ライフサイエンスコーパス: protein isoform

1 which are contingent on cell context and the protein isoform.

2 ree or four repeats present depending on the protein isoform.

3 the gene sequence independent of the encoded protein isoform.

4 the UL138 gene, also generates more than one protein isoform.

5 mass spectrometry confirm translation of the protein isoform.

6 redicted to encode an N-terminally truncated protein isoform.

7 ress primarily the liver-enriched inhibitory protein isoform.

8 sm that controls the functional diversity of protein isoforms.

9 so alternatively spliced to produce multiple protein isoforms.

10 HCMV gene, UL136, which is expressed as five protein isoforms.

11 UL136 is expressed as five protein isoforms.

12 is gene, including alternative promoters and protein isoforms.

13 d that HVCN1 was expressed in B cells as two protein isoforms.

14 e, predicted to affect expression of shorter protein isoforms.

15 binding are regulated by the different SNARE protein isoforms.

16 composed of different combinations of SNARE protein isoforms.

17 cient to account for the levels of expressed protein isoforms.

18 methodology to identify the relative age of protein isoforms.

19 roduce multiple types of mRNA and associated protein isoforms.

20 re ultimately translated into five different protein isoforms.

21 g demonstrates larger molecular weight SEPT9 protein isoforms.

22 the core gene directs the synthesis of core protein isoforms.

23 that comprise a total of at least 10 encoded protein isoforms.

24 in the domain architecture of corresponding protein isoforms.

25 ed (bun), which encodes both large and small protein isoforms.

26 uggesting that splicing efficiency can alter protein isoforms.

27 that is due to their expression as multiple protein isoforms.

28 encoding at least 12 functionally different protein isoforms.

29 an be translated into thousands of different protein isoforms.

30 ion, alternative mRNA splicing may alter ECM protein isoforms.

31 ting that identify a total of 28 mRNA and 20 protein isoforms.

32 spliced mRNAs that encode 66 and 46 kDa ESR1 protein isoforms.

33 ely in the nervous system to produce diverse protein isoforms.

34 sitions 157 and 161, and in subsets of major protein isoforms.

35 ves to promote tissue-specific expression of protein isoforms.

36 g enables expression of functionally diverse protein isoforms.

37 noncoding splice variants and nonfunctional protein isoforms.

38 rnative polyadenylation events result in new protein isoforms.

39 g of Smad2 exon 3 gives rise to two distinct protein isoforms.

40 riches, and detects disease-associated prion protein isoforms.

41 native splicing gives rise to different Mena protein isoforms.

42 arcomere and changes in contractile filament protein isoforms.

43 y that RE splicing might generate functional protein isoforms.

44 that cannot be distinguished from bona fide protein isoforms.

45 sm responsible for the expression of the two protein isoforms.

46 the generation of eight mRNA and three major protein isoforms.

47 neuron expression of clustered protocadherin protein isoforms.

48 n to express diverse, functionally distinct, protein isoforms.

49 t route for the light-dependent switching of protein isoforms.

50 ANKRD55 protein isoforms 005 and 001 were predominantly located

51 hat the protein was adenosine deaminase-like protein isoform 1 (ADAL1).

52 such proteins are transmembrane channel-like protein isoform 1 (TMC1) and tetraspan membrane protein

53 studies implicate transmembrane channel-like protein isoform 1 (TMC1) channels in the mammalian cochl

54 Transmembrane channel-like protein isoforms 1 (TMC1) and 2 (TMC2) have been propose

55 on with BAPTA, in transmembrane channel-like protein isoforms 1/2 (Tmc1:Tmc2) double mutants, and dur

56 Transmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five

57 ive RNA processing, as a small single-domain protein (isoform 3 [iso3]).

