ライフサイエンスコーパス: protein degradation

1 very slow growth (to mitigate the effects of protein degradation).

2 ionally regulates LIN-28 by promoting LIN-28 protein degradation.

3 cell growth and a new paradigm for circadian protein degradation.

4 nevitably commit a protein for ER-associated protein degradation.

5 ession of FoxO-regulated, autophagy-mediated protein degradation.

6 lications for the regulation of PQC-mediated protein degradation.

7 ination is a well known process required for protein degradation.

8 l during protein refolding and regulation of protein degradation.

9 ctivity, peptide cleavage, and ATP-dependent protein degradation.

10 cation of small molecules inducing selective protein degradation.

11 al neurons to investigate the pathway for SV protein degradation.

12 n synthesis and instead was due to decreased protein degradation.

13 ivity on lymphocytes, lipid peroxidation and protein degradation.

14 of Kv1.2 channels in forward trafficking and protein degradation.

15 s by activating ClpP and causing unregulated protein degradation.

16 ssing, inhibition of enzymatic function, and protein degradation.

17 ide more conclusive evidence on the sites of protein degradation.

18 the function of SGTA in ER translocation and protein degradation.

19 some, a process referred to as ER-associated protein degradation.

20 pC1, thus inhibiting essential ATP-dependent protein degradation.

21 st likely, leads to rapid and host-dependent protein degradation.

22 nd distinct mediators of ubiquitin-dependent protein degradation.

23 ynthesized proteins from the cytosol and the protein degradation.

24 in the de novo synthesis of GluA1 and not in protein degradation.

25 at is regulated by the N-end rule pathway of protein degradation.

26 PLD resistance to cycloheximide-induced EGFR protein degradation.

27 the fusion product and regulates transporter protein degradation.

28 d altering subsequent downstream patterns of protein degradation.

29 substrate exhibited decreased ubiquitylated protein degradation.

30 tion of ORF57 to prevent proteasome-mediated protein degradation.

31 ed changes in transcriptional regulation and protein degradation.

32 ependent protein translocation and misfolded protein degradation.

33 ally during endoplasmic reticulum-associated protein degradation.

34 whereas both ClpP1 and ClpP2 contributed to protein degradation.

35 s a negative-feedback loop by promoting Tbx6 protein degradation.

36 relative growth rate to estimate the rate of protein degradation.

37 ional defects, including accelerated PRKAR1A protein degradation.

38 ssion of genes needed for autophagy-mediated protein degradation.

39 biquitin ligase Cbl-b, which triggers NFATc1 protein degradation.

40 lation of PSII proteins, inactivation and D1 protein degradation.

41 py numbers might be an important function of protein degradation.

42 TFEB promoted phagosomal acidification and protein degradation.

43 ls of RpoS by affecting both translation and protein degradation.

44 he 26S proteasome, thereby facilitating RelA protein degradation.

45 ein import analogous to p97 in ER-associated protein degradation.

46 sicular zinc accumulation and secretion, and protein degradation.

47 identify a new mechanism involving regulated protein degradation.

48 between gene expression, cellular growth and protein degradation.

49 isruption of genes involved in physiological protein degradation.

50 ey interactive domains controlling selective protein degradation.

51 lesterol-dependent inhibition of transporter protein degradation.

52 trols, suggesting a role for PHEX in SIBLING protein degradation.

53 hers at the meiosis stage, indicating active protein degradation.

54 proteins and inhibitor of chaperone-assisted protein degradation.

55 in ligases that are important for eukaryotic protein degradation.

56 owerful small-molecule approach for inducing protein degradation.

57 to other drug discovery efforts in targeted protein degradation.

58 argeting any peptide resulting from cellular protein degradation.

59 e TP53 gene is wild type, by preventing TP53 protein degradation.

60 on, and decreased muscle fibrosis and muscle protein degradation.

61 pha (HIF-1alpha) and increased heme-mediated protein degradation.

