigen-dependent CD8+ T-cell proliferation,
77 al models, treatment with 5H3, a fully human protective antigen-directed monoclonal antibody (PA-MAb)
79 increased mortality (0.8 +/- 0.3, p = .006), protective antigen-directed monoclonal antibody alone re
80 normal saline for 6 hrs or combining it with protective antigen-directed monoclonal antibody followin
81 reatment either alone or in combination with protective antigen-directed monoclonal antibody in a let
82 t significant for all) or when combined with protective antigen-directed monoclonal antibody, so this
85 pleiotropic functions, it is not a dominant, protective antigen for antibody-mediated protection agai
87 eu5Ac is an essential virulence factor and a protective antigen for GBM, E. coli K1, and P. haemolyti
90 ependent surface feature and promising novel protective antigen for preventing P. aeruginosa infectio
93 strains, we sought to determine if YopE is a protective antigen for Yersinia pseudotuberculosis and i
94 oteomic analysis as a point of discovery for protective antigens for possible inclusion in a vaccine
95 red for virulence and antigenic may serve as protective antigens for vaccination; thus, five represen
98 ally important activities of its target, the protective antigen from Bacillus anthracis We show how r
100 oprotein, the viral neutralization and major protective antigen, from an added transcriptional unit.
101 spores with a deletion of the pBCXO1-carried protective antigen gene (pagA1) were severely attenuated
106 ly on homology with previously characterized protective antigens; however, homology-based methods wil
107 use toxemia model against recombinant LF and protective antigen, (iii) approximately 50% survival adv
108 ected macrophages against recombinant LF and protective antigen in a cell-based assay, (ii) 100% prot
109 ysaccharide (Ft LPS) is thought to be a main protective antigen in mice and humans, and we have previ
110 romotes influenza virus entry and is the key protective antigen in natural immunity and vaccines.
113 nt report demonstrates expression of anthrax protective antigen in tobacco chloroplasts--this materia
114 D) and IpaB, have been identified as broadly protective antigens in the mouse lethal pneumonia model.
115 apparatus (T3SA) proteins IpaB and IpaD are protective antigens in the mouse lethal pulmonary model.
119 To support data exchange, the information of protective antigens is stored in the Vaccine Ontology (V
122 The tripartite anthrax toxin consists of protective antigen, lethal factor (LF), and edema factor
123 ed in vitro assembly system, anthrax toxins, protective antigen, lethal factor and their domains, fus
124 ructural genes for the toxin proteins, i.e., protective antigen, lethal factor, and edema factor, dis
125 The Bacillus anthracis secretome includes protective antigen, lethal factor, and edema factor, whi
128 ores formed in the endosomal membrane by the protective antigen moiety of anthrax toxin serve as port
129 ores formed in the endosomal membrane by the Protective Antigen moiety of anthrax toxin translocate t
131 hese are both binary-type toxins composed of protective antigen necessary for their cellular uptake a
132 The immobilization of a model ligand, the protective antigen of anthrax on the gold surface, is mo
134 eered for stable plasmid-based expression of protective antigen of anthrax toxin (PA83) fused with th
136 to form large pores in the membrane and the protective antigen of anthrax toxin, where a heptameric
137 ata suggest that the O antigen is a critical protective antigen of B. parapertussis and its inclusion
138 gment (scFvs) with increased affinity to the protective antigen of Bacillus anthracis were isolated f
140 ot affect the expression of the gene for the protective antigen of the anthrax toxin, pagA, or that o
141 >8)-alpha-Neu5Ac is a virulence factor and a protective antigen of these three pathogens, it is also
142 influenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce a
143 ugh the detection of its polypeptide entity, protective antigen (PA toxin) using a PA toxin ssDNA apt
144 n only the protease-activated 63-kDa form of protective antigen (PA(63)) and the residual 20-kDa frag
145 The action of anthrax toxin begins when the protective antigen (PA(83), 83 kDa) moiety binds to a ma
146 gle-chain variable fragments (scFvs) against protective antigen (PA) and 2 scFvs against lethal facto
147 ively) receptor decoys bind to anthrax toxin protective antigen (PA) and compete with cellular recept
