ライフサイエンスコーパス: protein level

1 sed by functional assays at both genetic and protein level.

2 t difference on methylome, transcriptome and protein level.

3 ically took several hours to manifest on the protein level.

4 d not just at the RNA level, but also at the protein level.

5 immune responses at the transcriptional and protein level.

6 ation of these pathways was confirmed at the protein level.

7 the absence of PsbQ' protein at genetic and protein level.

8 e amount of HDM2 protein correlates with HBx protein level.

9 hese pathways were validated at the mRNA and protein level.

10 phages led to significant reduction of STAT3 protein level.

11 immune response was verified at the mRNA and protein level.

12 some inhibitor partially restores the alpha1 protein level.

13 g PIF4 activity, through a reduction in PIF4 protein level.

14 rotein Vif (viral infectivity factor) at the protein level.

15 levels in HCEC, but had no effect on CYP27B1 protein levels.

16 ressed VitD Receptor (VDR), both on mRNA and protein levels.

17 and up-regulation of MT1-MMP at the gene and protein levels.

18 tial for DNA damage-induced increase of PTEN protein levels.

19 the decreased lysosomal gene expression and protein levels.

20 he left ventricles of RacET mice on mRNA and protein levels.

21 xpression of RANKL was evaluated at mRNA and protein levels.

22 of thyroid cancer cell lines at the mRNA and protein levels.

23 phenotypic information such as cell-surface protein levels.

24 aptic strength, dynamically regulates Tomo-1 protein levels.

25 protein cholesterol but increased C-reactive protein levels.

26 al hypertrophic phenotype by regulating IP3R protein levels.

27 decreased interleukin (IL)-4, IL10 and IL-13 protein levels.

28 nalysis Consortium at the peptide, gene, and protein levels.

29 N 1 (RCAN1) in the DRG at the transcript and protein levels.

30 nt in regulating cellular NEIL1 steady state protein levels.

31 , which degrade and suppress steady-state LT protein levels.

32 ecreased in Ct-infected ESC at both mRNA and protein levels.

33 antly reduced gene expression at the RNA and protein levels.

34 rts Gln into glutamate, at both the mRNA and protein levels.

35 olyubiquitination of TRAF2 and reduces TRAF2 protein levels.

36 the transcriptional, cellular, and secreted protein levels.

37 distribution and dramatically decreases MBP protein levels.

38 P-mutant mice show a reduction in alpha-SNAP protein levels.

39 ith GLUT5 mRNA levels but is linked to GLUT5 protein levels.

40 lysis were used to measure messenger RNA and protein levels.

41 increased IFN-lambda levels at the gene and protein levels.

42 mor necrosis factor (TNF)-alpha and IL-1beta protein levels.

43 ECD translation as the mechanism for reduced protein levels.

44 ARP-1 ubiquitination, which decreased PARP-1 protein levels.

45 or of cardiac hypertrophy by regulating IP3R protein levels.

46 these two sites and results in reduced Cbl-b protein levels.

47 bon concentration at both the transcript and protein levels.

48 nd ATF4 levels but robust increases in GRP78 protein levels.

49 e fine regulation at the transcriptional and protein levels.

50 Some had paresthesias (17%), elevated CSF protein level (13%), and other features sometimes consid

51 ed no evidence of decreasing AmCYAN1 and PMI protein levels across generations and no transgene silen

52 Protein-level adaptations to hypoxic high-altitude condi

53 ession of these signature genes, at mRNA and protein levels, after small interfering RNA-mediated sil

54 Biophysical characterization and protein-level analysis of the DeltapntA mutant revealed

55 ns leading to reduced, but not absent, P4HA1 protein level and C-P4H activity in dermal fibroblasts c

56 1 KD in hippocampal neurons increased Tomo-1 protein level and dendritic spine density.

57 fection significantly upregulates the CaV2.1 protein level and enhances CaV2.1 protein stability.

58 was substantially less active, normalized to protein level and expressed poorly.

59 f mice expressing EAAC1 leads to reduced D1R protein level and increased stereotyped movement executi

60 n vivo data; sirtinol decreased liver PEPCK1 protein level and prevented pyruvate-induced blood gluco

61 and a concomitant reduction in IRP1 and IRP2 protein level and RNA-binding activity.

