ライフサイエンスコーパス: protein kinase C-delta

1 cleavage of poly(ADP-ribose) polymerase and protein kinase C delta.

2 pressing a physiologically relevant protein, protein kinase C delta.

3 and prevented by inhibitors of caspase-3 and protein kinase C delta.

4 ed expression of dominant-negative mutant of protein kinase C delta.

5 ion and Jak1 activation and was dependent on protein kinase C delta.

6 of procaspase-9, procaspase-3, gelsolin, and protein kinase C-delta.

7 mitogen-activated protein kinase kinase and protein kinase C-delta.

8 locked by rottlerin, a specific inhibitor of protein kinase C-delta.

9 r complex containing mTOR, STAT1, as well as protein kinase C delta, a known STAT1alpha kinase.

10 Our results favor protein kinase C delta activation as a mediator of norma

11 Protein kinase C delta activation increased in protein k

12 Protein kinase C delta activation is also observed durin

13 PKC (protein kinase C) delta, AKT, and SHC phosphorylation ch

14 with antisense transfections, we showed that protein kinase C delta and , but not proline-rich tyrosi

15 ROS-activated protein kinase C delta and c-jun N-terminal kinases, res

16 nked diglycerides inhibit immunoprecipitated protein kinase C delta and epsilon but not zeta activity

17 s stimulates the tyrosine phosphorylation of protein kinase C delta and inhibits its enzymatic activi

18 RCC cells in vitro through interaction with protein kinase C delta and is mediated by a specific ami

19 DAM9 and ADAM17 is associated with increased protein kinase C delta and Lyn signaling.

20 s and the antisense approach, we showed that protein kinase C delta and mediate proline-rich tyrosine

21 a binding site, involving the requirement of protein kinase C-delta and c-Src that is distinct from a

22 rmore, p38 mitogen-activated protein kinase, protein kinase C-delta, and a novel TLR2-specific signal

23 omology 2-containing inositol-5-phosphatase, protein kinase C-delta, and Erk2.

24 ly(ADP-ribose) polymerase; (iii) cleavage of protein kinase C delta; and (iv) induction of an Ac-DEVD

25 d ErbB3-binding protein 1 phosphorylation by protein kinase C delta are both required for optimal PCN

26 ck to the same position on the C1b domain of protein kinase C delta as do the phorbol esters, with th

27 We identify protein kinase C-delta as the kinase responsible for H3T

28 -induced Mvarphi polarization, and PKCdelta (protein kinase C delta) as a downstream target.

29 er vestibular nuclei were well innervated by protein kinase C delta axons and terminals.

30 hibition of intracellular calcium release or protein kinase C delta, both of which are involved in th

31 60-90-fold weaker affinity compared with the protein kinase C delta C1b domain.

32 We show here that protein kinase C-delta co-localized with lamin B during

33 nger ZBDs, the interleaved RING like ZBDs of protein kinase C delta (Cys(2)HisCys and HisCys(3)), and

34 Mice knocked out for the protein kinase C delta gene (PKCdelta KO) show a marked

35 abrogated by pretreatment of cells with the protein kinase C delta inhibitor rottlerin, but not by c

36 gents and maneuvers, such as erythropoietin, protein kinase C delta inhibitors, iron chelation, and i

37 Protein kinase C-delta is activated during apoptosis, fo

38 to PKCalpha and does not encompass the novel protein kinase C delta isoenzyme.

39 both tyrosine kinase and Ca(2+)-independent protein kinase C delta-mediated pathways involving eithe

40 C) and that this disassembly is regulated by protein kinase C delta-mediated phosphorylation of kerat

41 e, p38 mitogen-activated protein kinase, and protein kinase C delta might be involved in STAT1 phosph

42 s in response to epidermal growth factor and protein kinase C-delta overexpression, as well as PMA an

43 This effect requires the protein kinase C delta, phosphatidylinositol 3'-kinase,

44 Downregulation of protein kinase C delta (PKC delta) by treatment with the

45 LD2 also reversed increases in p21(Cip1) and protein kinase C delta (PKC delta) cleavage seen with hi

46 inhibitors were used, including rottlerin, a protein kinase C delta (PKC delta) inhibitor.

47 Protein kinase C delta (PKC delta) is tyrosine-phosphory

48 Protein kinase C delta (PKC delta) mediates apoptosis do

49 We recently demonstrated that protein kinase C delta (PKC delta) selectively regulates

50 and PI-PLC are required for translocation of protein kinase C delta (PKC delta) to the periphery of J

51 ated that Fli1 is directly phosphorylated by protein kinase C delta (PKC delta).

52 lls) become transformed by downregulation of protein kinase C delta (PKC delta).

53 llagen I expression by a mechanism involving protein kinase C delta (PKC delta): (a) PCPH knockdown i

54 Protein kinase C delta (PKC-delta) protein levels are fr

55 Protein kinase C-delta (PKC delta) plays an important ro

56 rylation of p47phox in a manner dependent on protein kinase C-delta (PKC-delta) activity.

