ライフサイエンスコーパス: protein complex

1 ing the formation of a ternary ligand-GPCR-G-protein complex.

2 -Matthews-Olson (FMO) photosynthetic pigment protein complex.

3 d to elucidate the atomic details of a sugar-protein complex.

4 wed that LH2 and FKBP65 are part of a common protein complex.

5 sential phylogenetically conserved octameric protein complex.

6 ochemical characterization of the respective protein complex.

7 directly contacting subunits within a multi-protein complex.

8 ified UNG2, PCNA, and RPA can form a ternary protein complex.

9 n the recruitment of this DNA damage-sensing protein complex.

10 g processes mediated by the heterotrimeric G-protein complex.

11 minus disrupt formation of the PCNA-UNG2-RPA protein complex.

12 d been inaccessible conformations of the DNA-protein complex.

13 es lipids between MlaD and an outer membrane protein complex.

14 s essential for the formation of an NDPK-B/G protein complex.

15 er characterized the major merozoite surface protein complex.

16 and assembly protein 40 (AtMIA40), forming a protein complex.

17 ers in cells and the number of subunits in a protein complex.

18 rders are distributed through spatiotemporal protein complexes.

19 roteins, the cytoskeleton, or other membrane protein complexes.

20 ading to a change in the composition of mRNA-protein complexes.

21 molecules) of detergent-solubilized membrane protein complexes.

22 of interacting residues between nucleic acid-protein complexes.

23 aluable tool in the analysis of proteins and protein complexes.

24 ools for the MS study of native proteins and protein complexes.

25 astructural features represent bona fide HIV protein complexes.

26 as energy transfer in photosynthetic pigment-protein complexes.

27 genetic variation in coding genes comprising protein complexes.

28 , we show that OA treatment disrupts pre-miR/protein complexes.

29 e that extracts structural features from DNA-protein complexes.

30 uire structural information for proteins and protein complexes.

31 ent protein-protein interactions in membrane protein complexes.

32 and/or by the formation of distinct protein-protein complexes.

33 e study of large macromolecular proteins and protein complexes.

34 from the nanodiscs upon insertion of larger protein complexes.

35 ing centers (MTOCs) are large, multi-subunit protein complexes.

36 d to the experimental results for a group of protein complexes.

37 has been difficult for all but a few GPCR-G protein complexes.

38 for the assembly of multiple macromolecular protein complexes.

39 the exposure of the multilevel diversity of protein complexes.

40 teins are contained in high molecular weight protein complexes.

41 ntermolecular hydrogen bonds in carbohydrate-protein complexes.

42 Many biological functions are carried out by protein complexes.

43 s in providing high-resolution structures of protein complexes.

44 e processing of pri-miRs by remodeling their protein complexes.

45 y into a series of multi-component synthetic protein complexes.

46 ity, a challenging problem for oligomers and protein complexes.

47 uires characterization of individual pigment-protein complexes.

48 on the structure of vesicles formed by COPI protein complexes.

49 xhaustive characterization of the associated protein complexes.

50 tworks in regulating the assembly of dynamic protein complexes.

51 TLR7 ligand enhances formation of IRF5-NXF1 protein complexes.

52 hich exist in plasma membrane (PM)-localised protein complexes.

53 models for five illustrative cases of binary protein complexes.

54 in systems biology to automatically identify protein complexes.

55 a previously used large benchmark set of 49 protein complexes.

56 insights into the structure and function of protein complexes.

57 ization of native protein-ligand and protein-protein complexes.

58 orb cationic AMPs and form negative particle-protein complexes.

59 interactions and efficiently transmit labile protein complexes.

60 inting to investigate the HOS of protein and protein complexes.

61 (CRB), Partitioning-defective, and Scribble protein complexes.

62 it is unclear how large, possibly insoluble protein complexes [10] are delivered into the matrix.

