ライフサイエンスコーパス: protein arginine methyltransferase

1 lation, and we designate the enzyme as Rmt2 (protein arginine methyltransferase).

2 we generated an enzyme-dead knock-in of this protein arginine methyltransferase.

3 D physically interacts with PRMT1, the major protein arginine methyltransferase.

4 stone H4-specific methyltransferase PRMT1, a protein arginine methyltransferase.

5 nfirm its activity as the prototype type III protein arginine methyltransferase.

6 d protein kinase, and by Hsl7, a presumptive protein-arginine methyltransferase.

7 ated arginine methyltransferase 1 (CARM1), a protein-arginine methyltransferase.

8 tification of an array of substrates for the protein arginine methyltransferases.

9 insight into the structure and catalysis of protein arginine methyltransferases.

10 diverse product specificity displayed by the protein-arginine methyltransferases.

11 o-hydrolase, and is derived by the action of protein-arginine-methyltransferases.

12 w that glycogen synthase kinase 3 (GSK3) and protein arginine methyltransferase 1 (PRMT-1) cooperate

13 We recently reported defects in protein arginine methyltransferase 1 (PRMT1) activity an

14 Protein arginine methyltransferase 1 (PRMT1) acts as a t

15 ion of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetr

16 Here we identified the type I protein arginine methyltransferase 1 (PRMT1) as a restri

17 Protein arginine methyltransferase 1 (PRMT1) catalyzes t

18 logical activity of RIP140 was suppressed by protein arginine methyltransferase 1 (PRMT1) due to RIP1

19 and R200 of the EGFR extracellular domain by protein arginine methyltransferase 1 (PRMT1) enhances bi

20 Protein arginine methyltransferase 1 (PRMT1) is an essen

21 Protein arginine methyltransferase 1 (PRMT1) is involved

22 Here, we report that protein arginine methyltransferase 1 (PRMT1) is required

23 Protein arginine methyltransferase 1 (PRMT1) is up-regul

24 , steroid receptor coactivator 1 (SRC1), and protein arginine methyltransferase 1 (PRMT1) only modest

25 As the major arginine methylation enzyme, protein arginine methyltransferase 1 (PRMT1) strictly ge

26 In the current study, protein arginine methyltransferase 1 (PRMT1), another ar

27 ty is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nu

28 S by the class 1 arginine methyltransferase, protein arginine methyltransferase 1 (PRMT1), regulates

29 Protein arginine methyltransferase 1 (PRMT1), the predom

30 implementation to label substrates of human protein arginine methyltransferase 1 (PRMT1).

31 e chain of a peptide substrate by the enzyme protein arginine methyltransferase 1 (RMT1).

32 SG-nucleating protein G3BP1 is methylated by protein arginine methyltransferase 1 and 5 (PRMT1 and PR

33 IP45 acts as an enhancer for the assembly of protein arginine methyltransferase 1 and the protein arg

34 s of protein methylation and coexpression of protein arginine methyltransferase 1 did not influence N

35 t LANA is subject to arginine methylation by protein arginine methyltransferase 1 in vitro and in viv

36 asymmetric dimethyl H4R3 catalyzed by PRMT1 (protein arginine methyltransferase 1) facilitates histon

37 overy of a novel AE9a binding partner PRMT1 (protein arginine methyltransferase 1).

38 bonucleoprotein K (hnRNP K) protein by human protein arginine methyltransferase 1, variant 1 (hPRMT1v

39 EYA1 physically interacts with protein arginine methyltransferase 1, which methylates E

40 protein arginine methyltransferase 1 and the protein arginine methyltransferase 1-linked histone 4 ar

41 FGG-amide), a highly effective substrate for protein arginine methyltransferase 1.

42 phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, funct

43 When protein-arginine methyltransferase 1 expression was redu

44 Protein-arginine methyltransferase 1 has much less effec

45 transferase (EC 2.1.1.23) gene "PRMT1, " for protein-arginine methyltransferase 1.