62 w that NiCl2 (Ni(II)) or hypoxia reduces the protein level and shortens the half-life of cytoplasmic

63 eased pyruvate dehydrogenase kinase 1 (PDK1) protein levels and a decreased pyruvate dehydrogenase en

64 Further experiments demonstrated that the protein levels and activities of oxidative phosphorylati

65 we show that activated CF MPhis have reduced protein levels and altered localization of the remaining

66 in ligase complex, reduces Aiolos and Ikaros protein levels and BAFF- and CD40L-induced proliferation

67 We find that histone H3.3 stabilizes DAXX protein levels and can affect DAXX-regulated gene expres

68 We also found that PPM1F protein levels and colocalization with CAMK2G were alter

69 Results showed that MMP13 protein levels and enzymatic activity decreased signific

70 Y transcripts but dramatically decreased PSY protein levels and enzymatic activity, leading to reduce

71 FISH reports mRNA changes that correspond to protein levels and gene copy number.

72 (WF) and gingival biopsies were analyzed for protein levels and gene expression, respectively, of rel

73 We quantify 539 associations between protein levels and gene variants (pQTLs) in a German coh

74 decreased oxidative metabolism, whereas DLST protein levels and hence oxidative metabolism were parti

75 ations in DONSON substantially reduce DONSON protein levels and impair fork stability in cells from p

76 IR is associated with lower protein levels and intron-retaining transcripts that esc

77 , but not mutagenized, C1qbp restored OXPHOS protein levels and mitochondrial enzyme activities in C1

78 alyses show progressive changes in ribosomal protein levels and mitochondrial function as early disea

79 ingdom), which reduced both serum C-reactive protein levels and peripheral blood monocyte secretion o

80 ion, while PKCzeta knockdown stabilizes RAGE protein levels and prevents ODN2006-mediated degradation

81 f age, wildtype mice showed altered synaptic protein levels and relatively superior cognitive perform

82 tion from Grn(-/-) mice normalizes lysosomal protein levels and rescues FTLD-related behavioral abnor

83 quitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1beta release after TLR

84 onstrated that these mutations reduce MRPS34 protein levels and the synthesis of OXPHOS subunits enco

85 K, also showed significantly decreased total protein levels and trafficking to the cell surface, whil

86 fied alterations of Her2 at the DNA, RNA and protein level, and demonstrate that Her2 relevance as a

87 y upregulated MTSS1 at the messenger RNA and protein level, and the accumulated protein was functiona

88 the dynamics of VSG coat replacement at the protein level, and the impact of this process on success

89 patic lipogenesis as judged by the activity, protein levels, and expression of several fatty acid syn

90 radation tightly couples RGS2 transcription, protein levels, and function.

91 onsistently, T63 up-regulated RUNX2 mRNA and protein levels, and knockdown of RUNX2 reduced the osteo

92 l as XLKO Ocy454 cells, showed elevated SNX9 protein levels, and siRNA-mediated knockdown of SNX9 in

93 m lung cancer patients, both at the mRNA and protein levels, and that low caveolin-1 expression is as

94 isease, mutation details at the DNA, RNA and protein levels, and updates to the ZFIN single box searc

95 Here we report that MCPIP1 protein levels are decreased during renal cancer progres

96 out mice and their upstream regulator, FoxO1 protein levels are decreased via proteasome-dependent de

97 MyD88 protein levels are increased during in vitro myogenesis

98 Heat shock protein levels are often elevated in both carcinogenesis

99 s in TBK1 that cause a 50% reduction of TBK1 protein levels are pathogenic.

100 emonstrate that E2F1 mRNA stability and E2F1 protein levels are reduced in cells lacking RALY express

101 present in spinal cord microglia, and RGS10 protein levels are suppressed in the spinal cord in a ne

102 accurate measurement of the extent to which proteins levels are adjusted to counter external stimuli

103 itatively characterized actin transcript and protein levels, as well as cellular phenotypes, in both

104 CA mutated tumors expressed higher p-AKT/AKT protein levels, both within primary (p < 0.001) and meta

105 1S heterozygotes showed no decrease of PINK1 protein levels but a sustained, significant reduction in

106 ins by impairing SIRT2 catalytic activity or protein levels but not its localization or binding with

