ライフサイエンスコーパス: protein

1 Fus2p, a pheromone-induced amphiphysin-like protein.

2 that are formed by loops of the major capsid protein.

3 n eliciting dose of 300 mg or less of peanut protein.

4 ative regulator of the Ras small GTP-binding protein.

5 versal biomarker for the influenza virus, M1 protein.

6 ly with the stress elicited by oncogenic Ras protein.

7 ted 4E-binding protein 1, and p-S6 ribosomal protein.

8 SA assay for sensitive diagnosis of Zika NS1 protein.

9 volved in galactosylation of arabinogalactan proteins.

10 of Ef-Tu retain binding capabilities to host proteins.

11 conserved between COPI and clathrin/adaptor proteins.

12 ulating lytic replication, but lacked capsid proteins.

13 in-coupled receptor signaling by scaffolding proteins.

14 ected peptide queries, peptides and inferred proteins.

15 c route to incorporating phosphothreonine in proteins.

16 e expression of oncogenes and anti-apoptotic proteins.

17 ng sequences lead to mRNAs encoding distinct proteins.

18 gnaling pathways and sulfhydration of target proteins.

19 s between regulators on downstream genes and proteins.

20 s including the mimicry of prosurvival Bcl-2 proteins.

21 r acetylating N termini of the transmembrane proteins.

22 ructures of RNA, with or without the help of proteins.

23 ing interferon-beta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of IFN-regulato

24 ent stages of infection (viral nonstructural protein 1 and immunoglobulin M) has greatly simplified l

25 odies to 5 proteins of the Merozoite Surface Protein 1 complex were differentially acquired between t

26 tiation factor 4E, phosphorylated 4E-binding protein 1, and p-S6 ribosomal protein.

27 Hmox1(+/+) SCs with monocyte chemoattractant protein-1, IL-6, IL-1beta, and is associated with increa

28 -13, interleukin-17, macrophage inflammatory proteins-1alpha, and macrophage inflammatory proteins-1b

29 proteins-1alpha, and macrophage inflammatory proteins-1beta) when CD73 was lacking.

30 RNA binding motif protein 25 (RBM25) is a putative splicing factor strongl

31 ubiquitin ligase tripartite motif-containing protein 32 (Trim32).

32 vated the transcription factors GATA-binding protein 4 (GATA-4) and hypoxia-inducible factor (HIF)-1a

33 n DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner.

34 h functions to clear endogenous mannosylated proteins, a principle used to endow insulin analogs with

35 y and dynamics are essential for controlling protein activity.

36 endonucleolytic cleavage of DNA at sites of protein adducts requires ATP hydrolysis at both sites, a

37 Work-related asthma patients exposed to protein allergens and isocyanates elicit similar nasal p

38 uorescent output [green and red fluorescence proteins] allowed measurement of biosensor functionality

39 truncated versions of the membrane scaffold protein, allowing the preparation of a range of stepwise

40 ng signals through primate signal regulatory protein alpha.

41 on by AMPylation and point toward a role for protein AMPylation in the regulation of cellular protein

42 Western blotting of MKK2 protein and its T31 phosphorylated peptide verified the

43 ocation or ABHD5 interactions with perilipin proteins and ABHD5 ligands, demonstrating that ABHD5 lip

44 Detecting their presence and location in proteins and cells is important for understanding biolog

45 AAA+ disaggregases solubilize aggregated proteins and confer heat tolerance to cells.

46 cture, evolution and function of these FASTK proteins and discuss the individual role that each has i

47 trations of CO2 at the level of transcripts, proteins and enzyme activity.

48 a receptor for multiple extracellular matrix proteins and its dysfunction leads to a form of muscular

49 n interaction with target proteases or other proteins and may play an important role in the various b

50 subsequent proteolytic digestion of unbound proteins and peptide-based phosphorylation enrichment.

51 1 IRES structure adapts to hijack a cellular protein, and it suggests that the SLII domain is a poten

52 Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of

53 Many bromodomain-containing proteins are aberrantly expressed in diseases, as best s

54 tner of NUPR1, because its other interacting proteins are also unfolded.

