ライフサイエンスコーパス: protein degradation

1 very slow growth (to mitigate the effects of protein degradation).

2 actors including urea, lactate, and salivary protein degradation.

3 site- and target-specific ubiquitination and protein degradation.

4 , a component of the Arg/N-degron pathway of protein degradation.

5 i-modally at the stages of transcription and protein degradation.

6 xonal projections through impaired lysosomal protein degradation.

7 some system (UPS) components have implicated protein degradation.

8 independently of its impact on beta-catenin protein degradation.

9 ined by the balance of protein synthesis and protein degradation.

10 and control cellular functions by promoting protein degradation.

11 tic strategies based on altering pathways of protein degradation.

12 PIN), that faithfully measures the degree of protein degradation.

13 sible for proper lysosomal acidification and protein degradation.

14 ues pointing on manifold control of targeted protein degradation.

15 molecular machine responsible for regulated protein degradation.

16 d N-terminal and protein modifiers linked to protein degradation.

17 size through inhibiting proteasome-mediated protein degradation.

18 nd transcriptomic data allowed prediction of protein degradation.

19 lator 1 (LZTR1), that acts as an adaptor for protein degradation.

20 as unrelated to BACE1 gene transcription and protein degradation.

21 phosphorylate S249 of SNAI1, which leads to protein degradation.

22 or chloroplast outer envelope membrane (OEM) protein degradation.

23 the fusion product and regulates transporter protein degradation.

24 endent mechanisms, including increased IRS-1 protein degradation.

25 ting machinery required for vacuole membrane protein degradation.

26 cation of small molecules inducing selective protein degradation.

27 trols, suggesting a role for PHEX in SIBLING protein degradation.

28 in ligases that are important for eukaryotic protein degradation.

29 owerful small-molecule approach for inducing protein degradation.

30 to other drug discovery efforts in targeted protein degradation.

31 argeting any peptide resulting from cellular protein degradation.

32 e TP53 gene is wild type, by preventing TP53 protein degradation.

33 on, and decreased muscle fibrosis and muscle protein degradation.

34 pha (HIF-1alpha) and increased heme-mediated protein degradation.

35 A stability using gene replacement and rapid protein degradation.

36 ibitory effects of AKG on muscle atrophy and protein degradation.

37 extraction and 26S proteasome for subsequent protein degradation.

38 c strategy was developed to achieve targeted protein degradation.

39 rotects HIF1alpha against ubiquitin-mediated protein degradation.

40 hibits its deacetylase activity and promotes protein degradation.

41 e crosstalk between PTMs involving HIF1alpha protein degradation.

42 facilitate synaptic remodeling through local protein degradation.

43 proteasome is the main engine of Plasmodium protein degradation.

44 the initiation of inflammatory responses by protein degradation.

45 ast step of endocytosis required for surface protein degradation.

46 her agents that raise cGMP may also regulate protein degradation.

47 4 (referred to as Ub-DMD) and its subsequent protein degradation.

48 effectors, or other proteins; or can trigger protein degradation.

49 optical activation of small molecule-induced protein degradation.

50 cessary for NO to trigger ubiquitination and protein degradation.

51 rds target genes without the requirement for protein degradation.

52 tisubunit protease, plays a critical role in protein degradation.

53 ation contributed to loss of firmness due to protein degradation.

54 ygen species (ROS) production, and lipid and protein degradation.

55 ized that Cx43 reduction was due to enhanced protein degradation.

56 levels, thus mainly abrogating the increased protein degradation.

57 ced the ubiquitination of c-Myc and promoted protein degradation.

58 to-PROTAC, which is light-induced control of protein degradation.

59 , intracellular traffic, disease/defense and protein degradation.

60 ficient for SEL-10-mediated, MPK-1-dependent protein degradation.

61 oth necessary and sufficient for kinetochore protein degradation.

62 n the context of a ubiquitin ligase, lead to protein degradation(1).

63 athways including (1) energy metabolism, (2) protein degradation, (3) fatty acid metabolism and (4) a

64 Mutations in an enzyme involved in protein degradation affect a signaling pathway that stim

65 rader by demonstrating the improved targeted protein degradation after pre-fusion the HyT degrader wi

66 ethylated arginine residues can promote AGO2 protein degradation and are also bound by Tudor-domain p

67 pyruvate, while L. pneumophila induces host protein degradation and blocks protein translation.

68 ecreases Klotho expression through increased protein degradation and decreased transcription mediated

69 teine redox biology could be associated with protein degradation and degron recognition.

70 hways involved in morphological development, protein degradation and DNA repair, and is unaffected by

71 ino acid metabolism, and the upregulation of protein degradation and endocytosis.