46 We found that both protein-arginine methyltransferases 1 and 5 methylate Ar

47 hydrolase protein expression was reduced and protein-arginine-methyltransferase-1 increased in alcoho

48 Protein arginine methyltransferase 10 (PRMT10) is a type

49 ed yeast two-hybrid screening and identified protein arginine methyltransferase 2 (PRMT2) as a new ER

50 The mammalian protein arginine methyltransferase 3 (PRMT3) catalyzes t

51 with myocardial infarction, the PRMT3 gene (protein arginine methyltransferase 3) with stroke, and t

52 we report a novel regulation of pRb through protein arginine methyltransferase 4 (PRMT4)-mediated ar

53 We have identified a mutant, protein arginine methyltransferase 5 (atprmt5), that fai

54 ase (MTAP) confers a selective dependence on protein arginine methyltransferase 5 (PRMT5) and its bin

55 UsnRNPs) requires assembly factors united in protein arginine methyltransferase 5 (PRMT5) and surviva

56 ion and characterization of a complex of the protein arginine methyltransferase 5 (Prmt5) and the met

57 cance of PDCD4 in breast cancer and identify protein arginine methyltransferase 5 (PRMT5) as a cofact

58 Here, we describe the identification of the protein arginine methyltransferase 5 (PRMT5) as an effec

59 rification and mass spectrometry to identify protein arginine methyltransferase 5 (PRMT5) as part of

60 Protein arginine methyltransferase 5 (PRMT5) complexed w

61 a positive feedback loop between BCR-ABL and protein arginine methyltransferase 5 (PRMT5) in CML cell

62 Protein arginine methyltransferase 5 (PRMT5) is a key ep

63 Protein arginine methyltransferase 5 (PRMT5) is an argin

64 Protein arginine methyltransferase 5 (PRMT5) is an emerg

65 evidence suggest that the methyltransferase protein arginine methyltransferase 5 (PRMT5) is responsi

66 cleaved kinases (M6CKs) bind subunits of the protein arginine methyltransferase 5 (PRMT5) molecular c

67 Protein arginine methyltransferase 5 (PRMT5) plays multi

68 tumor suppressor, but its coexpression with protein arginine methyltransferase 5 (PRMT5) promotes ac

69 transformation to document the relevance of protein arginine methyltransferase 5 (PRMT5) to regulati

70 Menin directly interacts with protein arginine methyltransferase 5 (PRMT5), a negative

71 Protein arginine methyltransferase 5 (PRMT5), a protein

72 Here, we report that protein arginine methyltransferase 5 (PRMT5), an enzyme

73 ll nuclear ribonucleoprotein D3b (SmD3b) and protein arginine methyltransferase 5 (PRMT5), which are

74 y posttranslational methylation at Arg-57 by protein arginine methyltransferase 5 (PRMT5).

75 sphorylation through an association with the protein arginine methyltransferase 5 (PRMT5).

76 cted requirement for arginine methylation by protein arginine methyltransferase 5 (PRMT5).

77 forward genetic analysis we demonstrate that protein arginine methyltransferase 5 (PRMT5; At4g31120)

78 that E2F-1 is directly methylated by PRMT5 (protein arginine methyltransferase 5), and that arginine

79 free transcriptional system and contains the protein arginine methyltransferase 5, which acts synergi

80 ppaB is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5).

81 on of the known Ajuba binding partner Prmt5 (protein arginine methyltransferase-5) inhibited the Ajub

82 tor arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro an

83 Protein arginine methyltransferase 6 (PRMT6) is a nuclea

84 We show here that protein arginine methyltransferase 6 (PRMT6) is a specif

85 Protein arginine methyltransferase 7 (PRMT7) catalyzes t

86 Full-length human protein arginine methyltransferase 7 (PRMT7) expressed a

87 The mammalian protein arginine methyltransferase 7 (PRMT7) has been im

88 Here, we show that the protein arginine methyltransferase 7 (PRMT7) is a plurip

89 Protein arginine methyltransferase 7 (PRMT7) methylates

90 us are associated with blunted expression of protein arginine methyltransferase 7 (Prmt7) on chromoso

91 The protein arginine methyltransferase 7 (PRMT7), but not PR

92 We found that the selective inhibitor of protein arginine methyltransferases 7,7'-carbonylbis(aza

93 Here we use mice lacking protein arginine methyltransferase 8 (PRMT8) in the brai

94 The multifunctional protein arginine methyltransferase 8 (PRMT8) possesses b

95 +), FDH(+/-), and FDH(-/-) mice have similar protein arginine methyltransferase activities but high,

96 lts provide an example for the regulation of protein arginine methyltransferase activity by phosphory

97 most 80% identical to human PRMT1, the major protein arginine methyltransferase activity in mammalian

98 uential recruitment of CARM1 not only adds a protein arginine methyltransferase activity to the ER-co

99 In a previous study, this protein arginine methyltransferase activity was identifi

100 ediate-early protein, was then shown to have protein arginine methyltransferase activity.

