ライフサイエンスコーパス: protein conformation

1 olled via pH adjustment without changing the protein conformation.

2 ositions that have the potential to regulate protein conformation.

3 n the concept of trapping a nonnative capsid protein conformation.

4 ion of Env, suggesting subtle changes in Env protein conformation.

5 on-Crick-like dG*dTTP base pair and a closed protein conformation.

6 hile the dG*dTTP-Mg2+ complex adopts an open protein conformation.

7 none binds to TtRp and stabilizes an altered protein conformation.

8 onant energy transfer (FRET) pair to monitor protein conformation.

9 in protein carbonylation and alterations in protein conformation.

10 in complexation induced minor alterations of protein conformation.

11 reases Ca(2+) binding, and tunes the overall protein conformation.

12 e coupling between pH, protonation state and protein conformation.

13 sted that the R445L mutation alters mouse a3 protein conformation.

14 to the modification site with an appropriate protein conformation.

15 substrate-mediated interactions on shifting protein conformation.

16 x states of the metal centers and a distinct protein conformation.

17 nm (A(230)) is also known to be sensitive to protein conformation.

18 ylation at the Asn-89 site of vIL-6 affected protein conformation.

19 Protein function is dictated by protein conformation.

20 protein damage in age-associated diseases of protein conformation.

21 nized as an important element in peptide and protein conformation.

22 tramolecular interactions to confer globular protein conformation.

23 o demonstrate that the two species differ in protein conformation.

24 hat are solvent exposed only upon changes in protein conformation.

25 uctural models, they may indicate changes in protein conformation.

26 bonds played a major role in maintaining the protein conformation.

27 that synonymous codon variations may impact protein conformation.

28 to amplify signals or stabilize a particular protein conformation.

29 oncentration in the resin bed and determined protein conformation.

30 gested that these mutations alter RHOXF2/F2B protein conformation.

31 rgy landscape to the disorder induced by the protein conformations.

32 to the ligand binding to S2 through altering protein conformations.

33 sed here are directly related to features of protein conformations.

34 able to explore the structure of short-lived protein conformations.

35 are widely used to study the flexibility of protein conformations.

36 hemotypes that exploit subtle differences in protein conformations.

37 eneous and consists of clusters with various protein conformations.

38 ts acting on a protein and uses ensembles of protein conformations.

39 used to efficiently sample a broad range of protein conformations.

40 ficult to obtain due to unknown and unstable protein conformations.

41 interaction sites that differ markedly among protein conformations.

42 tion and the detailed structure of transient protein conformations.

43 t can exist in the Boltzmann distribution of protein conformations.

44 ons to obtain scattering characterization of protein conformations.

45 all alternative isoforms result in unstable protein conformations.

46 ation properties, suggesting a difference in protein conformations.

47 haracterize the transition mechanism between protein conformations.

48 genetically transmitted as self-perpetuating protein conformations.

49 s that are transmitted as altered, heritable protein conformations.

50 to investigate enzyme flexibility and sample protein conformations.

51 tes phosphorylation signaling by controlling protein conformation after phosphorylation, and its upre

52 lates cell signaling uniquely by controlling protein conformation after phosphorylation, but its role

53 and have implications for neurodegenerative, protein conformation ailments including Alzheimer's dise

54 re reveals how small changes in both RNA and protein conformation allow the amide to establish hydrog

55 Docking experiments indicate that the closed protein conformation allows smaller ligands such as ticl

56 stinct dihydrofolate reductase (DHFR) ligand-protein conformations, allows interrogation of regions u

57 cysteine residues that result in changes to protein conformation and active site heme, leading to an

58 T3 phosphorylation alters Huntingtin exon 1 protein conformation and aggregation properties.

59 ations of biomolecules primarily investigate protein conformation and binding to drug-like molecules,

60 y to identify oxidation-dependent effects on protein conformation and calcium liganding.

61 Relationships between protein conformation and characteristics related to past

62 ass spectrometry (MS) has been used to study protein conformation and conformational dynamics.

63 s accepted as a standard method for studying protein conformation and conformational dynamics.

64 ge amount of data, containing information on protein conformation and conformational dynamics.

65 atched polbeta ternary complex with a closed protein conformation and coplanar base pair, the first s

66 nt proteins such as Bcr-Abl where changes in protein conformation and dynamics are believed to result

67 Global and local protein conformation and dynamics in solution were asses

68 or protein folding, allosteric regulation of protein conformation and dynamics is fundamentally impor

69 domain as a site of light-induced change in protein conformation and dynamics.

