ライフサイエンスコーパス: protein glycosylation

1 and enables proteome-wide discovery of O-Man protein glycosylation.

2 alyzing the first committed step of N-linked protein glycosylation.

3 silsesquioxane, dendrimer), (d) peptide and protein glycosylation.

4 tive in its reliance on mechanical force and protein glycosylation.

5 not by tunicamycin treatment, which inhibits protein glycosylation.

6 des a semiquantitative assessment of overall protein glycosylation.

7 ct cellular localization, and regulation for protein glycosylation.

8 abolishes the ability of ACER2 to regulation protein glycosylation.

9 binding affinity for PrP was not altered by protein glycosylation.

10 LNT enzyme in initiating mucin type O-linked protein glycosylation.

11 covery further advances our understanding of protein glycosylation.

12 icamycin (TM), an agent that blocks N-linked protein glycosylation.

13 acter jejuni has systems for N- and O-linked protein glycosylation.

14 vertebrate nucleotidases may play a role in protein glycosylation.

15 affect either DNA synthesis or UDP-dependent protein glycosylation.

16 are required for DNA, RNA, and UDP-dependent protein glycosylation.

17 ains is at least partly mediated by envelope protein glycosylation.

18 jejuni virulence by affecting the degree of protein glycosylation.

19 can be employed to modulate the patterns of protein glycosylation.

20 (ER) stress, which results from a decline in protein glycosylation.

21 ts suggest that the genes may be involved in protein glycosylation.

22 hexose metabolism in a manner beneficial for protein glycosylation.

23 prevention of intravascular thrombosis, and protein glycosylation.

24 used glucose deprivation as a tool to alter protein glycosylation.

25 her dendrites also possess the machinery for protein glycosylation.

26 N-acetylglucosamine and thus is a measure of protein glycosylation.

27 n be made to promote further explorations of protein glycosylation.

28 ial to determining the microheterogeneity of protein glycosylation.

29 ino acid residues, forming multiple types of protein glycosylation.

30 e development and maintenance, or defects in protein glycosylation.

31 cells with knock-in/out enzymes involved in protein glycosylation.

32 as a method to compensate for deficiency in protein glycosylation.

33 niae encodes an unusual pathway for N-linked protein glycosylation.

34 to UDP-sugar biosynthesis to support virion protein glycosylation.

35 needed to reveal the biological function of protein glycosylation.

36 rst two committed steps of asparagine-linked protein glycosylation.

37 he impact of nucleotide and NS metabolism on protein glycosylation.

38 , genes required for mannose utilization and protein glycosylation, activated a pheromone-response-pa

39 N-acetylglucosamine (O-GlcNAc) is one of the protein glycosylations affecting various intracellular e

40 oligosaccharide precursor and total cellular protein glycosylation, along with hypoglycosylation of a

41 s the use of DEN-gas sheathless CE-ESI-MS in protein glycosylation analysis, where precision is essen

42 Altered protein glycosylation and antibodies that recognize endo

43 Protein glycosylation and capsular polysaccharide format

44 hose members include essential components of protein glycosylation and cell-wall synthesis pathways.

45 proteins involved in vesicular transport and protein glycosylation and degradation, pointing to key n

46 a has different vesicles that play a role in protein glycosylation and folding quality control, analo

47 notype of B. fragilis mutants with defective protein glycosylation and found that the glycan added to

48 Thus, protein glycosylation and HCF-1 cleavage occur in the sa

49 Decreased KCC2 surface expression, reduced protein glycosylation and impaired chloride extrusion co

50 ferred by enforced beta cell-specific GnT-4a protein glycosylation and involved the maintenance of gl

51 This review focuses on bacterial protein glycosylation and its impact in pathogenesis.

52 emented with galactose showed restoration of protein glycosylation and no evidence of glycogen accumu

53 ol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as t

54 IL-1beta stimulates GLUT1 protein glycosylation and plasma membrane incorporation.

55 o provide the glycosyl subunits required for protein glycosylation and production of high titers of i

56 ited defects in manganese-dependent steps in protein glycosylation and showed an overall decrease in

57 es but also has striking negative effects on protein glycosylation and sorting.