58 ion studies have identified ORM (yeast)-like protein isoform 3 (ORMDL3) as a gene associated with sus

59 studies have identified the ORM (yeast)-like protein isoform 3 (ORMDL3) gene locus on human chromosom

60 ORM (yeast)-like protein isoform 3 (ORMDL3) has recently been identified

61 osis modulator: 2 of its known mitochondrial protein isoforms, 43-kilodaltons and 40-kilodaltons, hav

62 Tripartite motif protein isoform 5 alpha (TRIM5alpha) is a potent antivir

63 d in robust myocyte expression of a distinct protein isoform, a response that was conserved in humans

64 more, the data allowed us to discern between protein isoforms according to expression patterns, which

65 at the level of protein stability, and this protein isoform accumulates particularly in response to

66 ising 441 transcription factor and signaling protein isoforms across 68 Yoruba (YRI) HapMap lymphobla

67 AS) often focused on the spatial patterns of protein isoforms across different tissues.

68 pipe encodes ten putative protein isoforms, all of which exhibit similarity to ver

69 PKC protein isoforms alpha, beta, epsilon, iota, lambda, and

70 E (ApoE) as a model protein, we developed a protein isoform analysis method utilizing stable isotope

71 Protein isoform analysis revealed that beta-myosin is pr

72 The ApoE protein isoform analysis using SILT allows for the simul

73 Toward scalable protein isoform analysis, we introduce a microfluidic "s

74 he unique capability of fully characterizing protein isoforms and combinatorial post-translational mo

75 sociated with sex-specific expression of Lon protein isoforms and proteolytic activity.

76 g is specific for a subset of exocytic SNARE protein isoforms and requires membrane integration of th

77 s of these create complex patterns of intact protein isoforms and species.

78 ion of intact proteins, including individual protein isoforms and specific posttranslationally modifi

79 ocus on obtaining better characterization of protein isoforms and specific PTMs.

80 pT peptides to differentiate closely related protein isoforms and to enable the detection of many pos

81 gene encodes the human pantothenate kinase 2 protein isoforms, and PANK2 mutations are linked to pant

82 The Orb2 has two protein isoforms, and the rare Orb2A isoform is critical

83 stems need to be able to measure millions of proteins, isoforms, and complexes simultaneously.

84 lipoprotein E family consists of three major protein isoforms: apolipoprotein E4 (ApoE4), ApoE3, and

85 itate discovery of novel RNA transcripts and protein isoforms, applications ranging from neuromuscula

86 Two protein isoforms are generated from three alternatively

87 le to predict their fate in terms of whether protein isoforms are generated or specific transcripts a

88 integration of the resultant tissue-specific protein isoforms are typically unknown.

89 Protein isoforms are widely expressed in biological syst

90 Quaking protein isoforms arise from a single Quaking gene and bi

91 A diverse repertoire of protein isoforms arising from alternative splicing is ex

92 The diversity of protein isoforms arising from alternative splicing is th

93 Parsing protein isoforms as a function of disease will be essent

94 ealed differences in abundance and number of protein isoforms at numerous steps in glycolysis.

95 nes encode two functional enoyl-acyl carrier protein isoforms based on their ability to complement th

96 A dearth of protein isoform-based clinical diagnostics currently hin

97 pression of a specific Ca(V)1.2 beta-subunit protein isoform (beta(2a)).

98 APOE in disease risk, involving not only the protein isoforms but also an epigenetically regulated tr

99 proteins control the production of the short protein isoform by suppressing inclusion of NF1 exon 23a

100 The vertebrate Fgf8 gene produces multiple protein isoforms by alternative splicing.

101 efficient translation re-initiation into the protein isoforms C/EBPalpha-p30 and C/EBPbeta-LIP, which

102 /or post-translational generation of various protein isoforms can be indicative of initial pathologic

103 F) complex and its interaction with the Fbw7 protein isoforms can take place independently of phospho

104 We show that loss of Drosophila Apc2 causes protein isoform changes reflecting misregulation of post

105 set of Alzheimer's disease (AD) through apoE protein isoforms changing the probability of amyloid-bet

106 cluding an intronic variant that codes for a protein isoform containing a truncated kinase domain.

107 fibre atrophy and the changes in myofilament protein isoform contents, ssTnT deficiency significantly

108 , we find that alternative Prickle (Pk-Sple) protein isoforms control the polarity of this MT network

109 ouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet und

110 cated human constitutive androstane receptor protein isoforms (DeltaNCARs).

