ライフサイエンスコーパス: protein abundance

1 partially to changes in the whole cell host protein abundance.

2 exogenous signals and differentially control protein abundance.

3 of CFI mRNAs is a limited indicator of their protein abundance.

4 s to establish assays for use in determining protein abundance.

5 housands of individuals with high versus low protein abundance.

6 oter methylation and increases Cdh1 mRNA and protein abundance.

7 lygon-shaped tile, with an area representing protein abundance.

8 ects associated with transcript variation to protein abundance.

9 for therapeutic intervention targeting TRAF protein abundance.

10 pread and important mechanism for regulating protein abundance.

11 etrotransposition without altering L1 RNA or protein abundance.

12 transcriptional complexes and decreased MYC protein abundance.

13 m degradation and results in increased PDX-1 protein abundance.

14 velopment is dependent on the control of Myc protein abundance.

15 tion of clpC enhances isdB transcription and protein abundance.

16 ene-targeting approach that preserves normal protein abundance.

17 the LeETR4 phosphorylation state rather than protein abundance.

18 anscription dominates translation to control protein abundance.

19 correlation between protein conservation and protein abundance.

20 ral trend where expression noise scales with protein abundance.

21 leads to cell-to-cell variations, noise, in protein abundance.

22 itude than corresponding changes observed in protein abundance.

23 aSyn was causing a lowering in synapsin-I/II protein abundance.

24 om the growth-dependent global modulation of protein abundance.

25 RT1 deficiency resulted in higher liver CES1 protein abundance.

26 ion of 6-d-old mice increased IL-33 and TSLP protein abundance.

27 hepatic Srebp2 mRNA level and mature Srebp2 protein abundance.

28 for oxidative phosphorylation and modulates protein abundance.

29 oss of enzymatic activity and/or decrease in protein abundance.

30 nces for complex formation and regulation of protein abundance.

31 s into account enables precise modulation of protein abundance.

32 therapeutic intervention by modulating PIAS4 protein abundance.

33 okinesis, suggesting a tight control of CIF2 protein abundance.

34 a and beta1 subunits, but no change in total protein abundance.

35 ing, i.e. the characteristic time scales and protein abundance.

36 have been described that are correlated with protein abundances.

37 lator CheY increases with overall chemotaxis protein abundances.

38 rved temporal relationships between mRNA and protein abundances.

39 ly altered independently of the steady state protein abundances.

40 n of time and to cell-to-cell variability of protein abundances.

41 of gene expression help to regulate cellular protein abundances.

42 ion regulation - in controlling steady-state protein abundances.

43 gically significant changes in corresponding protein abundances.

44 an unprecedented ability to survey mRNA and protein abundances.

45 40%, 11%, and 10%, respectively, of relative protein abundances.

46 that cell-to-cell variability, or noise, in protein abundance acts within a network of more than six

47 ssion, DNA copy numbers, DNA methylation and protein abundance, all available in The Cancer Genome At

48 he observed values and test for differential protein abundance along with descriptive statistics and

49 Estimates of absolute protein abundance also reveal principles for optimizing

50 stion and will increase the dynamic range of protein abundances amenable by SRM in animal tissue.

51 ere were significant differences in mRNA and protein abundance among ages, tissues, and between males

52 iency resulted in a general decrease in PSII protein abundances, an effect that was shown to be rever

53 uperoxide; vascular leak; increased thrombin protein abundance and activity; activation of ERK; great

54 compound AICAR as a novel inhibitor of EGFR protein abundance and as a potential anticancer agent fo

55 KB mutations resulted in marked reduction in protein abundance and chloride current, especially those

56 was not required for this regulation of PAA2 protein abundance and Cu addition did not affect PAA2 tr

57 We measured protein abundance and localization changes in 4,085 GFP-

58 reliable and simple means to compare RNA and protein abundance and localization.

59 r correspondence between loci that influence protein abundance and loci that influence mRNA abundance

60 perience and internal state to control Orb2A protein abundance and long-term memory formation.

