ライフサイエンスコーパス: protein kinase

1 ting PAK3 as well as MAPK (mitogen-activated protein kinase).

2 of cell growth metabolism and play roles in protein kinase.

3 n as TrkA that upregulates mitogen-activated protein kinase.

4 the phosphorylation of p38 mitogen-activated protein kinase.

5 ent adhesion, NADPH oxidase, and a subset of protein kinases.

6 mparable with other heterologously expressed protein kinases.

7 discovery) associates with three trypanosome protein kinases.

8 activity of the PDK1-regulated AGC family of protein kinases.

9 iated with distinct distributions of cognate protein kinases.

10 ping highly sensitive biosensors for various protein kinases.

11 s an inactive conformation known to recur in protein kinases.

12 functionally redundant Hal4 (Sat4) and Hal5 protein kinases.

13 Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the o

14 hich it regulates invasion.Calcium dependent protein kinase 1 (CDPK1) plays an important role in asex

15 of Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) are leading candidates for tr

16 Homeodomain-Interacting Protein Kinase 1 (HIPK1) phosphorylates PAGE4 at S9 and

17 activation and mitogen- and stress-activated protein kinase 1 (MSK1)-ranges of intracellular signalin

18 e of activated mitogen- and stress-activated protein kinase 1 (MSK1).

19 impaired recruitment of the serine/threonine-protein kinase 1 (PAK1) to HER2, resulted in the blockad

20 g down receptor-interacting serine/threonine protein kinase 1 (Ripk1) increased both intracellular an

21 the kinase activity of receptor-interacting protein kinase 1 (RIPK1), a key regulator of cell death,

22 uch as receptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-interacting serine/th

23 ), and receptor-interacting serine/threonine protein kinase 1 (RIPK1).

24 ion of Rho-associated coiled-coil containing protein kinase 1 (ROCK1).

25 PRKG1 encodes cyclic GMP-dependent protein kinase 1, which is involved in learning, memory

26 way results in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphorylation of

27 horylation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2).

28 The receptor interacting protein kinases-1 (RIPK1) and RIPK3 are at the core of n

29 We show that Abelson tyrosine-protein kinase 2 (Abl2) has a key role in regulating myo

30 Homeodomain-interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine k

31 tivated protein kinase (MAPK)-MAPK-activated protein kinase 2 (MK2) pathway to promote actin polymeri

32 we discovered a fundamental role of S-phase protein kinase 2 (Skp2) in the formation and progression

33 Here we report that serine-arginine protein kinase 2 (SRPK2) phosphorylates delta-secretase

34 Here, we report that mitogen-activated protein kinase 3 (MPK3) and MPK6 interact with and phosp

35 IPK1), receptor-interacting serine/threonine-protein kinase 3 (RIPK3), TIR-domain-containing adapter-

36 trate the presence of a receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL

37 necroptosis", driven by receptor-interacting protein kinase 3 (RIPK3).

38 ctivation of the kinase receptor interacting protein kinase 3 and its downstream effector, the pseudo

39 mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineag

40 form (pNCC) as well as WNK lysine deficient protein kinase 4 (WNK4) and STE20/SPS1-related, proline

41 g does not affect levels of cyclin-dependent protein kinase 5 (Cdk5), glycogen synthase kinase 3beta,

42 Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during devel

43 onstrated that Arabidopsis mitogen-activated protein kinase 6 (MPK6) and MPK3 play critical roles in

44 ccurs via the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA)-dependent signaling pathway.

45 Protein kinase A (PKA) activation, which mediates CD dis

46 f PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase

47 potentiation requires the activation of both protein kinase A (PKA) and the GTPase Ras, and is induce

48 Cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) are important mediators and regul

49 A protein kinase A (PKA) biosensor allowed us to resolve m

50 lin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) both in vitro and in heterologous

51 Protein kinase A (PKA) integrates inputs from G-protein-

52 Ser133 phosphorylation by protein kinase A (PKA) is a well-characterized CREB acti

53 n was emulated by positive modulators of the protein kinase A (PKA) pathway, inhibited by the CB1R an

54 In yeast, glucose activates protein kinase A (PKA) to accelerate aging by inhibiting

55 s with inhibitors of protein kinase G (PKG), protein kinase A (PKA), phosphodiesterase 3B (PDE3B), an

56 eurons, and these effects were mediated by a protein kinase A (PKA)-dependent enhancement of presynap

57 neurons, with GLP-1R activation promoting a protein kinase A (PKA)-dependent signaling cascade leadi

58 transcription principally by activating the protein kinase A (PKA)-targeted transcription factors.