62 A stability using gene replacement and rapid protein degradation.

63 endent mechanisms, including increased IRS-1 protein degradation.

64 ibitory effects of AKG on muscle atrophy and protein degradation.

65 c strategy was developed to achieve targeted protein degradation.

66 rotects HIF1alpha against ubiquitin-mediated protein degradation.

67 hibits its deacetylase activity and promotes protein degradation.

68 ting machinery required for vacuole membrane protein degradation.

69 e crosstalk between PTMs involving HIF1alpha protein degradation.

70 facilitate synaptic remodeling through local protein degradation.

71 proteasome is the main engine of Plasmodium protein degradation.

72 the initiation of inflammatory responses by protein degradation.

73 ast step of endocytosis required for surface protein degradation.

74 o gene expression and the inhibition of LYK5 protein degradation.

75 ity in the functional units of Hrd1-mediated protein degradation.

76 of upstream regulators and promotion of AMS protein degradation.

77 eting chimera (PROTAC) concept to induce BET protein degradation.

78 Mutations in an enzyme involved in protein degradation affect a signaling pathway that stim

79 en gene transcription, mRNA translation, and protein degradation, among other factors.

80 ring RUNX1-mediated transcription, promoting protein degradation and affecting protein interactions.

81 oted autophagic flux by enhancing autophagic protein degradation and autolysosome clearance.

82 ency were related to increased mitochondrial protein degradation and decreased protein synthesis, res

83 teine redox biology could be associated with protein degradation and degron recognition.

84 chaperone Grp78/BiP, suggestive of impaired protein degradation and endoplasmic reticulum stress.

85 (AAP, FAP, and MP, respectively), as well as protein degradation and lipid oxidation, were determined

86 ein were collected by a nasogastric tube and protein degradation and peptide release was compared wit

87 imary metabolism processes, such as targeted protein degradation and peptidoglycan synthesis.

88 Protein degradation and phosphorylation are known to reg

89 Rpgrip1l deficiency causes an impairment of protein degradation and protein processing.

90 Here we use cell-specific protein degradation and quantitative photoactivated loca

91 ffectively attenuated corticosterone-induced protein degradation and rescued the muscle atrophy and d

92 quitin receptor S5a/PSMD4/Rpn10 inhibits p53 protein degradation and results in the accumulation of u

93 nk between the lipid droplet and proteasomal protein degradation and suggest that dynamic regulation

94 wn role for Srp1 and Sts1 in cotranslational protein degradation and suggests a novel model whereby S

95 Upregulation of genes involved in protein degradation and synthesis was also observed, sug

96 uired for both efficient proteasome-mediated protein degradation and the dynamic regulation of lipid

97 d darkness, autophagy deficiency compromises protein degradation and the generation of amino acids us

98 to the coupling of neuronal activity with SV protein degradation and the maintenance of functional SV

99 ession of c-Myc through mechanisms involving protein degradation and upregulation of p21.

100 Bufalin strongly promoted SRC-3 protein degradation and was able to block cancer cell gr

101 ure of events immediately downstream of SMXL protein degradation and whether all SMXL proteins mediat

102 three constraints: 1) protein synthesis, 2) protein degradation, and 3) positive feedback.

103 of disease and are influenced by synthesis, protein degradation, and gene-environment interactions.

104 for A549 cell rounding, extracellular matrix protein degradation, and IL-8 degradation, additional Xp

105 cytoplasmic stress responses, cell division, protein degradation, and much more.

106 ing; gene transcription; ribosomal proteins; protein degradation; and metabolism regulation.

107 red in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation

108 g stably or transiently with the cytoplasmic protein degradation apparatus.

109 are limited, the mechanisms regulating clock protein degradation are only beginning to be elucidated.