111 mma coactivator 1-alpha 4 (PGC-1alpha4) is a protein isoform derived by alternative splicing of the P

112 The identification of novel protein isoforms derived from alternatively spliced ie3

113 In the F2 genotypes, the expression of aphid protein isoforms derived from the competent parental lin

114 that is 20 exons long and produces two known protein isoforms differing in C-terminal amino acid comp

115 trated that the five variants generate three protein isoforms differing in their N-terminal length.

116 r identified a role of APA in switching Araf protein isoforms during microglia activation, impacting

117 g of the WT1 transcript generates four major protein isoforms, each having different functional prope

118 The EcR gene encodes three protein isoforms (EcR-A, EcR-B1, and EcR-B2) that have u

119 In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-ind

120 lgS97, a SAP97 homolog, and one of two major protein isoforms encoded by dlg1 via alternative splicin

121 AMCase protein isoforms, encoded by two gene-wide haplotypes, a

122 eta is a transcription factor in which three protein isoforms exist because of alternative translatio

123 We also show that the dmPTB protein isoform expressed in the male germline is by far

124 response depended on the mRNA variant or the protein isoform expressed, on the specificity of the cel

125 ive mRNA splicing is a mechanism to regulate protein isoform expression and is regulated by alternati

126 hat aldosterone selectively increased 14-3-3 protein isoform expression and that the association of 1

127 lt from structural maturation and changes in protein isoform expression.

128 The single Fgf8 gene in mice produces eight protein isoforms (Fgf8a-h) with different N-termini by a

129 A panel of purified fluorescent protein isoforms (FPs) was screened for the ability to d

130 which allows the generation of more than one protein isoform from a single gene.

131 of synaptic modulation exerted by different protein isoforms from a single gene locus is dependent o

132 e to multiple alternatively spliced mRNA and protein isoforms from a single gene locus.

133 e splicing of pre-mRNA generates two or more protein isoforms from a single gene, thereby contributin

134 e splicing generates multiple transcript and protein isoforms from the same gene and thus is importan

135 exon VII results in two naturally occurring protein isoforms: full-length Ets1 (p51-Ets1) and Ets1(D

136 acterization of the soluble CTLA-4 (sCTLA-4) protein isoform generated by an alternatively spliced mR

137 res, demonstrating functional cooperation of protein isoforms generated by coordinated alterative spl

138 M are dictated by the expression of multiple protein isoforms generated by extensive alternative spli

139 The major protein isoforms generated by P1 and P2 are RUNX1C and R

140 teristics of some genes, the extent to which protein isoforms globally contribute to functional compl

141 gene is alternatively spliced producing two protein isoforms: GPBP and GPBPDelta26.

142 sue-specific activity of alternative Pk-Sple protein isoforms has been observed to rectify the interp

143 These protein isoforms have a conserved N-terminus (signal pep

144 Antibodies specific to p53 protein isoforms have proven difficult to develop, thus

145 owed a reduced expression of the short Homer protein isoform Homer 1a, and an increased coupling of m

146 We reveal that because the most common protein isoform in normal adult breast and breast tumors

147 further investigation of the truncated MTMR2 protein isoform in Schwann cells and in CMT4B1 pathogene

148 nce that DeltaNp63alpha, the predominant p63 protein isoform in squamous epithelia and YB-1, can phys

149 or role in regulating expression of selected protein isoforms in a tissue-specific manner.

150 e midzone protein [5], appeared as two short protein isoforms in addition to the full-length protein.

151 The pathological prion protein isoforms in BASE strain-infected humanized Tg mo

152 Intriguingly, overexpressing the two MTMR2 protein isoforms in HeLa cells revealed that both locali

153 The assay reported protein isoforms in immune-purified sample and raw cell

154 To measure protein isoforms in individual mammalian cells, we repor

155 utions of variable expression of myofilament protein isoforms in mediating the timing of myocardial a

156 easured the expression of M1 and M2 mRNA and protein isoforms in mouse tissues, tumor cell lines, and

157 ed as an inefficient start codon to generate protein isoforms in mouse.

158 ay (NIA) to quantify total and low-abundance protein isoforms in nanoliter volumes.