55 isting literature concerning which autophagy proteins are capable of curvature recognition.

56 Vps13 proteins are conserved in eukaryotes, but their molecula

57 The second prediction is that iron-related proteins are dramatically affected by mitochondrial ferr

58 SPA proteins are essential cofactors of COP1, but their exac

59 JARID1 proteins are histone demethylases that both regulate nor

60 Essential proteins are indispensable to the survival and developme

61 rigin and complex diversity, many tectiviral proteins are ORFans of unknown function.

62 Misfolded endoplasmic reticulum proteins are retro-translocated through the membrane int

63 l. identify a putative novel function of tau protein as a regulator of insulin signaling in the brain

64 ture proteomics that the TbSTT3A and TbSTT3B proteins associate with each other in large complexes th

65 ponding to the arrival of the early and late proteins at the plasma membrane.

66 encing of a member of the Bone Morphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp),

67 hat phosphorylation of the Ctf19 kinetochore protein by a conserved kinase, DDK, provides a binding s

68 e indicates that the phosphorylation of Dam1 protein by Ipl1 kinase destabilizes this interaction.

69 ation of specific enzymes in self-assembling protein cages is a hallmark of bacterial compartments th

70 Here we report the amount of a protein can also be selectively increased using ASOs des

71 e force spectroscopy to show that an adhesin protein can regenerate its thioester in the absence of p

72 nderstand how a polymer composed of a single protein can switch between different supercoiled states

73 ties and processes to interact with multiple proteins, can have profound biological impacts on cells.

74 ransduction domains (PTDs) have been used as protein carriers, however they often require covalent fu

75 zation dependent on MinD and the DivIVA-like protein Cdv3, indicating that two distinct pools of MinC

76 Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure

77 ng set of sequences-the bacterial chemotaxis protein CheY, the N-terminal receiver domain of the nitr

78 nt of an extensively studied flavodoxin fold protein CheY.

79 We found that both proteins co-migrated in native gels in a complex of appr

80 eased its adaptability, as many mutations in protein-coding genes occurred during the outbreak.

81 g RNAs, and even supporting evolution of new protein-coding genes.

82 sition by activating transcription, altering protein-coding sequences, producing noncoding RNAs, and

83 bly through a membrane-associated regulatory protein complex composed of beta-Arrestin1, ARHGAP21 and

84 y a highly conserved heterotrimeric membrane protein complex denoted Sec61 in eukaryotes and SecYEG i

85 h inhibiting and stabilizing specific 14-3-3 protein complexes by small molecules, peptide mimetics,

86 tosynthesis begins when a network of pigment-protein complexes captures solar energy and transports i

87 Multiple protein complexes regulate the Rag GTPases in response t

88 nal properties and isoflavone profile of soy protein concentrate.

89 to amplify signals or stabilize a particular protein conformation.

90 55 proteins contained the lipoprotein signal peptide recogn

91 nvestigated the hypothesis that differential protein content of PLINs and their distribution with LDs

92 uclear organization and Polycomb group (PcG) proteins contribute to epigenetically inheritable phenot

93 DNA repair protein counteracting oxidative promoter lesions may mod

94 nd that bile salt receptors VDR and Takeda G-protein coupled receptor5 (TGR5) were highly expressed i

95 Microarray analyses revealed G-protein-coupled receptor (GPR) signaling as a prominent

96 representing a novel mode of regulation of G protein-coupled receptor signaling by scaffolding protei

97 bitors, and most notably by stimulation of G protein-coupled receptors (GPCR).

98 Family A G protein-coupled receptors (GPCRs) control diverse biolog

99 Cerato-platanin proteins (CPs), which are secreted by filamentous fungi,

100 ic residues to form intra- or intermolecular protein crosslinks.

101 n contacts and triggering/promoting membrane protein crystallization, and to visualize the detergent

102 rimental structures of urea transporters and proteins crystallized in the presence of urea or urea de

103 RT1), a conserved mammalian NAD(+)-dependent protein deacetylase, senses environmental stress to alte

104 hway termed endoplasmic reticulum-associated protein degradation (ERAD).