110 Thus, proteasome function and protein degradation are regulated by cAMP through PKA an

111 ibosomal protein translation and proteasomal protein degradation as critical nononcogene dependencies

112 protein synthesis and only partially delayed protein degradation as measured by a slight increase in

113 quality control system and display enhanced protein degradation as well as defective membrane traffi

114 lation inhibitors, such as cycloheximide, in protein degradation assays may result in artefacts, thes

115 atched by a concomitant reduction in retinal protein degradation associated with preserved retinal ma

116 inversely correlates with conjugation to the protein degradation-associated Lys-48-linked ubiquitin-c

117 nsiderable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain

118 of BCL2 were shown to be due to a defect in protein degradation because of no or little expression o

119 bited translation initiation and accelerated protein degradation-both dependent on the intron-prevent

120 RP associates with the 20S CP to facilitate protein degradation but also plays a 20S CP-independent

121 y through cytokine-induced transcription and protein degradation, but mechanisms regulating its activ

122 , as well as X-linked inhibitor of apoptosis protein degradation, but these depended on trypsinogen a

123 in the Drosophila Delta9-desaturase mediates protein degradation by a calcium-dependent cysteine prot

124 hance protein synthesis and suppress overall protein degradation by activating the protein kinase mam

125 deubiquitinating enzyme Usp14/Ubp6 inhibits protein degradation by catalyzing substrate deubiquitina

126 hat the adaptor TrfA adds temporal nuance to protein degradation by ClpCP in S. aureus.

127 Rv3780 enhanced peptide and protein degradation by proteasomes in an adenosine triph

128 ) is a deubiquitinating enzyme that prevents protein degradation by removing polyubiquitin chains fro

129 rs autophagosome formation without promoting protein degradation by the lysosome.

130 ry, our study reveals mechanistic details of protein degradation by the PDZ-protease Prc bound to its

131 Ubiquitin conjugation signals for selective protein degradation by the proteasome.

132 Although rates of protein degradation by the ubiquitin-proteasome pathway

133 uch as genome replication, transcription, or protein degradation, by translocating a long substrate t

134 o of 20S to 26S proteasomes, preservation of protein degradation capacity and reduced proteotoxic str

135 led to the definition and exemplification of protein degradation concepts and their resulting applica

136 Through these analyses, selective protein degradation could be achieved between the two pr

137 The observed activity of protein degradation could in part be rationalized throug

138 This process, called cotranslational protein degradation (CTPD), has been observed for years,

139 of all detected proteins and did not affect protein degradation despite suppressing autophagy.

140 e of enzyme-substrate interactions and rapid protein degradation, detection of substrates remains a c

141 owed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation

142 RNA decay, endoplasmic reticulum-associated protein degradation, dominant negative suppression of pa

143 tile-basic-nitrogen (TVBN) excluded (P>0.05) protein degradation due to microbial activity.

144 involving proteolytic adaptors that regulate protein degradation during cell cycle progression or dur

145 Protein degradation during in vitro GID was evaluated by

146 equire Wnt signaling via exosomes to prevent protein degradation during their lengthy travels through

147 ides, protein interactions, determination of protein degradation elements, identification of protein

148 g ubiquitin-proteasome system (UPS) mediated protein degradation, endoplasmic reticulum-associated de

149 ow the endoplasmic reticulum (ER)-associated protein degradation (ERAD) machinery efficiently targets

150 folded proteins through either ER-associated protein degradation (ERAD) or autophagy.

151 rus protein US11 exploits this ER-associated protein degradation (ERAD) pathway to downregulate HLA c

152 The ER-associated protein degradation (ERAD) pathway, an important UPR fun

153 Cdc48) is a key member of the ER-associated protein degradation (ERAD) pathway.

154 jor components involved in the ER-associated protein degradation (ERAD) system in eukaryotic organism

155 hway termed endoplasmic reticulum-associated protein degradation (ERAD).

156 d degraded in a process termed ER-associated protein degradation (ERAD).