63 time we provide a proteomic comparison of a protein complex across asexual blood, sexual and sporozo

64 y shuttling electrons between membrane-bound protein complexes acting as electron acceptors and donor

65 o modulate the concentration of weakly bound protein complexes, allowing us to detect their dissociat

66 motors to forcibly pull fluorescently tagged protein complexes along filopodial actin filaments.

67 ACs to form the ternary ligase-PROTAC-target protein complex and a MSD assay to measure cellular degr

68 physiology of mutant cells and isolated PSII protein complex and concluded that PsbQ' is involved in

69 urons, RNF138 and CaV2.1 coexist in the same protein complex and display notable subcellular colocali

70 ctural changes in the actin-bound junctional protein complex and physical forces spanning multicellul

71 mport systems composed of the Mid1-Cch1-Ecm7 protein complex and the Fig1 protein.

72 include thermal fluctuations of the pigment-protein complexes and changing local environments.

73 ene-interaction networks recapitulating both protein complexes and functional cooperation among compl

74 The experimental study of such protein complexes and interactions has been arduous.

75 identify locus-specific chromatin-regulating protein complexes and long-range DNA interactions.

76 The interaction between P-protein complexes and RTA was examined by surface plasmo

77 ads to receptor dimerization, recruitment of protein complexes, and activation of multiple signaling

78 rse spleen ferritin, a approximately 490 kDa protein complex approximately 20-fold larger than the pr

79 osidic structures such as glucans and glucan-protein complexes are among the polysaccharides found in

80 These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a n

81 Protein complexes are one of the keys to studying the be

82 10 subunit of the annexin A2 (AnxA2)-S100A10 protein complex as a novel Munc13-4 interactor and show

83 of CF-MS profiles shows promise in detecting protein complexes as a whole but is limited in its abili

84 We foresee such DNA cage-protein complexes as new tools to study the role of this

85 eracting proteins that are known to regulate protein complex assembly and protein folding.

86 e endoplasmic reticulum that may function in protein complex assembly and protein folding.

87 e to which membrane regions could facilitate protein complex assembly remains largely unclear.

88 inear ion trap, and can now probe the intact protein complex assembly, through its constituent subuni

89 -related PX domains function as scaffolds in protein complex assembly.

90 ion-dependent protein interfaces and dynamic protein complex assembly.

91 ana tabacum) 14-3-3 proteins to describe the protein complex at atomic detail.

92 The in vitro formation of exon-protein complexes between the mutant molecules and prote

93 atures of expression of individual proteins, protein complexes, biochemical and metabolic pathways.

94 tructures and functions of many proteins and protein complexes but can severely degrade performance o

95 tructures and functions of many proteins and protein complexes, but many buffers adversely affect pro

96 show the imaging of individual proteins and protein complexes by low-energy electron holography.

97 mit the information that can be obtained for protein complexes by SID.

98 h inhibiting and stabilizing specific 14-3-3 protein complexes by small molecules, peptide mimetics,

99 othelial barrier is primarily regulated by a protein complex called adherens junctions.

100 n in Escherichia coli is mediated by a large protein complex called the divisome.

101 MyoA is part of a membrane-associated protein complex called the glideosome, which is essentia

102 pyroptosis, which is mediated by a cytosolic protein complex called the inflammasome that senses micr

103 In all, targeting the ABCC4-MPP1 protein complex can lead to new therapies to improve tre

104 tips, from which the masses of proteins and protein complexes can be obtained.

105 tosynthesis begins when a network of pigment-protein complexes captures solar energy and transports i

106 Signaling properties of G protein complexes carrying mutant Gbeta1 subunits were f

107 n and alters the double-strand break-induced protein complex centring 53BP1.

108 raction network by isolating complexes after protein complex components were deleted from the genome.