59 iosynthetic enzyme, ferrochelatase (FECH) by protein kinase A (PKA).

60 ttle agonist action of I942 towards EPAC2 or protein kinase A (PKA).

61 nd systems: cAMP-bound regulatory subunit of Protein Kinase A (RIalpha) and IBMX-bound phosphodiester

62 maps of the kinase domain of cAMP-dependent protein kinase A allow for a molecular explanation for t

63 3 antagonizes TGFbeta-mediated activation of protein kinase A and inhibition of Protein kinase B (AKT

64 enylyl cyclase inhibitor MDL 12330A, and the protein kinase A antagonist cAMPS-Rp.

65 nge is caused by cocaine-exacerbated D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons

66 Treatment with the protein kinase A inhibitor H89 or the anion exchange inh

67 tion coupling is cAMP-dependent, neither the protein kinase A nor the exchange protein directly activ

68 In addition, activating the protein kinase A pathway diminished the contractile sexu

69 arrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta t

70 Protein kinase A-anchoring protein 79/150 (AKAP), residi

71 and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S

72 neurons is induced by neuronal activity and protein kinase A.

73 ssociation with 14-3-3 proteins and involves protein kinase A.

74 equent stimulation of CFTR by cAMP-dependent protein kinase A.

75 o study the cAMP binding domain A (CBD-A) of Protein kinase A.

76 We focus on protein kinases, a superfamily of phosphotransferases th

77 plants maintain wild-type mitogen-activated protein kinase activation and PHI1, WRKY33, and FRK1 imm

78 ive machine learning based classification of protein kinase active/inactive conformations, taking int

79 rylation, H917A abolished both the lipid and protein kinase activities of PI3Kalpha.

80 FERONIA protein kinase activity in nanodiscs was higher than tha

81 Signaling proteins such as protein kinases adopt a diverse array of conformations t

82 The role of the protein kinase Akt1 in dopamine neurotransmission is wel

83 AMP-activated protein kinase (AMPK) activation triggered this pathway,

84 ibed the effects of aspirin to AMP-activated protein kinase (AMPK) activation, mTORC1 inhibition, and

85 pathways of the CR mediators, AMP-activated protein kinase (AMPK) and sirtuin-1 are activated.

86 The AMP-activated protein kinase (AMPK) and the Gsk3 kinase inhibit TOR du

87 LKB1, and its substrate, AMP-dependent protein kinase (AMPK) are important for HNK-mediated inh

88 identify the metabolic sensor AMP-activated protein kinase (AMPK) as a beta1-integrin inhibitor in f

89 y increased phosphorylation of AMP activated protein kinase (Ampk) at tyrosine 172 and of unc-51 like

90 Activation of AMP-activated protein kinase (AMPK) by metformin, inhibition of mTORC

91 5'-Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy ho

92 trols calcium homeostasis, and AMP-activated protein kinase (AMPK) is regulated, in part, by intracel

93 the master metabolic regulator AMP-activated protein kinase (AMPK) plays a critical role in blocking

94 AMP-activated protein kinase (AMPK) plays an essential role as a cellu

95 AMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways are activated,

96 stically, inhibiting VEGFR2 or AMP-activated protein kinase (AMPK), a major decorin-activated energy

97 ic target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and autophagy pathways-processes

98 (IL-1R8) and the activation of AMP-activated protein kinase (AMPK), because both inhibition of AMPK a

99 Here, we showed that AMP-activated protein kinase (AMPK), the master metabolic regulator of

100 ectrical activity by promoting AMP-activated protein kinase (AMPK)-dependent trafficking of KATP and

101 mutant p53 G245D decreases the AMP-activated protein kinase (AMPK)-mediated phosphorylation of FOXO3a

102 Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinas

103 A expression levels of p38 mitogen activated protein kinase and nuclear factor kappa-light-chain-enha

104 ve oxygen species in a p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase-depend

105 phospho-5' adenosine monophosphate-activated protein kinase and phospho-AKT serine/threonine kinase 1

