ライフサイエンスコーパス: protein kinase A

1 aling, and activation of cAMP-dependent PKA (protein kinase A).

2 erlotinib was independent of cAMP, cGMP, and protein kinase A.

3 hosphorylation of NMDA and AMPA receptors by protein kinase A.

4 cycle regulator, and the metabolic regulator protein kinase A.

5 pendently of the classical effector of cAMP, protein kinase A.

6 rocess is associated with fast activation of protein kinase A.

7 ibitory hexapeptide GRGDSP and inhibition of protein kinase A.

8 o study the cAMP binding domain A (CBD-A) of Protein kinase A.

9 neurons is induced by neuronal activity and protein kinase A.

10 n axonal specification through activation of protein kinase A.

11 n the extensive cytosolic domain of STIM1 by protein kinase A.

12 ssociation with 14-3-3 proteins and involves protein kinase A.

13 obligatory dependence on phosphorylation by protein kinase A.

14 equent stimulation of CFTR by cAMP-dependent protein kinase A.

15 s dependent on Pg phosphorylation at S665 by protein kinase A.

16 transcription factor that acts downstream of protein kinase A.

17 ith forskolin and H89 to activate or inhibit protein kinase A (a family of enzymes whose activity dep

18 ardiac myosin-binding protein-C (cMyBP-C) by protein kinase A accelerates the kinetics of force devel

19 2 on PAR-4 expression, whereas cicaprost via protein kinase A activation counteracted this effect.

20 t the molecular level, capacitation requires protein kinase A activation, changes in membrane potenti

21 This repression is released by calcium and protein kinase A activation.

22 Protein kinase-A activation downstream of T-cell recepto

23 involving both an increase in cAMP-dependent protein kinase A activity and the GLI3R to GLI3A ratio.

24 wed that this approach can be used to detect protein kinase A activity in lysate from HEK293 cells.

25 protein level, female ARVMs exhibited higher protein kinase A activity, consistent with pathway enric

26 drenergic receptor Abs, as well as increased protein kinase A activity, suggesting a potential mechan

27 maps of the kinase domain of cAMP-dependent protein kinase A allow for a molecular explanation for t

28 demonstrate that Shp2 is a component of the protein kinase A anchoring protein (AKAP)-Lbc complex.

29 We identified protein kinase A anchoring protein 150 (AKAP150), via ta

30 calization of the enzyme by interaction with protein kinase A anchoring proteins (AKAPs).

31 ate kinases, including SAP97 and PSD-95, and protein kinase A-anchoring protein (AKAP) 5 in the plasm

32 Protein kinase A-anchoring protein 79/150 (AKAP), residi

33 x of patients, upregulated activities of the protein kinase A and C pathways and changes in neurotran

34 virus genomes, we show that costimulation of protein kinase A and C-delta signaling cascades in conju

35 c stimulation or increased pacing because of protein kinase A and CaMKIIdelta phosphorylations of cMy

36 mote human Th17 responses via cAMP-dependent protein kinase A and caspase-1/inflammasome-dependent IL

37 fically Ca2+/calmodulin activated kinase II, protein kinase A and exchange protein activated by cAMP

38 lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes wit

39 eta2 -adrenergic receptor phosphorylation at protein kinase A and G-protein receptor kinase sites in

40 3 antagonizes TGFbeta-mediated activation of protein kinase A and inhibition of Protein kinase B (AKT

41 Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involv

42 ugh the signaling of protein kinases such as protein kinase A and p38 mitogen-activated protein kinas

43 ncreased phosphorylation of phospholamban by protein kinase A and relief of sarco/endoplasmic reticul

44 ive Escherichia coli, an action dependent on protein kinase A and STAT3 in macrophages.

45 As a scaffolding protein for Protein Kinases A and C (PKA and PKC, respectively), AKA

46 etal muscle, and brain and phosphorylated by protein kinases A and C at Ser-68 and Ser-63, respective

47 on (e.g. by Pho85-Pho80, Cdc28-cyclin B, and protein kinases A and C) and dephosphorylation (e.g. by

48 t S373, S365, and S368, well-known Cx43 Akt, protein kinase A, and protein kinase C phosphorylation s

49 enylyl cyclase inhibitor MDL 12330A, and the protein kinase A antagonist cAMPS-Rp.