157 s and known to be important in ER-associated protein degradation (ERAD).

158 This process is termed ER-associated protein degradation (ERAD).

159 The follow-up protein degradation experiments identified five substrat

160 en the importance of autophagy and lysosomal protein degradation for cellular proteostasis and cleara

161 Currently the molecular basis of protein degradation for CLC-1 channels is virtually unkn

162 K-Rta transactivation activity requires a protein degradation function; thus, we hypothesized that

163 apoptotic signal arising from anti-apoptotic protein degradation, generation of a switch-like apoptot

164 The ubiquitin-proteasome system (UPS) for protein degradation has been under intensive study, and

165 oteasome activator for ubiquitin-independent protein degradation, has been shown to degrade certain i

166 owth and normal epithelial integral membrane protein degradation, highlighting the specific role of m

167 Starvation-induced protein degradation, however, is considered to be nonsel

168 ys 48-linked polyubiquitin chains signal for protein degradation; however, the structural basis for L

169 vealed protein profiles indicative of severe protein degradation in 34 of 37 AASK-N urine samples.

170 G F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induc

171 Protein degradation in bacteria is a highly controlled p

172 CDC-48/p97 required for chromatin-associated protein degradation in both Caenorhabditis elegans and h

173 teins which has a knock-on effect on overall protein degradation in C. elegans.

174 e of the most promising avenues for targeted protein degradation in cancer therapy, but cereblon bind

175 e complexes that execute ubiquitin-dependent protein degradation in eukaryotes, can be degraded by a

176 the major pathway of selective intracellular protein degradation in eukaryotes.

177 Protein degradation in eukaryotic cells is performed by

178 interaction seems to inactivate SCF-mediated protein degradation in general, since the unrelated beta

179 the pathophysiology underlying the defective protein degradation in hPAP alveolar macrophages remains

180 roteasome system (UPS), which catalyzes most protein degradation in mammalian cells, also increases w

181 asome pathway is responsible for most of the protein degradation in mammalian cells.

182 Proteasomes are essential for protein degradation in proliferating cells.

183 vity by SIS3 suppresses oxidative stress and protein degradation in the diaphragm and prevents the re

184 On a larger scale, protein degradation in the ER was found to be a minor fa

185 ergy, and disposal of nitrogenous waste from protein degradation in the form of urea metabolism.

186 uced highly selective cereblon-dependent BET protein degradation in vitro and in vivo and delayed leu

187 r of Hh signal transduction by inducing GLI1 protein degradation in vitro and in vivo.

188 plains why Mpa is unable to stimulate robust protein degradation in vitro in the absence of other, ye

189 protein synthesis was further decreased and protein degradation increased, while cell wall synthesis

190 regulates many cellular processes including protein degradation, intracellular trafficking, cell sig

191 ut the early history of studies on regulated protein degradation introduces several detailed reviews

192 Ubiquitin-mediated protein degradation is a common feature in diverse plant

193 Proteasomal protein degradation is a key determinant of protein half

194 Thus, local protein degradation is a major feature of growth cones a

195 Targeted protein degradation is a powerful tool in determining th

196 Inhibiting p27 protein degradation is an actively developing cancer the

197 The N-end rule pathway of targeted protein degradation is an important regulator of diverse

198 inhibitors have demonstrated that targeting protein degradation is effective therapy in multiple mye

199 tion is well studied, proteasome-mediated RB protein degradation is emerging as an important regulato

200 Protein degradation is essential for all living things.

201 Protein degradation is essential for cellular homeostasi

202 Regulated protein degradation is essential.

203 Timely ubiquitin-mediated protein degradation is fundamental to cell cycle control

204 We further demonstrate that cotranslational protein degradation is generally impaired in the srp1-49

205 Protein degradation is instrumental in regulating cellul

206 effects of OS9, indicating that OS9-induced protein degradation is N-glycan-dependent.