159 plicing of the tau gene, MAPT, generates six protein isoforms in the adult human central nervous syst

160 xpressed different mRNA variants and whirlin protein isoforms in the cochlea and retina, where these

161 as multigene families that give rise to many protein isoforms in the same individual displaying high

162 mature NT-3 are the predominant NGF and NT-3 protein isoforms in the SCG, yet it is unknown whether t

163 ase, showed the presence of pathogenic prion protein isoforms in the spleen, indicating that the BASE

164 ave developed a novel method for quantifying protein isoforms, in both relative and absolute terms, b

165 PSD-95, Discs-large, ZO-1) domain-containing protein isoforms, in the modulation of the gut immune re

166 ical labeling, as well as previously unknown protein isoforms including pSPs.

167 gives rise to multiple functionally distinct protein isoforms, including the DeltaNp63 class of isofo

168 omologous corrinoid/methyltransferase fusion protein isoforms involved in methyl sulfide metabolism.

169 MYLK encodes protein isoforms involved in multiple components of the

170 e human tissues; for hKCNE4, only the longer protein isoform is detectable.

171 to specifically detect and quantify receptor protein isoforms is a major impediment to functional stu

172 EBPbeta is an intronless gene encoding three protein isoforms--LAP1, LAP2, and LIP.

173 defects in splicing could lead to changes in protein isoform levels, they could also impact gene expr

174 hese transcripts, which produce two distinct protein isoforms localizing to the plasma membrane and t

175 More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-

176 RCAN1 gene, which can generate several RCAN1 protein isoforms, may be at least partially responsible

177 istent with requirements for tissue-specific protein isoforms needed to sustain muscle-specific funct

178 uroplastin gene encodes two synapse-enriched protein isoforms, Np55 and Np65, which are transmembrane

179 Several ADAM33 protein isoforms occur in adult bronchial smooth muscle

180 d expression of the Gad1 gene-encoded 67-kDa protein isoform of glutamic acid decarboxylase (GAD67) i

181 The major protein isoform of p63 expressed in SCC is DeltaNp63alph

182 TOG2, the large protein isoform of TOG, is the only isoform detected in

183 hese methods to a number of the amyloid-beta protein isoforms of Abeta40 and Abeta42 and showed that

184 These results suggest that the two protein isoforms of AEBP2 may have opposite functions fo

185 psilon3/epsilon4, which translate into three protein isoforms of apoE2, E3 and E4.

186 We identify two distinct protein isoforms of CEP135 that antagonize each other to

187 rovides cells with the opportunity to create protein isoforms of differing, even opposing, functions

188 Secreted protein isoforms of Dscam were detected in the hemolymph

189 demonstrated the predicted existence of two protein isoforms of Irgm1 derived from differential spli

190 Of the two protein isoforms of Orb2, the amyloid-like oligomer form

191 a-7sv4 and canine mda-7sv5) that encode four protein isoforms of the canine MDA-7 protein.

192 C9orf72 encodes two C9orf72 protein isoforms of unclear function.

193 ement mice "humanized" for the coding exons (protein isoform) of human epsilon2 (apoE2), epsilon3 (ap

194 ative splicing of hth generates two types of protein isoforms, one that contains a DNA-binding homeod

195 ed as AUF1 (A + U-rich RNA-binding factor 1) protein isoform p45 (a product of the heterogeneous nucl

196 rofiling to functionally compare hundreds of protein isoform pairs.

197 major question in the field is why two human protein isoforms, PAPSS1 and -S2, are required that cann

198 y three prolyl hydroxylase domain-containing protein isoforms (Phd1, Phd2 and Phd3).

199 we show that at least some heterotrimeric G protein isoforms physically dissociate after activation

200 ted from human SMN genes and reveals a novel protein isoform predicted to be stably expressed during

201 Self-perpetuating amyloid-based protein isoforms (prions) transmit neurodegenerative dis

202 y, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenyla

203 Thus the main NOD2/CARD15 protein isoform produced in humans and other primates is

204 Since we demonstrated that the protein isoform produced through premature polyadenylati

205 DM2) is an N-terminally truncated mixture of protein isoforms produced by the initiation of translati

206 period, levels of the disease-causing prion protein isoform, PrPSc, and NICD increased concomitantly

207 The scrapie prion protein isoform, PrPSc, is a prion-associated marker tha

208 Here we identify a short protein isoform (pUL138-S) initiating from codon 16 that

209 The existence of neuron-specific endocytic protein isoforms raises questions about their importance

210 exons, 9, 10, and 11, resulting in predicted protein isoforms ranging from 82 to 64 kDa.

