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1 esis involving double-stranded RNA-dependent protein kinase (PKR).
2 the mammalian double-stranded RNA-activated protein kinase (PKR).
3 ), a cellular inhibitor of the RNA-dependent protein kinase (PKR).
4 eron-inducible double-stranded RNA-dependent protein kinase (PKR).
5 ing a role for double-stranded RNA-dependent protein kinase (PKR).
6 ed enzyme, the double-stranded-RNA-activated protein kinase (PKR).
7 system protein double-stranded RNA-activated protein kinase (PKR).
8 termediate dsRNA through the dsRNA-activated protein kinase (PKR).
9 gulating the expression of the RNA-dependent protein kinase (PKR).
10 and promotes degradation of dsRNA-dependent protein kinase (PKR).
11 st mediated by double-stranded-RNA-dependent protein kinase (PKR).
12 ivation of the double-stranded RNA-dependent protein kinase (PKR).
13 of the dsRNA sensors TLR3 or dsRNA-activated protein kinase (PKR).
14 of the double-stranded RNA (dsRNA)-activated protein kinase (PKR).
15 e levels in the absence of the RNA-activated protein kinase (PKR).
16 activation of double-stranded RNA-dependent protein kinase (PKR).
17 rferon-induced double-stranded RNA-activated protein kinase (PKR).
18 the interferon-induced enzyme RNA-activated protein kinase (PKR).
19 actions with the IFN-induced dsRNA-activated protein kinase (PKR).
20 is mediated by double-stranded-RNA-dependent protein kinase PKR.
21 the RNA-binding domain of the RNA-activated protein kinase PKR.
22 on-induced dsRNA-dependent activation of the protein kinase PKR.
23 ediated by the double-stranded-RNA-dependent protein kinase PKR.
24 ral IFN effector, the translation-inhibiting protein kinase PKR.
25 n of the dsRNA-dependent, interferon-induced protein kinase PKR.
26 heir ability to activate the dsRNA-dependent protein kinase PKR.
27 ctor of the C phenotype is the RNA-dependent protein kinase PKR.
28 y regulated by double-stranded RNA-dependent protein kinase PKR.
29 d as an inhibitor of the interferon-induced, protein kinase, PKR.
30 A) and inhibit the antiviral dsRNA-dependent protein kinase, PKR.
31 at can directly bind and activate the latent protein kinase, PKR.
32 ability to interact with the dsRNA-dependent protein kinase, PKR.
33 ructured RNAs as well as the dsRNA-activated protein kinase, PKR.
34 or the interferon-inducible, dsRNA-dependent protein kinase, PKR.
35 PACT is an activator of the protein kinase, PKR.
36 ng the double-stranded RNA (dsRNA)-dependent protein kinase, PKR.
37 to inhibit the double-stranded RNA-activated protein kinase, PKR.
38 feron-induced, double-stranded RNA-dependent protein kinase, PKR.
39 feron-induced, double-stranded RNA-activated protein kinase, PKR.
40 ng the interferon-inducible, dsRNA-activated protein kinase, PKR.