61 Co-expression of barttin increased protein abundance and membrane trafficking of hClC-Kb an

62 After PD treatment POS receptor protein abundance and phagocytosis show a coincident in

63 elled cell Subsets) approach, we now compare protein abundance and phosphorylation changes in interph

64 Protein abundance and phosphorylation of STAT3 signaling

65 9) and IDOL and thereby enhance hepatic LDLR protein abundance and plasma LDL cholesterol reduction.

66 The temporal regulation of protein abundance and post-translational modifications i

67 erned by transcriptional changes but also by protein abundance and post-translational modifications m

68 imbibition, increased GA levels reduce DELLA protein abundance and release ATML1/PDF2 to activate L1

69 Gene silencing of c-Cbl restores Nck1 protein abundance and stress fibres in synaptopodin knoc

70 ovides invaluable information regarding both protein abundance and subcellular localization.

71 s limited regarding the differences in human protein abundance and the genetic basis for this differe

72 tic inactivation selectively decreases RAD51 protein abundance and the nuclear export of RAD51 mRNA,

73 only a single peptide match, indicating low protein abundance and/or false-positive peptide matches.

74 pHapo conveys functionality by (i) adjusting protein abundances and (ii) affecting the rheological pr

75 Increasing protein abundances and enzymatic activities of glutathio

76 the composition of proteomes with a focus on protein abundances and functions.

77 Western blot analysis for comparison of protein abundances and glycosylation patterns did not sh

78 s, since complex diseases like cancer change protein abundances and modifications.

79 nderstanding of mechanisms for regulation of protein abundances and their transient behaviors.

80 ion is to perturb the form (e.g., change the protein abundances) and observe the resulting changes in

81 protein, or phosphorylated (pS2808, pS2814) protein abundance, and [(3)H]ryanodine binding was not d

82 a concomitant decrease in green fluorescent protein abundance, and blocks primer extension by DNA po

83 vels: in olfactory cued behavior, in RNA and protein abundance, and in the oxidation state of a broad

84 both necessary and sufficient to promote Hiw protein abundance, and it does so by binding to Hiw and

85 insulin stimulated a 5-fold increase in ATF4 protein abundance, and knockdown of ATF4 expression supp

86 We focus on low mRNA numbers, high protein abundance, and monomeric transcription-factor bi

87 mproved urine concentrating ability and AQP2 protein abundance, and reversed the lithium-induced incr

88 tion significantly reduced glycogen synthase protein abundance, and the remaining protein was predomi

89 grating the protein OS enrichment score, the protein abundance, and the retina transcriptome, the pro

90 ted the depletion mechanism with known yeast protein abundances, and we observed greater than threefo

91 ic constraints on cell-to-cell variations in protein abundance are imposed by a given functional phen

92 Both Kit mRNA and KIT protein abundance are influenced by miR-221/222 function

93 The measured protein abundances are consistent with previous work, an

94 ssessing microbial community structure using protein abundance as a measure for biomass contributions

95 , most studies use messenger RNA rather than protein abundance as the measure of gene expression.

96 Finally, visualization of changes in protein abundance associated with a particular process p

97 ta show a conspicuous increase in H(+)-PPase protein abundance at the vasculature of the transgenic p

98 are known to have significant differences in protein abundance based on bottom-up analysis.

99 proteomics involves statistical inference on protein abundance, based on the intensities of each prot

100 phenotype we analyzed global differences in protein abundance between wild-type and knock-out femora

101 Glycoprotein changes occur in not only protein abundance but also the occupancy of each glycosy

102 rols showed no differences in SMCHD1 mRNA or protein abundance but revealed regulatory changes in gen

103 rom TMG-treated rats did not exhibit altered protein abundance but showed overall elevated O-GlcNAcyl

104 hich stabilizes PTEN, resulting in increased protein abundance but suppressed PTEN phosphatase activi

105 onstrate its utility in quantifying not only protein abundance, but also activity.