207 ottleneck step: it is time consuming and the protein degradation is not always complete.

208 obacterium Caulobacter crescentus, regulated protein degradation is required for stress responses, de

209 Skeletal muscle atrophy due to excessive protein degradation is the main cause for muscle dysfunc

210 As an alternative, induced protein degradation lacks these limitations.

211 Despite its central role in protein degradation little is known about the molecular

212 Trim-Away harnesses the cellular protein degradation machinery to remove unmodified nativ

213 survival, including protein chaperones, the protein degradation machinery, anti-apoptotic proteins,

214 ulate cellular homeostasis together with the protein degradation machinery.

215 d targets it for destruction by the cellular protein degradation machinery.

216 Here, we set out to delineate the protein degradation mechanism of human CaV2.1 subunit by

217 nts not only suggest that tension suppresses protein degradation mediated and/or initiated by various

218 ctivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component

219 gnals that trigger phosphorylation-dependent protein degradation of multiple proteins required for ce

220 tein levels was essentially due to increased protein degradation of the immature form of NKCC2.

221 ed evidence that Cav1.233L channels enhanced protein degradation of wild type channels via the ubiqui

222 lutionarily conserved mechanism of regulated protein degradation on PcG homeostasis and epigenetic ac

223 ased protein synthesis, but markedly reduced protein degradation only in innervated muscles.

224 th K48- and K63-linked conjugates that drive protein degradation or complex assembly, respectively.

225 que postmitotic cells, in which irreversible protein degradation or damage can lead to impaired heari

226 discovery as a post-translational signal for protein degradation, our understanding of ubiquitin (Ub)

227 ral hijacking of both the ubiquitin-mediated protein degradation pathway and the p53 tumour suppresso

228 portant in the TRC pathway, the mislocalized protein degradation pathway, and the endoplasmic reticul

229 arly by the endoplasmic reticulum-associated protein degradation pathway.

230 We further show that protein degradation pathways are induced downstream of D

231 ow how selective and non-selective lysosomal protein degradation pathways cooperate to ensure cell su

232 nding of the regulated and stress-responsive protein degradation pathways in Caulobacter.

233 implicating a misregulation or impairment of protein degradation pathways involving the proteasome an

234 Alternative protein degradation pathways may provide inputs to the R

235 r/STAT92E/JNK cascade that may be coupled to protein degradation pathways such as autophagy or more t

236 y the unfolded protein response and involves protein degradation pathways to ensure quality control.

237 esis, but a reduction in ubiquitin-dependent protein degradation pathways was also observed.

238 er, the precise role of SUMOylation on other protein degradation pathways, particularly autophagy, re

239 new ALS-associated gene variant mediated by protein degradation pathways.

240 gene expression, a framework to characterize protein degradation patterns based on the observed tempo

241 dicated that regulation of transcription and protein degradation play important roles in shoot senesc

242 kocyte antigen (HLA) proteins, which present protein degradation products at the cell surface to circ

243 ples with 0.5% acetic acid produced the same protein degradation profile as that of AASK-N urine.

244 We evaluated three arms of the protein degradation/ quality control process (the autoph

245 opsis thaliana rosette to characterize their protein degradation rate and understand its determinants

246 tion without de novo synthesis; (ii) reduced protein degradation rates due to a 6 degrees C reduction

247 developed a sensitive approach to examining protein degradation rates in Saccharomyces cerevisiae by

248 Faster mitochondrial protein degradation rates not only for ICP55 cleaved pro

249 hat regulation of MT2 occurs at the level of protein degradation rather than by changes in the rate o

250 energy and fatty acid metabolism, increased protein degradation, reduced protein synthesis, decrease

251 biquitinases are important components of the protein degradation regulatory network.