41 -inducible double-stranded RNA-dependent p68 protein kinase (PKR), a key enzyme in the host-mediated
42 ed cellular activator of the dsRNA-dependent protein kinase (PKR), a key regulator of protein synthes
44 The double-stranded RNA (dsRNA)-activated protein kinase (PKR), a serine/threonine protein kinase,
45 evidence that double-stranded RNA-activated protein kinase (PKR), a stress kinase, is involved in HI
47 th the double-stranded RNA (dsRNA)-activated protein kinase (PKR), a well-characterized antiviral pro
48 ive in blocking binding to the RNA-dependent protein kinase PKR, a cytoplasmic dsRNA-binding protein
49 r pathways and that inhibits the activity of protein kinase PKR, a primary mediator of the antiviral
50 ified constitutive and induced RNA-dependent protein kinase (PKR) activation in Fanconi anemia cells
51 ify a role for double-stranded RNA-dependent protein kinase (PKR, also known as EIF2AK2) in inflammas
52 proteins that bind to the interferon-induced protein kinase PKR and inhibit phosphorylation of eIF2al
53 ology with the double-stranded RNA-activated protein kinase PKR and its substrate, the eukaryotic tra
56 irus infection and interferon, the eIF2alpha protein kinase PKR and the 2'-5' oligoadenylate syntheta
57 horylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor
58 g for the antiviral proteins dsRNA-activated protein kinase (PKR) and 2',5'-oligoadenylate synthetase
59 bition through double-stranded RNA-activated protein kinase (PKR) and also through a new pathway invo
60 phorylation of double-stranded RNA-activated protein kinase (PKR) and blocking phosphorylation of PKR
61 activation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2a
62 phorylation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2a
63 ncrease of the double-stranded RNA-dependent protein kinase (PKR) and following inactivation of eIF2a
65 lycytidylic acid activated the RNA-dependent protein kinase (PKR) and induced significant levels of I
67 )-induced double-stranded (ds) RNA-activated protein kinase (PKR) and is an important regulator of PK
68 ent of double-stranded RNA (dsRNA)-activated protein kinase (PKR) and its protein activator PACT in t
69 feron-induced, double-stranded-RNA-activated protein kinase (PKR) and the endoribonuclease of the 2',
70 viral gene expression by the dsRNA-activated protein kinase (PKR) and the NF-kappaB transcription fac
71 degradation of double-stranded RNA-dependent protein kinase (PKR), and it suppresses host transcripti
72 and inhibits the IFN-induced, RNA-dependent protein kinase, PKR, and that NS5A interacts with at lea
73 sine deaminase (ADAR1) and the RNA-dependent protein kinase (PKR) are both interferon-inducible doubl
75 etases (2-5AS), RNase L, and dsRNA-dependent protein kinase (PKR) are expressed by pancreatic islet c
76 ered by TLR4 identified the dsRNA responsive protein kinase PKR as a critical mediator of pathogen-in
78 ) results in the activation of RNA-dependent protein kinase (PKR) but that the alpha subunit of eIF-2
79 ion in an IFN-responsive gene, RNA-dependent protein kinase (PKR), but not 2',5'-oligoadenylate synth
80 nhibit the activation of the dsRNA-dependent protein kinase PKR by sequestering and/or unwinding doub
83 revious studies have shown activation of the protein kinase, PKR, by expanded CUG repeats in vitro.
85 evidence that double-stranded RNA-dependent protein kinase (PKR) can respond to nutrient signals as
86 by macrophages isolated from dsRNA-dependent protein kinase (PKR)-deficient mice, indicating that PKR
87 ere compared to vector control (CON(kd)) and protein kinase PKR-deficient (PKR(kd)) cells for IFN-bet
88 infection and of activation of the antiviral protein kinase (PKR) (double-stranded-RNA [dsRNA]-activa
89 t includes the double-stranded RNA-activated protein kinase (PKR), Drosophila Staufen and Xenopus xlr
92 cated that the double-stranded RNA-dependent protein kinase, PKR, exerted some early antiviral effect
93 e depletion of double-stranded RNA-dependent protein kinase (PKR) from these MEFs restored the IFN re
95 human double-stranded RNA- (dsRNA) activated protein kinase (PKR) has a dsRNA-binding domain (dsRBD)
96 feron-induced, double-stranded RNA-activated protein kinase (PKR) has been implicated in processes th
97 eron-inducible double-stranded RNA-activated protein kinase (PKR) has been reported in acute leukemia
98 on of the double-stranded (ds) RNA-dependent protein kinase, PKR, has been shown to mediate both dsRN
99 lacking both RNase L and the dsRNA-activated protein kinase (PKR), i. e., the two best-characterized
100 2alpha kinase, double-stranded-RNA-dependent protein kinase (PKR), impeded growth of S. pombe due to
101 ivation of the double-stranded RNA-dependent protein kinase PKR in cell-free systems, and within late
102 vement of double stranded (ds) RNA-activated protein kinase PKR in tunicamycin-induced apoptosis.