101 sferase I (PRMT1) contributes >90% of type I protein-arginine methyltransferase activity in cells and

102 Protein-arginine methyltransferases aid in the regulatio

103 identify PRMT3 as the first type I ribosomal protein arginine methyltransferase and suggest that it r

104 t specificity and the catalytic mechanism of protein arginine methyltransferases and have important i

105 Multiple protein arginine methyltransferases are involved in tran

106 Recent discoveries of protein arginine methyltransferases, CARM1 and PRMT1, as

107 Type I protein arginine methyltransferases catalyze the formati

108 We have recently described a large (20 S) protein arginine methyltransferase complex, termed the m

109 Protein arginine methyltransferase enzyme 5 (PRMT5) regu

110 lude that PRMT1 contributes the major type I protein arginine methyltransferase enzyme activity prese

111 We identify the protein arginine methyltransferase enzymes that catalyze

112 Our data suggest that protein arginine methyltransferases exert key regulatory

113 s catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-do

114 Other members of the protein arginine methyltransferase family, which methyla

115 , which is highly conserved among the entire protein arginine methyltransferase family.

116 The RMT1 (protein-arginine methyltransferase), formerly ODP1, gene

117 Here we demonstrate a role for the protein arginine methyltransferase Hmt1 in this process.

118 Previously, we demonstrated that the protein arginine methyltransferase Hmt1 plays a role in

119 modified within its RGG domain by the type I protein-arginine methyltransferase, Hmt1p.

120 the JCI, Liao et al. investigate the role of protein arginine methyltransferase I (PRMT1) in regulati

121 Protein-arginine methyltransferase I (PRMT1) contributes

122 ot a substrate for PRMT1, the most prominent protein-arginine methyltransferase in mammalian cells, w

123 data suggest a novel mechanism by which the protein arginine methyltransferase is involved in the co

124 tructure can be seen as a ternary complex of protein arginine methyltransferase (one subunit) complex

125 tion, which is catalyzed by a family of nine protein arginine methyltransferases, or PRMTs.

126 It is the first to demonstrate that protein arginine methyltransferases participate in the D

127 ated arginine methyltransferase 1 (CARM1), a protein-arginine methyltransferase previously shown to s

128 methylated on specific arginine residues by protein arginine methyltransferase (PRMT) 1 and PRMT5 in

129 Protein arginine methyltransferase (PRMT) 8 is unique am

130 Human protein arginine methyltransferase (PRMT) 9 symmetricall

131 Protein arginine methyltransferase (PRMT) activity has b

132 CARM1 contains a conserved protein arginine methyltransferase (PRMT) catalytic core

133 However, a conclusive role for the protein arginine methyltransferase (PRMT) enzymes that c

134 thyltransferase 1 (CARM1) is a member of the protein arginine methyltransferase (PRMT) family and met

135 a residue completely conserved in the type I protein arginine methyltransferase (PRMT) family of enzy

136 and HMGA1b proteins by three members of the protein arginine methyltransferase (PRMT) family: PRMT1,

137 Trypanosoma brucei PRMT7 (TbPRMT7) is a protein arginine methyltransferase (PRMT) that strictly

138 AtPRMT5 encodes a type II protein arginine methyltransferase (PRMT) that, in winte

139 Mass spectrometry identified LRP6 binding to protein arginine methyltransferase (PRMT)-1, and nuclear

140 cDNA for PRMT7, a recently discovered human protein-arginine methyltransferase (PRMT), was cloned an

141 Through an shRNA screen, we identified the protein arginine methyltransferase Prmt1 as a vulnerable

142 ceptor signaling increased expression of the protein arginine methyltransferase PRMT1, which in turn

143 emonstrate (1) the additional involvement of protein arginine methyltransferases PRMT1 and CARM1 in p

144 at SPT5 was specifically associated with the protein arginine methyltransferases PRMT1 and PRMT5 and

145 ere we show that S-HDAg can be methylated by protein arginine methyltransferase (PRMT1) in vitro and

146 The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose mem

147 and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methyla

148 e report the selective overexpression of the protein arginine methyltransferase PRMT5 as a novel cand

149 body components and identify the ortholog of protein arginine methyltransferase PRMT5 as the enzyme r

150 esis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the

151 The major type II protein arginine methyltransferase PRMT5 catalyzes the f

152 Here, we show that the type-II protein arginine methyltransferase PRMT5 controls H4R3me

153 Protein arginine methyltransferase PRMT5 interacts with

154 Among the target genes, we confirmed the protein arginine methyltransferase Prmt5 is a direct tar

155 The protein arginine methyltransferase PRMT5 is complexed wi

156 The type II protein arginine methyltransferase Prmt5 symmetrically d

157 cancer cells is impaired by depletion of the protein arginine methyltransferase PRMT5.