107 ER stress induction led to a reduced ECD protein level, but this effect was not seen in PKR-like

108 sitivity and a reduction in SS18 and SMARCB1 protein levels, but an SSX18-SSX1 Delta71-78 fusion cont

109 Protein levels, but not mRNAs levels, of EtOH-metabolizi

110 ompanied by a 74% increase in cellular LFABP protein levels, but only when cells were exposed to 0.4

111 HTRA2 regulates TRAP1 protein levels, but TRAP1 is not a direct target of HTRA

112 27A1 in prostate cancer was confirmed at the protein level by immunostaining for CYP27A1 in annotated

113 is well-known that Nrf2 is regulated at the protein level by proteasomal degradation via Kelch-like

114 ature, carbonic anhydrase XII (CA12), at the protein level by western blot and immunohistochemistry.

115 Specific findings were confirmed at the protein level by Western blot.

116 6 (hereafter CDK4/6) in vivo increases PD-L1 protein levels by impeding cyclin D-CDK4-mediated phosph

117 ed both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGR

118 e expression by RNA sequencing and for serum protein levels by Luminex and enzyme-linked immunosorben

119 Control of protein levels by nucleic-acid-based technologies has pr

120 C6 ceramide increases IQGAP1 protein levels by preventing its cleavage.

121 e profiling of glycosylation patterns at the protein level, by comparing originator and biosimilars m

122 Increasing or decreasing hypothalamic MANF protein levels causes hyperphagia or hypophagia, respect

123 ificantly higher highly sensitive-C-reactive protein levels compared to Controls (2.1 +/- 0.4 vs. 1.0

124 changes including reduced filaggrin mRNA and protein levels, compromised barrier function, marked ult

125 Moreover, the suppression of NORE1A protein levels correlated almost perfectly with elevatio

126 Cav-1 protein levels correlated positively with nab-paclitaxel

127 Low EZH2 protein levels correlated with poor prognosis in AML pat

128 itinates GDU1 at cytosolic lysines, and GDU1 protein levels decreased upon co-expression with active,

129 Although LH2 protein levels did not change, FKBP65 deficiency signifi

130 Unexpectedly, tau mRNA and protein levels did not differ between the forebrain and

131 While gene expression and protein levels did not reveal any changes in the physiol

132 In Aiptasia, NF-kappaB protein levels, DNA-binding activity, and tissue express

133 n mediating disease, but gene expression and protein levels do not always correlate.

134 As a result, protein levels do not scale linearly with mRNA levels, b

135 CDC-42 to control actin organization and AJ protein levels during epithelial morphogenesis.

136 ll lines, including those with abundant IRF7 protein levels (e.g. dendritic cells).

137 At the protein level, female ARVMs exhibited higher protein kin

138 At the protein level, ferredoxin, the cytochrome-b6f complex, a

139 t, in mice, liver mass, hepatocyte size, and protein levels follow a daily rhythm, whose amplitude de

140 Expression changes were confirmed at protein level for TGF-beta1 and ENG.

141 d to understand degradation mechanism at the protein level for the lignin/dye/fungus system.

142 t notably hemideletion females show elevated protein levels for ERK1 as well as the related kinase ER

143 gene replacements allowing for modulation of protein levels for otherwise lethal knockouts (KOs).

144 urgent unmet need to accurately quantify SMN protein levels for screening and therapeutic monitoring

145 Serum protein levels for these candidates were measured in a 2

146 ant decrease in synaptic gene expression and protein levels, glutamate neurotransmitter release, and,

147 uch research attention because its decreased protein level has been associated with poor prognosis of

148 Astrocyte-specific rescue of SMN protein levels has been shown to mitigate disease manife

149 show that Plk3 in turn suppresses the SIAH2 protein level in a kinase activity-dependent manner.

150 s) into Mtm1KO mice efficiently reduces DNM2 protein level in muscle and prevents the myopathy from d

151 y post-translational modifications at native protein level in order to correlate their influence on t

152 ld greater activity (323%) at any given FN3K protein level in the erythrocytes of the negative-GGap g

153 1 with rapamycin induces PIM3 transcript and protein levels in a variety of settings.

154 emonstrate a reduction of membralin mRNA and protein levels in Alzheimer's disease (AD) brain, the la

155 ulated and positively correlated with MYC at protein levels in breast cancer.