103 r-kappaB (NF-kappaB) and the dsRNA-dependent protein kinase (PKR) in dsRNA + IFN-gamma-induced nitric
104 le of the double-stranded (ds) RNA-dependent protein kinase (PKR) in macrophage activation was examin
105 mouse double-stranded RNA (dsRNA)-dependent protein kinase (PKR) in place of NSs, were protected fro
106 ron-inducible, double-stranded RNA-activated protein kinase (PKR) in the induction of apoptosis by TN
107 ar function of double-stranded RNA-activated protein kinase (PKR) in the pathogenesis of acute myeloi
108 ression of the double-stranded RNA-dependent protein kinase (PKR) in the promonocytic U937 cells.
109 denosine deaminase [ADAR1] and RNA-dependent protein kinase [PKR]) in a tissue-specific manner compar
110 human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phospho
112 te that ADAR1 interacts with dsRNA-activated protein kinase PKR, inhibits its kinase activity, and su
113 duced, double-stranded RNA (dsRNA)-activated protein kinase, PKR, inhibits protein synthesis via phos
114 o shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and
115 The mammalian double-stranded RNA-activated protein kinase PKR is a component of the cellular antivi
117 The double stranded RNA (dsRNA)-activated protein kinase PKR is a ubiquitously expressed serine/th
123 The double-stranded RNA (dsRNA)-activated protein kinase PKR is an interferon (IFN)-induced enzyme
128 ucible double-stranded RNA (dsRNA)-activated protein kinase PKR is regulated by dsRNAs that interact
129 ucible double-stranded RNA (dsRNA)-dependent protein kinase PKR is reported to initiate apoptosis in
130 rferon-induced double-stranded RNA-activated protein kinase PKR is the prototype of a class of double
132 8) of the interferon-induced dsRNA-activated protein kinase (PKR) is a cellular protein recruited by
133 rferon-induced double-stranded RNA-activated protein kinase (PKR) is a cellular protein that is activ
136 anded-RNA (dsRNA)-activated serine-threonine protein kinase (PKR) is a major mediator of the antivira
138 ex virus 1 the double-stranded RNA-dependent protein kinase (PKR) is activated but phosphorylation of
140 Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection,
142 nduced double-stranded RNA (dsRNA)-activated protein kinase (PKR) is an antiviral agent that is activ
144 The human double-stranded RNA-dependent protein kinase (PKR) is an important component of the in
150 how that dsRNA activation of dsRNA-activated protein kinase (PKR) is associated with induction of TNF
151 infection, the double-stranded RNA-dependent protein kinase (PKR) is best known for triggering cell d
154 ression of the double-stranded RNA-activated protein kinase (PKR) is induced by interferons, with PKR
155 show that the double-stranded RNA-dependent protein kinase (PKR) is involved in the long-term effect
156 duced, double-stranded RNA (dsRNA)-activated protein kinase (PKR) is mediated through dsRNA binding l
157 dence that the double-stranded RNA-dependent protein kinase (PKR) is not required for virus-induced e
160 -stranded (ds)RNA-activated serine-threonine protein kinase, PKR, is a key mediator of the antiviral
161 t that the double-stranded (ds)RNA-dependent protein kinase, PKR, is a regulator of diverse cellular
162 The interferon-induced serine/threonine protein kinase, PKR, is activated in response to various
164 ently that the double-stranded RNA-dependent protein kinase, PKR, is involved in translational regula
165 feron-induced, double-stranded RNA-activated protein kinase, PKR, is responsible for reovirus-induced
166 ylation of the double-stranded RNA-dependent protein kinase PKR leading to phosphorylation of its dow
167 pha) by the interferon-induced RNA-dependent protein kinase, PKR, leads to inhibition of translation
168 absence of the double-stranded RNA-dependent protein kinase PKR led to a profound defect in the capac
169 including the double-stranded RNA-activated protein kinase (PKR)-like endoplasmic reticulum kinase (
170 RE1alpha), and double-stranded RNA-activated protein kinase (PKR)-like ER kinase (PERK) blocked the m
171 he ER resident protein kinase, RNA-dependent protein kinase (PKR)-like ER kinase (PERK) have paradoxi