50 Prior studies have identified protein kinase A as a downstream effector of cAMP that c

51 by beta-adrenergic receptors, cyclic AMP and protein kinase A as revealed by pharmacological experime

52 nhibition of beta2-adrenergic receptor 2 and protein kinase A, as well as silencing of hypoxia-induci

53 xpression levels of AKAP7, a gene encoding a protein kinase A-binding scaffolding molecule, were sign

54 II reduced its subsequent phosphorylation by protein kinase A but not by protein kinase C.

55 d through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosi

56 gnaling cascade--adenylyl cyclase to cAMP to protein kinase A--but with opposing effects.

57 ccurs via the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA)-dependent signaling pathway.

58 Cyclic AMP/protein kinase A (cAMP/PKA) and glucocorticoids promote

59 1 was not activated through the classic cAMP/protein kinase A (cAMP/PKA) pathway or via the AKT, MK2,

60 pressing ROS is independent of AMP-activated protein kinase, a canonical substrate of LKB1.

61 Toxoplasma gondii encodes three protein kinase A catalytic (PKAc1-3) and one regulatory

62 tifying cancer-associated mutations in human protein kinases, a class of signaling proteins known to

63 solution properties, as little as 0.1 U/muL protein kinase A could be detected in short reaction tim

64 ipal component analysis of available GRK and protein kinase A crystal structures to identify their do

65 67 kDa laminin-receptor (67LR) resulting in protein kinase A dependent activation of protein phospha

66 roduction of cyclic adenosine monophosphate, protein kinase A-dependent activation of the extracellul

67 Although beta2AR stimulation in DC induces protein kinase A-dependent cAMP-responsive element-bindi

68 Protein kinase A-dependent increase in the potency of in

69 n an exchange protein activated by cAMP- and protein kinase A-dependent manner.

70 ntraction in the Langendorff model through a protein kinase A-dependent mechanism.

71 ted cardiomyocyte calcium handling through a protein kinase A-dependent mechanism.

72 tion via adenosine receptors A2a-, A2b-, and protein kinase A-dependent pathways.

73 cular level, metoprolol expectedly decreased protein kinase A-dependent phospholamban and ryanodine r

74 tidase enzyme as well as apoptosis through a protein-kinase-A-dependent pathway.

75 Inhibition of protein kinase A did not affect the 2-PAA-related enhanc

76 of CPG2 binding to the actin cytoskeleton by protein kinase A directly impacts recruitment of EndoB2

77 nge is caused by cocaine-exacerbated D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons

78 TP induction is caused by sensitized D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons

79 optimal linker allows its phosphorylation by protein kinase A during bacterial co-expression and subs

80 allows for convergent activation of PDK1 and protein kinase A during paired stimulation to initiate c

81 probability >0.3) in the absence of ATP and protein kinase A, each normally required for CFTR activi

82 nels are not characteristically activated by protein kinase A even though the phosphorylation levels

83 s of renal tubule epithelial cells; elevates protein kinase A, extracellular signal-regulated kinases

84 e the hydrogels with a peptide substrate for protein kinase A further enhanced the sensitivity of the

85 d receptor kinases (GRKs) are members of the protein kinase A, G, and C families (AGC) and play a cen

86 l stiffness, which was partially restored by protein kinase A in both mild and severe RV dysfunction.

87 protein-coupled receptor kinase/arrestin and protein kinase A in salmeterol-mediated desensitization

88 r282, and Ser302) that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replace

89 ines produced upon LPS challenge occurs in a protein kinase A-independent manner and, rather, is asso

90 skolin, and CCR8 expression was sensitive to protein kinase A inhibition.

91 Treatment with the protein kinase A inhibitor H89 or the anion exchange inh

92 these effects were blocked by co-addition of protein kinase A inhibitor.

93 Protein kinase A is a key mediator of cAMP signalling do

94 Phosphorylation of LKB1 by protein kinase A is essential to establish the asymmetri

95 The holoenzyme complex of protein kinase A is in an inactive state; activation inv

96 t the phosphorylation of the T389 residue by protein kinase A is mediated by the association of plasm

97 ntact myocytes and selective displacement of protein kinase A isoforms, we demonstrate that the antih

98 rt by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller.

99 o and found that a positive feedback loop on protein kinase A mediated by the AMP-activated protein k

100 One involves cAMP/protein kinase A-mediated activation of the Src homology

101 acts as a strong agonist in highly amplified protein kinase A-mediated events.

