ライフサイエンスコーパス: protein dimerization

1 found with the coiled-coil domain needed for protein dimerization.

2 function of the HLH domain from its role in protein dimerization.

3 domain make inter-chain contacts leading to protein dimerization.

4 face suggest a mechanism for heparin-induced protein dimerization.

5 e show that binding of ssDNA to Pif1 induces protein dimerization.

6 p53-DNA association and also interfere with protein dimerization.

7 /LWEQ module also contains a determinant for protein dimerization.

8 g the DNA by about 20 degrees at the site of protein dimerization.

9 s DREAM as a monomer, whereas Ca(2+) induces protein dimerization.

10 -residue motif, LIxxGVxxGVxxT, that mediates protein dimerization.

11 restingly, both ATP and ADP can also promote protein dimerization.

12 er membrane of Escherichia coli and mediated protein dimerization.

13 s 1 and 130 and that binding is dependent on protein dimerization.

14 as building blocks for chemical inducers of protein dimerization.

15 -finger domains that mediate DNA binding and protein dimerization.

16 a DNA binding motif whose formation requires protein dimerization.

17 been shown to mediate both dsRNA binding and protein dimerization.

18 otein is stimulated by ss DNA binding and by protein dimerization.

19 a small cell-permeable molecule can mediate protein dimerization.

20 hroughout the DP-1 gene but generally leaves protein dimerization activity intact.

21 onal activation, DNA binding properties, and protein dimerization activity of three HNF-4alpha missen

22 C-terminal SPRY domain, but did require both protein dimerization and a B-box 2 residue (Arg121) prev

23 ne protein to bind and 30-bp dsRNA to induce protein dimerization and activation by autophosphorylati

24 tes HCAs through a novel mechanism involving protein dimerization and activation of PKG-Ialpha and su

25 Protein dimerization and DNA binding are thus obligatori

26 Analysis of the structural requirement for protein dimerization and DNA binding by Roaz reveals the

27 inge (H) domain, and a carboxyl-terminal (C) protein dimerization and DNA binding domain.

28 sactivation domain but retain the C-terminal protein dimerization and DNA binding domains.

29 The kinetics of coupling of protein dimerization and DNA binding have been investiga

30 The roles of protein dimerization and double-stranded RNA (dsRNA) bin

31 ophobic heptad repeat domain responsible for protein dimerization and interaction with the mSin3A tra

32 distinct conformational changes resulting in protein dimerization and markedly increased folding stab

33 amily tyrosine kinases (Jaks), allowing STAT protein dimerization and nuclear translocation.

34 cluster of FNR is oxygen labile and controls protein dimerization and site-specific DNA binding.

35 s knowledge of the coupled energetics of its protein dimerization and site-specific DNA binding.

36 xperimental analysis of residues involved in protein dimerization and studies on a reported ligand fo

37 The findings indicate a unique mechanism of protein dimerization and the ability of nucleotide signa

38 on and with features predicting DNA binding, protein dimerization, and activation domains.

39 these mutations on FlhF enzymatic activity, protein dimerization, and bacterial motility.

40 SCAN is known to mediate protein dimerization, and the CA protein multimerizes to

41 ted it in vitro and in vivo for DNA binding, protein dimerization, and transactivation activity.

42 indicate that site-specific DNA binding and protein dimerization are obligatorily linked in the syst

43 ractice the affinity for DNA is dominated by protein dimerization as DNA binding by the monomer is ne

44 We observed that protein dimerization, ATP binding, and ATP hydrolysis we

45 ins (TADs), fused to the HLF DNA binding and protein dimerization basic leucine zipper (bZIP) domain.

46 a heterologous leucine zipper that promotes protein dimerization but not RNA binding established tha

47 h is thought to bind autoinducer and mediate protein dimerization, but abolishes translation of the c

48 At higher concentrations, apo-protein dimerization can apparently precede cooperative

49 Here we show how free energies of membrane protein dimerization can be measured in mammalian plasma

50 FP (mXFP) mutation that prevents fluorescent protein dimerization complements the mutant channel effe

51 These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for i

52 Protein dimerization decreases with an approximately 8-f

53 DREAM to DNA targets and that Ca(2+)-induced protein dimerization disrupts DNA binding.

54 These results support a model in which Rep protein dimerization disturbs one of two DNA binding dom

55 Functions of these proteins (dimerization, DNA binding, and interaction wit

56 The N-terminal transacting and C-terminal protein dimerization/DNA binding domains independently a

57 yc that lacks the C-terminal DNA binding and protein dimerization domain of c-Myc.

