ライフサイエンスコーパス: protein aggregation

1 vivo affect the fate of biomolecules (e.g., protein aggregation).

2 the presence of increased or larger cargos (protein aggregation).

3 used in protein evolution to limit unwanted protein aggregation.

4 ults in cytotoxicity associated with massive protein aggregation.

5 lded substrate proteins and prevent cellular protein aggregation.

6 ffering insight into disease-related in vivo protein aggregation.

7 gy for controlling and understanding amyloid protein aggregation.

8 n species or acting as chaperones to prevent protein aggregation.

9 preserving protein structure and minimising protein aggregation.

10 rization contributes to ALS/FTLD RNA-binding protein aggregation.

11 screening of potential inhibitors of amyloid protein aggregation.

12 general function for O-GlcNAc in preventing protein aggregation.

13 n mediate allosteric interactions that drive protein aggregation.

14 urodegeneration occurs in the absence of FUS protein aggregation.

15 product, leading to mutant huntingtin (mHTT) protein aggregation.

16 usion chromatography (SEC) for understanding protein aggregation.

17 ting of the roles of crystallin fragments in protein aggregation.

18 s losing surfactant functions and leading to protein aggregation.

19 ll heat shock protein involved in preventing protein aggregation.

20 stress, cell differentiation, and huntingtin protein aggregation.

21 fied the protein MOAG-2/LIR-3 as a driver of protein aggregation.

22 or investigating ways to tackle disorders of protein aggregation.

23 disease: genetic mutations or variation, and protein aggregation.

24 ive stress from reactive oxygen species, and protein aggregation.

25 dicating rapid folding, most likely to avoid protein aggregation.

26 ll no consensus on the mechanistic basis for protein aggregation.

27 ularly those caused by molecules that induce protein aggregation.

28 ontaneously induces local DNA compaction and protein aggregation.

29 ding with consequent aberrant intermolecular protein aggregation.

30 rarchy of electrostatic effects that control protein aggregation.

31 quence within N17 and links it to effects on protein aggregation.

32 o treat neurodegenerative diseases linked to protein aggregation.

33 led to straightforward biophysical models of protein aggregation.

34 chemical properties, presumably important to protein aggregation.

35 ria-mediated pathway linked to mitochondrial protein aggregation.

36 ermediates is often correlated with enhanced protein aggregation.

37 pensity to form secondary structures through protein aggregation.

38 ired by the molecular interactions governing protein aggregation.

39 gradation and protein adductation as well as protein aggregation.

40 are typically required to completely inhibit protein aggregation.

41 a-crystallins to suppress chemically-induced protein aggregation.

42 ain self-assembled chromophore formed due to protein aggregation.

43 ch are efficient inhibitors of non-fibrillar protein aggregation.

44 wever, is their ability to cause substantial protein aggregation.

45 synthetic genetic tool to sense and control protein aggregation.

46 ssect the complicated misfolding pathways of protein aggregation.

47 ar species formed during the early stages of protein aggregation.

48 icle fission and fusion, and shape-dependent protein aggregation.

49 allmarks of proteostasis collapse, including protein aggregation.

50 oteins probably by lowering the threshold of protein aggregation.

51 te in maintaining proteostasis by preventing protein aggregation.

52 the understanding of the molecular onset of protein aggregation.

53 proteins display prion-like transmission of protein aggregation.

54 Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded

55 We show that the device induces protein aggregation after exposure to an extensional flo

56 To prevent or regulate protein aggregation, all cells contain an extensive prot

57 progress due to transcellular propagation of protein aggregation among neurons.

58 system, innate immunity, LPS scavenging, and protein aggregation/amyloid formation.

59 Hsp70 is a protein chaperone that prevents protein aggregation and aids protein folding by binding

60 g proteome and are responsible for increased protein aggregation and altered cell proteostasis.

61 y of ALS remains poorly understood, abnormal protein aggregation and altered proteostasis are common

62 nts to treat cataracts and diseases in which protein aggregation and apoptosis are contributing facto

63 structure, protein-protein interaction, and protein aggregation and are central in Alzheimer's and o

64 Protein aggregation and axonal transport deficits have b

65 ative design, for example, in the control of protein aggregation and binding.

66 posing hydrophobic surfaces, with consequent protein aggregation and cataract formation.

67 tal dopamine dysfunction precedes detectable protein aggregation and cell death in the development of

68 lipid transport efficiency or in AD-related protein aggregation and clearance.