106 aling receptor, activating mitogen-activated protein kinase and signal transducer and activator of tr

107 , early phosphorylation of mitogen-activated protein kinases and Akt, and upregulation of p53, p21, a

108 Although it is known that protein kinases and phosphatases modulate GPCR signaling

109 entify key principles of targeted therapy of protein kinases and their application to the management

110 5A is known to be phosphorylated by cellular protein kinases, and in this study, we set out to determ

111 Protein kinases are frequently mutated in human cancers,

112 Calcium Dependent Protein Kinases are key effectors of calcium signaling i

113 AMPK-related protein kinases (ARKs) coordinate cell growth, prolifera

114 In this work, the starvation-induced Ser/Thr protein kinase ArnS (Saci_1181) which is located proxima

115 inase B1 and the energy sensor AMP-activated protein kinase, as well as enhanced fatty acid beta-oxid

116 ked potency in ABC DLBCL models, whereas the protein kinase B (AKT) inhibitor AZD5363 induced apoptos

117 ibition of the phosphatidylinositol 3 kinase/protein kinase B (Akt) pathway.

118 vation of protein kinase A and inhibition of Protein kinase B (AKT).

119 The PI3K-protein kinase B (PKB; also known as Akt) signaling path

120 ssion of the TYRO3/phosphoinositide 3-kinase/protein kinase B signal transduction pathway, and that c

121 Insulin-stimulated phosphorylation of protein kinase B was increased in hIRECO EC as was Nox2

122 ular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalian target of rap

123 Here we show that Protein Kinase B-mechanistic Target of Rapamycin (PKB/AK

124 is largely independent of the AMP-activated protein kinase, but is mediated by the MAP/microtubule a

125 We previously reported that conventional protein kinase C (cPKC) contributes to nuclear size redu

126 equired for the activation of a conventional protein kinase C (cPKC).

127 subunit (Galphaq)/phospholipase C (PLC)beta1/protein kinase C (PKC) activity.

128 actor (FGF) receptor, phospholipase C (PLC), protein kinase C (PKC) and phosphoinositide-3-kinase (PI

129 Here we demonstrate that activation of protein kinase C (PKC) by phorbol myristate acetate, Gq/

130 Although various kinases such as protein kinase C (PKC) contribute to the expression of l

131 RP) stimulated CLR endocytosis and activated protein kinase C (PKC) in the cytosol and extracellular

132 as histone deacetylase (HDAC) inhibitors and protein kinase C (PKC) modulators, provides a promising

133 q)/phospholipase C (PLC)beta1 activities and protein kinase C (PKC) phosphorylation, although it is u

134 Protein kinase C (PKC) theta, a serine/threonine kinase,

135 the timely activation of kinases, including protein kinase C (PKC).

136 Protein kinase C (Pkc1) relays signals in the pathway by

137 ations of diabetes and is caused by abnormal protein kinase C activation as a result of increased dia

138 am-V or phorbol 12-myristate 13-acetate, two protein kinase C activators, leads to altered morphology

139 n E2, PGE2-G, mobilizes Ca(2+) and activates protein kinase C and ERK, suggesting the involvement of

140 ell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases: polarisation

141 The roles of protein kinase C and the small GTPase, Rab9, in alpha1B-

142 Protein kinase C beta (PKCbeta) regulated MIF-induced IL

143 Bisindolylmaleimide (BIM; a protein kinase C blocker), a protein kinase C inhibitory

144 It binds to protein kinase C competitively with diacylglycerol, the

145 ecreased expression of the calcium-dependent protein kinase C conventional subclass alpha/beta leadin

146 pendent or -independent for co-dependency on protein kinase C delta (PKCdelta).

147 -induced Mvarphi polarization, and PKCdelta (protein kinase C delta) as a downstream target.

148 tivation of focal adhesion kinase (FAK) in a protein kinase C dependent manner.