102 Finally, we revealed that protein kinase A-mediated extracellular signal-regulated

103 and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S

104 The mutations increased protein kinase A-mediated PDE3A phosphorylation and resu

105 a-adrenergic stimulation as a consequence of protein kinase A-mediated phosphorylation or as a result

106 sed imaging reveals that activity-driven and Protein Kinase A-mediated PS1 phosphorylation at three d

107 2 activation inhibited protein kinase C- and protein kinase A-mediated sensitization processes throug

108 t-evoked temporal Ca(2+) release profile and protein kinase A modulation of Ca(2+) release are marked

109 tion coupling is cAMP-dependent, neither the protein kinase A nor the exchange protein directly activ

110 the kidney by a direct stimulatory action of protein kinase A on the plasma membrane trafficking and

111 Protein kinase A or C blockade prevented PTH but not FGF

112 calization mutant, or a mutant lacking the 5 protein kinase A or C phosphorylation sites interfered w

113 ease in intracellular cAMP, independently of protein kinase A or exchange protein directly activated

114 Protein kinase A or exchange protein directly activated

115 ed and to actin when it is phosphorylated by protein kinase A or other kinases.

116 The prephosphorylation of Pah1 by protein kinase A or protein kinase C reduced its subsequ

117 block of signalling pathways involving ATP, protein kinase A or the formation of lipid rafts, and do

118 o increased by pharmacological activation of protein kinases A or C and decreased by inhibition of th

119 mplicated the cyclic adenosine monophosphate/protein kinase A pathway as well as FosB and dynorphin-B

120 Inhibiting the protein kinase A pathway did not affect glucose-induced

121 In addition, activating the protein kinase A pathway diminished the contractile sexu

122 es for NDI that target the canonical VP/cAMP/protein kinase A pathway have so far proven ineffective,

123 is provided for the involvement of the cAMP-protein kinase A pathway in gating the recovery.

124 arrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta t

125 lic adenosine monophosphate (cAMP)-dependent protein kinase A pathway to inhibit HIV-1 activation and

126 e cardiac function, particularly through the protein kinase A pathway, and could potentially be respo

127 action of GnIH on the adenylate cyclase/cAMP/protein kinase A pathway, suggesting a common inhibitory

128 e to EPO regulation through a cAMP-dependent protein kinase A pathway.

129 dopamine receptors was mediated through the protein kinase A pathway.

130 stream regulator of the cyclic AMP-dependent Protein Kinase A pathway.

131 hways, such as the A-kinase anchor protein 2/protein kinase A pathway.

132 n (Pg) and direct phosphorylation at S665 by protein kinase A: Pg deficiency as well as overexpressio

133 Using a novel mouse model lacking protein kinase A-phosphorylatable troponin I (TnI) and M

134 Biochemical measurements confirmed that protein kinase A phosphorylated ser273, ser282, and ser3

135 PKD and was associated with higher levels of protein kinase A-phosphorylated (Ser133) cAMP-responsive

136 Protein kinase A phosphorylation of ArgBP2gamma at neigh

137 Protein kinase A phosphorylation of B2AR increases the f

138 ction between PSD95 and KV1 channels enables protein kinase A phosphorylation of KV1 channels in cVSM

139 These findings provide initial evidence that protein kinase A phosphorylation of KV1 channels is enab

140 This process is regulated by protein kinase A phosphorylation of the PLAT domain, whi

141 yR1 from Tric-a KO mice are not activated by protein kinase A phosphorylation, demonstrating a defect

142 Here, we study the effect of cAMP/protein kinase A (PKA) activation on whole cell K(+) cur

143 at cAMP inhibits myometrial contractions via protein kinase A (PKA) activation, but this has yet to b

144 Lm211 can inhibit Nrg1III by limiting protein kinase A (PKA) activation, which is required to

145 Protein kinase A (PKA) activation, which mediates CD dis

146 This effect correlated with increased protein kinase A (PKA) activity and hyperphosphorylation

147 The inhibitor of protein kinase A (pkA) activity KT5720 blocked growth of

148 We show here that elevated protein kinase A (PKA) activity results in WC-independen

149 -activated current was not affected when the protein kinase A (PKA) activity was blocked with H89, or

150 T generate an ITF that depends on persistent protein kinase A (PKA) activity, whereas an ITF produced

151 1 (PDZ) in the C-tail of the beta1-AR and on protein kinase A (PKA) activity.

152 f PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase

153 depend on phosphorylation by cAMP-dependent protein kinase A (PKA) and CFTR-ATPase activity.