69 In vivo, CCPG1 protects against ER luminal protein aggregation and consequent unfolded protein resp

70 xygen species with N-acetylcysteine lessened protein aggregation and decreased apoptosis, suggesting

71 a network of molecular chaperones to prevent protein aggregation and even reverse existing protein ag

72 tein, is one mechanism proposed to stimulate protein aggregation and facilitate disease pathogenesis.

73 cent interchain beta-sheets, consistent with protein aggregation and fiber bundling during clot defor

74 uss potential consequences for mechanisms of protein aggregation and intermolecular amyloid formation

75 ts and aerosolization stresses, resulting in protein aggregation and loss of activity, were overcome

76 proteins, we hypothesized that CDDO-induced protein aggregation and lymphoma apoptosis occur by inac

77 muscle display pathological desmin-positive protein aggregation and misalignment of Z-disks, which a

78 essential part of the machinery that avoids protein aggregation and misfolding in vivo.

79 e increasing family of pathologies caused by protein aggregation and misfolding.

80 type 1, a hereditary disease associated with protein aggregation and misfolding.

81 he glycosylation site on ephrin-A1 result in protein aggregation and mislocalization.

82 Aberrant protein aggregation and mitochondrial dysfunction have e

83 h model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.

84 y (MFM) and cardiomyopathy, characterized by protein aggregation and myofibrillar degeneration.

85 n that HSP40 proteins play a crucial role in protein aggregation and neurodegeneration in several neu

86 As a causal relationship between protein aggregation and neurodegeneration remains elusiv

87 as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for c

88 erexpression of certain chaperones abrogates protein aggregation and protects a UPR mutant against ER

89 te protoporphyria with consequent hepatocyte protein aggregation and proteotoxic multiorganelle alter

90 sed by heating at 80 degrees C, which caused protein aggregation and solution turbidity.

91 ldin plays a role in quality control against protein aggregation and that dysfunction of prefoldin is

92 omplex proteostasis network actively combats protein aggregation and that such an efficient system ca

93 rexpression of active HYPE similarly induced protein aggregation and the HSF1-dependent heat shock re

94 Understanding the fundamentals of prion protein aggregation and the molecular architecture of Pr

95 ar and cellular factors that protect against protein aggregation and those that promote it.

96 hibit Cu/Zn superoxide dismutase 1 dependent protein aggregation and to extend survival in the ALS mo

97 ties to act as an antioxidant, to reduce tau protein aggregation and to improve energy metabolism.

98 AC6) is a tubulin deacetylase that regulates protein aggregation and turnover.

99 ons in proteostasis characterized by diffuse protein aggregation and ubiquitination.

100 llular space, substoichiometrically inhibits protein aggregation, and attenuates proteotoxicity of di

101 f action of this molecular chaperone against protein aggregation, and demonstrate that the role of mo

102 relation between polyglutamine tract length, protein aggregation, and disease severity.

103 dox, highlighting the roles of biochemistry, protein aggregation, and disruption of cellular microstr

104 aling, vesicular biogenesis and trafficking, protein aggregation, and protein degradation.

105 ant role in antioxidant defenses, preventing protein aggregation, and reducing inflammation.

106 ishomeostasis, aberrant protein folding, and protein aggregation are indeed involved in several disea

107 Intraneuronal protein aggregation as a trigger for inflammation and ne

108 lude evidence of Alzheimer's disease-related protein aggregation as an underlying mechanism of age-re

109 ion in zebrafish liver causes multiorganelle protein aggregation as determined by mass spectrometry a

110 ed how this cellular pathway, which involves protein aggregation as part of its normal function, migh

111 ng systems, such as protecting cells against protein aggregation, assisting protein folding, remodeli

112 rful model for understanding the dynamics of protein aggregation associated with a number of human ne

113 The amyloid protein aggregation associated with diseases such as Alz

114 hydrogel states could underlie pathological protein aggregation associated with neurodegenerative di

115 ritical role in preventing the extracellular protein aggregation associated with numerous human disea

116 of natural product-inspired drugs to combat protein aggregation-associated diseases by stimulating c

117 tial for accurately predicting and profiling protein aggregation at various stages of biopharmaceutic

118 e cell biology that underlies propagation of protein aggregation between cells, including a discussio

119 Prions are a prototypic model to study protein aggregation biology and therapeutic development.

120 moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mous

121 Proline is known to minimize protein aggregation, but a detailed study of how proline

122 of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract.