149 of which were suppressed by chelerythrine, a protein kinase C inhibitor, DPI, a NADPH-dependent oxida

150 leimide (BIM; a protein kinase C blocker), a protein kinase C inhibitory peptide or bafilomycin A (a

151 KF neurons was not enhanced by activation of protein kinase C or in slices from morphine-treated rats

152 Conversely, activation of protein kinase C promoted aggregation of neurons into cl

153 titively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol es

154 e HIF-alpha network, we identified the major protein kinase C substrate MARCKS (myristoylated alanine

155 ly in part by spatially restricting atypical protein kinase C, a negative regulator of non-muscle myo

156 We modified this structure by modulation of protein kinase C, an enzyme regulating neurite growth an

157 s dependent on C5aR1, intracellular calcium, protein kinase C, and calmodulin, and downstream signali

158 ecules crucial to PMA-induced NETs including protein kinase C, calcium, reactive oxygen species, the

159 A431 epithelial cells transduced Gbetagamma-protein kinase C- and Gbetagamma-metalloproteinase/EGFR-

160 f KV 1.5, but not KV 2.1, channels through a protein kinase C- and lysosome-dependent mechanism, redu

161 cribe a mechanism by which Ang II stimulates protein kinase C-dependent KV 1.5 channel degradation, r

162 n/LLGL1 interaction is inhibited by atypical protein kinase C-mediated phosphorylation of LLGL1, rest

163 echniques to dissect the roles of individual protein kinase Calpha (PKCalpha) regulatory domains in m

164 amily (Hsp40) member B1 gene (DNAJB1) to the protein kinase cAMP-activated catalytic subunit alpha ge

165 Although protein kinase casein kinase 2 (CK2) is readily detected

166 Here we show that protein kinase Cbeta (PKCbeta) and brain nitric oxide sy

167 cytic leukaemia (CLL) cells is overexpressed protein kinase CbetaII (PKCbetaII), an S/T kinase import

168 A group of "plant-like" Ca(2+)-dependent protein kinases (CDPKs) transduces cytosolic Ca(2+) flux

169 fission yeast Schizosaccharomyces pombe, the protein kinase Cdr1 is a mitotic inducer that promotes m

170 We identified multiple receptor-like protein kinases changing in abundance, including cystein

171 e calcium sensors (CBLs) and CBL-interacting protein kinases (CIPKs) are involved in Al resistance.

172 were contingent on the crucial AIS protein, protein kinase CK2.

173 1 (unc51-like autophagy activating kinase 1) protein kinase complex and the PI3KC3-C1 (class III phos

174 target of rapamycin complex 1 (mTORC1) is a protein kinase complex that localizes to lysosomes to up

175 Protein kinases comprise a large family of structurally

176 The more than 500 protein kinases comprising the human kinome catalyze hun

177 cell death required the common receptor-like protein kinase coreceptor BAK1.

178 ted using the Chaetomium thermophilum RIOK-2 protein kinase (Ct-RIOK-2) crystal structure 4GYG as a t

179 Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated

180 ts in the 3'-UTR of the dystrophia myotonica protein kinase (DMPK) gene.

181 when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is chemically inhibited or whe

182 host interaction and reveals novel potential protein kinase drug targets.

183 lysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the developm

184 The bifunctional protein kinase-endoribonuclease Ire1 initiates splicing

185 tions were detected for 1 in a wide panel of protein kinase, enzyme, and receptor ligand assays.

186 ibitor vemurafenib and the mitogen-activated protein kinase/extracellular signal-regulated kinase inh

187 e (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological

188 alization in a knockout mutant of a receptor protein kinase, FERONIA, we found that the intracellular

189 Experiments with inhibitors of protein kinase G (PKG), protein kinase A (PKA), phosphod

190 Protein kinase G (PknG), a thioredoxin-fold-containing e

191 The TTK protein kinase gene (TTK) on chromosome 6q14.1 was the m

192 3, and mutations affecting mitogen-activated protein kinase genes.

193 Our data show that the protein kinase GSK-3, one of the first targets identifie

194 Mechanistically, calmodulin-dependent protein kinase I phosphorylates a RhoA-specific GEF, GEF

195 409 (Ser-409) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) bo

196 ine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2-S2814

197 w that activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) strongly interacts with a nov

198 d calcium/calmodulin (Ca(2+)/CaMK)-dependent protein kinase II (CaMKII) to the hippocampal PSD.

199 trast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the i

200 xcitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1

201 n-dependent calcium and calmodulin-dependent protein kinase II activity, which could be prevented by

202 Calcium/calmodulin-dependent protein kinase II gamma knockout mice displayed reduced

203 hibition of calcium and calmodulin-dependent protein kinase II with 2.5 microM of KN93 prevented the

204 sphorylation of calcium/calmodulin-dependent protein kinase II, which promoted both hepatic insulin r

205 stimulation of calcium/calmodulin-dependent protein kinase II-positive principal cells as well as of

206 x and linked to calcium/calmodulin-dependent protein kinase II.