252 Current methods for selective protein degradation require drug treatment or take hours

253 ish the role of directionality in mechanical protein degradation, show that degron placement can chan

254 Cell-specific protein degradation showed that only the mother cell com

255 ome, and it can readily be modified to study protein degradation signals and pathways in other organi

256 its the hydroxylases that promote HIF-1alpha protein degradation, stabilized HIF-1 activity during no

257 ated MELK knockout, a novel chemical-induced protein degradation strategy, RNA interference and CRISP

258 aryotic cells, with functional importance in protein degradation, subcellular localization and signal

259 USP28 largely reversed HDAC5-KD-induced LSD1 protein degradation, suggesting a role of HDAC5 as a pos

260 re resistant to epithelial integral membrane protein degradation, suggesting that barrier integrity r

261 potential for targeting other nonproteasomal protein degradation systems as an additional strategy to

262 is currently unclear how quality control and protein degradation systems coordinate with each other t

263 Activation of protein degradation systems has been proposed to be a po

264 y provide a template for designing inducible protein-degradation systems.

265 y assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic sti

266 hts into a mechanism linking translation and protein degradation that targets defective proteins imme

267 Both major pathways of protein degradation, the proteasome and autophagy, show

268 ar ATPase inhibitor that inhibits autophagic protein degradation, these results suggested that HCV de

269 that AKG rescues skeletal muscle atrophy and protein degradation through a PHD3/ADRB2 mediated mechan

270 iRNA-539-3p/USP13 signaling to increase MITF protein degradation through a reduction of de-ubiquitina

271 on of Cavalpha1.2 retrograde trafficking and protein degradation through the prevention of dynamin-me

272 LY RESPONSIVE GENE1 (OsHOS1), which mediates protein degradation through the proteasome complex.

273 at pollen compatibility in UI is mediated by protein degradation through the ubiquitin-proteasome pat

274 Hypoxia led to Tip110 protein degradation through the ubiquitin-proteasome sys

275 Targeted protein degradation through ubiquitination is an importa

276 late various cellular processes ranging from protein degradation to cellular signaling.

277 functions in diverse processes ranging from protein degradation to DNA damage repair and membrane fu

278 odifier that controls processes ranging from protein degradation to endocytosis, but early-acting reg

279 Our data, therefore, directly link impaired protein degradation to inclusion formation that is assoc

280 ubiquitin ligase (E3) cascade is crucial to protein degradation, transcription regulation, and cell

281 yces cerevisiae, two principal ER-associated protein degradation ubiquitin ligases (E3s) reside in th

282 rategy that promotes ligand-dependent target protein degradation using as an example the transcriptio

283 Targeted protein degradation, using bifunctional small molecules

284 hat LT reduces c-Jun both by promoting c-Jun protein degradation via inactivation of MKK1/2-Erk1/2 si

285 lating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor

286 NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasom

287 of PIPKIgammai5 significantly promotes Mig6 protein degradation via proteasomes, but it does not aff

288 machinery to SV pools, thereby initiating SV protein degradation via the ESCRT pathway.

289 dicating that cAMP signaling broadly affects protein degradation via the ubiquitin/proteasome pathway

290 Caspase protein degradation was partially reversed by lysosomal

291 were 3-fold faster in the day than at night, protein degradation was slow (3%-4% d(-1)), and flux to

292 dopsis thaliana) mutants defective in matrix protein degradation, we isolated unique mutations in PEX

293 gins of the grana turn out to be the site of protein degradation, well separated from active PS II in

294 creased while apoptosis, cell viability, and protein degradation were largely unaffected.

295 is sufficient to induce oxidative stress and protein degradation, whereas inhibition of Smad3 activit

296 we adopted a strategy to reversibly regulate protein degradation with a small molecule by using a des

297 Blockade of proteasome-dependent protein degradation with the 26S proteasome inhibitor MG

298 Protein degradation with time was assessed by gel-electr

299 oter reference technique (PRT), an assay for protein degradation with two advantageous features: a re

300 ive and cytotoxic activity along with client protein degradation without induction of the heat-shock