123 gation and to provide a new strategy to tune protein aggregation by modulating the exposure of aggreg

124 amined the effect of hydrophobic crowders on protein aggregation by using discontinuous molecular dyn

125 s facilitated by our previous discovery that protein aggregation can be significantly minimized by re

126 y cells, we demonstrate that cell growth and protein aggregation can be tracked in individual cells f

127 ion to reducing bioactive material recovery, protein aggregation can have major effects on drug poten

128 Since peptide and protein aggregation can obscure specific binding, and si

129 es previously linked to autophagy, including protein aggregation, cell survival, bacterial replicatio

130 n were found to have significantly increased protein aggregation compared to wild type protein or a c

131 novel disease-relevant phenotypes, including protein aggregation, compromised neuritic outgrowth, and

132 Protein aggregation continues to attract significant int

133 The polymorphic nature of protein aggregation could be magnified in the cross-seed

134 ns unclear how mitochondrial dysfunction and protein aggregation could be related.

135 In nematodes, osmotic stress induces massive protein aggregation coupled with unfolded protein respon

136 concentration is essential for understanding protein aggregation, crystallization, and protein phase

137 helicase action, ubiquitin modification, and protein aggregation, culminating in kinase activation an

138 egation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood.

139 idence that the toxic oligomeric entities in protein aggregation diseases contain antiparallel, out-o

140 read connecting nine fatal neurodegenerative protein aggregation diseases is an abnormally expanded p

141 The growing importance of protein aggregation diseases requires the development of

142 ediction, which is used to create models for protein aggregation diseases such as Alzheimer's Disease

143 in ER function associated with degenerative protein aggregation diseases.

144 their metastability may underlie devastating protein aggregation diseases.

145 fects of proteasome dysfunction in aging and protein aggregation disorders, or increase effectiveness

146 Analogous to protein aggregation disorders, our results suggest that

147 e can increase amyloidogenesis and aggravate protein aggregation disorders.

148 alassemia fits into the broader framework of protein-aggregation disorders that use PQC pathways as c

149 experiments, which avoid complications from protein aggregation, do not exhibit clear solvent-induce

150 8-linked polyubiquitin and reduced levels of protein aggregation during aging.

151 alpha- and gamma-gliadins in DDGS indicated protein aggregation during the drum drying processing st

152 count to achieve a complete understanding of protein aggregation events in vitro as well as in vivo.

153 se bonds are ultimately responsible for wine protein aggregation following a nucleation-growth kineti

154 neurodegenerative proteinopathies involving protein aggregation; for example, in the accumulation of

155 attenuation of protein translation, massive protein aggregation, growth arrest, and lethality.

156 Although aberrant protein aggregation has been conclusively linked to doze

157 Although the inhibition of amyloid protein aggregation has been well-studied, the disaggreg

158 ck proteins (sHsps), normally act to prevent protein aggregation; however, it remains to be determine

159 n depends on: (i) the specific mechanisms of protein aggregation, (ii) the hierarchical structure of

160 basin and during folding, and early steps of protein aggregation in amyloidogenesis.

161 th crystallins are responsible, in part, for protein aggregation in cataracts.

162 t of a tightly regulated pathway controlling protein aggregation in changing environments.

163 -induced carbonylation, a model that induces protein aggregation in cultured cells.

164 ra pars compacta (SNc) and the importance of protein aggregation in driving the disease process remai

165 to the site of retrotranslocation to prevent protein aggregation in ERAD.

166 simple molecular-level framework to describe protein aggregation in general and to visualize the kine

167 lation of distinct LMW peptides that promote protein aggregation in lenses expressing wt-APH.

168 phin function also accelerated age-dependent protein aggregation in muscle cells, suggesting a defect

169 ch as sodium 4-phenylbutyrate (PBA), reduces protein aggregation in neural stem cells in vitro and in

170 sponse, form a first line of defense against protein aggregation in order to maintain protein homeost

171 p a theoretical model for reversible protein-protein aggregation in salt solutions.

172 a class of illnesses marked by pathological protein aggregation in the brains of affected individual

173 uman disease, is a dendritic spinopathy with protein aggregation in the dendritic spines and an assoc

174 so involved in glycolipid transportation and protein aggregation in the future.

175 Protein aggregation in the nuclear and cytoplasmic fract

176 led, non-pathological, physiological role of protein aggregation in the regulation of a major metabol

177 Analytical methods for studying protein aggregation in these diseases are important for

178 at BBR exhibited chaperone activity, reduced protein aggregation in vitro and alleviated tunicamycin-

179 Although progress towards understanding protein aggregation in vitro has been made, little of th

180 Hsp110/Sse1 also can prevent protein aggregation in vitro via its substrate-binding d

181 MB inhibited recombinant protein aggregation in vitro, even when added to preform

182 focus by the current progress in demarcating protein aggregation in vitro, exposing new mechanistic d

183 gress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of

184 ity of the different forms of ABC to prevent protein aggregation in vitro.