72 mory destabilization process is regulated by protein degradation and GluR2-endocytosis in the amygdal

73 The proteasome mediates selective protein degradation and is dynamically regulated in resp

74 n expression; this, in turn, attenuated CDK6 protein degradation and led to CDK6 protein accumulation

75 genes play a rate-limiting role in increased protein degradation and muscle atrophy in insulin-defici

76 ein were collected by a nasogastric tube and protein degradation and peptide release was compared wit

77 imary metabolism processes, such as targeted protein degradation and peptidoglycan synthesis.

78 Protein degradation and phosphorylation are known to reg

79 ted missense mutation (N64I) in MEIOB causes protein degradation and reduced crossover formation in m

80 )-conjugating enzymes and Ub ligases control protein degradation and regulate many cellular processes

81 ffectively attenuated corticosterone-induced protein degradation and rescued the muscle atrophy and d

82 and trigger pathways of mRNA decay, nascent protein degradation and ribosome recycling.

83 Ubiquitylation, an essential process for protein degradation and signal transduction, is critical

84 erodimerization partner E47, promoting Ascl1 protein degradation and stem cell quiescence.

85 nk between the lipid droplet and proteasomal protein degradation and suggest that dynamic regulation

86 s vFLIP directly causing complex disruption, protein degradation and suppression of NF-kappaB signali

87 atrophy is regulated by the balance between protein degradation and synthesis.

88 uired for both efficient proteasome-mediated protein degradation and the dynamic regulation of lipid

89 d darkness, autophagy deficiency compromises protein degradation and the generation of amino acids us

90 Although the pathways of chloroplast protein degradation and the types of chloroplast proteas

91 GAs induce DELLA repressor protein degradation and thereby control a number of crit

92 antibacterial products that target bacterial protein degradation and therefore may have utility for t

93 ure of events immediately downstream of SMXL protein degradation and whether all SMXL proteins mediat

94 ear expression was associated with increased protein degradation and zif268 expression in the same po

95 three constraints: 1) protein synthesis, 2) protein degradation, and 3) positive feedback.

96 easomes, protein ubiquitination, and overall protein degradation, and agents that raise cGMP may help

97 ity of samples tested are not compromised by protein degradation, and establish the PIN score as a ge

98 ases have so far been exploited for targeted protein degradation, and expansion of knowledge in this

99 vities, including nucleic acid modification, protein degradation, and many others.

100 id the solubilization of misfolded proteins, protein degradation, and transport.

101 g in protein translocation across membranes, protein degradation, and unfolding.

102 ing; gene transcription; ribosomal proteins; protein degradation; and metabolism regulation.

103 modulate ubiquitin ligase activity to induce protein degradation are a major new class of therapeutic

104 , neuronal protein synthesis and proteasomal protein degradation are enhanced, with endoplasmic retic

105 Our study establishes regulated protein degradation as a fundamental mechanism underlyin

106 that priming is the rate-determining step in protein degradation as directed by the yeast ERAD RING E

107 protein synthesis and only partially delayed protein degradation as measured by a slight increase in

108 Additionally, the rate of Tat protein degradation as measured by cycloheximide (CHX) c

109 Methods and tools for evaluating protein degradation as well as a discussion of physical

110 lation inhibitors, such as cycloheximide, in protein degradation assays may result in artefacts, thes

111 complex multipathway response that leads to protein degradation at higher BPA concentrations.

112 rotein aggregation is nearly as effective as protein degradation at lowering levels of excess protein

113 whether this strategy is used to facilitate protein degradation at specific locations within the cel

114 al an unexpected mechanism of APC/C-mediated protein degradation at the INM that coordinates nuclear

115 Moreover, it necessitates hippocampal protein degradation at the proteasome and engages hippoc

116 nsiderable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain

117 egulation, post-translational modifications, protein degradation, binding to cofactors and subcellula

118 previous observations, was not mainly due to protein degradation but instead correlated with reduced

119 y through cytokine-induced transcription and protein degradation, but mechanisms regulating its activ

120 of mitochondrial biology through specialized protein degradation, but the underlying mechanisms of th

121 in the Drosophila Delta9-desaturase mediates protein degradation by a calcium-dependent cysteine prot

122 ort and nitrate assimilation, restriction of protein degradation by autophagy and subsequent N remobi

123 Small molecule-induced targeted protein degradation by heterobifunctional ligands or mol

124 Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder ca

125 Inducing protein degradation by proteolysis targeting chimeras (P

126 le ULK2 has a unique role in basal selective protein degradation by stimulating the recognition and p

127 Nt-acetylation critically regulates protein degradation by the N-end rule pathways, suggesti

128 ry, our study reveals mechanistic details of protein degradation by the PDZ-protease Prc bound to its

129 MHC-I-bound peptides originate from protein degradation by the proteasome, suggesting that s

130 During protein degradation by the ubiquitin-proteasome pathway,

131 Protein degradation by the ubiquitin-proteasome system i

132 ) and related molecules that induce targeted protein degradation by the ubiquitin-proteasome system r

133 iew, we will discuss the basic mechanisms of protein degradation by the UPS.