105 Because the GTPase activity of each of these proteins depends on interactions with both ribosomal sub

106 followed by aggregation and accumulation of protein deposits in neuronal cells.

107 Except for alphaLA, the proteins did not interact with NIS alone.

108 We investigated the impact of six protein diets on oxidation and anti-oxidation status in

109 In this study, we report a new family of proteins distantly related to outer kinetochore proteins

110 siological levels of Fe/S cluster biogenesis proteins during iron deprivation.

111 tream pathways to ameliorate consequences of protein dysfunction; however, targeting the source of th

112 arameters linked to the amount of structural proteins (e.g. collagen, elastin) and lipids (e.g. foam

113 oRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how

114 echanisms by which mRNAs encoding cold shock proteins escape cooling-induced translational repression

115 Talin, a cytoskeletal protein essential in mediating integrin activation, has

116 The level of IFNAR1*557Gluext*46 mutant protein expressed in patient fibroblasts was comparable

117 G521R ER cells despite appropriate receptor protein expression and nuclear localization.

118 We focused on FOXP1 and assessed its protein expression by immunohistochemistry (IHC) in 763

119 The induction of EBI3 protein expression in mouse NK cells is a late activatio

120 explains approximately 5% of the variance in protein expression.

121 molecular level, and importantly no aberrant protein expression.

122 Leaf protein extraction and purification is applied by other

123 Paramyxovirus viral fusion proteins (F) insert into the target cell membrane, and f

124 g selectivity for different isoforms of this protein family.

125 Macrodomain is a conserved protein fold found in several plus-strand RNA viruses th

126 lfide links are absolutely required to allow protein folding and, conversely, that protein folding oc

127 allow protein folding and, conversely, that protein folding occurs prior to disulfide formation.

128 orly understood are the very early stages of protein folding, which are likely defined by intrinsic l

129 er they often require covalent fusion to the protein for efficient delivery.

130 wheat, which are primary sources of dietary protein for many countries.

131 acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positive regulator of un

132 mechanisms target aggregated Golgi membrane proteins for lysosomal degradation.

133 In total, 7622 proteins from the scPDB database of binding sites have b

134 e membrane and the continuous release of the proteins from the vesicle to the plasma membrane.

135 Fluorescent protein fusions to the amino terminus of small capsid pr

136 ectrode surface in an optimal orientation by protein G interaction.

137 le nucleotide polymorphisms within the prion protein gene have been linked to differential susceptibi

138 ll injury biomarker, glial fibrillary acidic protein (GFAP)-breakdown product (GBDPs) in injured cort

139 imaging by engineering a green fluorescence protein (GFP)-mimicking turn-on RNA aptamer, Broccoli, i

140 This essential protein has also been implicated in mediating several fo

141 physiologically relevant htt exon-1 (Httex1) protein has been challenging.

142 Eukaryotic 14-3-3 proteins have been implicated in the regulation of diver

143 vities and the biological functions of these proteins have been largely unexplored.

144 Host cell proteins (HCP) are a major class of impurities derived f

145 mplexation with human growth hormone binding protein (hGHBp) to the different NOTA-modified somatropi

146 ein AMPylation in the regulation of cellular protein homeostasis beyond the endoplasmic reticulum.

147 RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR i

148 ke progress by studying the colicin immunity protein Im9.

149 s best studied in cancers, where bromodomain proteins impact the expression of oncogenes and anti-apo

150 is primarily recognized as a focal adhesion protein in EC, was not anticipated to have a role in vas

151 e formation are e, f, g, diabetes-associated protein in insulin-sensitive tissues (DAPIT), and the 6.