70 terpretation of EPR measurements in terms of protein conformation and dynamics.

71 horylation at Tyr(137) allosterically alters protein conformation and effector binding, providing a m

72 that the W268R substitution influences FXII protein conformation and exposure of the activation loop

73 Modest changes in protein conformation and flexibility are also apparent i

74 veal how reversible phosphorylation modifies protein conformation and function and the biochemical me

75 tion by protons can drive dynamic changes in protein conformation and function.

76 resistance in human cancer cells, can affect protein conformation and function.

77 nteracts the effects of the sSNP and rescues protein conformation and function.

78 localization to membranes and helps maintain protein conformation and function.

79 memory through self-perpetuating changes in protein conformation and function.

80 encapsulation and release did not affect the protein conformation and functionality.

81 l for BSA/lutein binding were independent of protein conformation and Hofmeister salts.

82 not n-tau, readily leads to an MC-1-positive protein conformation and impaired mitochondrial transpor

83 The techniques are both sensitive to protein conformation and interactions and are namely: 1)

84 site of the A2 domain (N582) of FVIII affect protein conformation and intracellular trafficking.

85 onsistent with the concept that abnormal AAT protein conformation and intrahepatic accumulation have

86 Adjusting both protein conformation and ligand orientation in the activ

87 active-site residues and observed changes in protein conformation and metal coordination provide insi

88 A fully quantitative theory connecting protein conformation and optical spectroscopy would faci

89 phobic pocket is supported by differences in protein conformation and pocket accessibility between wi

90 nce is quantified coincident with changes to protein conformation and post-translational modification

91 Their activity is regulated by changes in protein conformation and protein clustering.

92 spectroscopy revealed the effects of UVR on protein conformation and protein composition, which were

93 catalytically competent state with a closed protein conformation and pseudo-Watson-Crick base pair.

94 c resonance spectroscopy studies, alters the protein conformation and reduces the mean (SD) number (2

95 physical principles that underlie changes in protein conformation and result in alterations in the or

96 nment has made it a useful tool for studying protein conformation and stability.

97 omaterial scaffold, which retains the native protein conformation and tensile strength of the natural

98 Protein conformation and the 3D water structure play imp

99 nge and red states and reflecting changes in protein conformation and the distances from TMR to the c

100 Furthermore, our approach disentangles the protein conformation and the nucleotide binding state of

101 ons between protein and graphene to preserve protein conformation and to enable the protein to adopt

102 mechanosensing, which range from changes in protein conformation and transcription factor localizati

103 was correctly predicted irrespective of the protein conformation and without accounting for protein

104 y, whereas the other residues have a role in protein conformation and/or interaction with Spo0A.

105 Here, we use silica gels to trap protein conformations and a new kind of laser photolysis

106 s increase the repertoire of known IRE1alpha protein conformations and can guide the discovery of hig

107 s revealed the utility of including multiple protein conformations and chemical clustering in the vir

108 ing lipids play key roles in regulating both protein conformations and function.

109 c agents that bind specifically to precursor protein conformations and inhibit amyloid assembly is an

110 Changes in protein conformations and interactions affect the cellul

111 he cross-talk between allosteric ligands and protein conformations and its effect on the dynamic prop

112 spectrometry offers a rapid method to study protein conformations and protein-protein interactions.

113 computational methods incorporating multiple protein conformations and stability and binding affinity

114 the polbeta-Fm7dG:dTTP structure shows open protein conformations and staggered base pair conformati

115 ment of thermal fluctuations and disorder in protein conformations and tend to be experimentally chal

116 lation between the population of native-like protein conformations and the degree of detergent attach

117 landscape models we use here are the maps of protein conformations and their associated transitions t

118 raphic approaches to define functional minor protein conformations and, in combination with NMR analy

119 ms of membrane tension, membrane adaptation, protein conformation, and energetics.

120 i) 15 pairs of x-ray and NMR-derived sets of protein conformations; and (iii) a set of decoys for 3 p

121 s used in spectroscopic tools to investigate protein conformation are similar across all proteins.