158 we have functionally analyzed two different protein arginine methyltransferases, Prmt5 and Prmt4, bo

159 Human protein arginine methyltransferase PRMT8 has been recent

160 ion during flagellar dynamics, we focused on protein arginine methyltransferases (PRMTs) 1, 3, 5, and

161 Protein arginine methyltransferases (PRMTs) affect many

162 Protein arginine methyltransferases (PRMTs) aid in the r

163 proteins methylated on arginine residues by protein arginine methyltransferases (PRMTs) and is degra

164 Protein arginine methyltransferases (PRMTs) are (S)-aden

165 The protein arginine methyltransferases (PRMTs) are a family

166 Protein arginine methyltransferases (PRMTs) are a group

167 Protein arginine methyltransferases (PRMTs) are enzymes

168 Well-characterized selective inhibitors of protein arginine methyltransferases (PRMTs) are invaluab

169 Protein arginine methyltransferases (PRMTs) are proved t

170 Protein arginine methyltransferases (PRMTs) are SAM-depe

171 Misregulation of protein arginine methyltransferases (PRMTs) has been lin

172 Protein arginine methyltransferases (PRMTs) have been im

173 Protein arginine methyltransferases (PRMTs) have emerged

174 Covalent modification of histones by protein arginine methyltransferases (PRMTs) impacts geno

175 stone lysine methyltransferases (HKMTs), and protein arginine methyltransferases (PRMTs) in pancreati

176 The protein arginine methyltransferases (PRMTs) include a fa

177 Protein arginine methyltransferases (PRMTs) introduce ar

178 Malfunction of protein arginine methyltransferases (PRMTs) is correlate

179 oper epigenetic modification of chromatin by protein arginine methyltransferases (PRMTs) is crucial f

180 Protein arginine methyltransferases (PRMTs) mediate the

181 Protein arginine methyltransferases (PRMTs) mediate the

182 Protein arginine methyltransferases (PRMTs) play an impo

183 Protein arginine methyltransferases (PRMTs) play importa

184 Protein arginine methyltransferases (PRMTs) represent an

185 onal modification in eukaryotes catalyzed by protein arginine methyltransferases (PRMTs) that are typ

186 In the family of protein arginine methyltransferases (PRMTs) that predomi

187 Using purified recombinant protein arginine methyltransferases (PRMTs), we showed t

188 ication of proteins catalyzed by a family of protein arginine methyltransferases (PRMTs).

189 unrelated Rossman-fold enzymes that include protein arginine methyltransferases (PRMTs).

190 rotein lysine methyltransferases (PKMTs) and protein arginine methyltransferases (PRMTs).

191 in lysine methyltransferases (PKMTs) and the protein arginine methyltransferases (PRMTs).

192 an interplay between the SWI/SNF complex and protein-arginine methyltransferases (PRMTs).

193 Depletion of PRMT5, the primary protein arginine methyltransferase responsible for symme

194 ll, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methyla

195 n-regulation of the major trypanosome type 1 protein arginine methyltransferase, TbPRMT1, disrupts fo

196 The protein arginine methyltransferase, TbPRMT1, interacts w

197 id not cooperate with PRMT1, a CARM1-related protein arginine methyltransferase that also functions a

198 PRMT5 encodes a type II protein arginine methyltransferase that catalyzes the sy

199 tein arginine methyltransferase 5 (PRMT5), a protein arginine methyltransferase that catalyzes the sy

200 ed arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that methylates histo

201 CARM1 is one of nine protein arginine methyltransferases that methylate argin

202 4 substrates suggest that type I and type II protein-arginine methyltransferases use distinct molecul

203 4 have been methylated in vitro by a nuclear protein arginine methyltransferase using recombinant (un

204 electively modulates enzymatic activity of a protein arginine methyltransferase vital to abiotic stre

205 IL-4 upregulates the expression of protein arginine methyltransferases, which are essential

206 Protein arginine methyltransferases, which catalyze the

207 omolog of a recently characterized mammalian protein-arginine methyltransferase whose activity may be

208 PRMT5 is a type II protein arginine methyltransferase with roles in stem ce