106 st-transcriptional modifications can control protein abundance, but the extent to which these alterat

107 that mRNA abundances broadly correlate with protein abundance, but these two are often imperfectly c

108 Reduction of PIF3 protein abundance by DELLAs correlates closely with redu

109 identified posttranscriptional regulation of protein abundance by GSK-3, with approximately 47 protei

110 PR17 activation also diminishes myelin basic protein abundance by lessening stimulation of the exchan

111 Control of protein abundance by the ubiquitin-proteasome system is

112 s of iron sparing include down regulation of protein abundance by transcript reduction or protein deg

113 omposition by DEXA, tissue insulin signaling protein abundance by Western blotting, glucose tolerance

114 on is a powerful tool for the measurement of protein abundances by mass spectrometric methods.

115 r, because temporal changes in intracellular protein abundances cannot be measured directly in live c

116 Previously, we analyzed protein abundance changes across a 'minimally perturbed'

117 Recently, we analysed gene expression and protein abundance changes during interphase under minima

118 We employed proteomic approaches to assess protein abundance changes in seeds from Bt-transgenic oi

119 unique opportunity to model the longitudinal protein abundance changes occurring during hepatitis C v

120 Somatic variants displayed reduced protein abundance compared to germline variants.

121 Our findings suggest that ApoE2 protein abundance, coupled with its inability to bind to

122 analysis of highly multivariate quantitative protein abundance data generated using mass-spectrometry

123 Immunoblots showed that PAA2 protein abundance decreased significantly and specifical

124 moter methylation increases and its mRNA and protein abundance decreases in epithelium giving rise to

125 stabilized by overexpression of SLP-1, c-Myc protein abundance decreases, suggesting that the SCF(Fbw

126 Protein abundance did not alter with ageing, but neopept

127 duced transient rise in pHapo These elevated protein abundances did not directly arise from high tiss

128 hips, with generally increased magnitudes of protein abundance differences between brain regions comp

129 ranscript abundance did not reliably predict protein abundance differences between tumours.

130 s a sensitive and rapid approach to quantify protein abundance differences in Arabidopsis for specifi

131 ycle down-modulates endogenous p220 mRNA and protein abundance directly in both G0/G1 and S/G2.

132 By contrast, protein abundances display more varied responses.

133 cellular fractionation to generate signature protein abundance distribution profiles.

134 n that integrates multi-source data--such as protein abundances, domain-domain interactions and funct

135 trategy to determine alterations in relative protein abundance due to a particular carbon source, in

136 ws cells to differentially regulate specific protein abundance during cellular stress.

137 l correlations between transcript levels and protein abundance during grain development.

138 dance of each peptide and the fold change in protein abundance during growth.

139 Transcript and protein abundance followed near normal distributions, in

140 of the variance in the population's average protein abundance for half of the GFP fusions tested.

141 we obtained highly accurate measurements of protein abundance for over 2,000 unique sequence variant

142 In silico estimates of protein abundances from publicly available protein spect

143 eterminants of transcript levels, mapping of protein abundance has lagged.

144 show enrichment for variants with increased protein abundance in a manner that does not compromise c

145 st prominent features successfully explained protein abundance in an additional, independently constr

146 genotype can provide accurate predictions of protein abundance in an independent cohort of collaborat

147 Cell-to-cell variations in protein abundance in clonal cell populations are ubiquit

148 The global change in protein abundance in colorectal cancer (CRC) and its con

149 two- to threefold, respectively, as well as protein abundance in culture supernatants by five- and t

150 blocking vivo-morpholinos reduced gill SGK1 protein abundance in fish transferred from fresh to seaw

151 We propose that DOG1 protein abundance in freshly harvested seeds acts as a t

152 Here we showed that ApoE protein abundance in human postmortem cortex follows an

153 ives precise and objective quantification of protein abundance in large numbers of individual muscle

154 Experimental manipulation of protein abundance in living cells or organisms is an ess

155 nown about the genetic basis of variation in protein abundance in man.

156 , and reliable method to quantify changes in protein abundance in meat samples.

