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1 and during freezing (charge separated state protein conformation).
2 to amplify signals or stabilize a particular protein conformation.
3 hile the dG*dTTP-Mg2+ complex adopts an open protein conformation.
4 none binds to TtRp and stabilizes an altered protein conformation.
5 onant energy transfer (FRET) pair to monitor protein conformation.
6 in protein carbonylation and alterations in protein conformation.
7 in complexation induced minor alterations of protein conformation.
8 reases Ca(2+) binding, and tunes the overall protein conformation.
9 e coupling between pH, protonation state and protein conformation.
10 sted that the R445L mutation alters mouse a3 protein conformation.
11 substrate-mediated interactions on shifting protein conformation.
12 nm (A(230)) is also known to be sensitive to protein conformation.
13 ylation at the Asn-89 site of vIL-6 affected protein conformation.
14 Protein function is dictated by protein conformation.
15 protein damage in age-associated diseases of protein conformation.
16 nized as an important element in peptide and protein conformation.
17 tramolecular interactions to confer globular protein conformation.
18 o demonstrate that the two species differ in protein conformation.
19 proline introduces critical bends within the protein conformation.
20 at prevents protein aggregation and modifies protein conformation.
21 yptophans (Trps) is an important reporter of protein conformation.
22 provide complimentary information regarding protein conformation.
23 oncentration in the resin bed and determined protein conformation.
24 gested that these mutations alter RHOXF2/F2B protein conformation.
25 ositions that have the potential to regulate protein conformation.
26 n the concept of trapping a nonnative capsid protein conformation.
27 ion of Env, suggesting subtle changes in Env protein conformation.
28 on-Crick-like dG*dTTP base pair and a closed protein conformation.
29 are widely used to study the flexibility of protein conformations.
30 hemotypes that exploit subtle differences in protein conformations.
31 eneous and consists of clusters with various protein conformations.
32 ts acting on a protein and uses ensembles of protein conformations.
33 used to efficiently sample a broad range of protein conformations.
34 ficult to obtain due to unknown and unstable protein conformations.
35 tion and the detailed structure of transient protein conformations.
36 s that are transmitted as altered, heritable protein conformations.
37 t can exist in the Boltzmann distribution of protein conformations.
38 ons to obtain scattering characterization of protein conformations.
39 all alternative isoforms result in unstable protein conformations.
40 ation properties, suggesting a difference in protein conformations.
41 haracterize the transition mechanism between protein conformations.
42 isting crystallographically characterized Fe protein conformations.
43 to investigate enzyme flexibility and sample protein conformations.
44 re conferred by altered and self-propagating protein conformations.
45 Prions are self-propagating, infectious protein conformations.
46 amics simulations to explore a wide range of protein conformations.
47 sine modification sites were present in both protein conformations.
48 energy and the structural similarity of the protein conformations.
49 rgy landscape to the disorder induced by the protein conformations.
50 sed here are directly related to features of protein conformations.
51 able to explore the structure of short-lived protein conformations.
52 genetically transmitted as self-perpetuating protein conformations.
53 tes phosphorylation signaling by controlling protein conformation after phosphorylation, and its upre
54 lates cell signaling uniquely by controlling protein conformation after phosphorylation, but its role
55 and have implications for neurodegenerative, protein conformation ailments including Alzheimer's dise
56 re reveals how small changes in both RNA and protein conformation allow the amide to establish hydrog
57 Docking experiments indicate that the closed protein conformation allows smaller ligands such as ticl
58 cysteine residues that result in changes to protein conformation and active site heme, leading to an
60 ing hydrogen bonds that maintain a favorable protein conformation and by the introduction of a cavity
64 atched polbeta ternary complex with a closed protein conformation and coplanar base pair, the first s
65 nt proteins such as Bcr-Abl where changes in protein conformation and dynamics are believed to result
67 or protein folding, allosteric regulation of protein conformation and dynamics is fundamentally impor
71 horylation at Tyr(137) allosterically alters protein conformation and effector binding, providing a m
73 uality control system for maintaining proper protein conformation and for reorganizing and removing m
81 not n-tau, readily leads to an MC-1-positive protein conformation and impaired mitochondrial transpor
84 onsistent with the concept that abnormal AAT protein conformation and intrahepatic accumulation have
86 active-site residues and observed changes in protein conformation and metal coordination provide insi
88 phobic pocket is supported by differences in protein conformation and pocket accessibility between wi
90 spectroscopy revealed the effects of UVR on protein conformation and protein composition, which were
91 catalytically competent state with a closed protein conformation and pseudo-Watson-Crick base pair.