154 e differentially modulated by cAMP-dependent protein kinase A (PKA) and exchange protein directly act

155 ) is a cytosolic scaffolding protein binding protein kinase A (PKA) and glycogen synthase kinase 3bet

156 These include protein kinase A (PKA) and glycogen synthase kinase 3bet

157 a physical and functional connection between protein kinase A (PKA) and Gpr161 (an orphan GPCR) signa

158 a2 integrin activation on PMNs by activating protein kinase A (PKA) and inhibiting activation of the

159 e receptor activation induced CXCL8 via cAMP-protein kinase A (PKA) and mediated hematopoiesis.

160 potentiation requires the activation of both protein kinase A (PKA) and the GTPase Ras, and is induce

161 Cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) are important mediators and regul

162 cAMP production and protein kinase A (PKA) are the most widely studied steps

163 hat cAMP promotes phosphorylation of S897 by protein kinase A (PKA) as well as increases the phosphor

164 rdiac troponin I (cTnI) is phosphorylated by protein kinase A (PKA) at sites S23/S24, located at the

165 A protein kinase A (PKA) biosensor allowed us to resolve m

166 We generate a novel genetically encoded protein kinase A (PKA) biosensor anchored onto the myofi

167 ion of the A kinase activity reporter (AKAR) protein kinase A (PKA) biosensor as an example-first in

168 lin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) both in vitro and in heterologous

169 Activation of protein kinase A (PKA) by follicle stimulating hormone (

170 ased; this was associated with a decrease of protein kinase A (PKA) catalytic subunit alpha (Calpha)

171 ties of a BrS-associated SCN5A mutation in a protein kinase A (PKA) consensus phosphorylation site, R

172 a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA) display reduced adiposity and res

173 I(1-39)), is a target for phosphorylation by protein kinase A (PKA) during beta-adrenergic stimulatio

174 The consequent inhibition of protein kinase A (PKA) enhances Hh transduction.

175 Using voltage-clamp and cAMP-protein kinase A (PKA) FRET sensors, we hypothesized tha

176 ponses relies on the activation of localized protein kinase A (PKA) holoenzymes.

177 Protein kinase A (PKA) hyperactivation causes hereditary

178 gulates signal transduction through cAMP and protein kinase A (PKA) in melanocytes, is a major inheri

179 ring development and impacts the activity of Protein Kinase A (PKA) in striatal spiny projection neur

180 ophosphate, and the subsequent activation of protein kinase A (PKA) induce a mesenchymal-to-epithelia

181 ation of Ih observed in SNI neurons, whereas protein kinase A (PKA) inhibition further promoted this

182 Protein kinase A (PKA) integrates inputs from G-protein-

183 In eukaryotes, protein kinase A (PKA) is a master regulator of cell pro

184 cAMP-dependent protein kinase A (PKA) is a ubiquitously expressed serin

185 Ser133 phosphorylation by protein kinase A (PKA) is a well-characterized CREB acti

186 The extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of

187 rylation of the regulatory domain of CFTR by protein kinase A (PKA) is required for its channel activ

188 Protein Kinase A (PKA) is the major receptor for the cyc

189 ngoing cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) levels, strongly limiting SK chan

190 Protein Kinase A (PKA) mediates synaptic plasticity and

191 Protein Kinase A (PKA) modulates Hh signaling activity t

192 s of the spatially and temporally controlled protein kinase A (PKA) network in diverse eukaryotic mod

193 ity can be regulated by phosphorylation with protein kinase A (PKA) or AKT, which, in turn, inhibits

194 We show that cAMP signaling through the protein kinase A (PKA) pathway activates Src homology do

195 ormone (ACTH)-induced activation of the cAMP/protein kinase A (PKA) pathway by melanocortin 2 recepto

196 n was emulated by positive modulators of the protein kinase A (PKA) pathway, inhibited by the CB1R an

197 ated the downregulation of DMP1 via the cAMP/protein kinase A (PKA) pathway.

198 Protein kinase A (PKA) phosphorylates Gli proteins, acti

199 Here, we found that protein kinase A (PKA) phosphorylates UBE3A in a region

200 Protein kinase A (PKA) phosphorylation of GRK2 at Ser-68

201 Protein kinase A (PKA) phosphorylation of myofibril prot

202 racellular signal-regulated kinase (ERK) and protein kinase A (PKA) play important roles in LTP and s

203 Protein kinase A (PKA) plays critical roles in neuronal

204 is initiated by PDEs actively targeting the protein kinase A (PKA) R-subunit through formation of a

205 The regulation of L-type Ca(2+) channels by protein kinase A (PKA) represents a crucial element with

206 TG) mice expressing non-phosphorylatable TnI protein kinase A (PKA) residues (i.e. serine to alanine

207 ternalization is associated with a late cAMP/protein kinase A (PKA) response at the Golgi/TGN.