211 y allow for the potential influence of these protein isoforms, relying instead on cDNA-based transgen

212 ever, selective quantification of individual protein isoforms remains a challenge, because they simul

213 functions we have characterized the mRNA and protein isoform repertoire of PTBP3.

214 cnn), an essential gene encoding centrosomal protein isoforms required during syncytial development i

215 evant to detection of currently unmeasurable protein isoforms responsible for cancer progression.

216 Loss of the liver-enriched inhibitory protein isoform results in increased ATF4 mRNA levels in

217 ng fluorescently labeled tonoplast intrinsic protein isoforms reveal an altered tonoplast morphology

218 the Drosophila PcG protein SCM, encodes two protein isoforms: SCML2A that is bound to chromatin and

219 results in a novel mRNA coding for an sgp130 protein isoform (sgp130-E10) of 70-80 kDa.

220 The inaE-encoded protein isoforms show high sequence similarity to known

221 As remained constant, but the 929-amino-acid protein isoform showed increases up to about 3-fold in c

222 Experimental analysis of these protein isoforms showed that alternative splicing regula

223 001) per 1-SD increment in apolipoprotein(a) protein isoform size in serum due to rs2457564, which wa

224 le1b mice; for instance, the presence of the protein isoform Slamf6-H1 in Sle1b.Slamf6-H1 mice mitiga

225 ping of exon 7 and production of an unstable protein isoform, SMNDelta7.

226 that keratinocytes express all seven 14-3-3 protein isoforms, some of which form heterodimers with 1

227 duce 32 mRNA variants, encoding 24 different protein isoforms, some of which vary in biochemical and

228 ue-specific alternative splicing, generating protein isoforms specific to brain and muscle.

229 We have developed tools for IHC of RREB1 protein isoform-specific amplification of RREB1 mRNA and

230 tr1B, and ctr1C, little is known about their protein isoform-specific roles.

231 The spire locus encodes several distinct protein isoforms (SpireA, SpireC and SpireD).

232 ld-type, catalytic active, dominant-negative protein isoforms strengthened the association between ph

233 ose predicted to have substantial effects on protein isoform structure and function (e.g., intron ret

234 Here we demonstrate that Drosophila TAF1 protein isoforms TAF1-2 and TAF1-4 directly bind DNA ind

235 the 35-kD subunit of U2AF gives rise to two protein isoforms (termed U2AF35a and U2AF35b) that are e

236 codon (PTC), that leads to a 65kDa truncated protein isoform that opposes full-length eIF2Bepsilon to

237 ied two specific regions of the normal prion protein isoform that undergo a change in chemical enviro

238 We developed two methods to identify protein isoforms that are both phosphorylated and ubiqui

239 Prions are self-perpetuating protein isoforms that are responsible for infectious dis

240 The ATP13A2 gene encodes at least three protein isoforms that arise by alternate splicing.

241 ated glycoprotein (MAG), which generates two protein isoforms that associate with distinct cellular c

242 family member, AKAP13, encodes for multiple protein isoforms that contain binding sites for protein

243 Although all of these transcripts encode protein isoforms that contain the conserved C-terminal z

244 ation (CID)-FTICR MS was applied to identify protein isoforms that contribute to the separation of th

245 ubunit, which exists as a number of distinct protein isoforms that differ in several respects includi

246 e, we report that mouse Mbnl3, which encodes protein isoforms that differ in the number of tandem zin

247 pacity by generating alternatively initiated protein isoforms that may have distinct biological funct

248 malian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even

249 Alternative splicing produces three Fbw7 protein isoforms that occupy distinct compartments: Fbw7

250 The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular locali

251 s, splicing and editing events, and inferred protein isoforms that previously eluded discovery using

252 uating and, in most cases, aggregation-prone protein isoforms that transmit neurodegenerative disease

253 and -gamma gene clusters encode more than 50 protein isoforms, the combinatorial expression of which

254 ific localization of two tonoplast intrinsic protein isoforms, the small leaf vacuoles were identifie

255 riants that may encode functionally distinct protein isoforms, the transcriptomes of various tissues

256 ene Ultrabithorax (Ubx) produces a family of protein isoforms through alternative splicing.