92 c resonance spectroscopy studies, alters the protein conformation and reduces the mean (SD) number (2
93 physical principles that underlie changes in protein conformation and result in alterations in the or
96 olvation process for the preservation of the protein conformation and suggest that the conditions ach
97 nge and red states and reflecting changes in protein conformation and the distances from TMR to the c
98 Furthermore, our approach disentangles the protein conformation and the nucleotide binding state of
99 mechanosensing, which range from changes in protein conformation and transcription factor localizati
100 was correctly predicted irrespective of the protein conformation and without accounting for protein
101 y, whereas the other residues have a role in protein conformation and/or interaction with Spo0A.
104 s revealed the utility of including multiple protein conformations and chemical clustering in the vir
105 c agents that bind specifically to precursor protein conformations and inhibit amyloid assembly is an
107 he cross-talk between allosteric ligands and protein conformations and its effect on the dynamic prop
108 spectrometry offers a rapid method to study protein conformations and protein-protein interactions.
109 computational methods incorporating multiple protein conformations and stability and binding affinity
110 the polbeta-Fm7dG:dTTP structure shows open protein conformations and staggered base pair conformati
111 ment of thermal fluctuations and disorder in protein conformations and tend to be experimentally chal
112 lation between the population of native-like protein conformations and the degree of detergent attach
113 landscape models we use here are the maps of protein conformations and their associated transitions t
114 raphic approaches to define functional minor protein conformations and, in combination with NMR analy
116 ) to identify molecular weight distribution, protein conformation, and site-specific modification, as
117 i) 15 pairs of x-ray and NMR-derived sets of protein conformations; and (iii) a set of decoys for 3 p
119 s used in spectroscopic tools to investigate protein conformation are similar across all proteins.
120 ate analogues causing the most rigid, closed protein conformation are therefore not necessarily the m
123 ata provide direct biophysical evidence that protein conformations are transmitted in PrP amyloid str
125 e utility of developing assays that read out protein conformation as a prospective screening tool for
126 ate that PFCA-albumin interactions alter the protein conformation at low PFCA:albumin mole ratios (up
127 ion of HC Met257 and HC Met433 could disrupt protein conformation at the CH2-CH3 interface and preven
128 e these structural changes and determine the protein conformation at various pH and thermal treatment
129 ferences in protein intrinsic HDX rates when protein conformations at different solution conditions a
130 copy is a powerful tool to follow changes in protein conformations at interfaces and identify interfa
132 oxLDL uptake have important implications for protein conformation, binding of other ligands, function
134 tein and the membrane not only constrain the protein conformation but also decrease the solvent acces
135 sible changes in the particle morphology and protein conformation but no global protein unfolding.
136 have developed a novel method to overlay two protein conformations by their atomic coordinates using
138 ted the functional impact of this variant on protein conformation, cadmium transport, activation of s
139 a computational experiment to assess whether protein conformation can be determined from highly appro
143 iscuss mechano-transduction as it applies to protein conformation, cellular organization, and multi-c
144 ation step, which could be associated with a protein conformation change, might also be a rate-limiti
149 angle neutron scattering was used to measure protein conformation changes in response to laminar shea
150 the process by which ligand binding induces protein conformation changes is not well understood biop
151 rom the mean labeling ratio, suggesting that protein conformation changes rendered these cysteines ei
153 corneum proteins, making it feasible to use protein conformation changes to map CPE safety in vitro.
155 he IRP1:ferritin H IRE complex shows an open protein conformation compared with that of cytosolic aco
156 GPCRs, each ligand can stabilize a different protein conformation, complicating the use of cocrystall
158 terium exchange (HDX) is used to investigate protein conformation, conformational changes and surface
159 and Select, for determining the ensemble of protein conformations consistent with NMR dynamics data.
