ライフサイエンスコーパス: protein kinase D

1 hosphorylation events that release activated protein kinase D.

2 n by Ca(2+)-calmodulin protein kinase II and protein kinase D.

3 R (Bin-amphiphysin-Rvs) domain proteins, and protein kinase D.

4 pathway involving specific LPA receptors and protein kinase D.

5 olgi-targeted beta(1)gamma(2) also activates protein kinase D.

6 way, one that involves novel PKCs (nPKC) and protein kinase D.

7 ed in part via a PKC-dependent activation of protein kinase D.

8 on events and also serine phosphorylation by protein kinase D.

9 that erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetyla

10 in (F-actin) disassembly and an elevation in protein kinase D activity that altered Golgi organizatio

11 tion under conditions of persistent PKC (and protein kinase D) activity.

12 by expression of a dominant-negative mutant protein kinase D, an enzyme implicated in regulating con

13 A kinase defective protein kinase D and a phospholipase C beta inhibitor bl

14 Our results suggest that activation of protein kinase D and Akt1 are approaches to promote axon

15 esis confirmed telethonin as a substrate for protein kinase D and Ca(2+)/calmodulin-dependent kinase

16 ion, IL-2 production, and phosphorylation of protein kinase D and IkappaB.

17 cytosis (e.g., expression of kinase-inactive protein kinase D and low temperature incubation) cause a

18 ers on cell spreading requires activation of protein kinase D and the subsequent activation of Akt1.

19 Protein kinase C and protein kinase D are potently activated by agonist-evoke

20 tant mice that lacked the Rho-GEF and/or the protein kinase D-binding domains.

21 of p53 by recombinant protein kinase CK2 and protein kinase D, both associated with CSN3.

22 telethonin as an interaction partner for the protein kinase D catalytic domain.

23 lular locations, causes phospholipase C- and protein kinase D-dependent vesiculation of the Golgi in

24 The protein kinase D family of serine/threonine kinases, par

25 the protein kinase C-dependent activation of protein kinase D induced by these agonists.

26 Using mass spectrometry, we identified a protein kinase D-interacting substrate of 220 kD (Kidins

27 Using mass spectrometry, we identified protein kinase D-interacting substrate of 220 kDa (Kidin

28 The kinase PRKD2 (protein kinase D) is a crucial regulator of tumor cell-e

29 Protein kinase Cmu (PKCmu), also named protein kinase D, is an unusual member of the PKC family

30 We identify the protein kinase D-mediated phosphorylation of serine 92 o

31 Protein kinase D/PKCmu is a member of the protein kinase

32 Serine 351 is a substrate for protein kinase D (PKD [also known as PKCmu]) in vitro an

33 relay pathway in which the serine/threonine protein kinase D (PKD) activates the NF-kappaB transcrip

34 Rapid protein kinase D (PKD) activation and phosphorylation vi

35 A2 domains of PLC are required for long term protein kinase D (PKD) activation and subsequent inducti

36 hways to lysophosphatidic acid (LPA)-induced protein kinase D (PKD) activation, we tested the effect

37 n rat cardiac myocytes by phosphorylation of protein kinase D (PKD) and expression of collagens (COL1

38 We evaluated the contribution of protein kinase D (PKD) and Gbetagamma to this process.

39 Here we demonstrate a critical role of protein kinase D (PKD) and histone deacetylase 5 (HDAC5)

40 phosphorylated by the CSN-associated kinase protein kinase D (PKD) and its expression is decreased u

41 inhibited by Goedecke 6976, an inhibitor of protein kinase D (PKD) and PKCalpha, but not with GF1092

42 The results presented here demonstrate that protein kinase D (PKD) and PKCeta transiently coexpresse

43 Since both OSBP and PI4KB are substrates for protein kinase D (PKD) and PKD is known to be involved i

44 This study identifies a novel role for protein kinase D (PKD) as an in vivo cardiac CREB-Ser(13

45 ignaling pathway together with BCR-activated protein kinase D (PKD) as important cooperative factors

46 pproaches, we identified the upstream kinase protein kinase D (PKD) as the primary kinase targeting H

47 We show that tyrosine phosphorylation of protein kinase D (PKD) at Y463 in the Pleckstrin Homolog

48 Protein kinase D (PKD) binds to a pool of diacylglycerol

49 Protein kinase C (PKC) and protein kinase D (PKD) coordinate and regulate many fund

50 etween the GTPase RhoA and the serine kinase protein kinase D (PKD) during thymocyte development.