134 barnase by fusing the protein to a portable protein degradation cassette, the low-temperature degron

135 loss, decreased transcription, and increased protein degradation caused by inflammation or PTEN loss.

136 , including endoplasmic reticulum-associated protein degradation, cell motility, endocytosis, and end

137 Such chloroplast-associated protein degradation (CHLORAD) is vital for organellar fu

138 led to the definition and exemplification of protein degradation concepts and their resulting applica

139 lar infection model, and we demonstrate that protein degradation contributes to its antiviral activit

140 Viperin-targeted protein degradation contributes to the antiviral respons

141 Through these analyses, selective protein degradation could be achieved between the two pr

142 ciated degradation factors to promote mutant protein degradation could be beneficial for the treatmen

143 The observed activity of protein degradation could in part be rationalized throug

144 Guided by both phenotypic and protein degradation data, we describe a series of CELMoD

145 e that the activity of molecules that induce protein degradation depends on the strength of ligase-su

146 ation, protein folding, protein association, protein degradation, drug action, and second messengers

147 or the substrate adaptors ZYG11B and ZER1 in protein degradation during apoptosis.

148 involving proteolytic adaptors that regulate protein degradation during cell cycle progression or dur

149 Protein degradation during in vitro GID was evaluated by

150 l industry has made improvements to mitigate protein degradation during the drug manufacturing proces

151 formation of ternary complex and enhance the protein degradation efficiency.

152 The ER-associated protein degradation (ERAD) pathway, an important UPR fun

153 been well characterized by the ER-associated protein degradation (ERAD) pathway, but very little is k

154 Cdc48) is a key member of the ER-associated protein degradation (ERAD) pathway.

155 In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiqui

156 bly through endoplasmic reticulum-associated protein degradation (ERAD).

157 Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD).

158 hway termed endoplasmic reticulum-associated protein degradation (ERAD).

159 porter protein are critical to the design of protein degradation experiments.

160 igases, our strategy enables light-triggered protein degradation for any small molecule warhead.

161 K-Rta transactivation activity requires a protein degradation function; thus, we hypothesized that

162 Regulated protein degradation has emerged as a powerful means of p

163 protein perturbation, small molecule-induced protein degradation has gained significant attention as

164 Targeted protein degradation has recently emerged as a novel phar

165 epitranscriptome, translational control, and protein degradation have emerged as fundamental regulato

166 icing, translation, protein kinase activity, protein degradation, heme degradation, K+ channel functi

167 Pan-RAS protein degradation, however, affects proliferation irre

168 fness, which result from proteasome-mediated protein degradation impairing the longitudinal growth of

169 vealed protein profiles indicative of severe protein degradation in 34 of 37 AASK-N urine samples.

170 G F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induc

171 AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist

172 The proteasome is a key player of regulated protein degradation in all kingdoms of life.

173 Protein degradation in bacteria is a highly controlled p

174 iefly discuss lessons learned about targeted protein degradation in chemical biology and drug discove

175 cipal macromolecular machine responsible for protein degradation in eukaryotes.

176 somal machinery performs essential regulated protein degradation in eukaryotes.

177 system (UPS) is responsible for the bulk of protein degradation in eukaryotic cells, but the factors

178 ar machine that is responsible for selective protein degradation in eukaryotic cells.

179 oteasome system is the canonical pathway for protein degradation in eukaryotic cells.

180 However, the regulation of ubiquitinated protein degradation in healthy, nonatrophying skeletal m

181 macropinocytosis and increased extracellular protein degradation in lysosomes, which were suppressed

182 asome pathway is responsible for most of the protein degradation in mammalian cells.

183 inhibiting proteolysis imply suppression of protein degradation in muscle during arousals.

184 ped as a tool to achieve rapid and inducible protein degradation in nonplant systems.

185 th CDC48 proteins to negatively regulate INM protein degradation in plants.

186 Proteasomes are essential for protein degradation in proliferating cells.

187 gues report a novel mechanism by which BRCA1 protein degradation in response to DNA double-strand bre

188 vity by SIS3 suppresses oxidative stress and protein degradation in the diaphragm and prevents the re

189 ergy, and disposal of nitrogenous waste from protein degradation in the form of urea metabolism.