160 ar dichroism spectrum indicating a change in protein conformation, consistent with an increase in sec
161 arise from either the closed or the extended protein conformation depending on the degree of supercoi
162 he yeast prion Sup35/[PSI(+)], we found that protein conformation determined the size distribution of
165 rray of pathological phenotypes in mammalian protein conformation disorders and dominantly inherited
166 detrimental effects result from its altered protein conformation ("domain interaction"), making it h
167 is largely accepted that variations in prion protein conformation drive the molecular changes leading
168 nciples of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms
169 hat catalysis entails destabilization of the protein conformation, driven by ATP-binding energies dev
170 he basis for switching between alternative N protein conformations during important functions such as
171 and sedimentation results establish that PNP protein conformation (dynamic motion) correlates more cl
172 ch could provide new insights to the role of protein conformation dynamics during mitosis on the deve
173 ptor sensory rhodopsin I (SRI) exists in two protein conformations, each of which is converted to the
174 rotein ions in a TWIG is highly sensitive to protein conformation, enables the detection of conformer
175 normal Rho function and suggest that several protein conformations exist along the catalytic pathway.
178 interactions can be critical to establishing protein conformation (folding) and dynamics, as well as
181 independently predicted the lowest 10 mutant protein conformations for each of the 11 mutants and the
182 onal dialogue between allosteric ligands and protein conformations for the design of new functional m
184 ability to explicitly detect an ensemble of protein conformations from dynamics data is a paramount
185 rajectories are long enough, the ensemble of protein conformations generated allows thermodynamic and
186 croarray such as covalent attachment, native protein conformation, homogeneity of the protein monolay
187 ly amenable to the study of these non-native protein conformations; however, SANS is ideally suited t
188 mber of studies argues that self-propagating protein conformations (i.e., prions) feature in the path
192 ecome a powerful tool for characterizing the protein conformation in physiologically relevant environ
193 onic generation-based technique for studying protein conformation in solution and in real time to the
196 w a small sequence asymmetry in difH defines protein conformation in the synaptic complex and orchest
197 sed mass spectrometry can be used to measure protein conformation in vitro at atmospheric pressure.
198 ice for rapid and efficient determination of protein conformations in a range of medium conditions an
199 ism by which detergents preserve native-like protein conformations in a solvent free environment.
200 el for how ethanol can stabilize alternative protein conformations in alcohol-sensitive human protein
202 tion path connecting known initial and final protein conformations in such a way as to maximize an es
203 minimization of probe molecules onto static protein conformations in the absence of the natural aque
204 efficiency that corresponds to a diagram of protein conformations in the coordinates of temperature
205 rations of major types of macromolecules and protein conformations in the nucleoli of iPSC and human
206 in discriminating near-natives from misfold protein conformations in the Rosetta and I-TASSER protei
207 more than one but less than half of the 144 protein conformations in this ensemble were almost as ac
208 ormations can be as important as analyses of protein conformations in understanding protein-ligand in
209 difications may explain the emergence of new protein conformations in vivo and also provide a basis f
210 lass and evaluated for binding to multiple F protein conformations, in vitro inhibition of RSV infect
212 ion are exacerbated by aging and diseases of protein conformation including neurodegeneration, metabo
213 the large and growing family of diseases of protein conformation including neurodegeneration, metabo
215 rted and unwound DNA structure, exhibiting a protein conformation incompatible with binding to B-form
216 w grossly altered pf Such weak dependence on protein conformation indicates that a water-impermeable
217 tions associated with diverse aminoacids and protein conformations indicates that nucleoli of skin fi
218 increase in the random coil and alpha helix protein conformations, indicating changes in the subset
219 of the backbone atoms indicate that the coat protein conformation involves a 40-residue continuous al
220 ns unclear if this self-templating change in protein conformation is alone sufficient to create a sta
223 early indistinguishable, indicating that the protein conformation is essentially the same in the two
225 ey insight is that the search for the native protein conformation is influenced by the rate r at whic
226 ation of the environmental dependence of the protein conformation is required to fully understand the
228 A), which is implicated in the regulation of protein conformation, is necessary for the prolactin (PR
229 cate here is that the non-covalent change in protein conformation itself might serve as the initial o
230 s suggest that the C region affects V region protein conformation, leading to differences in fine spe
231 ue contacts, arising, e.g., from alternative protein conformations, ligand-mediated residue couplings
232 e pore changes that consistently explain the protein conformations observed at opposite voltage polar
233 l bias, we focus on ensembles of ligand-free protein conformations obtained by nuclear magnetic reson
234 y an important role in promoting the correct protein conformation of the mature LasA protease domain.