208 Inhibition of protein kinase A (PKA) restored phagocytosis and RhoA ac

209 al glucagon-like peptide-1 receptor (Glp-1r)-protein kinase A (Pka) signaling and a neuronal-mediated

210 t disease-related mutations that impair cAMP protein kinase A (PKA) signaling are present within the

211 (PGE2)-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling axis.

212 The cAMP and cAMP-dependent protein kinase A (PKA) signaling cascade is a ubiquitous

213 lincRNA signatures support a major role for protein kinase A (PKA) signaling in shaping the FLC gene

214 ministration of an agent that activates cAMP-protein kinase A (PKA) signaling led to attenuation of p

215 has been ascribed to the cAMP/cAMP-dependent protein kinase A (PKA) signaling pathway in retinoid tre

216 hrough activation of the beta-adrenergic and protein kinase A (PKA) signaling pathway.

217 ls respond to multiple signals that activate protein kinase A (PKA) signaling, which positively regul

218 response to dopamine acting via D1 receptor/protein kinase A (PKA) signaling.

219 rough beta-adrenergic receptor (betaARs) and protein kinase A (PKA) signaling.

220 ein levels leading to the hyperactivation of protein kinase A (PKA) signaling.

221 al activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

222 activation (LDA) under conditions of maximal protein kinase A (PKA) stimulation.

223 In yeast, glucose activates protein kinase A (PKA) to accelerate aging by inhibiting

224 ormally, the scaffold protein AKAP1 recruits protein kinase A (PKA) to the outer mitochondrial membra

225 proteins, as it was normalized to donors by protein kinase A (PKA) treatment.

226 ed PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha but not phospholipase

227 reased spark-to-spark delays; (2) activating protein kinase A (PKA) with forskolin accelerated amplit

228 rylation of tyrosine residues by Etk/Bmx and protein kinase A (PKA) within an assembled signaling com

229 cond-scale molecular-dynamics simulations of protein kinase A (PKA), an exemplar active kinase.

230 ry subunit 1beta (PRKAR1beta), activation of protein kinase A (PKA), and phosphorylation of alpha4-in

231 how that JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate

232 ctivate three cAMP sensors downstream of AC [protein kinase A (PKA), exchange protein activated by cA

233 s with inhibitors of protein kinase G (PKG), protein kinase A (PKA), phosphodiesterase 3B (PDE3B), an

234 anchoring protein AKAP79/150 interacts with protein kinase A (PKA), protein kinase C (PKC), and prot

235 rapid induction (4 h compared with 3 d); (2) protein kinase A (PKA), rather than PKCepsilon, dependen

236 Cyclic AMP (cAMP), acting via protein kinase A (PKA), regulates many cellular response

237 upled receptor that signals through cAMP and protein kinase A (PKA), regulates pigmentation, adaptive

238 phide between regulatory-RIalpha subunits of protein kinase A (PKA), which stimulates PKA-dependent E

239 r flight heart rate (HR) increases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII

240 lated phosphoprotein of 32 kDa (DARPP-32), a protein kinase A (PKA)-activated and calcineurin (CaN)-d

241 e C-terminal type I PDZ motif with SAP97 and protein kinase A (PKA)-anchoring protein (AKAP) 5, which

242 AGM is enriched for expression of targets of protein kinase A (PKA)-cAMP response element-binding pro

243 eurons, and these effects were mediated by a protein kinase A (PKA)-dependent enhancement of presynap

244 ation with mustard oil in a calcium and cAMP/protein kinase A (PKA)-dependent manner.

245 opus laevis oocytes by adenylyl cyclase- and protein kinase A (PKA)-dependent mechanisms.

246 Here, we show that PTH induces the protein kinase A (PKA)-dependent phosphorylation of HDAC

247 licle-stimulating hormone (FSH) promotes the protein kinase A (PKA)-dependent phosphorylation of insu

248 Here, we report that GLP-1 stimulates protein kinase A (PKA)-dependent phosphorylation of syna

249 esicles to the plasma membrane and increased protein kinase A (PKA)-dependent protein phosphorylation

250 neurons, with GLP-1R activation promoting a protein kinase A (PKA)-dependent signaling cascade leadi

251 ity profiling revealed that GD1a activated a protein kinase A (PKA)-dependent signaling pathway and i

252 major calcium signaling molecule, and report protein kinase A (PKA)-independent CFTR activation by ca