190 from its cargo trafficking function hinders protein degradation in the host and, simultaneously, ena

191 Phorbol myristate acetate induced TTF1 protein degradation in the ubiquitin-proteasome system i

192 plains why Mpa is unable to stimulate robust protein degradation in vitro in the absence of other, ye

193 ngle dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal

194 report an alternative mechanism of targeted protein degradation, in which a small molecule induces t

195 some acidification and inhibiting autophagic protein degradation including p62, which further activat

196 regulates many cellular processes including protein degradation, intracellular trafficking, cell sig

197 ng the salivary metabolome, it is clear that protein degradation is a key nutrient and the availabili

198 Our data suggests that targeted protein degradation is a promising drug development appr

199 Targeted protein degradation is a promising drug development para

200 Protein degradation is an essential mechanism for mainta

201 Targeted protein degradation is an important and pervasive regula

202 The N-end rule pathway of targeted protein degradation is an important regulator of diverse

203 Protein degradation is critical for maintaining cellular

204 Intracellular protein degradation is essential for the survival of all

205 Controlled ubiquitin-mediated protein degradation is essential for various cellular pr

206 Protein degradation is essential in plant growth and dev

207 ottleneck step: it is time consuming and the protein degradation is not always complete.

208 Skeletal muscle atrophy due to excessive protein degradation is the main cause for muscle dysfunc

209 ates has the potential to globally influence protein degradation kinetics within an infected cell.

210 pecifically designed for efficient and rapid protein degradation kinetics.

211 Despite its central role in protein degradation little is known about the molecular

212 ds involve the manipulation of intracellular protein degradation machinery and are therefore fundamen

213 einhardtii, we discovered that the cytosolic protein degradation machinery is concentrated within ~20

214 framework of how HIV-1 Vif hijacks the host protein degradation machinery to counteract viral restri

215 n of Vpr and its interaction with the cell's protein degradation machinery.

216 work provides proof-of-concept that targeted protein degradation may provide a new paradigm for the d

217 that combined BCR-ABL1 kinase inhibition and protein degradation may represent a strategy to address

218 enal epithelial cells and fibroblasts, via a protein degradation mechanism by promoting their ubiquit

219 Here, we set out to delineate the protein degradation mechanism of human CaV2.1 subunit by

220 challenges of developing drugs with targeted protein degradation mechanism.

221 also found that alterations in the cellular protein degradation mechanisms strongly influenced alpha

222 We show that, in contrast to the protein degradation mechanisms that control TRA-1 accumu

223 mal cells, this pathway is restrained by p53 protein degradation mediated by the E3-ubiquitin ligase

224 hat made this a cyclic process was regulated protein degradation, mediated by ubiquitin, catalyzed by

225 he day compared to night, whereas markers of protein degradation, murf messenger RNAs, are higher at

226 fore, CLPP2 contributes to the mitochondrial protein degradation network through supporting coordinat

227 Perspective highlights examples of targeted protein degradation observed for smaller, monomeric mole

228 r, can have very low escape efficiency, with protein degradation occurring in acidic endolysosomal co

229 e translation of r-proteins, but, notably, r-protein degradation occurs largely through non-autophagi

230 nt growth and development via TIR1-dependent protein degradation of canonical AUX/IAA proteins, which

231 nism of pathogenesis that relies on impaired protein degradation of the Ras GTPase RIT1.

232 Depletion of Nedd4 limits the protein degradation of VDAC2/3, which increases the sens

233 endocytic function aids the turnover (i.e., protein degradation) of TDP-43 and reduces TDP-43 toxici

234 Our results indicate that protein degradation only affects 5.9% of the samples tes

235 le in important cellular machineries such as protein degradation or chromatin-mediated signaling.

236 th K48- and K63-linked conjugates that drive protein degradation or complex assembly, respectively.

237 que postmitotic cells, in which irreversible protein degradation or damage can lead to impaired heari

238 e post-translational modification leading to protein degradation or delocalization, or altering prote

239 gulation of endoplasmic reticulum-associated protein degradation pathway components upon foxo knockdo

240 We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome sy

241 , we identify critical components for an INM protein degradation pathway.

242 asingly, we understand that dysregulation of protein degradation pathways is critical for many human

243 r/STAT92E/JNK cascade that may be coupled to protein degradation pathways such as autophagy or more t

244 y the unfolded protein response and involves protein degradation pathways to ensure quality control.