235 ffected cats that computationally alters the protein conformation of this gene and results in sarcome
236 t structure is another case of comparing two protein conformations of the same sequence, and the degr
237 er step between BA and HA, and the effect of protein conformation on the electron transfer rate.
238 energy, and the dramatic effects of altering protein conformations on neuronal function and survival.
239 alter the conformation of VWF, it stabilized protein conformation once it bound the sheared molecule.
240 ired for RNA binding or mediating changes in protein conformation or domain interactions necessary fo
241 thods can be used for analysis of individual protein conformations or to gain insight into dynamic ch
242 K) a sample frozen in the dark (ground state protein conformation) or (ii) illuminating at room tempe
243 with mutual chaperoning of both RNA and coat protein conformations, partially explaining the ability
244 is observation of the redox control of local protein conformation plasticity and water network flexib
246 tions with the transcriptional machinery and protein conformation plays a critical role in receptor f
248 ue capacity to bind and stabilize non-native protein conformations, prevent aggregation, and keep pro
249 ate computational predictions of alternative protein conformations, protein complex formation, and ev
250 analytical tools that can detect changes in protein conformation rapidly, accurately, and with high
253 tion plays an important role in regard to CA protein conformation required to support proper mature c
254 described the new algorithm iBP to generate protein conformations satisfying distance constraints, t
255 ipid membranes leads to a distinct change in protein conformation, stabilizing an extended amphipathi
256 MeG.dCTP/dTTP-Mg(2+) complexes adopt an open protein conformation, staggered base pair, and one activ
257 oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the che
259 s used to mediate transitions between client protein conformations, such as folding, or the correctio
260 erases have revealed a conserved yet unusual protein conformation surrounding their buried N termini
261 mption of approximately 10 ATPs coupled to a protein conformation switch followed by a slower phase,
264 ns on Asn-89 of vIL-6 specifically promote a protein conformation that allows the viral cytokine to b
265 cally altered, resulting in major changes of protein conformation that impacts its biological functio
266 ation of simple ions that trigger changes in protein conformation that lead to global changes in tran
267 d, most likely by eliciting or stabilizing a protein conformation that promotes strand separation, an
268 R) to promote a reversible, global change in protein conformation that regulates the flow of ions acr
269 bservation of transient native-like membrane protein conformations that are otherwise lost to structu
270 These results provide insights into the Fe protein conformations that define the role of MgATP in n
271 erativity of GK to the existence of distinct protein conformations that interconvert slowly and exhib
273 olution, both the sugar-free and sugar-bound protein conformations that were observed in the X-ray cr
276 ommodate the incorrect nucleotide and closed protein conformation, the template strand in the vicinit
277 ations and with strengths that depend on the protein conformation, the underlying DNA sequence and th
278 nce that each CooA heme state has a distinct protein conformation; the goal of this study was to char
280 -free MepR reveals the most open MarR family protein conformation to date, which will require a huge
281 ure termination and (ii) to stabilize mature protein conformation to ensure proper function of Vif an
283 reveals a quality control step that couples protein conformation to Golgi export and provides molecu
284 of information on the dynamic adaptation of protein conformations to the presence of the ligand, whi
286 e MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxyg
288 ible docking method that samples and weights protein conformations using experimentally derived confo
289 VWF was sheared in a quartz Couette cell and protein conformation was measured in real time over leng
290 econstituted freeze-dried livetins, the main protein conformations were also intramolecular (native)
291 he receptor population in a specific Meta II protein conformation, whereas the other half decays to i
292 perturb the local heme site and shake global protein conformation, which were found to completely rec
293 A*dCTP-Mg2+ complex adopts an 'intermediate' protein conformation while the dG*dTTP-Mg2+ complex adop
294 d at 2.4 A resolution revealed an unexpected protein conformation with a 30 degrees rotation of the N
296 ransition-state ensemble (TSE) is the set of protein conformations with an equal probability to fold
297 lipid can have a very significant effect on protein conformation, with micelles stabilizing a partic
298 oximal in at least one biologically relevant protein conformation within the family; we find little e
299 find that LDH/NADH samples quite a range of protein conformations within our 2.148 ns calculations,
300 LD outperforms LD in sampling of alternative protein conformations without loss of the accuracy and l
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