207 osis, fibrosis, calcium/calmodulin-dependent protein kinase IIdelta phosphorylation, brain natriureti

208 of CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, and CST reduced CaMKII

209 for activation and regulation of eukaryotic protein kinases in animals have been studied extensively

210 The central role of protein kinases in controlling disease processes has spu

211 in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members.

212 suppressed tumor growth in a BCR-ABL fusion protein kinase-induced mouse model of chronic myeloid le

213 Pyrazolo[3,4-d]pyrimidines are potent protein kinase inhibitors with promising antitumor activ

214 ve been identified as potent ATP-competitive protein kinase inhibitors.

215 Finally, it reveals that mitogen-activated protein kinase interacting kinase-1 has a pivotal role i

216 otein but not mRNA level of stress-activated-protein kinase interacting protein 1 (Sin1), which resul

217 p38alpha is a Ser/Thr protein kinase involved in a variety of cellular process

218 Identifying the substrates and protein kinases involved is vital to understand how thes

219 istic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes

220 -containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycobacterium t

221 Initial sorting is based on tyrosine-protein kinase Kit (c-Kit) expression that enriches for

222 ctions of the Hippo pathway serine/threonine-protein kinases Lats1 and Lats2, which phosphorylate and

223 ith DHA and Physcion activates AMP-activated protein kinase, leading to synergistic inhibition of hum

224 es endoplasmic reticulum stress sensor PERK (protein kinase-like kinase) and eIF2alpha-ATF4-CHOP sign

225 he MOR promoter, involving mitogen-activated protein kinase (MAPK) activation and mitogen- and stress

226 one activates a prototypic mitogen-activated protein kinase (MAPK) cascade and triggers a dose-depend

227 ced phosphorylation of p38 mitogen-activated protein kinase (MAPK) in podocytes.

228 Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in Saccharomyces cerevisiae that c

229 lammatory potential of p38 mitogen-activated protein kinase (MAPK) inhibitors was coincidentally expa

230 Mitogen-activated protein kinase (MAPK) pathway antagonists induce profoun

231 tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical respo

232 gulation of the downstream mitogen-activated protein kinase (MAPK) pathway in cancer cells.

233 alysis indicated decreased mitogen-activated protein kinase (MAPK) pathway signaling and increased ph

234 h constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling.

235 Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast

236 Mitogen-activated protein kinase (MAPK) scaffold proteins, such as IQ moti

237 at aberrantly activate the mitogen-activated protein kinase (MAPK) signaling pathway.

238 rnover in neurons and that mitogen-activated protein kinase (MAPK)-dependent phosphorylation of the R

239 ivated kinase, and the p38 mitogen-activated protein kinase (MAPK)-MAPK-activated protein kinase 2 (M

240 Inhibition of MEK (mitogen-activated protein kinase (MAPK)/ERK kinase) after DOX treatment re

241 un N-terminal kinase (JNK) mitogen-activated protein kinases (MAPK)] were assessed in response to N-f

242 s bind and dephosphorylate mitogen-activated protein kinases (MAPKs) and thereby critically modulate

243 The molecular actions of mitogen-activated protein kinases (MAPKs) are ultimately accomplished by t

244 Mitogen-activated protein kinases (MAPKs) form important signaling modules

245 Cellular mitogen-activated protein kinases (MAPKs) have been shown to play a role i

246 wth factor stimuli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), e

247 psis patients, whereas p38 mitogen activated protein kinase messenger RNA was up-regulated.

248 Mitogen-activated protein kinase (MPK) cascades are conserved mechanisms o

249 tablished that mitogen- and stress-activated protein kinases (MSKs) regulate IL-10 production via the

250 olo-like kinase 1 (Plk1), a serine/threonine protein kinase normally expressed in mitosis, is frequen

251 nts, suggesting the involvement of different protein kinases or trafficking mechanisms in PIN1 phosph

252 nse to high VPD, whereas plants with mutated protein kinase OST1 showed stunted VPD-induced responses

253 1, impairs the activity of mitogen-activated protein kinase p38, increases the activity of the mRNA-d

254 actin-regulating pathways [eg, p21-activated protein kinases (PAK1/2) and extracellular signal-regula

255 inhibitors of the RAS/RAF/mitogen-activated protein kinase pathway in RAS-mutant cancers are particu

256 portance of the activated mitogen-associated protein kinase pathway in this disease.