149 te anthrax lethal toxin (LeTx) consisting of protective antigen (PA) and lethal factor (LF) is a majo
152 and cell-mediated immune (CMI) responses to protective antigen (PA) and lethal factor were assayed b
153 s composed of the receptor-binding component protective antigen (PA) and of the adenylyl cyclase cata
154 ernatant of Bacillus anthracis, contains the protective antigen (PA) and traces of the lethal and ede
155 f three proteins: the translocase component, protective antigen (PA) and two enzyme components, letha
157 use a B-cell epitope from Bacillus anthracis protective antigen (PA) as a model antigen to characteri
158 a) 305 to 319 from the 2beta2-2beta3 loop of protective antigen (PA) can elicit high-titered antibody
159 cellular uptake of complexes containing the protective antigen (PA) carrier of anthrax toxin moietie
160 imals vaccinated with inactivated spores and protective antigen (PA) compared to vaccination with PA
161 acidic endosomal pH conditions, the toxin's protective antigen (PA) component forms a transmembrane
163 The neutralizing antibody response to the protective antigen (PA) component of anthrax toxin elici
164 wn that Lactobacillus gasseri expressing the protective antigen (PA) component of anthrax toxin genet
169 toxin is a tripartite toxin comprised of the protective antigen (PA) component, a homooligomeric tran
173 In this study, we modified the B. anthracis protective antigen (PA) gene for optimal expression and
174 ith the LT components lethal factor (LF) and protective antigen (PA) individually, or in combination.
177 man CMG2 receptor and the Bacillus anthracis protective antigen (PA) is essential for the transport o
182 stry differed in sensitivity mediated by the protective antigen (PA) moiety of anthrax toxin by more
185 toxin relies in part upon the ability of the protective antigen (PA) moiety to form a heptameric pore
188 n of immune-enhancing cytokine IL-15 and the protective antigen (PA) of B. anthracis into the Wyeth v
190 ss II tetramers containing peptides from the protective antigen (PA) of Bacillus anthracis to detect
191 3' UTR, regulating expression of the anthrax protective antigen (PA) or human proinsulin (Pins) fused
192 plexes, each containing a heptameric form of protective antigen (PA) plus up to a total of three mole
193 the anthrax bacillus is to determine how the protective antigen (PA) pore mediates translocation of t
194 ion, when these MAbs were mixed with MAbs to protective antigen (PA) previously generated in our labo
195 subprotective dose of a neutralizing MAb to protective antigen (PA) prolonged mean time to death of
197 5 adenovirus (Ad) vector expressing anthrax protective antigen (PA) provides rapid protection agains
199 tive, specific and easy detection of anthrax protective antigen (PA) toxin in picogram concentration
200 us acidophilus to deliver Bacillus anthracis protective antigen (PA) via specific dendritic cell-targ
201 Large polypeptides of the Bacillus anthracis protective antigen (PA) were inserted into an influenza
202 capsule and two binary toxins, complexes of protective antigen (PA) with lethal factor (LF) and edem
203 er a human monoclonal antibody (AVP-21D9) to protective antigen (PA) would protect mice, guinea pigs,
204 The currently available vaccine is based on protective antigen (PA), a central component of anthrax
205 ancing or neutralizing to Bacillus anthracis protective antigen (PA), a component of anthrax toxin, r
207 is composed of a translocase channel, called protective antigen (PA), and an enzyme, called lethal fa
208 , consisting of the cellular binding moiety, protective antigen (PA), and the catalytic moiety, letha
209 translocase channel-forming subunit, called protective antigen (PA), and two substrate proteins, cal
210 ith AVP-21D9, a human monoclonal antibody to protective antigen (PA), at the time of Bacillus anthrac
211 toxic complexes after one of these proteins, protective antigen (PA), binds to tumor endothelial mark
213 Anthrax toxin, comprising three proteins-protective antigen (PA), lethal factor (LF), and edema f
214 The anthrax toxins are three polypeptides-protective antigen (PA), lethal factor (LF), and edema f
215 The toxin is composed of three proteins, protective antigen (PA), lethal factor (LF), and edema f
216 gh degree of metabolic activity and secreted protective antigen (PA), lethal factor, and edema factor
217 plasmid pXO1 that encodes the toxin protein protective antigen (PA), lethal factor, and edema factor
218 x disease is caused by a toxin consisting of protective antigen (PA), lethal factor, and edema factor
