ライフサイエンスコーパス: protein farnesylation

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1 sm, may be linked to one another and require protein farnesylation.

2 al evidence indicates that AIPL1 can enhance protein farnesylation.

3 tly acted through a mechanism independent of protein farnesylation.

4 be made to probe the biological function of protein farnesylation.

5 While 3-allylfarnesol inhibits protein farnesylation, 3-vinylfarnesol instead leads to

6 m clinical trials administered inhibitors of protein farnesylation aimed at reducing toxicity of the

7 Prenylation of protein (farnesylation and geranylgeranylation) is invol

8 Lovastatin inhibits both protein farnesylation and geranylgeranylation by decreas

9 GGTI-298 or lovastatin, which inhibits both protein farnesylation and geranylgeranylation, arrested

10 FTI-277 and GGTI-298) that selectively block protein farnesylation and geranylgeranylation, respectiv

11 se 2 trial as well as its ability to inhibit protein farnesylation and oncogenic pathways in patients

12 nsferase inhibitors (FTIs) selectively block protein farnesylation and reduce the growth of many Ras-

13 s farnesyltransferase (FTase) expression and protein farnesylation and that FTase inhibitor (FTI) pre

14 requires protein geranylgeranylation but not protein farnesylation and that the tyrosine phosphorylat

15 Our study identifies protein farnesylation as a potential hub of the signalin

16 nhibits both protein geranylgeranylation and protein farnesylation, blocked PDGF receptor tyrosine ph

17 These data suggest that FTase catalyzes protein farnesylation by an associative mechanism with a

18 y intermediate in the mevalonate pathway and protein farnesylation, can act as an agonist for several

19 esis and suggest that specific inhibition of protein farnesylation could be a potential strategy for

20 ads to a G0/G1 arrest, whereas inhibition of protein farnesylation does not affect cell cycle distrib

21 To assess the importance of protein farnesylation for B-type lamins, we created knoc

22 st, treatment of cells with the inhibitor of protein farnesylation, FTI-277 (10 microM), blocked IL-1

23 In Arabidopsis thaliana, protein farnesylation has been shown to be necessary for

24 nsferase (FTase), the enzyme responsible for protein farnesylation, has become a key target for the r

25 Inhibition of protein farnesylation improves the hallmark nuclear shap

26 T inhibitors, and these compounds also block protein farnesylation in cultured parasites.

27 ngs provide the first evidence of a role for protein farnesylation in glucose-mediated regulation of

28 The role of protein farnesylation in lamin A biogenesis and the path

29 data support the concept that inhibition of protein farnesylation in progeria could be therapeutical

30 Here, we investigated roles of protein farnesylation in the signaling steps involved in

31 onstrated, confirming that SCH66336 inhibits protein farnesylation in vivo.

32 through pathways distinct from its role as a protein farnesylation inhibitor.

33 mparisons estimating increased survival with protein farnesylation inhibitors provide the first evide

34 The results suggest that protein farnesylation is a target for the development of

35 These results demonstrate that protein farnesylation is critical for maintaining normal

36 Protein farnesylation is important for a number of physi

37 Our findings suggest that protein farnesylation is important for cell cycle progre

38 The loss of protein farnesylation is not as severe but also results

39 Protein farnesylation is required for expression and sec

40 farnesol (FOL) with lovastatin, to stimulate protein farnesylation, prevented lovastatin-induced cell

41 Mg2+ ions accelerate the protein farnesylation reaction by up to 700-fold.

42 Thus, inhibition of protein farnesylation stimulates TbetaRII expression, wh

43 had only a modest influence whereas blocking protein farnesylation with manumycin severely disrupted

44 We hypothesized that interfering with protein farnesylation would block the targeting of proge

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