109 ort of oligosaccharides by an outer membrane protein complex composed of an extracellular SusD-like l

110 gamma-Secretase is an intramembranous protein complex composed of Aph1, Pen2, Nicastrin, and P

111 bly through a membrane-associated regulatory protein complex composed of beta-Arrestin1, ARHGAP21 and

112 Hcy is sensed by a constitutive protein complex composed of leucyl-tRNA-synthetase and f

113 e complex (complex II) is a highly conserved protein complex composed of the SDH1 to SDH4 subunits in

114 The HVCCs are multisubunit protein complexes composed of a pore-forming alpha1 and

115 Pf1 associates with a chromatin-interacting protein complex comprised of MRG15, Sin3B, and histone d

116 Here we show that the same is true for a protein complex comprising DNA ligase IIIalpha and the s

117 sMMO is a water-soluble three-component protein complex consisting of a hydroxylase with a nonhe

118 Some 90% of the mass of these large protein complexes consists of noncatalytic domains and s

119 coli RNA polymerase (RNAP) is a multisubunit protein complex containing the smallest subunit, omega.

120 re, using a proteomic approach we identify a protein complex, containing Wdr5, Hdac1, Hdac2 and Rere

121 iquitination is important for PLK2.alpha-syn protein complex degradation, and we hypothesize that thi

122 Coimmunoprecipitation of CB1R protein complexes demonstrated that central or distal C-

123 y a highly conserved heterotrimeric membrane protein complex denoted Sec61 in eukaryotes and SecYEG i

124 NA) approaches to expand the search space of protein complex detection.

125 hly conserved intraflagellar transport (IFT) protein complexes direct both the assembly of primary ci

126 depolymerization and negative regulation of protein complex disassembly are involved in adipocyte re

127 NET protein complexes (DNA-elastase and histone-elastase com

128 critical role in the resolution of bivalent protein complexes during development.

129 ort the Sertoli cell morphology and adhesion protein complexes (e.g., occludin-ZO-1, CAR-ZO-1, and N-

130 Specific disruption of this protein complex, either genetically or chemically, remov

131 iculum (ER), where the conserved ER membrane protein complex (EMC) was shown to be essential for effi

132 The nucleotide excision repair protein complex ERCC1-XPF is required for incision of DN

133 They are thought to form higher-order protein complexes for their functions, but studies of sh

134 o bind membrane lipids [21, 22] and scaffold protein complex formation [23].

135 monstrate the importance of studying protein-protein complex formation in membrane mimetic systems.

136 genome depends upon localized RNA processing protein complex formation in the nucleus.

137 m perturbations in biochemical signaling and protein complex formation within neurons.

138 They facilitate cotranslational protein complex formation, which establishes a role for

139 ning, drug delivery, antibody production and protein complex formation.

140 The protein complex formed by the Ca(2+) sensor neuronal cal

141 genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley.

142 a broad class of nucleic acids and transient protein complexes found in aqueous droplets.

143 teractions, and importing known pathways and protein complexes from curated databases, interaction pr

144 t decade, the main strategy used to identify protein complexes from high-throughput network data has

145 tributions are not obtained for proteins and protein complexes from six commonly used nonvolatile buf

146 The 1.07 MDa recombinant protein complex has histone-exchange activity.

147 hitecture and the structure of transenvelope protein complexes have been evolutionarily co-optimised

148 roteins (cytochrome C and BSA) as well as of protein complexes (hemoglobin), which are not the result

149 s-linked oligomers and high molecular weight protein complexes (HMWC) that are hypothesized to interf

150 sis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, firs

151 -SNAREs were incubated with the tethering/SM protein complex HOPS and the two other soluble SNAREs (l

152 e ADP ribosylation factor (Arf) and the coat protein complex I (COPI) are involved in vesicle transpo

153 tions is reminiscent of the operation of the protein complex I of the respiratory chain.

154 strict the search space of such conventional protein complex identification approaches.