51 Dependent on their cellular localization, Protein Kinase D (PKD) enzymes regulate different proces

52 Protein kinase D (PKD) exists as a family of structurall

53 The protein kinase D (PKD) family consists of three serine/t

54 The protein kinase D (PKD) family consists of three serine/t

55 Treatment of the cells with the protein kinase D (PKD) family inhibitors CRT0066101 and

56 The protein kinase D (PKD) family is a recent addition to th

57 Protein kinase D (PKD) family members (PKD1, 2, and 3) h

58 The members of the protein kinase D (PKD) family of serine/threonine kinase

59 or family of small G-proteins (ARFs) and the protein kinase D (PKD) family of serine/threonine kinase

60 The protein kinase D (PKD) family of serine/threonine kinase

61 The serine kinase protein kinase D (PKD) has a cysteine-rich domain (CRD)

62 In nonneuronal cells, protein kinase D (PKD) has an important role in stabiliz

63 apidly and transiently induces activation of protein kinase D (PKD) in aortic smooth muscle cells.

64 Use of a novel, highly selective protein kinase D (PKD) inhibitor and a nonphosphorylatab

65 The protein kinase D (PKD) inhibitor Go6976 blocked both bas

66 Blockade of DRAK2 activity with the protein kinase D (PKD) inhibitor Go6976 or expression of

67 Cells were pretreated or not with protein kinase D (PKD) inhibitors.

68 Protein kinase D (PKD) is a cytosolic protein, which upo

69 Protein kinase D (PKD) is a cytosolic serine-threonine k

70 Protein kinase D (PKD) is a family of novel diacylglycer

71 Protein kinase D (PKD) is a family of stress-responsive

72 Protein kinase D (PKD) is a member of the AGC family of

73 Protein kinase D (PKD) is a nodal point in cardiac hyper

74 Protein kinase D (PKD) is a novel family of serine/threo

75 Protein kinase D (PKD) is a protein serine kinase that i

76 Protein kinase D (PKD) is a serine kinase whose myocardi

77 Protein kinase D (PKD) is a serine/threonine kinase that

78 Protein kinase D (PKD) is a serine/threonine kinase with

79 Protein kinase D (PKD) is a serine/threonine protein kin

80 Protein kinase D (PKD) is a serine/threonine protein kin

81 Protein kinase D (PKD) is a serine/threonine protein kin

82 Protein kinase D (PKD) is a stress-responsive kinase tha

83 Protein kinase D (PKD) is an antigen receptor-activated

84 tive stress, and the serine/threonine kinase protein kinase D (PKD) is critical for signal relay to N

85 Protein kinase D (PKD) is known to be involved in Golgi-

86 Protein kinase D (PKD) is recruited to the trans-Golgi n

87 Protein kinase D (PKD) isoforms are effectors in signali

88 Protein kinase D (PKD) isoforms are involved in controll

89 Protein kinase D (PKD) isoforms are protein kinase C (PK

90 Protein kinase D (PKD) isoforms are protein kinase C eff

91 Protein kinase D (PKD) isoforms are protein kinase C eff

92 Protein kinase D (PKD) mediates signal transduction down

93 Protein kinase D (PKD) mediates signals from the platele

94 We examined whether protein kinase D (PKD) overexpression in Swiss 3T3 cells

95 Protein kinase D (PKD) participates in activation of the

96 Further analysis showed downstream protein kinase D (PKD) phosphorylation and phosphatase a

97 Protein kinase D (PKD) plays a critical role at the tran

98 In the present study we show that protein kinase D (PKD) plays an important role in the fo

99 Protein kinase D (PKD) potentiates cellular DNA synthesi

100 Here, we show that protein kinase D (PKD) regulates Bit1 apoptotic function

101 Protein kinase D (PKD) regulates many diverse cellular f

102 The protein kinase D (PKD) serine/threonine kinases are acti

103 kout approach to interrogate the function of protein kinase D (PKD) serine/threonine kinases in lymph