58 n allowed improved site-specific analysis of protein glycosylation and superior to positive ion mode

59 was primarily mediated via loss of envelope protein glycosylation and that this was associated with

60 It is considerably important to study protein glycosylation and the associated glycans for dia

61 numbers of proteins providing information on protein glycosylation and their microheterogeneity.

62 teases in Archaea, suggesting a link between protein glycosylation and this protease family.

63 ed protein, Golgb1 has specific functions in protein glycosylation and tissue morphogenesis.

64 respiratory chain), dolichols (important for protein glycosylation), and isoprenoids (lipid moieties

65 um (ER) is required for membrane biogenesis, protein glycosylation, and GPI anchoring.

66 uption of calcium homeostasis, inhibition of protein glycosylation, and reduction of disulfide bonds

67 uption of calcium homeostasis, inhibition of protein glycosylation, and reduction of disulfide bonds,

68 nthesis of cell wall matrix polysaccharides, protein glycosylation, and vesicle trafficking.

69 Alterations in protein glycosylation are a key feature of oncogenesis a

70 Both de novo DNA synthesis and UDP-dependent protein glycosylation are important for the perplexed ph

71 Changes in O-linked protein glycosylation are known to correlate with diseas

72 Regulatory pathways for protein glycosylation are poorly understood, but express

73 However, the molecular mechanisms underlying protein glycosylation are still poorly understood.

74 eterogeneous group of diseases with aberrant protein glycosylation as a hallmark.

75 h3 and ZRSR2 mutants identify cell cycle and protein glycosylation as common pathways disrupted.

76 for cell wall carbohydrate biosynthesis and protein glycosylation as well as for AsA biosynthesis.

77 Investigating aberrant protein glycosylation associated with diseases is useful

78 to enable and expedite the identification of protein glycosylation based on protein size and affinity

79 of the endoplasmic reticulum calcium stores, protein glycosylation block, and formation of aberrant p

80 are subjected to calcium depletion stress or protein glycosylation block, the transcription of a fami

81 Here, we highlight how regulated changes in protein glycosylation both at the cell surface and on se

82 However, direct analysis of protein glycosylation by glycopeptide-based mass mapping

83 the reliable structural characterization of protein glycosylation by mass spectrometry at the picomo

84 Protein glycosylation by ST6Gal-I restricts access of an

85 ary fragmentation techniques for analysis of protein glycosylation by tandem mass spectrometry.

86 th various biochemical probes at the site of protein glycosylation by using the Staudinger ligation.

87 Decreasing protein glycosylation can disrupt protein folding, preve

88 ansform insect cells, which has enhanced its protein glycosylation capabilities.

89 Protein glycosylation catalyzed by the O-GlcNAc transfer

90 MPI mutations in humans impair protein glycosylation causing congenital disorder of gly

91 nditional (temperature-sensitive) defects in protein glycosylation (CHO K12 and BHK tsBN7) induce CHO

92 ental and essential property as mutants with protein glycosylation defects have impaired growth and a

93 e animals and cells derived from them showed protein glycosylation deficiencies similar to those foun

94 by a severe reduction in the HEV-associated proteins, glycosylation-dependent cell adhesion molecule

95 nd activity in invasive cancers, and altered protein glycosylation detected in malignant tumors at al

96 Candida albicans mutant strains defective in protein glycosylation did not show altered plasminogen b

97 rbohydrate interactions allowing us to study protein glycosylation directly on unmodified glycoprotei

98 ine pathway, as well as direct inhibitors of protein glycosylation efficiently inhibited TSP-1 transc

99 homeostasis, resulting in global changes in protein glycosylation, expression and functional effects

100 was used to characterize the requirement of protein glycosylation for cell membrane stability during

101 erscores the importance of asparagine-linked protein glycosylation for proper functioning of the neur

102 ndings underscore the importance of N-linked protein glycosylation for proper functioning of the neur

103 hreonine side chains represent the two major protein glycosylation forms.

104 roles for a number of novel gene products in protein glycosylation, GPI-anchor attachment, ER quality

105 Protein glycosylation has an important influence on a br

106 Protein glycosylation has been implicated in key biologi

107 Protein glycosylation has been long recognized as an imp

108 anslational modifications (PTMs) in mammals, protein glycosylation has been observed to alter in mult

109 While protein glycosylation has been reported in several spiro

110 ed role for TRAPPC11 in LLO biosynthesis and protein glycosylation in addition to its established fun

111 irst study to conclusively identify sites of protein glycosylation in any of the mollicutes.