219 lf-assembly of its three component proteins--protective antigen (PA), lethal factor, and edema factor
221 illus anthracis edema toxin (ET) consists of protective antigen (PA), necessary for host cell toxin u
223 ate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema fact
226 iated vasculature and acts as a receptor for Protective Antigen (PA), the cell-binding component of t
227 ies to the immune system in combination with protective antigen (PA), the principal immunogen in AVA,
228 cillus anthracis vaccine consists largely of protective antigen (PA), the protein of anthrax toxin th
230 bipartite toxin in which the first protein, protective antigen (PA), transports the second protein,
231 nto the host-cell cytosol by a third factor, protective antigen (PA), which binds to cellular anthrax
232 nto host cells through interactions with the protective antigen (PA), which binds to host cellular re
233 ty-enhanced monoclonal antibody (ETI-204) to protective antigen (PA), which is the central cell-bindi
235 genotypes, haplotypes, and homozygosity and protective antigen (PA)-specific cellular immune respons
248 creted by fully virulent Bacillus anthracis, protective antigen (PA, 83 kDa), lethal factor (LF, 90 k
249 cation pathway and found that binding of the protective-antigen (PA) component of LT to cells and the
250 hrax edema toxin (ET; edema factor [EF] plus protective antigen [PA]) and lethal toxin (LT; lethal fa
252 into cancer cells using a toxin transporter (Protective antigen, PA) which was redirected to Epiderma
253 that bound and neutralized the pagA1-encoded protective antigen (PA1) but not the PA2 orthologue enco
254 plasmid that encodes the Bacillus anthracis protective antigen (PA63) gene fragment, it was shown th
256 tro against the fluorescent peptide, anthrax protective antigen (PA83), and influenza hemagglutinin s
259 hem, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a
261 h direct electron counting, we determine the protective antigen pore structure at 2.9-A resolution.
265 wcaM)8 mutation resulted in higher levels of protective antigen production during in vitro growth.
266 mid with lux expression under control of the protective antigen promoter displayed luminescence only
270 his sandwich immunoassay, the model analyte, protective antigen protein from B. anthracis, was captur
272 the expression of a major neutralization and protective antigen, resulting in reduced immunogenicity.
273 Immunization with a recombinant form of the protective antigen (rPA) from Bacillus anthracis has bee
274 mmunized with recombinant Bacillus anthracis protective antigen (rPA) mixed in NE as an adjuvant.
277 ether spontaneous deamidation of recombinant protective antigen (rPA)--the major component of new-gen
279 otective antigen prepores are available, how protective antigen senses low pH, converts to active por
280 ss of vaccine adjuvants, capable of inducing protective antigen-specific immune responses through nee
281 diphtheria toxin, anthrax lethal factor and protective antigen, Staphylococcus aureus enterotoxin B,
282 idence for a "loop swap" between neighboring protective antigen subunits, which is required for effic
283 a chimpanzee-derived monoclonal antibody to protective antigen that improved survival when administe
284 plague bacterium Yersinia pestis is a potent protective antigen that is under development as a vaccin
285 is of this immunity or the identification of protective antigens that enable vaccine development was
286 xpresses a variety of structurally conserved protective antigens that include cell surface polysaccha
290 creted by Bacillus anthracis, interacts with protective antigen to form a bipartite toxin (lethal tox
291 , the ability of rTP0136 protein to act as a protective antigen to subsequent challenge with infectio
292 e of glucose increased the expression of the protective antigen toxin component-encoding gene (pagA)
294 form of the CFA/I fimbrial tip adhesin, is a protective antigen, using a lethal neonatal mouse ETEC c
295 munoassay, a limit of detection of 4.1 ng/mL protective antigen was observed with an upper limit of 5
296 the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy and safet
298 challenge with B. melitensis 16M strain, two protective antigens were found: the periplasmic protein,
299 GENpro correctly classifies 82% of the known protective antigens when trained using only the protein
300 Bacillus anthracis infection is a complex of protective antigen, which localizes the toxin to the cel
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