152 2 (LCN2) was the most substantially elevated protein in the CNS after peripheral administration of li

153 assembly of charged nanoparticles (NPs) and proteins in aqueous solutions can be directed by modifyi

154 r targeting, but the role of vacuole-related proteins in BR receptor dynamics and BR responses remain

155 lthough the important roles of co-opted host proteins in RNA virus replication have been appreciated

156 entation coefficient and binding affinity of proteins in the micromolar range, the implementation of

157 Pals1 interacting proteins, including Crb3 and Wwtr1/Taz, have been linked

158 Further, DNA-bound RecA protein increases the rate of ATP hydrolysis catalysed b

159 However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by which mRN

160 e both a direct stabilizing effect of ligand-protein interactions and an indirect destabilizing effec

161 RNA-protein interactions are essential for proper gene expre

162 can also alter RNA structures to affect RNA-protein interactions in cells.

163 To investigate such protein interactions, we establish a ribosome affinity p

164 mechanism for iron mineral formation at the protein interface.

165 Autocatalysis severs the protein into a large membrane-anchored beta subunit that

166 Translocation of secretory proteins into the lumen of the endoplasmic reticulum or

167 ired for cellular entry, as well as tegument proteins involved in regulating lytic replication, but l

168 over almost 2 decades have revealed some 30 proteins involved in the synthesis of cellular [2Fe-2S]

169 QuiC1 enzyme from P. putida reveals that the protein is a fusion of two distinct modules: an N-termin

170 profiling experiments show that this single protein is implicated in the regulation of MAP kinase-co

171 pancreatic ductal adenocarcinoma (PDAC) PAR2 protein is necessary for TGF-beta1-dependent cell motili

172 The autoimmune regulator (AIRE) protein is the key factor in thymic negative selection o

173 ognizes site II on both the pre-F and post-F proteins, is restricted to prophylaxis in neonates at hi

174 polymers of whey protein isolate (WPI), soy protein isolate (SPI) and casein (CN) and their binary m

175 d heterologous cross-linked polymers of whey protein isolate (WPI), soy protein isolate (SPI) and cas

176 However, since CusB is an adaptor protein, its role in operating this system is significan

177 the source of that dysfunction, the affected protein itself, seems most judicious to achieve a highly

178 stically, inhibiting VEGFR2 or AMP-activated protein kinase (AMPK), a major decorin-activated energy

179 ted using the Chaetomium thermophilum RIOK-2 protein kinase (Ct-RIOK-2) crystal structure 4GYG as a t

180 Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in Saccharomyces cerevisiae that c

181 uch as receptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-interacting serine/th

182 IPK1), receptor-interacting serine/threonine-protein kinase 3 (RIPK3), TIR-domain-containing adapter-

183 arrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta t

184 ular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalian target of rap

185 pendent or -independent for co-dependency on protein kinase C delta (PKCdelta).

186 A431 epithelial cells transduced Gbetagamma-protein kinase C- and Gbetagamma-metalloproteinase/EGFR-

187 Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated

188 The TTK protein kinase gene (TTK) on chromosome 6q14.1 was the m

189 ine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2-S2814

190 ve been identified as potent ATP-competitive protein kinase inhibitors.

191 ith DHA and Physcion activates AMP-activated protein kinase, leading to synergistic inhibition of hum

192 A dual enrichment strategy targets intact protein kinases via capture on immobilized multiplexed i

193 mulator (ICOS), lymphocyte activation gene 3 protein (LAG-3), and CD49b, and exert strongly suppressi

194 In contrast, loss of Mll3/4 proteins leads to strong depletion of enhancer Pol II oc

195 In turn, increased ferritin protein levels promote the expression of the promitotic

196 levels in HCEC, but had no effect on CYP27B1 protein levels.

197 for multiplexed single-molecule screening of protein libraries, and should enable the in vitro direct

198 s provides an extensive proteome-wide map of protein ligandability and facilitates the coordinated di

199 is an evolutionary conserved multifunctional protein localized primarily in the mitochondrial matrix

200 tic transcription factor FOXM1 (Forkhead box protein M1).