112 rk for understanding the process of N-linked protein glycosylation in Bacteria and for devising strat

113 The study of protein glycosylation in biological fluids and tissues h

114 identification of a unique system of general protein glycosylation in C. jejuni, a C. jejuni protein

115 AP) method provides a platform for analyzing protein glycosylation in clinical specimens and could co

116 to be used for characterizing site-specific protein glycosylation in complex samples.

117 sly unrecognized cell-type-specific role for protein glycosylation in epithelial phenotype developmen

118 The precise roles of protein glycosylation in multicellular development are p

119 samine, along with decreased O- and N-linked protein glycosylation in patients' cells.

120 amine pathway suggests a regulatory role for protein glycosylation in Synechocystis under HL.

121 dit an endogenous insect cell gene and alter protein glycosylation in the BICS.

122 unfolded protein response (UPR) by altering protein glycosylation in the endoplasmic reticulum (ER).

123 Protein glycosylation in the Golgi apparatus produces st

124 this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sort

125 d recently that there is a system of general protein glycosylation in the human enteropathogen Campyl

126 reduced hyaluronan accumulation and impaired protein glycosylation in the palatal mesenchyme.

127 Understanding the biosynthetic pathway of protein glycosylation in various expression cell lines i

128 rovide greater understanding of the roles of protein glycosylation in vertebrate development.

129 s provide new information about the roles of protein glycosylation in yeast and, in particular, the s

130 essing the biological importance of specific protein glycosylations in the production of safe and eff

131 s regulating goblet cell differentiation and protein glycosylation, including forkhead box A3 (Foxa3)

132 Because the level of protein glycosylation increased with iron limitation, ir

133 Tunicamycin, which is an inhibitor of protein glycosylation, induces ER stress and apoptosis.

134 Tunicamycin, which is an inhibitor of protein glycosylation, induces ER stress and apoptosis.

135 Since protein glycosylation influences the CSH status of C. al

136 In order to obtain site-specific protein glycosylation information, intact glycopeptides,

137 Pharmacological inhibition of GFAT or protein glycosylation inhibited increased proliferation

138 y more resistant to growth inhibition by the protein glycosylation inhibitor tunicamycin (Tm) than ei

139 zation, misfolded DAT, induced either by the protein glycosylation inhibitor tunicamycin or by its C-

140 In addition, we uncover a defect in protein glycosylation intrappc11mutants that is associat

141 RK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated c

142 Protein glycosylation is a common post-translational mod

143 Protein glycosylation is a common post-translational mod

144 N-Linked protein glycosylation is a frequent post-translational m

145 In B. fragilis, protein glycosylation is a fundamental and essential pro

146 Protein glycosylation is a heterogeneous post-translatio

147 Protein glycosylation is a post-translational modificati

148 Detailed structural elucidation of protein glycosylation is a tedious process often involvi

149 N-Linked protein glycosylation is a very common post-translationa

150 Nuclear and cytoplasmic protein glycosylation is a widespread and reversible pos

151 Protein glycosylation is among the most common and well-

152 N-Linked protein glycosylation is an essential and highly conserv

153 Since protein glycosylation is an important determinant of cel

154 Protein glycosylation is an important post-translational

155 Protein glycosylation is central to the physiology of B.

156 The analysis of protein glycosylation is conducted routinely in high per

157 Comprehensive characterization of protein glycosylation is critical for understanding the

158 Protein glycosylation is essential for cell survival and

159 Asparagine-linked protein glycosylation is essential for the virulence of

160 Taken together our results indicate that protein glycosylation is governed by more diversified re

161 Protein glycosylation is highly diverse and essential fo

162 The examination of protein glycosylation is of high importance, especially

163 Protein glycosylation is one of the most common protein

164 Protein glycosylation is one of the most important prote

165 N-Linked protein glycosylation is one of the most prevalent post-

166 Protein glycosylation is the most complex post-translati

167 Protein glycosylation is the most frequent post-translat

168 Protein glycosylation is widely recognized as a modulato

169 Protein glycosylation is widespread throughout all three

170 the boundaries, of the previously identified protein glycosylation locus of C. jejuni.

171 is of genes within the previously identified protein glycosylation locus.

