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1 cytokine IL-10 is essential for preventing a protective immune response.
2 enuated in pneumonic tularemia yet induced a protective immune response.
3 rus that is genetically stable and elicits a protective immune response.
4 n reflects some type of "consolidation" of a protective immune response.
5 roach is to identify products that enhance a protective immune response.
6 e also requiring a smaller dose to achieve a protective immune response.
7 n from a Gram-positive organism and induce a protective immune response.
8 based on this region could elicit a broadly protective immune response.
9 mycin inhibitors (mTOR-i) could recover this protective immune response.
10 virus-specific T cells, thereby eliciting a protective immune response.
11 t required for the induction of the adaptive protective immune response.
12 s to suppress the tumor growth and lead to a protective immune response.
13 esent in these vaccines actually elicits the protective immune response.
14 t exposure to these mutants did not induce a protective immune response.
15 lly administered vaccines that will induce a protective immune response.
16 rrhalis and in elucidating the elements of a protective immune response.
17 ion of other cytokines which contribute to a protective immune response.
18 parasite antigens for the initiation of the protective immune response.
19 of COPD and in elucidating the elements of a protective immune response.
20 that sense microbial attacks and initiate a protective immune response.
21 re thought to be an important component of a protective immune response.
22 ctivation of CD8(+) T cells is crucial for a protective immune response.
23 ole for antibodies and CD4(+) T cells in the protective immune response.
24 infection induces an effective and long-term protective immune response.
25 have long latencies even though there is no protective immune response.
26 exposure to B. burgdorferi may not elicit a protective immune response.
27 gnize pathogen-expressed Ags and elicit host-protective immune response.
28 attenuated disease in mice and stimulated a protective immune response.
29 mmon mechanism of viral escape from the host protective immune response.
30 this process are important for developing a protective immune response.
31 which affect their ability to contribute to protective immune responses.
32 tered at these locales, thereby accelerating protective immune responses.
33 immunosuppression, and with preservation of protective immune responses.
34 face of infected red blood cells and elicits protective immune responses.
35 r bacterium that activates both Th1 and Th17 protective immune responses.
36 infection does not reliably provoke durable, protective immune responses.
37 s contain adjuvants that are used to enhance protective immune responses.
38 it required a booster immunization to prime protective immune responses.
39 more effectively generating vaccine-induced protective immune responses.
40 ts and soluble factors coordinate to disrupt protective immune responses.
41 tory infection but are capable of generating protective immune responses.
42 at elicits broadly reactive and long-lasting protective immune responses.
43 immunogenic protein epitopes needed to mount protective immune responses.
44 but 2 doses of vaccine are needed to elicit protective immune responses.
45 used in a cell-based vaccine model to induce protective immune responses.
46 t compromising IL-6 classic signaling-driven protective immune responses.
47 antigen and enables the rapid initiation of protective immune responses.
48 as staphylococcal infections fail to induce protective immune responses.
49 ses on the development of vaccines to induce protective immune responses.
50 e molecules activate/recruit DCs and enhance protective immune responses.
51 erfere with complement deposition and elicit protective immune responses.
52 g Bacillus anthracis infection and eliciting protective immune responses.
53 PS but does not coincide with a reduction in protective immune responses.
54 exposure, where they elicit rapid and robust protective immune responses.
55 zed influenza vaccine and investigated their protective immune responses.
56 producing inhibitory substances, and priming protective immune responses.
57 accines are well tolerated and elicit potent protective immune responses.
58 due to reduced alloimmunity or less diverse protective immune responses.
59 such as the lung, plays an important role in protective immune responses.
60 early paradigm in which IL-2 is central for protective immune responses.
61 nism through which the pathogen could bypass protective immune responses.
62 t actively targets dendritic cells can evoke protective immune responses.
63 ition receptor required for the induction of protective immune responses.
64 spect that in humans this vaccine may induce protective immune responses.
65 an effort to begin to elucidate potentially protective immune responses.
66 is highly variable and does not elicit cross-protective immune responses.
67 persistent infections without development of protective immune responses.
68 elop strategies to enhance the durability of protective immune responses.
69 ost immune system, which might contribute to protective immune responses.
70 tral to understanding immune homeostasis and protective immune responses.
71 ellular A. fumigatus and collectively induce protective immune responses.
72 tenuated or inactivated vaccines at inducing protective immune responses.
73 and lipopolysaccharide (LPS) is a target of protective immune responses.
74 t reduce the ability of VSV to induce potent protective immune responses.