253 g brown adipocytes through cyclic AMP (cAMP)/protein kinase A (PKA)-mediated lipolysis and fatty acid

254 tractile impairments were caused by impaired protein kinase A (PKA)-mediated phosphorylation because

255 his scaffolding protein regulates a shift in protein kinase A (PKA)-mediated phosphorylation events u

256 Here we investigated the archetypical protein kinase A (PKA)-mediated phosphorylation of filam

257 to this site triggers the relief of Ig20 and protein kinase A (PKA)-mediated phosphorylation of Ser-2

258 nd that CL-II phosphorylation is promoted by protein kinase A (PKA)-mediated phosphorylation of Smo C

259 Specifically, protein kinase A (PKA)-mediated phosphorylation of T389

260 show that GIE deformability is regulated by protein kinase A (PKA)-mediated phosphorylation of the S

261 transcription principally by activating the protein kinase A (PKA)-targeted transcription factors.

262 ttle agonist action of I942 towards EPAC2 or protein kinase A (PKA).

263 cAMP is the single regulatory subunit (R) of protein kinase A (PKA).

264 ivation and relaxation and their response to protein kinase A (PKA).

265 iosynthetic enzyme, ferrochelatase (FECH) by protein kinase A (PKA).

266 by the action of regulatory proteins such as protein kinase A (PKA).

267 KAR1A codes for type-I regulatory subunit of protein kinase A (PKA).

268 ontractility and lusitropy via activation of protein kinase A (PKA).

269 tor forskolin and prevented by inhibitors of protein kinase A (PKA).

270 perilipin 1 (Plin1) in the lipid droplet by protein kinase A (PKA).

271 cell processes largely through activation of protein kinase A (PKA).

272 ex via phosphorylation of MeCP2 at Ser421 by Protein Kinase A (PKA).

273 mitters via activation of its main effector, protein kinase A (PKA).

274 beta-cell function is mediated through cAMP/protein kinase A (PKA)/nephrin-dependent pathways, we fo

275 oform of the second messenger cAMP-dependent protein kinase A (PKAalpha) rapidly phosphorylates USP20

276 rm capacitation, the immediate activation of protein kinase A plays a pivotal role, promoting the sub

277 teristic to preferentially phosphorylate the protein kinase A-primed tau.

278 mutations in either the catalytic subunit of protein kinase A (PRKACA) or the guanine nucleotide-bind

279 mber 1, DNAJB1, and the catalytic subunit of protein kinase A, PRKACA.

280 rotein 1 (Drp1) activation via inhibition of protein kinase A-regulated S637 phosphorylation, resulti

281 ctions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR).

282 was associated with decreased expression of protein kinase A regulatory subunit 1beta (PRKAR1beta),

283 ucleotide binding domains (NBD1 and NBD2) by protein kinase A results in increased channel open proba

284 nd systems: cAMP-bound regulatory subunit of Protein Kinase A (RIalpha) and IBMX-bound phosphodiester

285 its a remarkable degree of conservation with protein kinase A (root mean square deviation = 1.8 A), i

286 onserved cyclic nucleotide-binding domain of protein kinase A's (PKA) regulatory subunit as a prototy

287 yclic nucleotide-gated channels and the cAMP/protein kinase A signaling axis in promoting hyperexcita

288 ermine that ethanol activates a Galphas-cAMP-protein kinase A signaling pathway in IL2 neurons to sti

289 platelet aggregation by modulating the cAMP-protein kinase A signaling pathway, suggesting that MRP4

290 r, enhancement of particular aspects of cAMP/protein kinase A signaling seems to be beneficial for th

291 ward calcium-protein kinase C and cyclic AMP-protein kinase A signaling, which open potassium channel

292 -adrenergic receptor (beta2 AR) at both the protein kinase A site serine 261/262 and the G-protein-c

293 HSL) at S565, with higher phosphorylation at protein kinase A sites S563 and S660, increasing its hyd

294 We focus on protein kinases, a superfamily of phosphotransferases th

295 s of PGA2 by activating Rap1/Rac1 GTPase and protein kinase A targets at cell adhesions and cytoskele

296 erent isoforms, facilitate this by targeting protein kinase A to specific substrates.

297 of a local pool of cAMP and activation of a protein kinase A type II subset, leading to phosphorylat

298 Thus, inhibition of cAMP-dependent protein kinase A was abolished, and stimulation with a c

299 ially PAK-dependent and likely also involves protein kinase A, which is known to reduce PREX1 functio

300 affected either by blocking the activity of protein kinase A with H89, or by blocking the activity o