122 ate analogues causing the most rigid, closed protein conformation are therefore not necessarily the m

123 In most structures, two discrete protein conformations are observed simultaneously, and e

124 By probing protein conformation as a correlate to drug resistance w

125 e utility of developing assays that read out protein conformation as a prospective screening tool for

126 ate that PFCA-albumin interactions alter the protein conformation at low PFCA:albumin mole ratios (up

127 ion of HC Met257 and HC Met433 could disrupt protein conformation at the CH2-CH3 interface and preven

128 e these structural changes and determine the protein conformation at various pH and thermal treatment

129 ferences in protein intrinsic HDX rates when protein conformations at different solution conditions a

130 copy is a powerful tool to follow changes in protein conformations at interfaces and identify interfa

131 oxLDL uptake have important implications for protein conformation, binding of other ligands, function

132 tein and the membrane not only constrain the protein conformation but also decrease the solvent acces

133 he interaction between substrate binding and protein conformation by monitoring substrate-induced sol

134 Binding of EGCG to 2S albumins affects protein conformation, by causing an alpha-helix to beta-

135 ted the functional impact of this variant on protein conformation, cadmium transport, activation of s

136 mAbs that are sensitive to protein conformation can be helpful in studies of protei

137 the use of bis-ANS emission alone to monitor protein conformations can be misleading.

138 iscuss mechano-transduction as it applies to protein conformation, cellular organization, and multi-c

139 ation step, which could be associated with a protein conformation change, might also be a rate-limiti

140 s known about the coordination mechanism for protein conformation change.

141 r detecting protein-protein interactions and protein conformation change.

142 at may be useful in studies of shear-induced protein conformation change.

143 quantify the effect of hydrodynamic shear on protein conformation change.

144 Protein conformations change among distinct thermodynami

145 angle neutron scattering was used to measure protein conformation changes in response to laminar shea

146 the process by which ligand binding induces protein conformation changes is not well understood biop

147 rom the mean labeling ratio, suggesting that protein conformation changes rendered these cysteines ei

148 n of HIF-2 in cells, and trigger the largest protein conformation changes reported to date.

149 We study protein conformation changes upon ligand binding using a

150 GPCRs, each ligand can stabilize a different protein conformation, complicating the use of cocrystall

151 hatic side chain of residue 194 stabilizes a protein conformation conducive to binding.

152 terium exchange (HDX) is used to investigate protein conformation, conformational changes and surface

153 and Select, for determining the ensemble of protein conformations consistent with NMR dynamics data.

154 arise from either the closed or the extended protein conformation depending on the degree of supercoi

155 he yeast prion Sup35/[PSI(+)], we found that protein conformation determined the size distribution of

156 Protein conformation dictates a great deal of protein fu

157 s powerful implications for the treatment of protein conformation diseases.

158 rray of pathological phenotypes in mammalian protein conformation disorders and dominantly inherited

159 detrimental effects result from its altered protein conformation ("domain interaction"), making it h

160 is largely accepted that variations in prion protein conformation drive the molecular changes leading

161 nciples of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms

162 he basis for switching between alternative N protein conformations during important functions such as

163 and sedimentation results establish that PNP protein conformation (dynamic motion) correlates more cl

164 ch could provide new insights to the role of protein conformation dynamics during mitosis on the deve

165 ptor sensory rhodopsin I (SRI) exists in two protein conformations, each of which is converted to the

166 he cofactor configuration and eventually the protein conformation enable bacteriophytochromes to inte

167 The different protein conformations enable arginine 576 (R576) to inte

168 rotein ions in a TWIG is highly sensitive to protein conformation, enables the detection of conformer

169 For example PSFC can report changes in protein conformation, expression, interactions, and move

170 rigidity, pocket size, and shape, as well as protein conformation flexibility.

171 ture photons, LITE-1 strictly depends on its protein conformation for photon absorption.

172 binding modes for TMC125 and differences in protein conformation for TMC278.

173 independently predicted the lowest 10 mutant protein conformations for each of the 11 mutants and the

174 ification and the elucidation of alternative protein conformations for signal proteins, to name a few

175 onal dialogue between allosteric ligands and protein conformations for the design of new functional m

176 ct the generation and propagation of diverse protein conformations from a single polypeptide.

177 rajectories are long enough, the ensemble of protein conformations generated allows thermodynamic and

178 croarray such as covalent attachment, native protein conformation, homogeneity of the protein monolay

179 ly amenable to the study of these non-native protein conformations; however, SANS is ideally suited t

180 mber of studies argues that self-propagating protein conformations (i.e., prions) feature in the path

181 e that the P179R mutation alters PP2A-Aalpha protein conformation, impairing holoenzyme formation and

182 the utility of HDX with ESI-MS for analyzing protein conformation in amorphous solid samples.

183 ared (FTIR) spectroscopy were used to assess protein conformation in amorphous solids.

184 The protein conformation in our simulations with anionic mem

185 ecome a powerful tool for characterizing the protein conformation in physiologically relevant environ

186 onic generation-based technique for studying protein conformation in solution and in real time to the

187 e strategy for rapid characterization of the protein conformation in solution.