75 etion of CD4(+) T cells and dysregulation of protective immune responses.
76 )CD8(-) DCs with regard to the initiation of protective immune responses.
77 n animal model of autoimmunity while sparing protective immune responses.
78 protein antigen induced systemic and mucosal protective immune responses.
79 hatic tissues for the development of a local protective immune response after a URT influenza infecti
80 on with viable C. trachomatis in eliciting a protective immune response against a genital challenge i
81 low virulence in infected mice and induced a protective immune response against a lethal infection co
82 nd are impaired in the ability to generate a protective immune response against a second infection.
84 the human IgM antibody sHIgM12 can induce a protective immune response against a weakly antigenic ex
85 However, emerging data indicate that the protective immune response against attenuated F. tularen
86 pted us to examine its utility in inducing a protective immune response against Bordetella bronchisep
87 cine because they provided both safety and a protective immune response against challenge in pigs.
88 been shown to play an important role in the protective immune response against Encephalitozoon cunic
90 l infection resulted in the development of a protective immune response against lethal LVS intraperit
92 o identify a marker for the development of a protective immune response against M. tuberculosis chall
96 ride analogs of labile CPS induce a specific protective immune response against native CPS using S. p
97 herefore, the defect in the development of a protective immune response against O. volvulus in TLR4-m
98 4(+) T cells may provide a basis to induce a protective immune response against persistent infections
99 PspA) is highly immunogenic and can induce a protective immune response against pneumococcal infectio
100 ell-reactive antigens which elicit a durable protective immune response against pulmonary infection i
101 tics, greater understanding is needed of the protective immune response against S. aureus infection i
102 noninfectious T. gondii extract enhances the protective immune response against severe H5N1 influenza
103 er, after a single vaccination, they induced protective immune response against subsequent CHIKV chal
104 , and gammadelta T cells are involved in the protective immune response against viral challenge.
106 bies virus-based vaccine against CDV induces protective immune responses against both pathogens.
107 In contrast, experimental studies show that protective immune responses against cryptococcosis are a
108 vestigation into the mechanisms that mediate protective immune responses against IAV is important to
111 a role for gammadelta Trms in orchestrating protective immune responses against intestinal pathogens
112 deficient vaccine strains for stimulation of protective immune responses against intracellular bacter
114 n is likely to help us in tailoring the host protective immune responses against M. tuberculosis.
116 ence that interleukin-15 (IL-15) can enhance protective immune responses against Mycobacterium tuberc
117 oped represent a robust model for evaluating protective immune responses against P. vivax vaccines ba
120 safety profiles and proven ability to induce protective immune responses against Plasmodium falciparu
121 t vaccination with CJ9-gD elicits strong and protective immune responses against primary HSV-1 skin d
122 ic cells (DCs) is important in enhancing the protective immune responses against rabies virus (RABV).
123 s a powerful platform approach to generating protective immune responses against respiratory pathogen
124 about how the asthmatic phenotype influences protective immune responses against respiratory viral pa
125 e NP adjuvants to promote robust and durable protective immune responses against SIV in nonhuman prim
127 production), necessary for the generation of protective immune responses against the intracellular pa
128 Vs derived from V. cholerae induce long-term protective immune responses against this gastrointestina
129 simple method of vaccine delivery to elicit protective immune responses against virus infection.
131 iniae DeltaPGM mutant is able to stimulate a protective immune response and may have value as a live
132 ha/beta(+) T cells are sufficient to mount a protective immune response and that an IL-17A-mediated r
133 enza because HA is the primary target of the protective immune response and the main component of cur
134 are responsible for mucus production in both protective immune responses and allergic airway inflamma
135 been extremely useful for identification of protective immune responses and in vaccine development.
136 osenescence is characterized by decreases in protective immune responses and increases in inflammatio
137 ys a critical role in both the generation of protective immune responses and maintenance of tolerance
138 these myeloid cells is critical to maintain protective immune responses and minimize the deleterious
140 n strategies has the potential for enhancing protective immune responses and suppressing systemic res
141 nasally vaccinated with M2KO virus developed protective immune responses and survived a lethal challe
143 utinin (HA) protein is the primary target of protective immune responses and the major component in s
144 utinin (HA) protein is the primary target of protective immune responses and the major target of vacc