155 ow that our algorithm outperforms well-known protein complex identification tools in a balance betwee

156 The coat protein complex II (COPII) is essential for the transpor

157 The conserved coat protein complex II (COPII) mediates the initial steps of

158 um (ER), but we find, using a cell-free coat protein complex II (COPII) vesicle budding reaction, tha

159 tein Atg9 (autophagy-related 9), COPII (coat protein complex II) vesicles, and possibly other sources

160 ogenesis and expression of the mitochondrial proteins Complex III and IV, consistent with a defect in

161 that claudin-1 induction destabilized the SD protein complex in podocytes, with significantly reduced

162 ions among sites in a photosynthetic pigment-protein complex in the Fenna-Matthews-Olson model.

163 gh the NDH-1 complex is a well-characterized protein complex in the thylakoid membrane of Synechocyst

164 it is important to analyze structures of DNA-protein complexes in detail.

165 w specific viral proteins modify some of the protein complexes in the pathway.

166 re the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippocampal n

167 A protein complex including Nba1 and Nis1 is involved in p

168 otility of cilia relies on a number of large protein complexes including the force-generating outer d

169 ctivity is controlled by several proteins or protein complexes, including NEDD8, CAND1, and the CSN R

170 ltiple types of heterogeneity in the pigment-protein complexes, including structural heterogeneity, e

171 In this report, we have studied how these protein complexes integrate to control cellular shapes c

172 Gain of function of the exocyst, a conserved protein complex involved in tethering of exocytic vesicl

173 e-related organelles complex-1 (BLOC-1) is a protein complex involved in the formation of endosomal t

174 ecular scaffold protein that assembles multi-protein complexes involved in DNA single-strand break re

175 ecular assemblies, as we showcase on several protein complexes involved in translation, protein foldi

176 Here, protein and protein complex ions are formed directly from a 150 mM K

177 n of native mass spectrometry of protein and protein complex ions formed from a buffer containing phy

178 ass spectrometry by adducting to protein and protein complex ions, thereby reducing sensitivity and m

179 utations in either TSC1 or TSC2, and the TSC protein complex is an essential regulator of mTOR comple

180 The USH1 protein complex is associated with calyceal processes, w

181 This protein complex is internalized via clathrin-mediated en

182 tors (NMDARs) along with Tiam1 and that this protein complex is more abundant in hippocampal compared

183 that whatever mechanism is supported by this protein complex is present in both types of photorecepto

184 The spindle and kinetochore-associated (Ska) protein complex is required for accurate chromosome segr

185 in, an evolutionarily conserved multisubunit protein complex, is essential for chromosome condensatio

186 Here we identify a protein complex (KICSTOR) that is composed of four prote

187 Disruption of gene silencing by Polycomb protein complexes leads to homeotic transformations and

188 ial resolution at the suborganelle and large protein complex level.

189 Our work identifies a protein complex linking key epigenetic regulators acting

190 Several protein complexes localize to the gating zone and may re

191 A 134-kDa protein complex LptB2FG is unique among ATP-binding cass

192 ar aggregates in goji berries as compared to protein-complexed lutein from spinach.

193 ional structural information for large-scale protein complex mapping studies and should be broadly ap

194 In protein complex mass spectrometry studies, surface-induc

195 These different forms of a single protein complex may comprise functional variances that e

196 This protein complex mediates a highly electrogenic transport

197 Protein complex membership and specific protein domains

198 ructure and dynamics of individual proteins, protein complexes, membrane proteins, RNA and DNA, using

199 The bacterial protein complex Mnx contains a multicopper oxidase (MCO)

200 Arabidopsis heterotrimeric G-protein complex modulates pathogen-associated molecular

201 own about the compositional heterogeneity of protein complexes, mostly due to technical barriers of s

202 ould also prove relevant to other peripheral protein complexes.Natural supplies of bryostatin, a comp

203 inserts further functions into this smallest protein complex of the oxidative phosphorylation system

204 Protein complexes of sequential metabolic enzymes, often

205 Protein complexes often represent an ensemble of differe

206 r findings suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane vi

207 Samples of individual proteins and protein complexes on ultraclean freestanding graphene we

208 as a result of inactivation of either of the protein complexes or variations in the external conditio