156 ies confirmed an increase in IL-17C mRNA and protein levels in cells infected with cagA-positive infe

157 nslational control of ACC1 and adjusts Acc1p protein levels in different nutrients.

158 reased MMP-7 activity and reduced N-cadherin protein levels in HAAA sections compared to HA.

159 f this study was to determine SGLT2 mRNA and protein levels in human and animal models of diabetic ne

160 sized that vitamin D deficiency alters TRAIL protein levels in human breast milk and mammary epitheli

161 High Rep protein levels in S/G2 phase support AAV2 replication an

162 d that integrated investigations of mRNA and protein levels in single cells allows comprehensive anal

163 Both treatments reduced the O-GlcNAcylated protein levels in SKO mice, and dapagliflozin successful

164 S showed elevated NOS2 and decreased ADAMTS1 protein levels in the aorta.

165 s, cases had significantly higher C-reactive protein levels in the discovery, replication, and pooled

166 its deacetylase activity or diminishing its protein levels in the DNA-damage response.

167 phosphorylated cAMP-response element binding protein levels in the NAcSh that could account for the i

168 veral tissues, also leading to increased hGH protein levels in the serum.

169 VAR2CSA protein levels in var2csa-transcribing parasites are dep

170 Compromised Pdx1 mRNA and protein levels in weaned male mutant beta-cells were tig

171 nfirmed upregulation of MMP9 and MMP2 at the protein level, in AdMSC and T cells, respectively.

172 In the C-terminal Cys mutant, TF protein levels increase both in the cell and in the rele

173 Clinically, Bag-1L protein levels increase with progression to castration-r

174 with arginine (Arg) residues, cellular hD4R protein levels increase.

175 PGRN gene expression and protein levels increased concomitantly with the increase

176 A oscillated with highest levels in G2 while protein levels increased throughout the cell cycle, peak

177 repress mTORC1 activity and maintain ApoB100 protein levels independently of Atf4 expression, whereas

178 Evidence of this gene module at the protein level is found in patient tumor slices displayin

179 somolysis and in vitro siRNA silencing ( 85% protein level knockdown) of the model gene luciferase ac

180 t hosts with normal CSF white blood cell and protein levels (</=5 cells/mm(3) and </=50 mg/dl, respec

181 In addition to differences at the protein level, mass spectrometry-based shotgun lipidomic

182 ollected and analyzed histologically and TNF protein levels measured by enzyme-linked immunosorbent a

183 of 0.92 (reference range, 0.8-2.0), a urine protein level of 15 mg/dL (normal level, <20 mg/dL), a t

184 erence range, 79-125 mumol/L), a serum total protein level of 82 g/L (reference range, 66-81 g/L), a

185 We show that HCMV infection increases the protein level of a cellular trafficking factor, syntaxin

186 However, the protein level of a number of genes (MEP50, CCND1, MYC, H

187 repressing phosphorylation of 4E-BP1 and the protein level of c-Myc.

188 The protein level of FOF2 accumulates in response to light,

189 p300 increased the protein level of HIPK2 via its acetyltransferase activit

190 ed that sirtinol significantly decreased the protein level of PEPCK1, and was accompanied by the hype

191 The protein level of Sesn2 in hearts was gradually decreased

192 ADCs, which include significant decreases in protein level of the tumor supressor genes such as PDCD4

193 in cells and a simultaneous increase in the protein levels of ALIX and ALG-2 are required to elicit

194 suppressing the transcriptional activity and protein levels of both full-length and splice-variant AR

195 diac histomorphology, glutathione levels and protein levels of cathepsin K and those associated with

196 KSHV miR-K9 also decreased the protein levels of cleaved caspase-3, cleaved caspase-7,

197 Here, we investigated the protein levels of eight atypical cyclins in lung cancer

198 Further, the protein levels of ETA receptor were also increased in th

199 ly attenuated after claudin-1 knockdown, and protein levels of extracellular signal-related kinase 1/

200 Indeed, protein levels of fibrosis signaling mediator TGF-beta r

201 a, and its overexpression leads to decreased protein levels of GSK3beta.

202 a histone H3.3 chaperone, and stabilizes the protein levels of HIRA complex components.