145 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protecte
146 Dendritic cells (DCs) are key regulators of protective immune responses and tolerance to (self-)Ags.
147 egulatory properties of IL-10 can counteract protective immune responses and, thereby, promote persis
148 n of novel antigens, better understanding of protective immune responses, and steady progress in the
149 eins in HCV vaccines might be detrimental to protective immune responses, and/or structural proteins
150 al proteins known experimentally to elicit a protective immune response are relatively depleted in pe
151 Tools that enable the rapid evaluation of protective immune responses are essential to vaccine dev
153 cine for children, but the mechanisms behind protective immune responses are unclear, and the duratio
154 response and committal to a damaging, though protective, immune response are tightly controlled at mu
155 that must be considered to achieve the most protective immune response, as occurs naturally with man
156 CD8 TRM) cells are an essential component of protective immune responses at barrier tissues, includin
157 tegies of vaccination are required to induce protective immune responses at mucosal surfaces and in t
158 el epitope-rich vaccines and help to predict protective immune responses at the individual and popula
159 studies have used mass cytometry to profile protective immune responses, both postinfection and post
160 that the cells will not recover to induce a protective immune response but instead undergo mitochond
161 ant was able to infect the mice and induce a protective immune response but was avirulent compared to
162 demonstrates that it is possible to generate protective immune responses by vaccination with genetica
165 the mammalian immune system that triggers a protective immune response characterized by the producti
166 host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine
168 cells, two essential components of the early protective immune response directed against intracellula
169 on of the ability of plasmid DNA to generate protective immune responses, DNA vaccines have entered i
170 infection, indicating that activation of the protective immune response does not require platelets.
171 arasite replication and the development of a protective immune response during acute infection but do
172 n important mechanism for the suppression of protective immune responses during infection with C. par
173 T cells and induction of IFN-gamma-mediated protective immune responses during the early stage of re
176 he strategies defining key components of the protective immune response elicited by these vaccines ar
177 taompdc mutants provide new tools to examine protective immune responses elicited by vaccination with
178 ing in mice to levels sufficient to induce a protective immune response, even when the infecting dose
179 both induce priming and continually boost a protective immune response following a single inoculatio
180 monary granulomatous responses, hallmarks of protective immune responses following mycobacterial infe
181 thors show that replicating LAVs stimulate a protective immune response from a safe haven in the germ
182 not been thought to stimulate cross-reactive protective immune responses; however, in this study, we
183 ants with reduced genetic diversity elicit a protective immune response in an animal model of infecti
184 s resulted in the inability to mount a fully protective immune response in bone marrow chimeric mice.
185 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.
186 th lactic acid-producing bacteria triggers a protective immune response in GALTs and confers neuropro
188 ndidates against VL since they elicit strong protective immune response in human PBMCs from HVL, simi
190 icles of type 3 poliovirus that can induce a protective immune response in mice transgenic for the hu
191 technology demonstrated induction of a 100% protective immune response in mice, as all vaccinated C5
194 ells, production of antibodies, induction of protective immune response in swine, and virulence.
195 of small numbers of M. avium cells induces a protective immune response in the intestines against sub
198 e brain represents a significant barrier for protective immune responses in both infectious disease a
201 uvant, could rescue some defects in inducing protective immune responses in MHC-II-deficient mice.
205 of ST-5 CPS RU induced long-term memory and protective immune responses in rabbits superior to those
206 n-specific immunotherapy is the induction of protective immune responses in the absence of anaphylact
207 ns to lymph nodes (LNs) and are required for protective immune responses in the context of inflammati
212 analyses support the view that the maternal protective immune response is influenced by initial expo
215 the central role of memory B cells (MBC) in protective immune responses, little is understood about
216 relevant M. tuberculosis targets that elicit protective immune responses may have yet to be discovere
217 ichial immunity, possibly via decreasing the protective immune response mediated by interferon-gamma
218 f the tumor microenvironment, in promoting a protective immune response mediated by T cells against c
221 ults indicate that CD8+ T-cells mediated the protective immune response provided by the irradiated tm
222 erculosis organisms exhibited increased host-protective immune responses, reduced bacillary load, and
223 opment needs additional knowledge about host protective immune response(s), antigen characteristics,
224 enuated whole sporozoites can induce sterile protective immune responses targeting preerythrocytic an
225 ines have been shown to provide better cross-protective immune responses than inactivated vaccines by
226 ressive signals must be overcome to elicit a protective immune response that eliminates the virus.