209 biquitylated client proteins from membranes, protein complexes, or chromatin and has an essential rol

210 shydrogenase (PntAB) is an integral membrane protein complex participating in the regulation of NAD(P

211 Weakly bound protein complexes play a crucial role in metabolic, regu

212 Differential DNA binding of MADS domain protein complexes plays a role in the specificity of tar

213 tions, intact membrane-bound bitopic protein-protein complexes pose tremendous challenges for structu

214 urification of unspliced full-length HIV RNA-protein complexes preserved in vivo by formaldehyde cros

215 This detailed analysis of the AtZAR1-AtZED1 protein complex provides a better understanding of the i

216 Multiple protein complexes regulate the Rag GTPases in response t

217 ull-down, yielding information about dynamic protein complex regulation in vivo.

218 king a trans-outer membrane porin-cytochrome protein complex required for direct intercellular electr

219 Cohesin is a conserved protein complex required for sister chromatid cohesion,

220 The NLRP3 inflammasome is a protein complex responsible for caspase-1-dependent matu

221 achinery (BAM) is a conserved multicomponent protein complex responsible for the biogenesis of beta-b

222 The protein complex responsible for type IV pilus assembly i

223 We processed a large number of DNA-protein complexes retrieved from the Protein Data Bank a

224 ated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [LIM domain only 1

225 of spliceosome intermediates and associated protein complexes shed light on the molecular interactio

226 ow-abundance exosome-associated proteins and protein complexes, some with known significance in both

227 handles for biochemical isolation of native protein complexes.Split fluorescent proteins (FPs) have

228 These genes encode the beta subunit of the G-protein complex (STE4), the pheromone MAPK scaffold (CST

229 on a small but representative set of peptide-protein complex structures well resolved by X-ray crysta

230 otein, EMC10 (endoplasmic reticulum membrane protein complex subunit 10), showing activity in an angi

231 WD40 domain of the highly conserved Coatomer Protein Complex, Subunit Beta 2 (COPB2).

232 which is required for the assembly of large protein complexes, such as RNA polymerase II, small nucl

233 FT-ICR platform has been tested with several protein complex systems (homooligomers, a heterooligomer

234 Zhang et al. report on a protein complex that acts as a guardian to protect these

235 ic RNA exosome is an essential and conserved protein complex that can degrade or process RNA substrat

236 arge endoplasmic reticulum membrane-embedded protein complex that coordinates the destruction of fold

237 Telomerase is an RNA-protein complex that extends the 3' ends of linear chrom

238 ta2 subunit (Gbeta2) of the heterotrimeric G-protein complex that is being released from G-protein-co

239 teins involves the BBSome, an eight-membered protein complex that is recruited to ciliary membranes b

240 mma signals through the IFNgamma receptor, a protein complex that mediates downstream signaling event

241 the function of the retromer, a multisubunit protein complex that plays a specialized role in endosom

242 functional analogue of shelterin, the multi-protein complex that protects human telomeres.

243 rehensive characterization of an iron-sulfur protein complex that regulates Spo0A approximately P lev

244 es are protected by shelterin, a six-subunit protein complex that represses the DNA damage response (

245 Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specifi

246 pair enzymes search for DNA lesions and form protein complexes that act in DNA repair pathways.

247 Inflammasomes are multi-protein complexes that assemble in the cytosol of cells

248 assembly markedly similar to those of other protein complexes that bind nucleic acid.