172 is brefeldin A-sensitive and insensitive to protein glycosylation, monensin treatment, and low tempe

173 is brefeldin A-sensitive and insensitive to protein glycosylation, monensin treatment, and low tempe

174 US1 transcription in the mannose utilization/protein glycosylation mutants required some but not all

175 nthetic growth defect in mannose utilization/protein glycosylation mutants, we suggest that the Sho1

176 have developed a method using MRM to monitor protein glycosylation normalized to absolute protein con

177 N-linked protein glycosylation occurs in all three branches of li

178 To examine protein glycosylation of alpha-DG, a facile synthetic ap

179 d molecular chaperone activity that mediates protein glycosylation of bacterial adhesins.

180 obic proteins in pathogenesis and of surface protein glycosylation on exposure of the proteins, the l

181 files in serum/plasma are due to a change in protein glycosylation or a change in protein concentrati

182 Consistent with its role in protein glycosylation, OST3/6 resides in the endoplasmic

183 Since defects in the O-mannosylation protein glycosylation pathway are primarily responsible

184 The O-linked protein glycosylation pathway in Neisseria gonorrhoeae i

185 Campylobacter jejuni has an N-linked protein glycosylation pathway that is required for effic

186 tly discovered to contain a general N-linked protein glycosylation pathway.

187 he discovery of asparagine-linked (N-linked) protein glycosylation pathways in bacteria, major effort

188 relatively primordial nature of insect cell protein glycosylation pathways.

189 nt acetyltransferase in both N- and O-linked protein glycosylation pathways.

190 Protein glycosylation (pgl) genes have been annotated on

191 a starting point, two enzymes of the general protein glycosylation (Pgl) pathway in C. jejuni (PglF a

192 Herein, enzymes in the N-linked protein glycosylation (Pgl) pathway of Campylobacter jej

193 Mutants in the N-linked general protein glycosylation (pgl) system of C. jejuni are sign

194 d by post-translational processing involving protein glycosylation, phosphorylation, and proteolysis.

195 -inflammatory therapy response marker, since protein glycosylation plays an essential role in the inf

196 As a common post-translational modification, protein glycosylation plays an important role in many bi

197 Protein glycosylation plays an important role in various

198 the elucidation of the functional role that protein glycosylation plays in pathogenesis.

199 s in genes with diverse functions, including protein-glycosylation, polyunsaturated fatty acid metabo

200 Heterogeneity of protein glycosylation poses great challenges for analysi

201 Domain mapping studies in combination with a protein glycosylation prediction program identified mult

202 UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pa

203 chyl phosphate, an obligate lipid carrier in protein glycosylation reactions.

204 ons as an obligate glycosyl carrier lipid in protein glycosylation reactions.

205 Complete characterization of protein glycosylation requires the identification of int

206 ristic of defects in cell wall integrity and protein glycosylation, respectively.

207 Impaired protein glycosylation seems to be the major factor under

208 ejuni 81-176 pgl mutants impaired in general protein glycosylation showed reduced ability to adhere t

209 Addition of the E protein glycosylation site in a lineage II strain that l

210 Western blots, enzyme assays, protein glycosylation studies, and immunohistochemical s

211 The wide-spread conservation of this protein glycosylation system within the phylum suggests

212 nzymatic tagging; identification of sites of protein glycosylation; targeted glycoproteomics; and fun

213 ycosylation (CDGs) are disorders of abnormal protein glycosylation that affect multiple organ systems

214 uman diseases have been linked to defects in protein glycosylation that affects a wide range of organ

215 ntal processes, but the pivotal and specific protein glycosylation that is a necessary for recovery f

216 them, O-mannosylation is an unusual type of protein glycosylation that is largely restricted to the

217 Dolichol is a required cofactor for protein glycosylation, the most common posttranslational

218 , reducing experimental barriers to studying protein glycosylation, the most widespread and complex f

219 present a method to obtain information about protein glycosylation using a minimal amount of protein.

220 Protein glycosylation was variably affected.

221 o overcome the challenges in the analysis of protein glycosylation, we have developed a comprehensive

222 As an independent means to modify protein glycosylation, we used Chinese hamster ovary ldl

223 ed the effect of UDP-GlcNAc availability and protein glycosylation with O-linked N-acetylglucosamine