227 VPI 10463, C57BL/6 mice were able to mount a protective immune response that prevented diarrhea and d
228 e findings identify GM-CSF as central to the protective immune response that prevents progressive fun
229 In addition, this vaccine induced a cross-protective immune response that was able to protect 50%
230 in identifying the inflammatory pathways and protective immune responses that are elicited in the int
231 ent febrile malaria, possibly by maintaining protective immune responses that depend on ongoing paras
232 deeper understanding of cellular and humoral protective immune responses that eliminate pre-erythrocy
233 he lungs, enhance survival, and modulate the protective immune responses that eliminate the virus whi
234 d (ii) immunomodulatory HDTs that facilitate protective immune responses that kill Mtb or reduce dele
235 or controlling maternal viremia and inducing protective immune responses that prevent severe CMV-asso
236 ology was found to elicit broad, potent, and protective immune responses, that were comparable to a v
239 ariable abilities to induce inflammatory and protective immune responses; these preferential immune r
240 s-like particles (cVLPs), in boosting strong protective immune responses through an intranasal (i.n.)
242 lls combat viral infection and contribute to protective immune responses through multiple mechanisms,
243 also sufficiently immunocompetent to raise a protective immune response to a candidate subunit vaccin
244 ator that drives an efficient and controlled protective immune response to a sand fly-transmitted Lei
245 tself does not play an essential role in the protective immune response to BCG infection; however, th
248 endritic cells can potentially influence the protective immune response to concurrent infections.
250 thy adults and children, suggesting that the protective immune response to HMPV is incomplete and sho
252 PN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of
253 us strains influences the ability to mount a protective immune response to novel pandemic strains.
254 the ability of the mammalian host to mount a protective immune response to pandemic strains of influe
255 kinase provides critical checkpoints for the protective immune response to the spirochete during infe
256 BTLA(+) cells, thereby interfering with the protective immune response to this intestinal parasite.
257 To determine the role of NK cells during the protective immune response to vaccination in vivo, we st
258 sotype-switched IgG antibodies and long-term protective immune responses to a T-dependent influenza v
259 approaches that target PD-1-PD-L1 to enhance protective immune responses to A. fumigatus infections.
260 e is the necessity to produce fairly uniform protective immune responses to all four dengue virus ser
261 try of virus-specific lymphocytes, promoting protective immune responses to CNS viral infections that
262 or other intracellular pathogens, successful protective immune responses to Francisella tularensis re
263 estrating crucial T helper cell type 2 (Th2) protective immune responses to gastrointestinal nematode
265 s a role as a negative regulator in inducing protective immune responses to influenza vaccination.
266 monocytes, and/or macrophages initiate host-protective immune responses to intracellular pathogens i
267 nisms that interfere with the development of protective immune responses to M. tuberculosis, the stud
268 ntibody responses are critical components of protective immune responses to many pathogens, but param
269 Knowledge of the acquisition and nature of protective immune responses to P. falciparum is presentl
271 role of CCR7 signaling in the generation of protective immune responses to the intracellular protozo
272 accines require adjuvants in order to induce protective immune responses to the targeted pathogen.
274 ell expression of CCR7 for the generation of protective immune responses to Toxoplasma infection.
275 However, the roles of MHC-II in inducing protective immune responses to vaccination have not been
279 entify adjuvant strategies aimed at inducing protective immune responses to various pathogens, includ
280 tides as a vaccine delivery vector to induce protective immune responses to various strains of B. pse
282 -2/IFN-gamma coproduction, characteristic of protective immune responses to viral infections, was abs
283 step toward vaccine development is defining protective immune responses; toward that end, we here ch
284 riant natural killer T (iNKT) cells induce a protective immune response triggered by foreign glycolip
285 l and affordable means to elicit potentially protective immune responses upon vaccination, especially
286 Mycobacterium tuberculosis may modulate protective immune responses using diverse mechanisms, in
289 ccine to induce rapid, as well as sustained, protective immune responses was examined with two separa
291 cystis infection are incapable of mounting a protective immune response when transferred into Rag1(-/
292 une responses and counteraction of bacterial protective immune responses when developing a vaccine ag
293 of specialized immune receptors that induce protective immune responses when they detect highly cons
294 in delivery system is capable of stimulating protective immune responses where effective immunization
295 e are not associated with the development of protective immune responses, which is attributable to a
296 imulatory and inhibitory signals to maximize protective immune responses while maintaining immunologi
297 ells (Treg cells) is critical for generating protective immune responses while minimizing autoimmunit
298 bjects and reflect classical features of the protective immune response with high expression of IL-10
299 is V antigen (AdsecV) could stimulate strong protective immune responses without a requirement for re
300 ate and adaptive immune responses can induce protective immune responses without the need for potenti
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