58 in of E2A linked to the bZIP DNA-binding and protein dimerization domain of hepatic leukemia factor (

59 tion domain is linked to the DNA-binding and protein dimerization domain of hepatic leukemia factor (

60 basic leucine zipper (bZIP) DNA-binding and protein dimerization domain of HLF (hepatic leukemic fac

61 g only the carboxyl-terminal DNA binding and protein dimerization domain suggest that looping is depe

62 Fusing a protein dimerization domain, encoded by the C terminus o

63 In addition to the DNA-binding and protein dimerization domain, the E proteins share two hi

64 haromyces pombe contains a bZIP (DNA-binding/protein dimerization) domain characteristic of ATF/CREB

65 ies of protein chimeras comprising unrelated protein dimerization domains fused to thioredoxin superf

66 the coding sequences for the DNA-binding and protein dimerization domains gave the highest level of t

67 nthetic compounds in regulating two types of protein dimerization events inside engineered cells--ind

68 terminal half of TraR binds AAI and mediates protein dimerization; (ii) both DNA-binding domains in a

69 roscopy method that is directly sensitive to protein dimerization in a live-cell environment.

70 ithin residues 6 to 31) was not required for protein dimerization in vivo, but its deletion imparted

71 d system designed to facilitate the study of protein dimerization indicates that MvaT and MvaU can fo

72 y also allow a direct assessment of specific protein dimerization interactions in a biologically rele

73 co-crystal structure also reveals a protein-protein dimerization interface of PCBP2 KH1 located on t

74 ated that each of the p6 domains, as well as protein dimerization, is essential for p6 function in vi

75 sembly was high, suggesting that scaffolding protein dimerization may play a role in ensuring fidelit

76 pecific phospholipase (W47A/W242A) suggested protein dimerization might occur on the membrane.

77 Ly6 domain that abolish LPL binding lead to protein dimerization/multimerization.

78 associated with chylomicronemia, also led to protein dimerization/multimerization.

79 he activity of Sema6A is likely to depend on protein dimerization or oligomerization.

80 ns of sequence homology, and each contains a protein dimerization PAS domain.

81 th the Drosophila PER protein, including the protein dimerization PAS domain.

82 Guided by protein dimerization properties, we examined DNA binding

83 The protein dimerization rates as well as the dimer-DNA rate

84 ffect was mediated by the disruption of CD45 protein dimerization regulated by sialic acid.

85 domains of ModE in mediating DNA binding and protein dimerization, respectively.

86 mutations in conserved residues involved in protein dimerization reveals that the integrity of the d

87 This effect depends on protein dimerization, since monomeric Gal-1 fails to sti

88 ptor leads to the dissociation of heat shock proteins, dimerization, specific DNA binding, and target

89 aper, we characterize the Mn(II) binding and protein dimerization state using a combination of contin

90 eviously described a small molecule-directed protein dimerization strategy, using coumermycin to juxt

91 as structure-informed mutations that disrupt protein dimerization, substrate orientation or flap unwi

92 ized a rapidly reversible chemically induced protein dimerization system that enabled us to control R

93 with binding increases that correlated with protein dimerization, tetramerization, and oligomerizati

94 ha3 in both subunits, a mode of winged helix protein dimerization that is reminiscent of that of the

95 E.coli MutL, whose ATPase activity requires protein dimerization, the monomeric form of NhPMS2 is ac

96 Since neither DNA binding nor protein dimerization through the bZIP domain of HLF is r

97 ecently developed that permits intracellular protein dimerization to be reversibly activated in respo

98 ted from native gels and assayed for RNA and protein dimerization to test whether RNA dimerization af

99 gation studies demonstrate that Ca2+ induces protein dimerization upon exposure to 5 mM Ca2+.

100 The promotion of protein dimerization using the aggregation properties of

101 e the role of ligand conformation in induced protein dimerization, we synthesized a flexible methotre

102 the sugar binding, yet HM addition promoted protein dimerization, which was further confirmed by sma

103 emerging as a sequence-specific regulator of protein dimerization with hundreds of targets and wide-r