249 PLP1 is involved in the formation of protein-protein complexes that bridge the junctions between neig

250 sids of nonenveloped viruses are composed of protein complexes that encapsulate, or form a shell arou

251 serve as platforms for the assembly of multi-protein complexes that function as hubs of signal transd

252 ovides structural information on noncovalent protein complexes that is complementary to other techniq

253 Protein complexes that produce or enable a chemical sign

254 The role of DISC1 is to assemble protein complexes that promote neural development and si

255 s an interactome of known readers as well as protein complexes that were not known to rely on Thr4 fo

256 Unlike the RL-protein complexes, the number of surfactant molecules in

257 X-ray and NMR structures of protein-protein complexes, their associated binding affinities a

258 Therefore, targeting the ZEB2 protein complex through direct disruption of the ZEB2-KD

259 eceptor that we show engages in a multimeric protein complex to regulate the transcriptional output o

260 lly, LHX2 interacts with chromatin modifying protein complexes to edit the chromatin landscape of its

261 range of signaling processes converge on two protein complexes to initiate autophagy: the ULK1 (unc51

262 The recruitment of specific cellular protein complexes to these factories aids efficient and

263 ibute to differential affinities of the GAIT protein complex towards the elements.

264 t unphosphorylated Slr1 associates with mRNA-protein complexes transported to the tip.

265 ss spectrometry (MS) applications for intact protein complexes typically require electrospray (ES) io

266 ion conformational ensembles of RNAs and RNA-protein complexes under diverse solution conditions.

267 ations of membrane-bound full-length bitopic protein complexes under physiological conditions.

268 Photosystem II (PSII), a large pigment protein complex, undergoes rapid turnover under natural

269 yielded structures of small or medium-sized protein complexes, up to approximately 30-40 kDa.

270 We also structurally analyze these protein complexes using crystallography and molecular mo

271 a library of 230 proteins that form protein-protein complexes using the ToeLoop predictor of loop dy

272 cl-1 directly interacted with the dimeric Ku protein complex via its Bcl-2 homology 1 and 3 (BH1 and

273 with >60% correlation, even when the protein-protein complex was available.

274 ement of paramagnetic Cu(II) ions in the Mnx protein complex was examined by electron paramagnetic re

275 direct protein-protein contacts within human protein complexes we learn a sparse conditional dependen

276 esire to screen for ligand binding to intact protein complexes we report the development of a native

277 sides serve as initial coreceptors for these protein complexes, whereby a membrane protein receptor i

278 oss in PPI networks and even discover sparse protein complexes which have traditionally been a challe

279 TRAPPC12 is a member of the TRAPP protein complex, which functions in membrane trafficking

280 sections of native-like ions of proteins and protein complexes, which are in turn used as restraints

281 ice for determining the structure of dynamic protein complexes, which are typically recalcitrant to o

282 cyte contains numerous high molecular weight protein complexes, which may potentially be involved in

283 but steadily growing list of large, dynamic protein complexes whose atomic structure has been determ

284 Cells contain a multitude of protein complexes whose subunits interact with high spec

285 ages of Plasmodium and it is part of a novel protein complex with an overall composition overlapping

286 ct the position of Itch PRR engaged in a 1:2 protein complex with beta-PIX and a 1:1 complex with the

287 ssociated with the membrane via a peripheral protein complex with calmodulin.

288 Condensin is a protein complex with diverse functions in chromatin pack

289 e eukaryotic RNA exosome is a well-conserved protein complex with ribonuclease activity implicated in

290 e have demonstrated that HTT forms a ternary protein complex with the scaffolding protein DISC1 and c

291 rticularly versatile in this regard, forming protein complexes with a diverse set of cellular partner

292 t tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (

293 ffold for the assembly of essential enhancer-protein complexes with an impact on timely gene activati

294 wo subunits, 3'-UTRs enable the formation of protein complexes with diverse compositions.

295 Mechanistically, PHB forms protein complexes with HIRA, a histone H3.3 chaperone, a

296 ding, we successfully identified most of the protein complexes with overestimated association rates a

297 Phycocyanins are pigment-protein complexes with potential application as natural

298 tify, characterize and quantify proteins and protein complexes with potential implications for struct

299 correlation analysis on a benchmark of large protein complexes with solved three-dimensional structur

300 oters are predominantly bound by non-histone protein complexes, with little evidence for fragile nucl