203 Moreover, the protein levels of IL17A in BALF were also found greatly

204 lation/inactivation, accompanied by enhanced protein levels of PDH kinases 1 and 3 (PDK1 and PDK3).

205 mTORC2 signaling along with transcripts and protein levels of Pdx-1.

206 The protein levels of RNF31 and LMP1 are correlated in EBV-t

207 rmidine, which was correlated with increased protein levels of RpoS.

208 ophages or dendritic cells, and consequently protein levels of SAMHD1 remain unchanged.

209 odel, and in both mouse models it normalized protein levels of several SCA2-related proteins expresse

210 t puerarin treatment increased both mRNA and protein levels of SIRT1 in podocytes and that puerarin l

211 Interestingly, protein levels of SMC5/6 complex components in oocytes d

212 Paradoxically, protein levels of some Nrf2 antioxidant targets were sig

213 tivation increases the abundance of mRNA and protein levels of the core autophagy-related (Atg) prote

214 Protein levels of the kinase SGK1 did not change.

215 Transcript and protein levels of the PNKD long isoform were reduced in

216 nencapsulated siRNA against Tnf mRNA reduced protein levels of TNF in colon tissues, compared with mi

217 Importantly, we observed that protein levels of Top1 were negatively correlated with t

218 study used western blot analysis to compare protein levels of tyrosine hydroxylase (TH), glutamate d

219 Markedly increased mRNA and protein levels of ZIP7 were observed in ventricular card

220 ceptible CD28 variant, (b) no differences in protein levels on CD4(+) T cells, and

221 conducted to investigate impacts of dietary protein levels on gut bacterial community and gut barrie

222 Conformational HLA and denatured HLA protein levels on SAB were determined using W6/32 and HC

223 TMEM16A protein levels on the cell surface were increased in HEK

224 At the protein level, our data indicate that HBD2 and HBD3 are

225 rofiles, hs-CRP (high-sensitivity C-reactive protein) levels, oxidative stress markers (glutathione a

226 No significant difference in the membrane proteins levels Pdr5p and Can1p was found.

227 Neither vGAT, CB, or GAD67 protein levels per ChC bouton nor the number of boutons

228 nd in patients with CKD, elevated C-reactive protein level predicts cardiovascular risk.

229 In turn, increased ferritin protein levels promote the expression of the promitotic

230 e phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disea

231 In addition, TBK1 protein levels reduced by 50% have been proven for speci

232 overexpressing the AhRR showed lower ERalpha protein levels, reduced responsiveness to estradiol, and

233 oring LAMB4 variants exhibited reduced LAMB4 protein levels relative to controls.

234 L) results in autoactivity, but lowering the protein levels restored its specific activation response

235 The resulting reduction of BET protein levels sensitized cancer cells to BET inhibitors

236 ell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanis

237 vention strategies aimed at decreasing BACE1 protein levels should be regarded with caution, because

238 ated with TNBC patient survival, with ZNF326 protein levels showing a marked reduction in TNBC.

239 DLST protein levels significantly decreased on pressure overl

240 irt1(-/-) presented increased LEF1 and MMP13 protein levels, similar to human OA cartilage.

241 d induced cardiogenic markers at the RNA and protein level, similarly to miR combo treatment.

242 At the protein level, starting with a primitive form in cyanoba

243 ERalpha protein levels, subcellular localization, and transcript

244 asome inhibitor MG132 largely restored c-Jun protein levels, suggesting that LT promotes degradation

245 schizophrenia group had higher TH and GAD67 protein levels than controls (an increase of 69.6%, P=0.

246 s of VSMC and to understand how variation in protein levels that arise due to diabetes contribute to

247 l muscle, and white adipose tissue PPARdelta protein levels that may, in part, explain the observed l

248 lpha (Calpha) expression both at the RNA and protein levels that were also seen in human patients wit

249 At the protein level, the protective His363 NIPA variant exhibi

250 exhibited diminished STAT1 and NF-kappaB Rel protein levels, the essential inducers of iNOS in myeloi

251 At physiological protein levels, the slow HOPS- and SNARE-dependent fusio

252 tally validated that miR-210 regulated GPD1L protein level through direct interaction with its mRNA t

253 htly controlled at the mRNA level and at the protein level through endocytosis and degradation trigge

254 sults, complete blood cell count, C-reactive protein levels, thyroid-stimulating hormone levels, and

255 n Grn(-/-) brain at both transcriptional and protein levels, TMEM106B deficiency causes reduction in

256 ild-type troponin complex corrected troponin protein levels to 83% of controls in the TNNI3p.98trunc

257 igo extension reaction (OER), which converts protein levels to DNA levels, with reverse transcription

258 ence of a feedback circuit to match synaptic protein levels to the transport capacity of the axon.