157 C6 is also a stimulator of total renal NKCC2 protein abundance in medullary and cortical thick ascend

158 s spectrometry allows researchers to confirm protein abundance in mutant lines, even when discriminat

159 ness of SRM mass spectrometry in determining protein abundance in mutant lines, we selected two enzym

160 Investigations of MECP2 mRNA and protein abundance in patient-derived lymphoblastoid cell

161 CFTR biogenesis by reducing mRNA levels and protein abundance in primary differentiated human bronch

162 Protein abundance in quantitative proteomics is often ba

163 this suggestion, we analyzed changes in GWD protein abundance in relation to starch levels in wild-t

164 PIF protein abundance in SDs oscillates as a balance between

165 Crucially, protein abundance in single cells can vary significantly

166 In accordance, NKCC1 (and gammaENaC) protein abundance in the colon of the Nedd4L knock-out a

167 ected pigs had a 70% reduction in dystrophin protein abundance in the diaphragm, psoas major, and lon

168 In addition, omeprazole reduced tyrosinase protein abundance in the presence of cycloheximide, sugg

169 They can also be used to measure protein abundance in thousands to millions of cells usin

170 hat the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on

171 The protein abundances in vernix, and particularly that of p

172 al index (SI(N)), the exponentially modified protein abundance index (emPAI), the normalized spectral

173 this was associated with a decline of NRT2.1 protein abundance, indicating posttranscriptional regula

174 act coffee quality are related to changes in protein abundance, indicating that proteomic analysis ma

175 ion of synthesis and breakdown to changes in protein abundance induced by REX differ on a protein-by-

176 g and dementia, it was hypothesised that DBN protein abundance instructs the integrity and function o

177 Alterations in protein abundances, interactions, posttranslational modi

178 classified the stimulus-dependent changes in protein abundance into two sources: global changes due t

179 Moreover, ELF3 protein abundance inversely correlates with BBX19 expres

180 Furthermore, ML3 protein abundance is dependent on NAI1, a master regulat

181 ional and/or posttranslational regulation of protein abundance is involved in the contrasting shoot a

182 The mechanism for the increase in apoE protein abundance is not understood.

183 However, measuring specific protein abundance is particularly difficult in plant res

184 The model suggests that protein abundance is primarily determined by the transcr

185 Here we show that PD-L1 protein abundance is regulated by cyclin D-CDK4 and the

186 ation of observed cell-to-cell variations in protein abundances is not inherent in chemotaxis itself

187 d-specific gene expression and variations in protein abundance, isoform expression and phosphorylatio

188 ic variants contribute to the differences in protein abundance levels in human plasma.

189 ssociation show significant association with protein abundance levels.

190 red autophagy in C. reinhardtii based on the protein abundance, lipidation, cellular distribution, an

191 ux and permits the concurrent observation of protein abundance, localization, cell size, and growth p

192 Of 3688 protein abundances measured, 39 were up-regulated under

193 ) and continuous data (e.g. gene expression, protein abundance, metabolite levels).

194 of several genes were consistent with their protein abundance models.

195 We identified protein abundance modulation in pathways associated with

196 ndependent genetic control of transcript and protein abundance: More than half of the expression QTLs

197 Protein abundance must be precisely regulated throughout

198 expression (n=24 comparison group; n=22 SZ), protein abundance (n=8 comparison group; n=8 SZ), and NF

199 Due to their limited protein abundance, neither antibodies against literature

200 ors explaining 66% of the total variation of protein abundance observed in >800 genes in Escherichia

201 ficantly improved the accuracy in predicting protein abundance of a portion of the total modeled mRNA

202 uction not by altering ER quality control or protein abundance of BRI1; instead, TWD1 appears to be c

203 The protein abundance of CLC-1 was notably enhanced in the p

204 ctopic overexpression of UHRF1 downregulates protein abundance of endogenous or exogenous PML, doing

205 uncovered which consisted of an imbalance in protein abundance of inhibitory and activating regulator