104 ted kinase, ribosomal protein S6 kinase, and protein kinase D (PKD) that increase cAMP binding respon

105 Protein kinase D (PKD) transduces an abundance of signal

106 d by cell treatments with H(2)O(2) activates protein kinase D (PKD) via a protein kinase C (PKC)-depe

107 Persistent activation of protein kinase D (PKD) via protein kinase C (PKC)-mediat

108 omoter, whereas the combination of XBP-1 and protein kinase D (PKD) was required for efficient activa

109 ues show that AKAP-Lbc couples activation of protein kinase D (PKD) with the phosphorylation-dependen

110 We also demonstrate that protein kinase D (PKD), a downstream effector of PKC, di

111 Protein kinase D (PKD), a downstream effector of protein

112 ,13-dibutyrate led to striking activation of protein kinase D (PKD), a member of a novel family of se

113 Protein kinase D (PKD), a newly described serine/threoni

114 How these stimuli interact at the level of protein kinase D (PKD), a nodal point in cardiac hypertr

115 B) led to a rapid and striking activation of protein kinase D (PKD), a novel serine/threonine protein

116 Our previous studies demonstrated that protein kinase D (PKD), a serine/threonine kinase implic

117 Protein kinase D (PKD), a serine/threonine kinase, is ex

118 Protein kinase D (PKD), a serine/threonine kinase, is re

119 satory increase (32.6%) in the activation of protein kinase D (PKD), an alternate HDAC5 kinase.

120 that the downstream target of Gbetagamma is protein kinase D (PKD), an isoform of protein kinase C.

121 VAMP3 is bound by the contraction-activated protein kinase D (PKD), and contraction and VAMP3 overex

122 y active PLCepsilon, sustained activation of protein kinase D (PKD), and nuclear translocation of NF-

123 hich can inhibit protein kinase C as well as protein kinase D (PKD), blocked H2O2- but not TNF-induce

124 treatment led to activation of PKCmicro, or protein kinase D (PKD), but not PKCalpha/beta, PKCzeta/l

125 Although protein kinase D (PKD), like protein kinase C (PKC), pos

126 The BCR, but not CD40, activates protein kinase D (PKD), while CD40, but not the BCR, emp

127 C) isoforms-alpha and -delta and may involve protein kinase D (PKD).

128 ation complex for the lipid-dependent enzyme protein kinase D (PKD).

129 of nuclear calcium and activation of nuclear protein kinase D (PKD).

130 ell as phosphorylation of serine residues by protein kinase D (PKD).

131 against the optimal phosphorylation motif of protein kinase D (PKD).

132 Protein kinase D (PKD)/protein kinase C (PKC) mu is a se

133 Protein kinase D (PKD)/protein kinase C mu is a serine/t

134 at S. rectivirgula induces the activation of protein kinase D (PKD)1 in lung cells in vitro and in vi

135 e is known about the serine/threonine kinase protein kinase D (PKD)1 in mast cells.

136 e present study, we investigated the role of protein kinase D (PKD)1 in the proinflammatory responses

137 Protein kinase D (PKD, also known as PKCmu) is closely r

138 When a kinase inactive form of Protein Kinase D (PKD-K618N) was expressed in HeLa cells

139 Protein kinase D (PKD/PKCmu) immunoprecipitated from COS

140 Protein kinase D (PKD/PKCmu) immunoprecipitated from COS

141 on loop phosphorylation in the regulation of protein kinase D (PKD/protein kinase C (PKC) mu) activit

142 Protein kinase D (PKD; also known as PKCmicro) is a seri

143 Although protein kinase C-mediated protein kinase D(PKD)activation was implicated in the re

144 endogenous signaling pathways revealed that protein kinase D/protein kinase Cmicro (PKD/PKCmicro) an

145 rylation of MAPKs and the phosphorylation of protein kinase D/protein kinase Cmu and protein kinase C

146 tein kinase C-Zetalambda-Thr538 and phosphor-protein kinase D-Ser744-748 were reduced, whereas messen

147 Protein kinase D/PKCmu is a member of the protein kinase D serine/threonine kinase family that exh

148 Remarkably, the activity of protein kinase D, the kinase that mediates nuclear expor

149 We provide evidence that protein kinase D, which is phosphorylated and activated