245 ation of this process, which is connected to protein degradation pathways, such as autophagy and the

246 revealed that Regnase-3 and Regnase-1 share protein degradation pathways.

247 new ALS-associated gene variant mediated by protein degradation pathways.

248 Protein-degradation platforms such as proteolysis-target

249 Proteases and protein degradation play crucial roles in living systems

250 kocyte antigen (HLA) proteins, which present protein degradation products at the cell surface to circ

251 ples with 0.5% acetic acid produced the same protein degradation profile as that of AASK-N urine.

252 a constant low protein level and an enhanced protein degradation rate compared with the WT HO2.

253 e proteome-wide effect of prion infection on protein degradation rates in N2a neuroblastoma cells by

254 The browning and protein degradation rates of alfalfa treated under the o

255 energy and fatty acid metabolism, increased protein degradation, reduced protein synthesis, decrease

256 at differential B-class dimerization affects protein degradation, revealing an important consequence

257 tor of endoplasmic reticulum (ER) associated protein degradation, Sec61-dependent Ca(2+) homeostasis

258 III produced submicromolar AR antagonism and protein degradation selective to AR and AR splice varian

259 ish the role of directionality in mechanical protein degradation, show that degron placement can chan

260 ted to fungal cell wall remodeling, targeted protein degradation, signal transduction, adhesion, and

261 ls induced heat-shock proteins and increased protein degradation similar to other cells.

262 co-localized with 23% of all DNA-associated protein degradation sites.

263 vision and protein import, pexophagy, matrix protein degradation, solute transport, signaling, redox

264 Controlled protein degradation strategies revealed that the uninter

265 ated MELK knockout, a novel chemical-induced protein degradation strategy, RNA interference and CRISP

266 proteins by N-homocysteinylation, leading to protein degradation, stress and impaired function.

267 ently inactivated tumor suppressor KMT2D for protein degradation, subsequently regulating gene expres

268 erminal tails which assist with RQC-mediated protein degradation, suggesting a pathomechanism.

269 USP28 largely reversed HDAC5-KD-induced LSD1 protein degradation, suggesting a role of HDAC5 as a pos

270 A light-regulated protein degradation system was used to assay temporal de

271 potential for targeting other nonproteasomal protein degradation systems as an additional strategy to

272 progenitor stage, when p53, a principal MDM2 protein degradation target, was transiently upregulated.

273 We employed targeted protein degradation technology to convert a tau PET-prob

274 that AKG rescues skeletal muscle atrophy and protein degradation through a PHD3/ADRB2 mediated mechan

275 iRNA-539-3p/USP13 signaling to increase MITF protein degradation through a reduction of de-ubiquitina

276 tes numerous cellular functions by mediating protein degradation through its segregase activity.

277 Targeted protein degradation through ubiquitination is an importa

278 educed the glycolytic throughput and induced protein degradation to deliver energy for the alternativ

279 ogists have exploited natural mechanisms for protein degradation to direct the elimination of specifi

280 Targeted protein degradation (TPD) has emerged as a powerful tool

281 Targeted protein degradation (TPD) refers to the use of small mol

282 ubiquitin-proteasome system, which regulates protein degradation, trafficking, and signaling events i

283 ubiquitin ligase (E3) cascade is crucial to protein degradation, transcription regulation, and cell

284 r some paradigms of human disease related to protein degradation using selected examples.

285 Targeted protein degradation, using bifunctional small molecules

286 chieves DC(50) (concentration causing 50% of protein degradation) values of 0.17 and 0.43 nM in MCF-7

287 Targeted protein degradation via cereblon (CRBN), a substrate rec

288 tional modifications that are encompassed by protein degradation via the Cys/Arg branch of the N-degr

289 ws conditional genetics based on conditional protein degradation via the N-end rule or N-degron pathw

290 When protein degradation was inhibited, we observed a coordin

291 To objectively quantify the extent of protein degradation, we develop a numerical score, the P

292 Using inducible protein degradation, we show that PAR-6 and PKC-3, but n

293 itin carboxyl-terminal hydrolase involved in protein degradation were positively correlated to HS sam

294 on as a backup system for post-translational protein degradation which ensures robust development and

295 ce polymerization coupled to highly specific protein degradation, which in the case of BCL6 leads to

296 we adopted a strategy to reversibly regulate protein degradation with a small molecule by using a des

297 Targeted protein degradation with bifunctional degraders is posit

298 fully harness the potential of light-induced protein degradation with photoactive bifunctional molecu

299 Blockade of proteasome-dependent protein degradation with the 26S proteasome inhibitor MG

300 oter reference technique (PRT), an assay for protein degradation with two advantageous features: a re