185 on-mediated relief of proteotoxic stress and protein aggregation in vivo can also occur without degra

186 Consistent with this prediction, protein aggregation in yeast and worms was observed to i

187 ts active metabolite teriflunomide inhibited protein aggregation independently of their known role in

188 loss of the [4Fe-4S] clusters and subsequent protein aggregation, indicating that the [4Fe-4S] cluste

189 describe a mechanism for intracellular toxic protein aggregation induced by an unusual mutation event

190 Protein aggregation into beta-sheet-enriched amyloid fib

191 Protein aggregation into intracellular inclusions is a k

192 ark of nine neurodegenerative diseases, with protein aggregation intrinsically linked to disease prog

193 Protein aggregation is a common biological phenomenon, o

194 Intracellular protein aggregation is a common pathologic feature in ne

195 Aberrant protein aggregation is a dominant pathological feature i

196 Protein aggregation is a hallmark of each of these disea

197 Protein aggregation is a hallmark of many diseases but a

198 Protein aggregation is a significant problem in the biop

199 Protein aggregation is a widely studied phenomenon that

200 Together, these data suggest that protein aggregation is an early aging-associated differe

201 -derived cultured lymphoblasts, showing that protein aggregation is an important determinant of chemi

202 dicate that widespread amorphous and amyloid protein aggregation is an unanticipated outcome of such

203 Protein aggregation is associated with age-related neuro

204 Protein aggregation is associated with many debilitating

205 cells with cancer stem cell properties, p53 protein aggregation is associated with p53 inactivation

206 Protein aggregation is broadly important in diseases and

207 Aberrant protein aggregation is controlled by various chaperones,

208 Protein aggregation is determined by short (5-15 amino a

209 ights into the mechanism of theirDISASSEMBLY.Protein aggregation is detrimental to the maintenance of

210 lar rate of protein synthesis in response to protein aggregation is discussed.

211 Aberrant protein aggregation is inducible in rodents and primates

212 Protein aggregation is involved in many diseases.

213 Protein aggregation is linked to a growing list of disea

214 Protein aggregation is linked to more than 30 human path

215 Our model suggests that protein aggregation is not a haphazard process but rathe

216 rong support in favor of the hypothesis that protein aggregation is not a primary cause of cytotoxici

217 Abnormal protein aggregation is observed in an expanding number o

218 Protein aggregation is routinely suppressed by the prote

219 Protein aggregation is the abnormal association of prote

220 Protein aggregation is the hallmark of a number of neuro

221 An important goal in studies of protein aggregation is to obtain an understanding of the

222 m (ER) stress response (ERSR) and associated protein aggregation, is under investigation for its role

223 Extensive "in vitro" measurements of protein aggregation kinetics have been reported, but no

224 and how I138M, I139M, and S143N affect prion protein aggregation kinetics.

225 Furthermore, the polyubiquitinated protein aggregation level was increased in the brains of

226 rotects invertebrates and mammals from toxic protein aggregation linked to neurodegeneration and from

227 Protein aggregation, linked to many of diseases, is init

228 sents a critical link to the pathogenesis of protein aggregation-linked diseases.

229 To protect against undesired protein aggregation, living cells maintain a population

230 that the factors and components that control protein aggregation may be evolutionary conserved.

231 Drug-induced proteome stress that involves protein aggregation may cause adverse effects and underm

232 s uncover a translational stalling-dependent protein aggregation mechanism, and provide evidence that

233 pportunities to advance the understanding of protein aggregation mechanisms relevant to many amyloid

234 lity that GPI anchor-dependent modulation of protein aggregation might occur with other amyloidogenic

235 in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death.

236 oung mice, which recapitulated the increased protein aggregation observed in old mice.

237 f highly specific subpopulations of neurons, protein aggregation occurs in all cells, which indicates

238 t the DGJ response is negatively affected by protein aggregation of alpha-galactosidase mutants, reve

239 , but not mutant, LSS prevents intracellular protein aggregation of various cataract-causing mutant c

240 protein homoeostasis resulting from abnormal protein aggregation or a defect in the protein clearance

241 gressive motor dysfunction in the absence of protein aggregation or significant motoneuron loss, ques

242 athology and organism-level manifestation of protein aggregation phenomena in general.

243 possibility of routine noninvasive study of protein aggregation phenomena.