188 ges can propagate at the level of the global protein conformation in the picosecond timescale.

189 the presence of phages and investigate their protein conformation in the solid state.

190 w a small sequence asymmetry in difH defines protein conformation in the synaptic complex and orchest

191 sed mass spectrometry can be used to measure protein conformation in vitro at atmospheric pressure.

192 rin sensitivity is to stabilize their native protein conformation in vitro.

193 ice for rapid and efficient determination of protein conformations in a range of medium conditions an

194 ism by which detergents preserve native-like protein conformations in a solvent free environment.

195 decade as a powerful technique for exploring protein conformations in frozen solutions.

196 minimization of probe molecules onto static protein conformations in the absence of the natural aque

197 live cells (IC-FPOP), allowing the study of protein conformations in the complex cellular environmen

198 efficiency that corresponds to a diagram of protein conformations in the coordinates of temperature

199 rations of major types of macromolecules and protein conformations in the nucleoli of iPSC and human

200 in discriminating near-natives from misfold protein conformations in the Rosetta and I-TASSER protei

201 more than one but less than half of the 144 protein conformations in this ensemble were almost as ac

202 ormations can be as important as analyses of protein conformations in understanding protein-ligand in

203 difications may explain the emergence of new protein conformations in vivo and also provide a basis f

204 lass and evaluated for binding to multiple F protein conformations, in vitro inhibition of RSV infect

205 Methods for detecting these changes in protein conformation include 'protein footprinting,' usi

206 the large and growing family of diseases of protein conformation including neurodegeneration, metabo

207 ion are exacerbated by aging and diseases of protein conformation including neurodegeneration, metabo

208 in Raman spectra, even small alterations in protein conformations including increased exposure of bi

209 Small molecule modulators of protein conformations, including allosteric kinase inhib

210 rted and unwound DNA structure, exhibiting a protein conformation incompatible with binding to B-form

211 w grossly altered pf Such weak dependence on protein conformation indicates that a water-impermeable

212 tions associated with diverse aminoacids and protein conformations indicates that nucleoli of skin fi

213 increase in the random coil and alpha helix protein conformations, indicating changes in the subset

214 through diverse mechanisms such as changing protein conformations, interactions, and localization.

215 of the backbone atoms indicate that the coat protein conformation involves a 40-residue continuous al

216 ns unclear if this self-templating change in protein conformation is alone sufficient to create a sta

217 p53 protein conformation is an important determinant of its

218 We also show that native protein conformation is conserved in TENG-ESI, and that

219 ey insight is that the search for the native protein conformation is influenced by the rate r at whic

220 ation of the environmental dependence of the protein conformation is required to fully understand the

221 In this approach, an ensemble of protein conformations is first generated, typically usin

222 A), which is implicated in the regulation of protein conformation, is necessary for the prolactin (PR

223 cate here is that the non-covalent change in protein conformation itself might serve as the initial o

224 ue contacts, arising, e.g., from alternative protein conformations, ligand-mediated residue couplings

225 ailability of methods to better characterize protein conformation may improve detection of counterfit

226 have subsequently defined lipids that change protein conformation, mediate oligomeric states, and fac

227 in photonic bandgap design through directed protein conformation modulation.

228 e pore changes that consistently explain the protein conformations observed at opposite voltage polar

229 l bias, we focus on ensembles of ligand-free protein conformations obtained by nuclear magnetic reson

230 y an important role in promoting the correct protein conformation of the mature LasA protease domain.

231 e expected better consistency across varying protein conformations of the same sequence.

232 er step between BA and HA, and the effect of protein conformation on the electron transfer rate.

233 energy, and the dramatic effects of altering protein conformations on neuronal function and survival.

234 alter the conformation of VWF, it stabilized protein conformation once it bound the sheared molecule.

235 ired for RNA binding or mediating changes in protein conformation or domain interactions necessary fo

236 visualization of rapid, localized changes in protein conformation or posttranslational modification.

237 with mutual chaperoning of both RNA and coat protein conformations, partially explaining the ability

238 is observation of the redox control of local protein conformation plasticity and water network flexib

239 Protein conformations play crucial roles in most, if not

240 Protein conformation plays a crucial role in determining

241 ue capacity to bind and stabilize non-native protein conformations, prevent aggregation, and keep pro

242 ate computational predictions of alternative protein conformations, protein complex formation, and ev

243 analytical tools that can detect changes in protein conformation rapidly, accurately, and with high

244 ch phenotypes are encoded by self-templating protein conformations rather than nucleic acids.