259 mmation, their serum cytokine and C-reactive protein levels typically are elevated.

260 bosome loading onto Ccnb2 mRNA and Cyclin B2 protein level undergo minimal changes during meiotic ree

261 We record increased interferon alpha protein levels using digital ELISA, enhanced interferon

262 xplained up to 66% of interindividual plasma protein-level variation and, on average, accounted for 3

263 Although urinary Mup protein levels vary between inbred mouse strains, this d

264 ations of C1572 markedly reduced c-MYC (MYC) protein levels via a proteasome-dependent mechanism.

265 patic glucose production by regulating FoxO1 protein levels via proteasome-dependent degradation and,

266 hese findings indicate that LT reduces c-Jun protein levels via two distinct mechanisms, thereby inhi

267 Higher MGMT protein level was significantly associated with decrease

268 Regulation at the gene and protein levels was analyzed using beta-glucuronidase (GU

269 ince genome alteration are manifested at the protein level, we integrated protein and mRNA data of ov

270 l consequences of these FN1 mutations on the protein level, we introduced three disease-associated mi

271 e-rich C-kinase substrate (MARCKS) and LAMC2 protein level were increased with AKT1 inhibition, and M

272 sis-related genes and the circulating ADIPOQ protein level were lower in Brd4 heterozygous mice than

273 However, Cdc25C protein levels were actually increased following Mdm2 de

274 d by quantitative polymerase chain reaction, protein levels were analyzed by immunoblot assays.

275 ex, CD4 cell count, HIV load, and C-reactive protein levels were analyzed.

276 Substantia nigra, putamen, and cortical p11 protein levels were assessed in postmortem brain samples

277 tion of Ito, both Kcnd3 transcript and Kv4.3 protein levels were decreased in HFpEF rat hearts.

278 In addition, Trim32 protein levels were elevated in mice treated with IMQ.

279 DJ-1 protein levels were elevated in plasma from patients wit

280 GLUT5 protein levels were higher in tumor versus muscle tissue

281 stmortem findings, we found that Kal9-P2255T protein levels were higher than those of wild-type Kal9

282 In the Klhl31-knockout mice, FlnC protein levels were highly upregulated with no change in

283 Additionally, OSM protein levels were increased in induced sputum from ast

284 enhanced autophagy initiation, ULK1 mRNA and protein levels were increased in STAT1-deficient cells.

285 Peripheral p11 protein levels were investigated in distinct leukocyte p

286 miR-24 miRNA and menin protein levels were manipulated in vitro in Mz-ChA-1 cel

287 and brain-derived neurotrophic factor (BDNF) protein levels were measured.

288 However, neuronal protein levels were reduced in both mutants.

289 PDH mRNA and protein levels were up-regulated in crd1Delta cells, but

290 Significantly, VprBP protein levels were upregulated in high-grade serous ova

291 ygen consumption ratio (OCR) and higher VDAC protein levels when compared to WT and Myd88(-/-) cells.

292 increases TDP-43 toxicity, aggregation, and protein levels, whereas enhancing endocytosis reverses t

293 neutrophilic asthma and with sputum IL-1beta protein levels, whereas eosinophilic asthma was associat

294 the increased lysosomal gene expression and protein levels, while PGRN overexpression led to the dec

295 RTN3 deficiency causes elevation of BACE1 protein levels, while RTN1 deficiency shows no obvious e

296 h findings in other models of altered TBC1D1 protein levels, whole-animal and ex vivo skeletal muscle

297 The majority of differences are on the protein level with no corresponding change on the mRNA l

298 aize is supported by comparisons of relative protein levels with teosinte as well as by quantitative

299 t associations between type I IFN-alpha/beta protein levels with the DNA methylation status as well a

300 ases basal and gamma irradiation-induced p21 protein levels without affecting p21 mRNA expression.