257 ophils of sepsis patients, mitogen activated protein kinase phosphatase-1 messenger RNA levels were d

258 nduced protein 3 (A20) and mitogen activated protein kinase phosphatase-1 were determined in neutroph

259 he ability of cGMP and type 2 cGMP-dependent protein kinase (PKG2) to activate forkhead box O (FoxO)

260 n expression is independent of RNA-activated protein kinase (PKR) regulation.

261 th the double-stranded RNA (dsRNA)-activated protein kinase (PKR), a well-characterized antiviral pro

262 Protein kinases play a key role in regulating the activi

263 s regulate key processes in human cells, and protein kinases play a pivotal role in health and diseas

264 te that four closely related Photoregulatory Protein Kinases (previously referred to as MUT9-like kin

265 A gene predicted to encode the protein kinase PskA was also identified as being importa

266 CMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus re

267 uto-regulation of the innate immune effector protein kinase R, which phosphorylates the eukaryotic in

268 Only a few hundreds of protein kinases regulate key processes in human cells, a

269 Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathw

270 scription of sda, and Sda inhibits histidine protein kinases required for activation of the transcrip

271 ation by activation of p38 mitogen-activated protein kinases resulting in upregulated collagen genera

272 , which is triggered by receptor-interactive protein kinases (RIPK) 1 and 3.

273 we showed that the 3 UPR pathway transducers-protein kinase RNA-activated (PKR)-like ER kinase (PERK)

274 Rho-associated protein kinase (ROCK) is required for both high-speed mi

275 on of Rho-associated, coiled-coil containing protein kinase (ROCK).

276 n, and more generally, support the notion of protein kinase S-glutathionylation as a means of redox s

277 Stress-activated protein kinase (SAPK) pathways are evolutionarily conser

278 n system in the kidney and mitogen-activated protein kinase signaling in the heart.

279 ation during fasting and cAMP/cAMP-dependent protein kinase signaling, suggesting local regulation of

280 mice, along with decreased mitogen-activated protein kinase signaling, tumor angiogenesis and inflamm

281 tor of transcription 3 and mitogen-activated protein kinase signalling in an inoculum-dependent manne

282 teins and independently of the energy sensor protein kinases SnRK1.1 (SNF1-related kinase 1.1).

283 st Schizosaccharomyces pombe, the CaMKK-like protein kinase Ssp1 promotes cell cycle progression by a

284 region of adenosine monophosphate-activated protein kinase subunit beta 2 (AMPKbeta2).

285 Here, we establish that the HSV-1 Us3 protein kinase subverts the normal response to low-energ

286 hitin elicitor receptor kinase (HvCERK1) and protein kinases such as MAP kinase 3 (HvMPK3) and MAPK s

287 hich revealed the association of OsHAD1 with protein kinases such as OsNDPKs.

288 we implicate the atypical mitogen activated protein kinase, SWIP-13, in DAT regulation.

289 on of either IKKbeta or the serine/threonine protein kinase TAK1 in monocytes blocked TLR-induced cyt

290 onstitutively active, ubiquitously expressed protein kinase that regulates multiple signaling pathway

291 e secretion, phosphorylated PKM2 serves as a protein kinase to phosphorylate synaptosome-associated p

292 model is that PKG, a malarial cGMP-dependent protein kinase, triggers egress, activating malarial pro

293 Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is a key sensory/effecto

294 Liver kinase B1 (LKB1) is a serine/threonine protein kinase ubiquitously expressed in mammalian cells

295 formation of the activation loop (T-loop) of protein kinases underlies enzymatic activity and influen

296 A549 cells lacking LKB1, a serine/threonine protein kinase upstream of AMPK, failed to activate AMPK

297 A dual enrichment strategy targets intact protein kinases via capture on immobilized multiplexed i

298 n genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2.

299 njury converge on p38alpha mitogen-activated protein kinase within the fibroblast to program the fibr

300 In both contests, we employed the tyrosine-protein kinase Yes as an example target protein.