172 in mutation does not alter activation of the protein kinase PKR-like ER kinase (PERK), a trigger for
173 a cells, activation of a PERK (RNA-dependent protein kinase [PKR]-like ER kinase)-eIF2alpha (alpha su
174 rferon-induced double-stranded RNA-activated protein kinase, PKR, likely contributes to both the anti
175 degradation of double-stranded RNA-dependent protein kinase (PKR), little is known about the function
176 to their inability to prevent RNA-dependent protein kinase (PKR)-mediated inhibition of protein synt
177 strain in which double-strand RNA-dependent protein kinase (PKR)-mediated phosphorylation of eIF2alp
178 (IFN)-induced, double-stranded RNA-activated protein kinase (PKR) mediates the antiviral and antiprol
179 , induction of double-stranded RNA-activated protein kinase (PKR) mRNA and protein by IFN alpha and/o
180 in, ISG20, and double-stranded RNA-dependent protein kinase (PKR) noncytolytically inhibited the repl
181 1 (IRF-1), the double-stranded RNA-activated protein kinase (PKR), or RNase L (RNase L) (IRF-1(-/-),
182 lung inflammation via toll-like receptor or protein kinase PKR pathways as assessed by lung tissue i
183 L and double-stranded RNA (dsRNA)-dependent protein kinase (PKR) pathways in host interferon inducti
185 response, the double-stranded RNA activated protein kinase PKR phosphorylates the translation initia
187 ouble-stranded RNA (dsRNA)-activated Ser/Thr protein kinase (PKR) plays a role in the antiviral and a
188 stranded (ds) RNA-dependent serine/threonine protein kinase (PKR) plays a role in viral pathogenesis,
191 cible, double-stranded RNA (dsRNA)-activated protein kinase, PKR, plays key roles in regulation of ce
193 The double-stranded RNA (dsRNA)-activated protein kinase (PKR) provides a fundamental control step
194 e product, pK3, binds to the dsRNA-activated protein kinase, PKR, reducing its ability to interact wi
197 nducible, double-stranded (ds) RNA-dependent protein kinase (PKR) regulates protein synthesis initiat
199 ivation of the double-stranded RNA-activable protein kinase, PKR, resulting in the inhibition of prot
200 ression of the double-stranded RNA-regulated protein kinase (PKR) reveal requirements for both caspas
201 ouble-stranded (ds) RNA, the dsRNA-dependent protein kinase (PKR) sequentially undergoes autophosphor
202 ression of the double-stranded RNA-activated protein kinase (PKR) significantly increased the stabili
204 nase (JNK) and double-stranded RNA-dependent protein kinase (PKR) to induce autophagy with hallmarks
205 nes, including myxovirus resistance-1 (Mx1), protein kinase (PKR), transforming growth factor-beta1 (
206 (IFN)-induced, double-stranded RNA-activated protein kinase (PKR) via the PKR eukaryotic initiation f
207 expression of double-stranded RNA-activated protein kinase (PKR) was decreased by 55% in ALD livers.
208 ding the interferon-inducible, RNA-dependent protein kinase (PKR) was isolated as lambda phage and P1
210 ion of interferon-inducible, dsRNA-dependent protein kinase PKR, we sought to identify FANCC-binding
211 levels of the double-stranded RNA activated protein kinase (PKR) were expressed in HHV-8-infected ce
212 of the double-stranded RNA (dsRNA)-dependent protein kinase (PKR), whereas the isogenic parental viru
213 is required to activate the dsRNA-dependent protein kinase PKR, whereas hetero-dimerization between
214 ases including double-stranded RNA-dependent protein kinase (PKR), which has been recently implicated
216 to NF-kappaB depends on the dsRNA-responsive protein kinase (PKR), which in turn activates IKB kinase
217 dactivates the double-stranded RNA-dependent protein kinase (PKR), which leads to phosphorylation of
218 ts containing uridine activate RNA-dependent protein kinase (PKR), which then phosphorylates translat
219 ed by two intracellular enzymes, RNase L and protein kinase PKR, which function in interferon-treated
220 at the double-stranded RNA (dsRNA)-dependent protein kinase PKR, which has been shown to function as
221 ranscriptionally activate the RNA-responsive protein kinase PKR, which then interacts with RIP1 to in
222 ein that also binds and activates the latent protein kinase, PKR, which plays a major role in cellula
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