201 Targeting ADCC-Abs to internal proteins may be a potential mechanism of universal vacci

202 Both in G protein-mediated pathways and in beta-arrestin 2 recruit

203 RosettaMP, a general framework for membrane protein modeling.

204 cetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (

205 tabolism and cell cycle, as well as RNA- and protein-modifying enzymes that functionally diversify ma

206 ave reported recently that NUMB-like (NUMBL) protein modulates osteoclastogenesis by down regulating

207 acids that couple RNA and ATP binding to the protein (Motif III).

208 teins distantly related to outer kinetochore proteins Ndc80 and Nuf2.

209 nvestigate the effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular releas

210 l receiver domain of the nitrogen regulation protein NT-NtrC, and the sporulation response regulator

211 We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagg

212 biological molecules, including the adhesion proteins of several marine organisms.

213 Both models found that antibodies to 5 proteins of the Merozoite Surface Protein 1 complex were

214 RNA-binding proteins of the Musashi (Msi) have been implicated in th

215 (FBS), a physiologically relevant mixture of proteins, on Mg and Mg alloy degradation.

216 ble, in particular when working with dynamic proteins or weakly binding ligands.

217 s positively correlated with the size of the protein, or better, the density of contacts.

218 ons e.g. to model missing segments, flexible protein parts or hinge-regions into cryo-EM density maps

219 that the FX/SR-AI-complex comprises a third protein, pentraxin-2 (PTX2).

220 l amyloids and highlight connections between protein/peptide folding, unfolding and aggregation mecha

221 ze 10nm) to plasmalemmal vesicle-associated protein (Plvap) that is specifically localized to endoth

222 atalysis observed in enzymatic processes and protein polymerizations often relies on the use of supra

223 ectal delivery system using silk-elastinlike protein polymers (SELPs).

224 Species that have HP1 proteins possess multiple paralogs that perform non-over

225 We find that more than half the identified proteins possess multiple sites of phosphorylation that

226 thanol at a 3:1 ratio of solvent to milk for protein precipitation and dichloromethane for lipid remo

227 class of impurities derived from recombinant protein production processes.

228 pid droplet (LD)-associated perilipin (PLIN) proteins promote intramuscular triglyceride (IMTG) stora

229 ect the smallest size, critical for favoring protein-protein contacts and triggering/promoting membra

230 d quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or

231 Protein-protein interactions (PPIs) of these subunits pl

232 model with prior biological knowledge (i.e., protein-protein interactions) for biological network inf

233 gical processes by phosphorylation-dependent protein-protein interactions.

234 thus, can be applied to both high-efficiency protein purification and large-scale proteomics analysis

235 cellular release by infected CD4+ T cells on protein quality control and autophagy in cardiomyocytes.

236 y identifies hundreds of ribosome-associated proteins (RAPs) from categories including metabolism and

237 e key residues are eventually formed can the protein reach the transition state and continue folding.

238 Thus, in addition to their canonical role in protein recycling, REs also mediate forward secretory tr

239 is, triggering of the mitochondrial unfolded protein response, loss of mitochondrial membrane potenti

240 similar to that of intrinsically disordered proteins, resulting in a predominant form of iC3b that f

241 ates bearing defined mutations in the capsid protein revealed differences in their cytoplasmic and nu

242 Isolation of surface proteins revealed higher amounts of alpha4 or beta2 subu

243 tors (DAI) that contain receptor-interacting protein (RIP) homotypic interaction motifs (RHIM) play a

244 of structural biology is to understand how a protein's 3-dimensional conformation determines its capa

245 Optimization of a protein's pharmaceutical properties is usually carried o

246 ation of the mutually antagonistic signaling proteins, SasA and CikA.

247 Here we report the engineering of a protein scaffold for preferential binding to K-Ras G12D.

248 s resulted in extraction of the SDS from the protein-SDS complexes and refolding of betaLG, BSA, and

249 For all proteins, the addition of NIS to the protein-SDS samples resulted in extraction of the SDS fr

250 tween amino acids close to each other in the protein sequence.

251 Therefore, proteins should be taken into account when designing exp

252 Among them, eight proteins showed the same changing patterns in both 1 SL

253 The class III PI3K Vacuolar protein sorting 34 (Vps34) plays a role in both canonica

254 de bond with TG2, we demonstrated that these proteins specifically recognized each other in the extra

255 odeled the variants on the three-dimensional protein structure and performed subcellular localization

256 els and theory, numerical estimates for real protein structures are currently lacking.