206 The protein abundance of matrix metalloproteinases 3, 8, 9,

207 tion characterized by reduced transcript and protein abundance of MHC class II on tumor B cells, in l

208 ow by quantitative light microscopy that the protein abundance of NHE6 is developmentally regulated i

209 ation of these proteins, mRNA expression and protein abundance of nonheme and heme Fe transport prote

210 mine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the

211 Bmal1 deficiency or knockdown decreased the protein abundance of RICTOR, the key component of the mT

212 -virus-mediated gene delivery maintained the protein abundance of SERCA2a and markedly improved cardi

213 titutive phosphorylation of STAT3, increased protein abundance of SOCS3, and development of insulin r

214 and also direct but differing effects on the protein abundance of splicing regulators in somatic and

215 ion of Fbxl7 in lung epithelia decreases the protein abundance of survivin, a member of the inhibitor

216 Protein abundance of TfR1 was related to midgestation ma

217 The protein abundance of the auxin efflux carrier PIN2 is re

218 Protein abundance of the heme importer, proton-coupled f

219 We found that the protein abundance of the kinesin-1 light chain (KLC1) wa

220 ompromises clock function and diminishes the protein abundance of the other, our results highlight ho

221 rots (Daucus carota) is determined by a high protein abundance of the rate-limiting enzyme for carote

222 sociated increase in the transcriptional and protein abundance of uncoupling proteins that mediates t

223 signalling posttranslationally controls the protein abundance of vacuolar SNARE components.

224 of AAOs, as well as increased expression and protein abundance of versatile peroxidase 1, which direc

225 tification methods, we found that per-genome protein abundances of most targeted biomarkers did not s

226 Unsupervised hierarchical clustering of protein abundance on nascent DNA is sufficient to identi

227 IP approach that reveals differences between protein abundance on nascent leading and lagging strands

228 e correlation of both ribosome densities and protein abundance on transcript length, the importance o

229 ogists' long-held desire to measure absolute protein abundances on a genome-wide scale.

230 is not an upstream cause of increased CAMKII protein abundance or activation.

231 connect changes observed in gene expression, protein abundance or other global assays to proteins tha

232 utophagic capacity, and higher intracellular protein abundance phenotypes of aged and SSc cells.

233 d with eQTLs, ribosome occupancy (rQTLs), or protein abundance (pQTLs).

234 lular fractions with quantitative label-free protein abundance profiling by liquid chromatography-cou

235 man blood proteome is frequently assessed by protein abundance profiling using a combination of liqui

236 rs, including gene length, codon usage bias, protein abundance, protein function, and gene expression

237 agreement between changes in transcript and protein abundance (R(2) = 0.24), many proteins, includin

238 1B gene expression was positively related to protein abundance (r(s) = 0.39; P = 0.03; adjusted for a

239 vSP-1 interacts with RTA at the protein abundance regulatory signal (PARS) motifs, and t

240 rovide the first a proteome-wide analysis of protein abundance remodeling between prophase, prometaph

241 ndance are well-developed, those that assess protein abundance require tailoring to penetrate to low-

242 eased after 10 to 15 min, and transcript and protein abundance responded by 40 and 120 to 240 min, re

243 e whether vasopressin-induced alterations in protein abundance result from modulation of protein prod

244 reased renal type I collagen and fibronectin protein abundance resulting from experimentally induced

245 new protein abundance score, the normalized protein abundance scale (NPAS), expands on the number of

246 A new protein abundance score, the normalized protein abundanc

247 mRNA and protein abundance showed significant positive correlatio

248 e miR-326 and antisense miR-9 increased DRD2 protein abundance, suggesting an endogenous repression o

249 missense mutations dramatically reduce ASNS protein abundance, suggesting that the mutations cause l

250 tes, and that these have a greater impact on protein abundance than mRNA structure or codon usage.