245 logy toolbox, but separating closely related protein conformations remain challenging.

246 mentation, the resolution of closely related protein conformations remains challenging.

247 tion plays an important role in regard to CA protein conformation required to support proper mature c

248 te how RNA-mediated selection of alternative protein conformations, sampled during stochastic excursi

249 g and allow balancing multiple objectives in protein conformation sampling.

250 described the new algorithm iBP to generate protein conformations satisfying distance constraints, t

251 are inherently inaccurate and associate with protein conformation spaces overly rugged energy surface

252 MeG.dCTP/dTTP-Mg(2+) complexes adopt an open protein conformation, staggered base pair, and one activ

253 oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the che

254 Mutations in p53 that affect protein conformation (such as R175H) show strong binding

255 s used to mediate transitions between client protein conformations, such as folding, or the correctio

256 erases have revealed a conserved yet unusual protein conformation surrounding their buried N termini

257 mption of approximately 10 ATPs coupled to a protein conformation switch followed by a slower phase,

258 n constants (K(d)) for ligands that modulate protein conformation than hTS.

259 in this Asp-Asp motif is more related to the protein conformation than the primary sequence.

260 ns on Asn-89 of vIL-6 specifically promote a protein conformation that allows the viral cytokine to b

261 idue identities modulate the population of a protein conformation that brings the ET-flavin and Bf-fl

262 cally altered, resulting in major changes of protein conformation that impacts its biological functio

263 ation of simple ions that trigger changes in protein conformation that lead to global changes in tran

264 d, most likely by eliciting or stabilizing a protein conformation that promotes strand separation, an

265 R) to promote a reversible, global change in protein conformation that regulates the flow of ions acr

266 functions appear to be mediated by alternate protein conformations that are at equilibrium in the lig

267 bservation of transient native-like membrane protein conformations that are otherwise lost to structu

268 These results provide insights into the Fe protein conformations that define the role of MgATP in n

269 erativity of GK to the existence of distinct protein conformations that interconvert slowly and exhib

270 ructure of the vertex complex along with new protein conformations that play a vital role in maintain

271 Yeast prions are self-propagating protein conformations that transmit heritable phenotypes

272 olution, both the sugar-free and sugar-bound protein conformations that were observed in the X-ray cr

273 Within an invariant protein conformation, the beta-D-glucopyranose ring in t

274 Based on analysis of protein conformation, the immobilized proteins bind with

275 ommodate the incorrect nucleotide and closed protein conformation, the template strand in the vicinit

276 ations and with strengths that depend on the protein conformation, the underlying DNA sequence and th

277 nce that each CooA heme state has a distinct protein conformation; the goal of this study was to char

278 ics of mutations do not identify a change in protein conformation; therefore, it may not define suffi

279 n hydrated durum wheat kernels blocks gluten protein conformation through SS bonds formation and the

280 -free MepR reveals the most open MarR family protein conformation to date, which will require a huge

281 ure termination and (ii) to stabilize mature protein conformation to ensure proper function of Vif an

282 reveals a quality control step that couples protein conformation to Golgi export and provides molecu

283 of information on the dynamic adaptation of protein conformations to the presence of the ligand, whi

284 This association alters the protein conformation (to maximize the contiguous patch o

285 ecular orientation of adsorbates to films or protein conformation upon adsorption.

286 e MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxyg

287 Findings indicate that changes to protein conformation using various pH and temperature pr

288 ible docking method that samples and weights protein conformations using experimentally derived confo

289 VWF was sheared in a quartz Couette cell and protein conformation was measured in real time over leng

290 econstituted freeze-dried livetins, the main protein conformations were also intramolecular (native)

291 etry (IM-MS) measurements showed that folded protein conformations were detected for ions with low ch

292 he receptor population in a specific Meta II protein conformation, whereas the other half decays to i

293 perturb the local heme site and shake global protein conformation, which were found to completely rec

294 A*dCTP-Mg2+ complex adopts an 'intermediate' protein conformation while the dG*dTTP-Mg2+ complex adop

295 d at 2.4 A resolution revealed an unexpected protein conformation with a 30 degrees rotation of the N

296 This study showed that by manipulating protein conformation with pre-hydrolysis heat treatment,

297 ransition-state ensemble (TSE) is the set of protein conformations with an equal probability to fold

298 lipid can have a very significant effect on protein conformation, with micelles stabilizing a partic

299 oximal in at least one biologically relevant protein conformation within the family; we find little e

300 LD outperforms LD in sampling of alternative protein conformations without loss of the accuracy and l