257 SCOPe classifies the majority of protein structures released since SCOP development concl

258 e complexes that contain no other detectable protein subunits.

259 Adaptor proteins such as receptor-interacting serine/threonine-p

260 ed to encapsulate and release bulky globular proteins, such as mCherry, in a light-dependent manner.

261 le protein synthesis and can be augmented by protein supplementation (PS).

262 Large-scale RNA-binding pockets on protein surfaces are grouped by measuring their structur

263 Here, we present an approach of cell-free protein synthesis (CFPS) that provides proteins with two

264 ning (RET) has a beneficial effect on muscle protein synthesis and can be augmented by protein supple

265 nd associates with polyribosomes to increase protein synthesis in a CAP-independent manner.

266 Protein synthesis rates are determined, at the translati

267 genes to the disparate, cytoplasmic sites of protein synthesis.

268 of bioorthogonal tethering to SNAP and CLIP protein tags to create a family of light-gated metabotro

269 ssign glycation, oxidation and glycoxidation protein targets in diverse heated milks.

270 mic analysis that detects expression of 1129 protein targets.

271 al how the metamorphic properties of KaiB, a protein that adopts two distinct folds, and the post-ade

272 uch as R-spondin 1 (Rspo1), an extracellular protein that enhances beta-catenin-dependent Wnt signali

273 he branched actin network to the WASP-family proteins that create it.

274 KEY MESSAGE: We have identified 39 proteins that interact directly or indirectly with high

275 fication and mode of action of T6SS effector proteins that mediate this protective effect remain poor

276 arger networks of interactions, such as with proteins that serve as hubs for essential cellular funct

277 n approach to target an extracellular matrix protein, the fibronectin extra domain A isoform (FnEDA),

278 For all proteins, the addition of NIS to the protein-SDS samples

279 mode of recruitment for four of the studied proteins, the assembly of the other two is irreversible

280 e SecYEG channels with an arrested substrate protein to "freeze" them in their SecA-inserted state.

281 port describing the ability of the pH1N1 NS1 protein to naturally acquire mutations that restore this

282 me targeting with Fkbp/Frb dimerizing fusion proteins to allow chemical-induced proximity of a desire

283 Here, we used chimeric proteins to test whether DAT and SERT N and C termini co

284 relative contribution of endogenous TGF-beta proteins to the negative regulation of muscle mass via t

285 Crude protein, total dietary fibre, total polyunsaturated, tot

286 To overcome such limitations, protein transduction domains (PTDs) have been used as pr

287 pression of CDK inhibitors and decreased p53 protein turnover, which blocked their tumorigenic capaci

288 progressed, similar to the CAPZB-interacting protein TWF2.

289 viral defense through cascades controlled by protein ubiquitination and Ser/Thr phosphorylation.

290 ophila centrosomin (cnn) expresses two major protein variants: the centrosomal form (CnnC) and a non-

291 usions to the amino terminus of small capsid protein VP26 are the most widely used method to visualiz

292 The C-terminal extension of capsid protein VP3 folds into a globular protruding (P) domain,

293 The outer layer proteins, VP4 (cleaved to VP8* and VP5*) and VP7, surrou

294 s of a small family of immunoglobulin domain proteins, we found that OIG-8, a previously uncharacteri

295 tta biomolecular modeling suite for membrane proteins, we recently implemented RosettaMP, a general f

296 ean gums, potato fiber, milk, potato and soy proteins) were added to tomato sauce to investigate thei

297 , a previously uncharacterized transmembrane protein with a single immunoglobulin (Ig) domain, instru

298 ld enable the in vitro directed evolution of proteins with designer single-molecule conformational ph

299 d selectivity both for small drugs and large proteins with nearly base-pair resolution in an unbiased

300 -free protein synthesis (CFPS) that provides proteins with two different functional groups for post-t