251 taset is superior for identifying changes in protein abundance that are consistent with the metabolic

252 equired for the rapid and precise control of protein abundance that is essential for synaptic functio

253 hese transcriptomes, yielding the changes in protein abundance that mediate circadian regulation of p

254 Notably, we present a system with high protein abundance that nevertheless requires a probabili

255 gene expression noise causes fluctuations in protein abundances that may compromise repair.

256 understand biofilm differences, we compared protein abundances that were statistically enriched in b

257 scriptional rhythms underlie oscillations of protein abundance, thereby mediating circadian rhythms o

258 In addition, we show that GA promotes ARF2 protein abundance through a translation-dependent mechan

259 We measure single-cell protein abundance through the use of green fluorescent p

260 Nongenetic variation in protein abundances thus leads to genetic heterogeneity i

261 mporal correlations within and among RNA and protein abundances to identify systematic trends in gene

262 e' combining transcript, protein and phospho-protein abundances to nominate differentially abundant p

263 STAT3 transfection increased PTTG mRNA and protein abundance twofold in HCT116 human colon cancer c

264 te, systematic measurements of both mRNA and protein abundances under a wide range of different condi

265 ance of translational control in determining protein abundance, underscoring the value of measuring g

266 arker detection is the ELISA, which measures protein abundance using bulky fluorescent scanners that

267 Analysis of protein abundance using western-blot analysis and mass s

268 rotein approach provides highly reproducible protein abundance values.

269 ecision, suitable for the detection of small protein abundance variations between complex biological

270 Oncogenic RAS increased CK1alpha protein abundance via activation of the PI3K/AKT/mTOR pa

271 itatively confirmed by direct measurement of protein abundances via quantitative mass spectrometry.

272 Protein abundance was compared between different treatme

273 Consistent with these results, LYK5 protein abundance was higher in pub13 mutants compared w

274 d suppressor of cytokine signaling 3 (SOCS3) protein abundance was increased in skeletal muscle from

275 Emc10 protein abundance was increased in the infarcted region

276 CaMKII protein abundance was increased only in sarcomere-mutati

277 We found liver ENPP1 protein abundance was lower in individuals with T2DM tha

278 PSA2 protein abundance was not decreased in the absence of PS

279 e mass-spectrometry, a significant change in protein abundance was noted, of which 200 were proteins

280 Across the entire dataset, protein abundance was poorly correlated with mRNA levels

281 Interestingly, PAA2 protein abundance was significantly increased in paa1 mu

282 d receptor; however, glucocorticoid receptor protein abundance was unaffected in miR-433 decoy cells.

283 A significant pattern of changes in protein abundance was uncovered which consisted of an im

284 The proteins' abundance was computed using a spectral matchi

285 nd the expected changes in Luciferin Binding Protein abundance were arrested in L. polyedrum cysts.

286 tumors, IGF2BP1 gene copy number, mRNA, and protein abundance were determined and compared with clin

287 PTP1B gene expression and protein abundance were determined in the biopsied skelet

288 esses which displayed the largest changes in protein abundance were peptidoglycan and fatty acid (FA)

289 mber (increased in 84% of tumors), mRNA, and protein abundance were significantly higher in stage 4 c

290 ryocyte Orai1 transcript levels and membrane protein abundance were significantly reduced in sgk1(-/-

291 Differences in protein abundance were validated by quantitative immunoh

292 tandem-mass-spectrometry and differences in protein abundances were assessed.

293 hich mean activity becomes ultrasensitive to protein abundances when the enzymes operate at saturatio

294 reanalytical factors may affect the measured protein abundances which in turn influence the outcome o

295 ess on protein divergence is proportional to protein abundance, which provides mechanistic insights i

296 unfertilized Xenopus laevis egg and estimate protein abundance with approximately 2-fold precision.

297 e identified a class of cis QTLs that affect protein abundance with little or no effect on messenger

298 (-/-) mice had reduced renal Npt2a and Npt2c protein abundance, with approximately 80% of Npt2a resid

299 y were accompanied by comparable deficits in protein abundance without changes in mRNA expression, im

300 aggregates and robustly decreased polyQ-Htt protein abundance without concomitant cellular toxicity.