57 This pathway required protein kinase C-delta (PKC-delta) and the guanine nucle

58 We now provide evidence that protein kinase C-delta (PKC-delta) and the p38 mitogen-a

59 PP2A co-immunoprecipitated with NKCC1 and protein kinase C-delta (PKC-delta) and was pulled down b

60 Activation of protein kinase C-delta (PKC-delta) by 12-O-tetradecanoyl

61 Protein kinase C-delta (PKC-delta) has been demonstrated

62 d activation of target genes requires active protein kinase C-delta (PKC-delta) in addition to Smads

63 In an effort to determine the role of protein kinase C-delta (PKC-delta) in cellular transform

64 To investigate the potential role of protein kinase C-delta (PKC-delta) in insulin-like growt

65 Protein kinase C-delta (PKC-delta) is a ubiquitously exp

66 Protein kinase C-delta (PKC-delta) is expressed in plate

67 Protein kinase C-delta (PKC-delta) is involved in growth

68 rosis (SSc), we have examined the effects of protein kinase C-delta (PKC-delta) on type I collagen bi

69 We have previously reported that protein kinase C-delta (PKC-delta) plays a major role in

70 Protein kinase C-delta (PKC-delta) plays a pivotal role

71 During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitoc

72 w here that ES-62-mediated downregulation of protein kinase C-delta (PKC-delta), a TLR4-associated si

73 The overexpression of protein kinase C-delta (PKC-delta), but not PKC-epsilon,

74 e of serine/threonine autophosphorylation of protein kinase C-delta (PKC-delta), we mutated serine 64

75 tion of GABAergic neurons that are marked by protein kinase C-delta (PKC-delta).

76 of the central amygdala (CEl), which express protein kinase C-delta (PKC-delta).

77 ow that hyperglycemia persistently activates protein kinase C-delta (PKC-delta, encoded by Prkcd) and

78 gy allows the development of potential novel protein kinase C delta (PKCdelta) analogues for better t

79 ent study, we examined the novel PKC isoform protein kinase C delta (PKCdelta) and its role in vascul

80 Protein kinase C delta (PKCdelta) and p38delta are key p

81 ation of central amygdala neurons expressing protein kinase C delta (PKCdelta) as key elements of the

82 This study demonstrates that protein kinase C delta (PKCdelta) associates with SHPTP1

83 DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristat

84 ine whether testosterone (T) alters coronary protein kinase C delta (PKCdelta) expression and whether

85 Ang II caused activation of protein kinase C delta (PKCdelta) in C9 cells, and its s

86 In this study, we investigated the role of protein kinase C delta (PKCdelta) in K-ras-dependent lun

87 n known to cause tyrosine phosphorylation of protein kinase C delta (PKCdelta) in platelets, but the

88 We also found that protein kinase C delta (PKCdelta) inhibits GAPDH-driven

89 previously shown that the novel PKC isoform protein kinase C delta (PKCdelta) is activated by TGFbet

90 In this study the potential role of protein kinase C delta (PKCdelta) on meiotic spindle org

91 The inhibitors for protein kinase C delta (PKCdelta) or extracellular signa

92 Protein kinase C delta (PKCdelta) regulates apoptosis in

93 Overexpression of protein kinase C delta (PKCdelta) stimulates apoptosis i

94 Inhibition of protein kinase C delta (PKCdelta) with rottlerin or siRN

95 Protein kinase C delta (PKCdelta), a Ca(2+)-independent,

96 of PAI-1 via sequential activation of c-Src, protein kinase C delta (PKCdelta), and sphingosine kinas

97 cells, this adaptive response is mediated by protein kinase C delta (PKCdelta), but the mechanisms by

98 We have identified a key signaling kinase, protein kinase C delta (PKCdelta), whose alternative spl

99 pendent or -independent for co-dependency on protein kinase C delta (PKCdelta).

100 te that c-Abl associates constitutively with protein kinase C delta (PKCdelta).

101 we show that phorbol esters, acting through protein kinase C-delta (PKCdelta) and mitogen-activated

102 Previously, we identified protein kinase C-delta (PKCdelta) as an important regula

103 Protein kinase C-delta (PKCdelta) has been shown to be u

104 The diverse roles of protein kinase C-delta (PKCdelta) in cellular growth, su

105 mplicated activation of NF-kappaB as well as protein kinase C-delta (PKCdelta) in neutrophil apoptosi

106 Protein kinase C-delta (PKCdelta) is a key regulator of

107 Protein kinase C-delta (PKCdelta) is a Ser/Thr kinase th

108 Protein kinase C-delta (PKCdelta) is an allosterically a

109 Recently, we demonstrated that protein kinase C-delta (PKCdelta) is an oxidative stress

110 by both Ro-32-0432 and rotterlin, suggesting protein kinase C-delta (PKCdelta) may play a role in TGF

111 results in the caspase-dependent cleavage of protein kinase C-delta (PKCdelta) to a 40-kDa fragment,

112 amine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-

113 nuated dieldrin-induced histone acetylation, Protein kinase C delta proteolytic activation and DNA fr

114 Protein kinase C delta showed significant translocation

115 ctivation of Akt, PIP3-dependent kinase, and protein kinase C delta was defective.

116 rtantly, chemical inhibition or knockdown of protein kinase C delta was sufficient to rescue the phen

117 With the antibody to protein kinase C delta, we found scattered, weakly immun

118 hat some substrates (for example, c-Cbl, and protein kinase C delta) were Src family substrates where

119 were specifically sensitive to inhibition of protein kinase C delta, which was further confirmed by t

120 ifferentiation mediated by overexpression of protein kinase C, delta, which is a direct target of HDA

121 ld not be restored by the addition of ATP or protein kinase C delta with ATP, suggesting that dietary

122 Also, H(2)O(2) induced the association of protein kinase C-delta with the platelet-derived growth