257 omosome sequence polymorphisms identified by protein isoforms, transcribed mRNA, and methylation stat

258 a large number of genes coordinately express protein isoform transitions regulated by alternative spl

259 canonical transient receptor potential (TRP) protein isoform TRPC4 is a component of such channels, a

260 s to temporarily repress expression of adult protein isoforms until the final maturation of the neuro

261 sses including structured representations of protein isoforms, variants and modified forms.

262 n IRES that directs synthesis of five eIF4GI protein isoforms via alternative AUG initiation codon se

263 Individual mRNAs generate up to three protein isoforms via alternative translation initiation

264 Furthermore, the ADAR1 p110 protein isoform was detected in embryonic tissue, wherea

265 of a prion as an infectious self-propagating protein isoform was initially proposed to explain certai

266 stant mice and one of the two possible Iigp2 protein isoforms was preferentially expressed in suscept

267 logical activity of this unique PARP1 mutant protein isoform, we have uncoupled the transactivation a

268 ytotic processes mediated by different SNARE protein isoforms, we systematically analyzed the interac

269 The mutant protein isoforms were functionally characterized by meas

270 nalysis indicated that only two of four AUF1 protein isoforms were present in the uterine cytosolic e

271 odies could distinguish among the four ERCC1 protein isoforms, whereas only one isoform produced a pr

272 HMGA1 encodes the HMGA1a and HMGA1b protein isoforms, which function in regulating gene expr

273 have provided improved detection of C9orf72 protein isoforms, which will help elucidate its physiolo

274 lexity of the eukaryotic proteome-generating protein isoforms whose functions can be novel, diverse,

275 allows the cell to generate multiple RNA and protein isoforms whose levels change upon glucose deplet

276 ions, such as disulfide linkages, as well as protein isoforms whose sequences are absent from a datab

277 nitis pigmentosa (XLRP) and encodes multiple protein isoforms with a common N-terminal domain homolog

278 this differential TSS utilization results in protein isoforms with additional domains or targeted to

279 promoter usage, resulting in light-dependent protein isoforms with altered subcellular localization t

280 he AKR1B15 gene transcript gives rise to two protein isoforms with different N termini: AKR1B15.1 is

281 fferent mRNA sequences encoding 24 different protein isoforms with differing biochemical and pharmaco

282 ated through alternative splicing to produce protein isoforms with differing N- and C-terminal domain

283 on initiation site, splice variants generate protein isoforms with distinct N-termini.

284 re subject to alternate splicing to generate protein isoforms with divergent functions.

285 mRNA variants, RA and RB, which translate to protein isoforms with divergent neuroprotective capaciti

286 vely spliced transcripts to encode different protein isoforms with individual functions in the cell,

287 ene, is expressed as at least five different protein isoforms with overlapping and unique functions.

288 The scIEF assay resolves protein isoforms with resolution down to a single-charge

289 polyadenylation (IPA) can generate truncated protein isoforms with significantly altered functions.

290 in the tau primary transcript gives rise to protein isoforms with three (3R) or four (4R) MT binding

291 h exons 3 and 4 encodes MeCP2-e1 or MeCP2-e2 protein isoforms with unique amino termini.

292 t variants resulting in three possible Sirt3 protein isoforms with variable lengths at the N-terminus

293 of the neuronal nitric oxide synthase (nNOS) protein isoform within the rostral (RVLM) and caudal (CV

294 broad-spectrum neutralization across various protein isoforms within these protein families is a nece

295 process that includes facile measurement of protein isoforms would accelerate development of effecti

296 Recombinant protein isoforms WT-OCLN and OCLN-ex7ext, which retained

297 WT1 RNA leads to the expression of two major protein isoforms, WT1(+KTS) and WT1(-KTS).

298 ndergoes alternative splicing to produce two protein isoforms, XBAT35.1 and XBAT35.2.

299 us to human RPGR, because it encodes similar protein isoforms (ZFRPGR2(ORF15), ZFRPGR2(ex1-17)) and c

300 protein, Aquaporin-3 and the tight junction protein isoform, ZO-1 alpha+.