244 Protein aggregation plays a critical role in the pathoge

245 Protein aggregation plays a key role in neurodegenerativ

246 olyQ tract, which can initiate intracellular protein aggregation, preventing polyQ peptide aggregatio

247 nging because of the great complexity of the protein aggregation process itself.

248 automated real-time ex situ tracking of the protein aggregation process.

249 able technology to study and control diverse protein aggregation processes in cells.

250 udy of fundamental biophysical mechanisms of protein aggregation processes.

251 ion and decreased apoptosis, suggesting that protein aggregation promotes apoptosis.

252 extended polyglutamine (polyQ) sequences in proteins, aggregation-prone polyQ proteins accumulate in

253 of the protein native state determines both protein aggregation propensity and structural peculiarit

254 er, stress conditions shift the criteria for protein aggregation propensity.

255 Porphyrin-mediated selective protein aggregation provides a potential mechanism for p

256 suppresses degeneration by regulating toxic protein aggregation rather than stability.

257 The effects of sulphydryl (-SH) reagents on protein aggregation reactions in heated whey protein iso

258 utomated system for tracking the progress of protein aggregation reactions without the presence of ma

259 ded to tackle the molecular basis of all the protein-aggregation-related diseases.

260 Here, we developed a protein-aggregation reporter that uses huntingtin exon 1

261 Our results suggest that aberrant CAT-tailed protein aggregation results from a defect in Cdc48 recru

262 Both muscle cell death and protein aggregation showed wide variability among the mu

263 results identify osmotic stress as a potent protein aggregation stimuli in mammalian brain and furth

264 and controlling disorders that are linked to protein aggregation, such as Alzheimer's and Parkinson's

265 ence intensity is observed only with ordered protein aggregation, such as amyloid fibril formation, a

266 a number of neurological disorders caused by protein aggregation, such as amyotrophic lateral scleros

267 r chaperone ability that prevented amorphous protein aggregation, suggesting a potential role for N-t

268 siological assembly and prevent pathological protein aggregation, suggesting a potential treatment pa

269 new recurrent p.Leu254Gln mutation leads to protein aggregation, suggesting abnormal folding.

270 neurons were observed independently of overt protein aggregation, suggesting neurophysiological chang

271 Our results indicate that the protein aggregation systems of cooked hams and emulsion

272 ciated with these diseases recapitulates the protein aggregation that occurs in human disease.

273 Deficits in the ALP result in protein aggregation, the generation of toxic protein spe

274 Although polyglutamine expansion accelerates protein aggregation, the misfolding process is frequentl

275 an important model system for understanding protein aggregation, the new peptide may be an important

276 prefoldin, like other chaperones, modulates protein aggregation, the precise function of prefoldin a

277 on networks, the analysis of kinetic data of protein aggregation to obtain the underlying mechanisms

278 nd life and confer protection to age-related protein-aggregation toxicity are activated early in adul

279 In summary, we present a protein-aggregation-triggering mechanism that should be

280 edox homeostasis, or preventing irreversible protein aggregation under disulfide stress conditions ar

281 n, the precise function of prefoldin against protein aggregation under physiological conditions has n

282 Aberrant protein aggregation underlies a variety of age-related n

283 ropose, creates a permissive environment for protein aggregation, unresolved ER stress, and chronic i

284 As protein aggregation upon the inhibition of proteasomal a

285 al inhibition, whereas endoplasmic reticulum protein aggregation was more prominent in ALA-treated ce

286 Toward quantitative description of protein aggregation, we develop a computationally effici

287 capture the chemical and physical aspects of protein aggregation, we have been able to trace out the

288 o the mechanism of action of 7B2 in blocking protein aggregation, we performed structural studies of

289 ng data with a simple computational model of protein aggregation, we show that the establishment of a

290 llular polyamines, which are associated with protein aggregation, were significantly altered in SH-SY

291 table subproteome may help mitigate aberrant protein aggregation when protein homeostasis becomes com

292 u/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation, which extended survival of an amyot

293 ilitated degradation of TRiC increases polyQ protein aggregation, which is involved in HD.

294 indicates that transcellular propagation of protein aggregation, which is the basis of prion disease

295 llicin-induced protein modifications trigger protein aggregation, which largely stabilizes RpoH and t

296 t any therapeutic that reduces intracellular protein aggregation will benefit all.

297 rstanding the cellular mechanisms regulating protein aggregation will help develop future treatments.

298 Probes for monitoring protein aggregation with a variety of photophysical prop

299 teome imbalance is accompanied by widespread protein aggregation, with abundant proteins that exceed

300 Protein aggregation within the central nervous system ha